• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.4D
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• pp.459-467
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• 2008

Because of the insufficiency of ground space, the utilization of underground is getting more and more in these days. Moreover, underground space is being used not only buildings but multipurpose space for movement, storage and shopping. However, ground space has vital weakness for fire compared to ground space. Especially in case of underground shopping center, there are various stuffs to burn and poisonous gas can be exposed on this count when the space is burned. A large number of casualties can be also occurred from conflagration as underground space has closed structures that prevent rapid evacuation and access. Therefore, this research proposes the guidance methodology for evacuation from conflagration in large-sized underground facilities. In addition, suggested methodology uses high technology wireless sensor information from up-to-date ubiquitous sensor networks. Fire information collected by sensors is integrated with existing underground facilities information and this is sent to guidance systems by inducing process. In the end, this information is used for minimum time paths finding algorithm considering the passageway capacity and distance. Also, usefulness and inadequacies of proposed methodology is verified by a case study.

• 한국노년학
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• v.30 no.4
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• pp.1163-1177
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• 2010

This study was conducted to establish the appropriate facilities criteria of the Korean welfare devices center. We e-mail surveyed 194 welfare devices centers and analysed 13 blueprints of them. We established the following proper principles of facilities. First, consist type and area of room should depend on the type of welfare devices centers. Second, The flow of human and welfare devices should be simple. Third, the area calculated on the base of intent of center owner and the size of beds, wheelchairs, etc. Fourth, exhibit room facing with roadside may obtain advertising effect. Fifth, the storage and disinfecting room should use different entrance, and avoid the intersection of flow to prevent cross-contamination. Sixth, the access road to the exhibition and consulting room should be able to approach by the wheelchair. seventh, office room should be invisible to keep customer's privacy. Direct Cleaning-disinfecting type center on the premise that the maximum 165m², middle 150m², intermediate 140m², display at least Consultation, Cleaning-disinfecting room, storage (clean, contaminated), the office, equipped with a parking space. Entrust Cleaning-disinfecting type center on the premise that a maximum 134m², middle 119m², intermediate 109m² exhibited minimal activity room, consultation room, office, equipped with a parking space, collecting welfare when importing equipment warehouse (clean, pollution) have been proposed to equip up to.

• Journal of Life Science
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• v.34 no.5
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• pp.356-364
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• 2024

Lymph nodes (LNs) are crucial sites where immune responses are initiated to combat invading pathogens in the body. LNs are organized into distinctive compartments by stromal cells. Stromal cell subsets constitute special niches supporting the trafficking, activation, differentiation, and crosstalk of immune cells in LNs. Fibroblastic reticular cells (FRC) are a type of stromal cell that form the three-dimensional structure networks of the T cell-rich zones in LNs, providing guidance paths for immigrating T lymphocytes. FRCs imprint immune responses by supporting LN architecture, recruiting immune cells, coordinating immune cell crosstalk, and presenting antigens. During inflammation, FRCs exert both spatial and molecular regulation on immune cells through their topological and secretory responses, thereby steering immune responses. Here, we propose a model in which FRCs regulate immune responses through a three-part scheme: setting up, supporting, or suppressing immune responses. FRCs engage in bidirectional interactions that enhance T cell biological efficiency. In addition, FRCs have profound effects on the innate immune response through phagocytosis. Thus, FRCs in LNs act as gatekeepers of immune responses. Overall, this study aims to highlight the emerging roles of FRCs in controlling both innate and adaptive immunity. This collaborative feedback loop mediated by FRCs may help maintain tissue function during inflammatory responses.

• Korean Journal of Environment and Ecology
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• v.24 no.4
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• pp.351-362
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• 2010

This study was supposed to offer vegetation plans for functional improvement of the recreational forest by researching Mt. Chukryong which is located at Oebang-li Sudong-Myon Namyangju Kyong-gi Province in Korea. In this study, artificial vegetation and natural vegetation near trails in recreational forest were researched through biodiversity analysis. From this analysis process, a typical management improvement of the biodiversity functions were examined by reviewing functions biotope condition, vegetation structure and wild bird community condition. Typical vegetation system was divided into four detail parts: Managed artificial Pinus koraiensis forest, Not managed artificial Pinus koraiensis forest, Natural deciduous forest and Not managed deciduous forest. As a result of the vegetation structure, the numerical value of the deciduous forest species diversity was higher than that of artificial Pinus koraiensis, and the numerical value of the managed condition was higher than that of not managed condition. As a result of a habitat structure analysis of the wild bird community, managed Pinus koraiensis forests were inadequate structure for wild birds to habit in there because the forests had weak structure layers, but unmanaged deciduous forest and unmanaged Pinus koraiensis that had diverse layers was proper places for birds to in habit. Thus, based on the functional analysis of biodiversity, management patterns of the target area were concluded in two manners: conserving management and restoring management. Deciduous forest protection target areas included natural deciduous forest area and managed deciduous forest area, ecological restoration target area included unmanaged artificial Pinus koraiensis area and restoring management target area includes managed artificial Pinus koraiensis.

• Clean Technology
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• v.20 no.3
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• pp.306-313
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• 2014

Nanoporous $TiO_2$ films are commonly used as working electrodes in dye-sensitized solar cells (DSSCs). So far, there have been attempts to synthesize films with various $TiO_2$ nanostructures to increase the power-conversion efficiency. In this work, vertically aligned rutile $TiO_2$ nanorods were grown on fluorinated tin oxide (FTO) glass by hydrothermal synthesis, followed by deposition of an anatase $TiO_2$ film. This new method of anatase $TiO_2$ growth avoided the use of a seed layer that is usually required in hydrothermal synthesis of $TiO_2$ electrodes. The dense anatase $TiO_2$ layer was designed to behave as the electron-generating layer, while the less dense rutile nanorods acted as electron-transfer pathwaysto the FTO glass. In order to facilitate the electron transfer, the rutile phase nanorods were treated with a $TiCl_4$ solution so that the nanorods were coated with the anatase $TiO_2$ film after heat treatment. Compared to the electrode consisting of only rutile $TiO_2$, the power-conversion efficiency of the rutile-anatase hybrid $TiO_2$ electrode was found to be much higher. The total thickness of the rutile-anatase hybrid $TiO_2$ structures were around $4.5-5.0{\mu}m$, and the highest power efficiency of the cell assembled with the structured $TiO_2$ electrode was around 3.94%.

• Korean Journal of Plant Resources
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• v.29 no.5
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• pp.598-603
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• 2016

The aim of this study was to elucidate the influence of vigor of a bearing shoot in ‘Bluecrop’ Highbush Blueberry (Vaccinium corymbosum L.) on growth characteristics of shoots and fruits. Bearing shoots were classified with BS (bearing shoot) and BMB (bearing mother branch). The vigor of bearing shoots were divided into four arbitrary categories; A was thin (< 6.0 ㎜) BMB and short (< 10 ㎝) BS, B was thin BMB and long (≥ 10 ㎝) BS, C was thick (≥ 6 ㎜) BMB and short BS and D was thick BMB and long BS. Shoots from D were longer (6.5 ㎝) and thicker (1.70 ㎜) than those from the others. Shoots of D had more leaves (5.8 ea) than those of the others. Leaf area of D was larger (13.5 ㎠) than those of the others. The first harvest of D was one week faster than the others. Ratio of big berry (>14 ㎜) from the long BSs was higher (B : 41.7, D : 46.8%) than that from the short BSs. Soluble solid content of small berrys did not show any different according to vigor of bearing shoots, but soluble solid content of big berrys of the long BSs was higher (B : 16.2, D : 15.6°Bx) than those of the short BSs. The thickness of BMB did not affect ratio of fruit size and soluble soild content. The long BSs would be proper than the short BSs for bearing bigger fruits.

• Korean Journal of Environmental Biology
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• v.36 no.2
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• pp.180-189
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• 2018

Agricultural landscapes in Korea comprise a large cultivation area of rice paddies, other crops, and forests which surround the cropland and the farmers' residential village. The forests in this agricultural landscape play important roles as ecological corridors and refuges for plants and animals in this agroecosystem. The present study investigated the spatial and temporal diversity patterns among these components of the agroecosystem to provide baseline data that describes how fauna change in the studies system. Insect sampling was conducted at four sites in two regions, Chungcheong (Ockcheon and Geumsan) and Jeonnam (Younggwang and Haenam), from March to August of 2014, using an UV light trap for moths and five pitfall traps for beetles. Beetles comprised 225 species and 2,457 individuals in 35 families, while moths consisted of 141 species and 403 individuals in 17 families. Beetles showed higher diversity in Chungcheong than Jeonnam, while moths showed no difference in diversity between regions. Forests showed the highest number of species and individuals, followed by orchards and rice paddies. The food preference of beetles showed that forests contained a higher proportion of herbivores, while orchards and rice paddies had a higher proportion of carnivores. Temporal changes in moths in the two regions were synchronous, while those of beetles were nonsynchronous. Moths increased from spring to summer across all habitats, especially in rice paddies during summer. Beetles also increased from spring to summer in orchards and rice paddies, although the beetles in the forests increased in the middle of summer. A detailed and long-term study is needed to reveal the causes of different diversity patterns of taxa among the different habitats within the agroecosystems.

• Journal of Life Science
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• v.20 no.1
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• pp.103-112
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• 2010

Pemetrexed has demonstrated clinical activity in non-small cell lung cancer (NSCLC) as well as other solid tumors. It transports into the cells via reduced folate carrier (RFC) and is polyglutamated by folypolyglutamate synthetase (FPGS). Pemetrexed directly inhibits several folate-dependent enzymes such as thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). We investigated the effects of genetic variations and the expression of RFC, FPGS, TS and DHFR enzymes on drug sensitivity to pemetrexed in NSCLC cells. Polymorphisms in RFC, FPGS, and DHFR were genotyped in four NSCLC cells - A549, PC14, HCC-1588, and H226. Real-time RT-PCR and Western blot was performed to evaluate mRNA transcripts and protein of these genes. The cytotoxicity of pemetrexed was measured by SRB assay. In PC14 and H226 cells, increased mRNA expressions of RFC and FPGS were associated with higher cytotoxicity to pemetrexed. 2R/2R genotype of TS and its increased mRNA expression were associated with drug resistance to pemetrexed in A549 cells, whereas 3R/3R genotype in TS with decreased mRNA expression was associated with higher sensitivity in H226 cells. After pemetrexed treatment, an inverse change of DHFR mRNA and protein expression was found. The strongest linkage disequilibrium (LD) was discovered between-1726C>T and -1188A>C SNP of DHFR gene. Our findings suggest the cytotoxic effect of pemetrexed may be associated with genetic polymorphisms and the expression level of genes involved in pemetrexed metabolisms in NSCLC cells.

• Journal of the Korean Institute of Landscape Architecture
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• v.44 no.3
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• pp.1-12
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• 2016

This study aimed to interpret the fundamental cause of road-kill occurrences and analyzed spatial characteristics of the road-kill locations from Route 44 in Seorak National Park, Korea. Logistic regression analysis was utilized for backward elimination on variables. Seorak National Park Service has constructed GIS-data of 81 road-kill occurrences from 2008 to 2013 and these data were assigned as dependent variables in this study. Considered as independent variables from previous studies and field surveys, vegetation age-class, distance to streams, coverage of fences and retaining walls, and distance to building sites were assigned as road-kill impact factors. The coverage of fences and retaining walls(-1.0135) was shown as the most influential factor whereas vegetation age-class(0.0001) was the least influential among all of the significant factor estimates. Accordingly, the rate of road-kill occurrence can increase as the distance to building sites and stream becomes closer and vegetation age-class becomes higher. The predictive accuracy of road-kill occurrence was shown to be 72.2% as a result of analysis, assuming as partial causes of road-kill occurrences reflecting spatial characteristics. This study can be regarded as beneficial to provide objective basis for spatial decision making including road-kill occurrence mitigation policies and plans in the future.

• Korean Business Review
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• v.21 no.2
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• pp.137-170
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• 2008

This study is presenting the logistics strategy in the international logistics markets which makes competition and corporation among north-east Asian countries to establishing the multi-pass Eurasian railroads. The countries located in north-east area of Eurasia like China, Japan, Russia and Korea are paying higher costs and disutility to the transportations and communications due to repeated conflicts and confrontations causes from the politic problems. They are being used surface transportation for most of all logistics between Europe and Asia except special merchandises because of characteristic of cargo to be air, the Silk Road remains vestige only which was main logistic passage to this area since BC. So far the Trans-Siberian Railway is being used by Russia mostly as north of Eurasian transport because of difficulties of service. The Trans-China Railway built in 1992 is not accomplishing as a international logistic passages. It is expected to take a long lead time because of characteristic of resource development and poor logistic infrastructure to the countries like Uzbekistan, double landlocked country, Mongolia and Azerbaijan, the countries do not be adjacent to the sea, even they have great economic jump-up plans through the development of their own resources. The Shanghai Cooperation Organization(SCO) start to sail officially in 2001 is constructed with China, Russia, Tadzhikistan, Kyrgyzstan, Kazakhstan and Uzbekistan as regular members of 6 countries and Mongolia, India, Pakistan, Afghanistan and Iran as observers 5 countries. It is started as a military alliance to protect terror, but now, it is expended to cooperate with the traffic, transportation, trade and share of energies. The Russia is doing their best to activate TSR as a government target to developnorth area equivalently, and economic develop of far-east Siberia. And also it is agreed provisionally to improve and repair of rail road between Nahjin and Hassan to connect TSR and TKR( Trans-Korea Railroad) by Russia, North Korea and South Korea with Russian's aggressive efforts. The development plan of this area is over lapped with GTI(Greater Tumen Initiative) promoted by UNDP, and is a cooperated project by 5 countries of South Korea, Mongolia, China, Russia and North Korea, subject to review the appropriation of energy, tour, environment, rail road connection between Mongolia and China and establishing a ferry route to north-east Asia. It is Japanese situation to pay attention to Russia and China even they have been supplying large-scope of infrastructure in Mongol area without any charges, target to get East Asia Main Rail Road to connect Mongolia and Zalubino of Russia. In case of the program for the Denuclearization of North Korea is not creeping, it will be accelerated to connect the TKR and TSR, TKR and TCR by somehow attending United States, including developing program promoted by UN ESCAP. As the result, Korean peninsular will continue the central role of competition and cooperation as in the past, now and future of north-east Asia, as of geographical-economics and geographical-politics whether it is requested or not wanted by neighbor countries.