• Analytical Science and Technology
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• v.27 no.6
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• pp.292-299
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• 2014

Iopromide is an X-ray contrast agent that has been detected frequently with high concentration level in surface waters. Structural characterization of degradation products and measurement of degradation efficiency of iopromide by an electron beam irradiation were performed. For the fortified sample with iopromide, electron beam irradiation (UELV-10-10S, klysotrn, 10 MeV, 1 mA and 10 kW) was performed. The chemical structures of I_D_665 and I_D_663, which are degradation products of iopromide, were proposed by interpretation of mass spectra and chromatograms by LC/ESI-MS/MS. The mass fragmentation pathways of mass spectra in tandem mass spectrometry were also proposed. Iopromide was degraded 30.5~98.4% at dose of 0.3~5 kGy, and 97.8~30% in the concentration range $0.5{\sim}100{\mu}g/kg$ at electron beam dose of 0.3 kGy, respectively. Thus, increased degradation efficiency of iopromide by electron beam irradiation was observed with a higher dose of electron beam and lower concentration.

• Journal of radiological science and technology
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• v.44 no.1
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• pp.47-52
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• 2021

The incidence of adverse reactions to iodide contrast media was found to have increased owing to their increased use in computed tomography, but the exact reasons were unknown. Based on reported iodide contrast media adverse reactions data, it is recommended to the components of iodide contrast media before use to minimize adverse reactions. It was found that the use of iopromide and iomeprol in iodide contrast media resulted in a higher incidences of death and threat of life resulting from adverse reactions than other ingredients. Patients who are administered iodide contrast media containing iopromide and iomeprol during the computed tomography test should be carefully examined by the relevant medical professional, as the significance of gender and age varies from component to component. As multiple iodide contrast agents are available, the use of an appropriate iodide contrast media will reduce the incidence of iodide contrast media adverse reactions.