• Journal of Korean Academy of Nursing
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• v.26 no.3
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• pp.623-631
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• 1996

간호사가 사용하는 중재로서 관심을 표현하는 방법이며 의사소통의 통로인 접촉의 한 형태로서의 마사지가 이완과 안녕감을 증진시킬 수 있는지를 알아보기 위해 간편하면서도 장소에 거의 구애를 받지 않는 손마사지를 미국 미네소타주에 살고 있는 22명의 한국 이민노인에게 시행하였다. 자료수집 기간은 1992년 12월부터 1993년 6월까지 약 6개월이 소요되었다. 편의표출방법으로 대상자를 선정한 원시실험연구설계로, 독립 변수로 손마사지를 사용하였고 이완행동, 수축기혈압, 이완기 혈압, 맥박수로 측정한 이완의 정도와 안녕감을 종속변수로 사용하였다. 손마사지는 Snyder등이 개발한 방법으로 한 손에 2분 30초씩 5분이 소요되는데 이틀에 한번씩 6회 실시하였다. 안녕 감을 측정하는 Cantril ladder는 10개의 사다리로 된 도구로 첫번 마사지전, 세번째 마사지후, 그리고 여섯번째 마사지후에 대상자로 하여금 직접 사다리 점수를 매기도록 하였다. Luiselli등이 개발한 이완행동 측정도구로 각 마사지 전후에 대상자의 이완정도를 관찰하였고, 마사지 전후에 혈압과 맥박수를 측정하였다. 자료는 paired t-test와 ANOVA, repeated measures ANOVA로 분석하였다. 연구의 결과는 다음과 같다. 1. 1-6회 동안의 마사지전의 이완점수의 평균값과 1-6회 동안의 마사지후의 이완점수의 평균값을 비교한 결과 마사지후에 이완의 정도가 유의하게 증가하였고 (t=10.70, p=.000), repeated measures ANOVA로 검증한 시간에 따른 효과도 유의한 차이를 보였다. 2. 1-6회 동안의 마사지전의 수축기 혈압의 평균값과 1-6회 동안의 마사지후의 수축기 혈압의 평균값을 비교한 결과 마사지후에 수축기 혈압이 유의하게 저하되었 다(t=6.09, p=.000). 3. 1-6회 동안의 마사지전의 이완기 혈압의 평균값과 1-6회 동안의 마사지후의 이완기 혈압의 평균값을 비교한 결과 유의한 차이를 보이지 않았다(t=.27, p=.793). 4. 1-6회 동안의 마사지전의 맥박수의 평균값과 1-6회 동안의 마사지후의 맥박수의 평균값을 비교한 결과 마사지후의 맥박수가 유의하게 감소하였다. (t=4.45, p=.001). 5. Cantril 안녕감의 점수는 유의한 차이를 보이지 않았다(F=2.42, p=1.01)

• Korean Journal of Clinical Laboratory Science
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• v.52 no.1
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• pp.45-52
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• 2020

Hypertension often leads to cardiovascular disease and kidney disease, and hypertention is an important worldwide problem. Body mass index (BMI) has an important role for raising blood pressure. Further, hypertension can be affected by both environmental factors and genetic factors. Many single nucleotide polymorphisms have been associated with hypertension. Genome wide association study (GWAS) is a method of confirming a new locus of increasing the risk of disease, and GWAS has confirmed several single nucleotide polymorphisms (SNPs) that are associated with high blood pressure. This study analyzed the relationship between systolic blood pressure, diastolic blood pressure and SNP of the ATP2B1 gene in 994 Koreans. SNPs that showed the highest statistical significance with systolic and diastolic blood pressures were selected on the multiple linear regression analysis. One-way analysis of variance for systolic and diastolic blood pressures was performed, and multiple logistic regression analysis was performed on the risk of hypertension. The P values were two-tailed, and P<0.05 was considered significant. Four SNPs were associated with systolic blood pressure and six SNPs were associated with diastolic blood pressure. In addition, a genotype-based analysis showed significant odds ratios for the risk of hypertension in older men (adjusted OR, 5.743; 95% CI, 1.173~28.121; P=0.031). This study suggests that the ATP2B1 variants affect both the systolic and diastolic blood pressure.

• Journal of the Korean Society of Radiology
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• v.10 no.7
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• pp.511-519
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• 2016

Left ventricular diastolic dysfunction is mostly observed in patients with cardiac disease, such as myocardial ischemia or LVH, but linking is usually observed in healthy people without heart disease. Evaluation of left ventricular diastolic failure in normal cardiac output(systolic function) conditions can affect the progress and prognosis of heart failure. The direct relevance to the epicardial adipose tissue metabolism in cardiovascular engine for generating a bioactive moleculer, which leads to dysfunction of the later had a direct effect on myocardial heart. The purpose of this study is to measure the thickness of the epicardial adipose tissue was to study the relevance of the assessment of diastolic dysfunction in systolic function in normal conditions. Results epicardial adipose tissue thickness and diastolic dysfunction was analyzed to have a high correlation in a statistically significant level. In particular, the epicardial adipose tissue thickness measured at the measuring section EAT2 and diastolic function evaluation E' was found to have a high correlation. Thus epicardial adipose tissue thickness variation is believed can be used as a predictor to evaluate the left ventricular diastolic dysfunction.

• Proceedings of the KOSOMBE Conference
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• v.1995 no.11
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• pp.211-215
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• 1995

전기유압식 좌심실 보조장치에서 모터 전류 파형을 정보로 하여 작동기의 이완기 속도를 조절함으로써 좌심방으로부터 유입되는 혈류량을 조절하는 알고리즘을 개발하였다. 전기 유압식 좌심실 보조장치에서는 혈액의 유입이 능동적으로 이루어지므로, 좌심방 함몰로 인한 심근 손상 및 외부 공기 유입으로 인한 색전증을 방지하기 위해 유입혈류량을 현재 좌심방 내의 상태에 따라 적절히 조절해 주어야 한다. 좌심방 내의 혈액량 정도는 혈액을 유입해내는 작동기의 이완기 동작 시에 소모되는 에너지 크기에 반영되고, 작동기를 구동하는 모터에 들어가는 전류의 크기는 작동기에 공급되는 에너지에 비례하므로, 이 전류 파형의 정보들을 통해 좌심방 내의 상태를 추정해 볼 수 있다. 본 논문에서는 퍼지로직을 적용하여 모터 전류 파형의 이상 유무를 판단한 뒤 이에 따라 작동기의 이완기 속도를 조절하는 알고리즘을 개발하여 모의순환장치 실험을 통해 그 실효성을 검증한 결과를 정리하였다.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1995.10b
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• pp.387-392
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• 1995

전기 유압식 좌심실 보조장치에서 모터 전류 파형을 정보로 하여 작동기의 이완기 속도를 조절함으로써 좌심방으로부터 유입되는 혈류량을 조절하는 알고리즘을 개발하였다. 좌심실 보조장치(Left Ventricular Assist Device, LVAD)는 허혈성 심장질환 등으로 좌심실 의 혈액 박출 기능이 저하된 환자에게 시술하여 정상 상태의 심박출량을 유지할 수 있도록 하는 보조 혈액 박출 기능이이다. 전기 유압식 좌심실 보조장치에서는 혈액의 유입이 능동 적으로 이루어지므로, 좌심방 함몰로 인한 심근 손상 및 외부 공기 유입으로 인한 색전증을 방지하기 위해 유입혈류량을 현재 좌심방내의 상태에 따라 적절히 조절해 주어야 한다. 좌 심방 내의 혈액량 정도는 혈액을 유입해 내는 작동기의 이완기 동작 시에 소모되는 에너지 크기에 반영되고, 작동기를 구동하는 모터에 들어가는 전류의 크기는 작동기에 공급되는 에 너지에 비례하므로, 이전류 파형의 정보들을 통해 좌심방내의 상태를 추정해 볼 수 있다. 본 논문에서는 퍼지로직을 적용하여 모터 전류 파형의 정보들을 통해 좌심방 내의 상태를 추정 해 볼 수 있다. 본 논문에서는 퍼지로직을 적용하여 모터 전류 파형의 이상 유무를 판단한 뒤 에에 따라 작동기의 이완기 속도를 조절하는 알고리즘을 개발하여 모의순환장치 실험을 통해 그 실효성을 검증한 결과를 정리하였다.

• Clinical and Experimental Pediatrics
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• v.49 no.11
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• pp.1202-1210
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• 2006

Purpose : A quantitative and easily measured Doppler index of combined systolic and diastolic ventricular myocardial performance (Tei index) was recently proposed as a potentially useful predictor of global myocardial performance. However, presence of heart rate fluctuation makes it unreliable. Therefore, the modified Tei index was introduced by using tissue Doppler imaging (TDI) which enables measuring contraction and relaxation velocities from myocardium simultaneously. The purpose of this study was to investigate the effectiveness of the modified Tei index in the evaluation of global cardiac function. Methods : Forty eight patients in the acute phase of Kawasaki disease (KD) were studied. These patients were divided into two groups according to the modified Tei index. TDI and conventional echocardiography were performed. Systolic velocity, systolic displacement, E' velocity, E' displacement, A' velocity and A' displacement were measured at the base, mid-septum and the apex of the interventricular septum. Ejection fraction (EF), Tei index and modified Tei index were estimated. Results : Modified Tei index correlated negatively with systolic displacement, E' displacement and A' displacement at the base. Modified Tei index correlated positively with ESR and CRP. EF and Tei index were normal in KD patients. Conclusion : Modified Tei index is a safe, feasible and sensitive index for evaluating global ventricular functions in spite of normal EF and Tei index in KD.

• Journal of the Korea Convergence Society
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• v.11 no.8
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• pp.269-278
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• 2020

The purpose of this study was to investigate the effect of left ventricular diastolic function on exercise capacity in hypertensive patients with obesity compared to the obese group. Adults who visited a general hospital in Gyeonggi-do from 2016 to 2019(man: 308, women: 192) were divided into 4 groups according to hypertension and obesity. In the hypertensive obesity group(IV), the A wave and E/E' wave were significantly higher than the normotensive obesity group(II), and the E' wave was significantly lower(respectively p<0.001). The group IV had significantly lower METS(metabolic equivalents) and exercise duration than the group II(respectively p<0.001). In group IV, E/A ratio was positively correlated with METS(p=0.025) and exercise duration(p=0.026). In contrast, E/E' wave in these groups showed a negative correlation with the exercise duration(p=0.046).

• Sleep Medicine and Psychophysiology
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• v.9 no.1
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• pp.24-33
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• 2002

Objectives: Nasal continuous positive airway pressure (CPAP) corrected elevated blood pressure (BP) in some studies of obstructive sleep apnea syndrome (OSAS) but not in others. Such inconsistent results in previous studies might be due to differences in factors influencing the effects of CPAP on BP. The factors referred to include BP monitoring techniques, the characteristics of subjects, and method of CPAP application. Therefore, we evaluated the effects of one night CPAP application on BP and heart rate (HR) reactivity using non-invasive beat-to-beat BP measurement in normotensive and hypertensive subjects with OSAS. Methods: Finger arterial BP and oxygen saturation monitoring with nocturnal polysomnography were performed on 10 OSAS patients (mean age $52.2{\pm}12.4\;years$; 9 males, 1 female; respiratory disturbance index (RDI)>5) for one baseline night and another CPAP night. Beat-to-beat measurement of BP and HR was done with finger arterial BP monitor ($Finapres^{(R)}$) and mean arterial oxygen saturation ($SaO_2$) was also measured at 2-second intervals for both nights. We compared the mean values of cardiovascular and respiratory variables between baseline and CPAP nights using Wilcoxon signed ranks test. Delta ($\Delta$) BP, defined as the subtracted value of CPAP night BP from baseline night BP, was correlated with age, body mass index (BMI), baseline night values of BP, BP variability, HR, HR variability, mean $SaO_2$ and respiratory disturbance index (RDI), and CPAP night values of TWT% (total wake time%) and CPAP pressure, using Spearman's correlation. Results: 1) Although increase of mean $SaO_2$ (p<.01) and decrease of RDI (p<.01) were observed on the CPAP night, there were no significant differences in other variables between two nights. 2) However, delta BP tended to increase or decease depending on BP values of the baseline night and age. Delta systolic BP and baseline systolic BP showed a significant positive correlation (p<.01), but delta diastolic BP and baseline diastolic BP did not show a significant correlation except for a positive correlation in wake stage (p<.01). Delta diastolic BP and age showed a significant negative correlation (p<.05) during all stages except for REM stage, but delta systolic BP and age did not. 3) Delta systolic and diastolic BPs did not significantly correlate with other factors, such as BMI, baseline night values of BP variability, HR, HR variability, mean SaO2 and RDI, and CPAP night values of TWT% and CPAP pressure, except for a positive correlation of delta diastolic pressure and TWT% of CPAP night (p<.01). Conclusions: We observed that systolic BP and diastolic BP tended to decrease, increase or remain still in accordance with the systolic BP level of baseline night and aging. We suggest that BP reactivity by CPAP be dealt with as a complex phenomenon rather than a simple undifferentiated BP decrease.

• Proceedings of the KIEE Conference
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• 2011.07a
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• pp.1796-1797
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• 2011

본 연구에서는 기존 오실로메트리(oscillomatry) 혈압측정에서 가압 커프의 영향을 최소화 하기위하여, 캐패시턴스 센서를 추가하여 혈압측정 동안의 혈압 및 혈류의 변화량을 측정하여 얻은 신호로 수축기 혈압 및 이완기 혈압을 추정하였다. 필터를 적용한 캐패시턴스 센서의 값을 피크의 크기에 따른 알고리즘을 적용하였으며 얻어진 혈압값과 기존의 혈압계의 값을 비교분석 하였다. 피험자의 연령은 $25{\pm}4$세의 15명을 기준으로 실험하였으며 알콜 및 운동 등 혈압에 영향을 미치는 요소들에 대해 제한 시켰으며 측정 전 15분의 안정을 취했다. 결과적으로 피험자 15명에 대해 수축기 혈압에서의 오차범위는 ${\pm}4$ mmHg이하로 나타났으며 평균 및 표준편차는 각각 2.13 mmHg 과 1.36 mmHg이었다. 이완기 혈압에서는 오차범위가 11명에 대해 수축기혈압과 같았으며 4명은 ${\pm}7mmHg$이상 이였고 평균과 표준편차는 4.20 mmHg와 2.24 mmHg 로 수축기 혈압에서 오차 및 분산 모두 이완기혈압 추정보다 비교적 정확한 값을 검출했다.

• Clinical and Experimental Pediatrics
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• v.48 no.7
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• pp.745-752
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• 2005

Purpose : Adolescent obesity is known to be associated with complications such as hypertension, coronary artery disease and insulin resistance. We measured the common carotid artery by ultrasound as a predictor of atherosclerosis, and investigated the relationship between carotid artery parameters and serum cytokines in obese adolescents. Methods : Twenty-nine obese adolescents(16-17 years old, obesity index>130 percent) and twentyseven normal controls were included. Obesity index and body mass index were calculated from their height and weight. Skin fold thickness was measured at the triceps, and fat mass and fat distribution by bioelectrical impedence analysis. Blood pressure was measured at resting state and serum lipid, insulin, and homocysteine levels after a 12-hour fasting period. Intimal wall thickness, systolic and diastolic diameters of the common carotid artery were measured by ultrasound, and compliance and distensibility calculated by equation. Results : Systolic and diastolic diameters of the carotid artery significantly correlated with arm circumference, body mass index, fat distribution and fat mass. The higher systolic blood pressure was, the larger systolic and diastolic diameter. The higher diastolic blood pressure was, the larger carotid intimal thickness. Insulin levels had positive correlations with systolic, diastolic diameters and serum homocysteine level with intimal thickness. Conclusion : The carotid artery diameter significantly increased with the degree of obesity and blood pressure. The carotid intimal wall thickness significantly correlated with diastolic blood pressure. Measurement of carotid artery thickness, insulin and homocysteine levels might be useful to predict the development of coronary artery disease.