• Title/Summary/Keyword: 이식가능성

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The Study of Factor Concerning Ovum Pick-up and Conception Rate by Ultrasound-Guided Follicular Aspiration in Hanwoo Heifers (한우에 있어서 초음파기기를 이용한 생체내 난자 채취시 채란조건 및 수태율에 관한 연구)

  • 박성재;양보석;임기순;성환후;장원경;정일정;박충생
    • Korean Journal of Animal Reproduction
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    • v.24 no.2
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    • pp.199-208
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    • 2000
  • This study was carried out to investigate of factors concerning to ultrasound-guided follicular aspiration; level of vacuum pressure, diameter of use needle, effect of FSH hormone and conception rate after embryos transfer. 1. Oocytes collection number were 4.2$\pm$2.9 e.a to luteuml phase and follicular phase were 4.4$\pm$3.5 e.a to ovaries of Hanwoo. 2. We taked proper level of aspiration vacuum pressure was 40~120 mmHg to oocytes collection. Oocytes collected number were 4.2$\pm$3.2, 4.3$\pm$3.4, 4.5$\pm$3.4 e.a. to 40, 80, 120mmHg, respectively, follicles aspiration rate were 49, 47, 45%. 3. Effect of collection needle diameter was not difference significantly(P<0.05), oocytes collected number were 4.4$\pm$3.5 e.a to 170 and 3.0$\pm$1.8 e.a to 18G needle, collected oocytes quality were no difference significantly (P<0.05). 4. Follicles increase number to FSH hormone injection were 6.2$\pm$2.3 e.a to intramuscle and 1.1$\pm$2.7 e.a. to epithelial injection method. 5. Conception rate derived from E.T. was 11.1% to freezing embryos and 46.2% to fresh E.T., difference significantly(P<0.05).

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Surgical Results for Treating Postpneumonectomy Empyema with BPF by Using an Omental Pedicled Flap and Thoracoplasty (전폐절제술 후 기관지 흉막루를 동반한 농흉에서 유경성 대망 이식편과 흉곽성형술을 이용한 수술적 치료에 대한 임상 고찰)

  • Jeong, Seong-Cheol;Kim, Mi-Jung;Song, Chang-Min;Kim, Woo-Shik;Shin, Yong-Chul;Kim, Byung-Yul
    • Journal of Chest Surgery
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    • v.40 no.6 s.275
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    • pp.420-427
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    • 2007
  • Background: Postpneumonectomy empyema (PPE) due to bronchopleural fistula (BPF) can be a surgical challenge for surgeons. We analyzed the follow-up outcomes after performing omentopexy and thoracoplasty for the treatment of PPE with BPF after pneumonectomy. Material and Mehod: Between December 1991 and January 2006, 9 patients underwent BPF closure using an omental pedicled flap for the treatment of PPE with BPF after pneumonectomy. There were 7 males and 2 females (mean age: $45.9{\pm}9$ years). The patients were followed up for a mean of 58 months (median: 28 months, range: $6{\sim}169$). When we performed omentopexy, the surgical procedures for empyema were thoracoplasy for 8 patients and the Clagett procedure for 1 patient. Thoracoplasty was performed for the latter patient due to recurrence of empyema, Result: For the 8 patients who were treated by omentopexy and thoracoplasty, there was 1 operation-related death due to sepsis. During follow up, 1 patient, who was treated by omentopexy and a Clagett procedure, died of acute hepatitis 40 months postoperatively. The early mortality was 11.1% (8/9). Of the 8 patients, including the 1 late death patient, successful closure of the BPF were achieved in all patients (8/9) and the empyema was cured in 7 patients (7/8). Conclusion: The BPF closure using an omental pedicled flap was an effective method for treating PPE with BPF due to 75-destroyed lung, and thoracoplasty with simultaneous omentopexy was effective and safe for removing dead space if the patient was young and in a good general condition.

Deep Learning-based Professional Image Interpretation Using Expertise Transplant (전문성 이식을 통한 딥러닝 기반 전문 이미지 해석 방법론)

  • Kim, Taejin;Kim, Namgyu
    • Journal of Intelligence and Information Systems
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    • v.26 no.2
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    • pp.79-104
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    • 2020
  • Recently, as deep learning has attracted attention, the use of deep learning is being considered as a method for solving problems in various fields. In particular, deep learning is known to have excellent performance when applied to applying unstructured data such as text, sound and images, and many studies have proven its effectiveness. Owing to the remarkable development of text and image deep learning technology, interests in image captioning technology and its application is rapidly increasing. Image captioning is a technique that automatically generates relevant captions for a given image by handling both image comprehension and text generation simultaneously. In spite of the high entry barrier of image captioning that analysts should be able to process both image and text data, image captioning has established itself as one of the key fields in the A.I. research owing to its various applicability. In addition, many researches have been conducted to improve the performance of image captioning in various aspects. Recent researches attempt to create advanced captions that can not only describe an image accurately, but also convey the information contained in the image more sophisticatedly. Despite many recent efforts to improve the performance of image captioning, it is difficult to find any researches to interpret images from the perspective of domain experts in each field not from the perspective of the general public. Even for the same image, the part of interests may differ according to the professional field of the person who has encountered the image. Moreover, the way of interpreting and expressing the image also differs according to the level of expertise. The public tends to recognize the image from a holistic and general perspective, that is, from the perspective of identifying the image's constituent objects and their relationships. On the contrary, the domain experts tend to recognize the image by focusing on some specific elements necessary to interpret the given image based on their expertise. It implies that meaningful parts of an image are mutually different depending on viewers' perspective even for the same image. So, image captioning needs to implement this phenomenon. Therefore, in this study, we propose a method to generate captions specialized in each domain for the image by utilizing the expertise of experts in the corresponding domain. Specifically, after performing pre-training on a large amount of general data, the expertise in the field is transplanted through transfer-learning with a small amount of expertise data. However, simple adaption of transfer learning using expertise data may invoke another type of problems. Simultaneous learning with captions of various characteristics may invoke so-called 'inter-observation interference' problem, which make it difficult to perform pure learning of each characteristic point of view. For learning with vast amount of data, most of this interference is self-purified and has little impact on learning results. On the contrary, in the case of fine-tuning where learning is performed on a small amount of data, the impact of such interference on learning can be relatively large. To solve this problem, therefore, we propose a novel 'Character-Independent Transfer-learning' that performs transfer learning independently for each character. In order to confirm the feasibility of the proposed methodology, we performed experiments utilizing the results of pre-training on MSCOCO dataset which is comprised of 120,000 images and about 600,000 general captions. Additionally, according to the advice of an art therapist, about 300 pairs of 'image / expertise captions' were created, and the data was used for the experiments of expertise transplantation. As a result of the experiment, it was confirmed that the caption generated according to the proposed methodology generates captions from the perspective of implanted expertise whereas the caption generated through learning on general data contains a number of contents irrelevant to expertise interpretation. In this paper, we propose a novel approach of specialized image interpretation. To achieve this goal, we present a method to use transfer learning and generate captions specialized in the specific domain. In the future, by applying the proposed methodology to expertise transplant in various fields, we expected that many researches will be actively conducted to solve the problem of lack of expertise data and to improve performance of image captioning.

새롬미 F1의 유즙에서 EPO생산

  • 이연근;박진기;민관식;김광식;성환후;최선호;이향흔;장원경;정일정
    • Proceedings of the KSAR Conference
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    • 2001.03a
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    • pp.57-57
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    • 2001
  • Erythropoietin(EPO)는 혈액의 구성성분 중에서 적혈구 세포 증식에 중요한 기능을 한다고 알려져 있으며, 최근에는 암, 에이즈의 치료 등에도 효과가 있는 것으로 확인되고 있다. 따라서 본 연구팀은 지금까지 hEPO 유전자를 이용하여, 형질전환 돼지 "새롬이"의 생산에 성공한바 있다. 새롬이의 정액을 활용하여 인공수정을 실시 새롬이의 Fl를 24두 생산하였다. 이에 대하여 "형질전환 돼지의 계대번식시 유전자 전이효율에 관한 연구"라는 제목으로 발표 할 예정이며, 형질전환에 사용된 promoter가 WAP이므로, Fl이 임신, 분만을 하여야만 유즙을 통하여 hEPO물질을 생산할 수 있다. 따라서, Fl(♂)$\times$Fl(♀)의 교배에 의하여 5두가 임신, 분만을 하였으며, 이들 중 1두는 분만 후 21일에 폐사하였으며, 나머지는 현재 정상적으로 사육되고 있다. 이들 5두에 대하여 분만 후 유즙을 채취하여 유즙속에 EPO의 발현여부를 검토하였다. EPO-ELISA kit(medac)를 사용하여 분석결과, 유즙을 8,000배로 희석을 하여야만 Standard curve(1.25~160 mIU/$m\ell$)안에서 EPO의 단백질 발현을 검출할 수 있었다. 5두의 각각 농도는 28, 58, 17, 37, 27 IU/${\mu}\ell$ 였다. 또한 cDNA EPO와 genome EPO를 CHO 동물세포에서 생산하여 10배로 농축한 결과 5.5와 11 IU/${\mu}\ell$의 농도로 유즙과 비교하면 약 20~30배의 낮은 발현양을 나타내었으며, 또한 이러한 결과는 소변에서의 결과(1.1 IU/$m\ell$)보다는 약 30,000배 이상 높은 발현량을 화인 할 수 있었다. 현재, 이들 유즙 물질을 활용 빈혈 질환실험동물을 이용하여 생리활성을 검정, 체내에서 metabolic clearance rate(MCR)를 검토 중에 있다. 또한 F2의 자돈생산은 모돈 5두에서 총 25두가 생산되었는데, 이중 20두 약 80%가 EPO 유전자의 전환율을 나타내었다. 이상을 종합하면, 1) 돼지이용 생리활성물질(EPO)을 유즙에서 대량으로 생산할 수 있는 system의 활용가능성을 국내에서 처음으로 확인하였으며, 2) EPO에 있어서는 국제적으로도 형질전환 가축생산은 최초로 성공하였으며, 현재로서는 생산되어진 물질의 정제수준에 따라 활용가치가 결정되어 질 것으로 사료된다. 생리활성 물질을 생산할 수 있는 형질전환 돼지 생산의 성공은, 앞으로 형질전환 가축생산 뿐 만 아니라, 장기이식 및 복제돼지 생산의 활용 면에서의 응용가능성이 기대된다.

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Eliminating Request Starvation due to Expectation Discrepancy between NCQ and I/O Scheduler (NCQ와 입출력 스케줄러의 기대 불일치로 인한 입출력 요청의 굶주림 현상 제거)

  • Yu, Young-Jin;Shin, Dong-In;Jung, Im-Young;Yeom, Heon-Young
    • Journal of KIISE:Computing Practices and Letters
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    • v.15 no.5
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    • pp.400-404
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    • 2009
  • Native Command Queueing is a technology to maximize throughput of disk system by reordering requests in its command queue. Recent S-ATA 2 standard specifies a protocol for the purpose of dealing with NCQ feature, making most vendors implementing it in their disk devices. However, the new feature, NCQ, may lead to information gap between OS and disk drive. 05 considers that disk will service I/O requests in the order as OS has dispatched. Unfortunately, it isn't true any more since NCQ would simply ignore the policy of OS and reorder the sequence OS has expected. Let us define the term as expectation-discord. Due to the discord, serious performance anomalies or starvation of requests may occur in I/O subsystem. In this paper, we confirm that the expectation-discord actually brings about starvation of requests. We propose a solution to settle it. Our solution is very simple, effective, cheap(not requiring any hardware modification) and portable across various OS. Experimental results show that our solution can balance throughput and response time very well.

Guidelines of IRPA/ICNIRP for Non-ionizing Radiation (비이온화방사선에 대한 IRPA/ICNIRP의 제반지침)

  • Lee, Soo-Yong
    • Journal of Radiation Protection and Research
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    • v.20 no.3
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    • pp.143-154
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    • 1995
  • In recent years, the development of new technologies using static magnetic fields has increased the possibility of human exposure to these fields and raised some concern as to their possible health effects. In several countries, governmental or other competent authorities have issued exposure limits that are mainly intended for specific uses, i.e., magnetic resonance imaging (MRI) and particle accelerators for high-energy Physics. Since applications of magnetic fields in industry and medicine are likely to grow in the future, thus increasing the possibility of occupational and general public exposure, and since the number of people with ferromagnetic implants and implanted electronic devices that can be affected by the fields is growing, there is a need for international guidelines. In the present papers, guidelines on limits of exposure to static magnetic fields are selected and discussed in order to review the guidelines of the International Non-ionizing Radiation Committee of the International Radiation Protection Association (IRPA/INIRC) for non-ionizing radiation(NIR)

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Biocompatibility of Biodegradable Films by Natural Polymers (천연고분자 분해성 필름의 생체적합성 연구)

  • Hwang, Sung Kwy;Lee, Ki Chang;Rhim, Kook Hwan
    • Applied Chemistry for Engineering
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    • v.10 no.6
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    • pp.939-943
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    • 1999
  • Recently there has been an explosion of interest in the topic of biodegradable polymers for medical applications. In this study, films were prepared by solution casting method using natural polymers (xanthan, locust bean, guar gum, chitosan and algin) as biomaterials. Biocompatibility of films prepared from natural polymer as a skin implant was evaluated. These biodegradable films were subcutaneously implanted in the back of rats and their biodegradability was investigated by the evaluation of changes in structure, film weight and hematology as a function of time for the biotransformation. The result of rats test showed that locust bean and guar gum induced some suspects of non-biocompatibility in the tissue by foreign body reaction 24 and 48 hrs after implantation. These results showed the potential of partial biodegradable films prepared from natural polymer for ideal skin biomaterials at short period.

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Hardware Implementation of Facial Feature Detection Algorithm (얼굴 특징 검출 알고리즘의 하드웨어 설계)

  • Kim, Jung-Ho;Jeong, Yong-Jin
    • Journal of the Institute of Electronics Engineers of Korea CI
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    • v.45 no.1
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    • pp.1-10
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    • 2008
  • In this paper, we designed a facial feature(eyes, a moult and a nose) detection hardware based on the ICT transform which was developed for face detection earlier. Our design used a pipeline architecture for high throughput and it also tried to reduce memory size and memory access rate. The algerian and its hardware implementation were tested on the BioID database, which is a worldwide face detection test bed, and its facial feature detection rate was 100% both in software and hardware, assuming the face boundary was correctly detected. After synthesizing the hardware on Dongbu $0.18{\mu}m$ CMOS library, its die size was $376,821{\mu}m^2$ with the maximum operating clock 78MHz.

Chondrogenesis of Periosteum-derived Progenitor Cells on Hyaluronic Acid Fiber Scaffold (Hyalograft $3D^{\circledR}$)

  • Shin, Hyun-Chong;Choi, Yong-Soo;Lim, Sang-Min;Lee, Chang-Woo;Kim, Dong-Il
    • 한국생물공학회:학술대회논문집
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    • 2005.04a
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    • pp.239-243
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    • 2005
  • Periosteum-derived progenitor cells (PDPCs) were isolated and characterized by flow cytometric analysis using fluorescence-activated cell sorter (FACS). The chondrogenesis of PDPCs was performed on hyaluronic acid fibers ($Hyalrograft^{\circledR}$) 3D) in chondrogenic induction medium. PDPCs showed the chondrogenic potential when cultured on hyaluronic acid fibers. These results showed that the characterized PDPCs were the chondrogenic progenitor cells and $Hyalrograft^{\circledR}$ 3D served as a useful carrier for PDPCs in transplantation proliferation, matrix synthesis and differentiation. Therefore, it could be used as a matrix for healing the defected cartilage.

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Diagnosis and Management of Acute Liver Failure in Children (소아에서 급성 간부전의 진단과 치료)

  • Shim, Jung Ok
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.11 no.sup2
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    • pp.50-58
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    • 2008
  • Acute liver failure is a devastating disease in children. Most cases of acute liver failure in children are indeterminate; however, metabolic liver disease is one of the main causes in the pediatric age group. Though a major symptom of acute liver failure is hepatic encephalopathy, this is very difficult to diagnose, particularly in younger children. Liver transplantation has improved the chances of survival dramatically; however, it is not known which patients are ideal candidates for liver transplantation. Because patients may deteriorate rapidly, arranging care in a center with expertise will secure the best possible outcomes.

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