• Tuberculosis and Respiratory Diseases
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• v.44 no.3
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• pp.493-504
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• 1997

Background : Non-small cell lung cancer is one of the most frequent cause of death due to cancer in men, and its incidence among women is rapidly increasing. Although there has been a recent surge of interest in combined modality therapy for stageIII non-small cell lung cancer(NSCLC), the optimal treatment is still not well established. Thoracic irradiation has long been the gold standard for locally advanced unresectable NSCLC. However, although conventional radiotherapy(XRT) can palliate symptom and improve local control of disease, it has at most only a modest effect on survival. Recently, cisplatin(cis-diamminedichloroplatinum) has been reported to enhance the cell-killing effect of radiation For patients with unresectable NSCLC, cisplatin-based concurrent chemoradiotherapy(CCRT) had the advantage of therapeutic response over XRT alone and therapeutic side effect more commonly occurred in CCRT group in EORTC(European Organization for Research and Treatment of Cancer) and other trials. Objectives : We compared therapeutic response, compliance, and side effects between CCRT and XRT in patients with advanced NSCLC. Patients and Method : Thirty patients with biopsy-proven inoperable NSCLC were randomized to one of two treatment arms. Arm A consisted of XRT, radiotherapy for 4~6 weeks(1.8 Gy given 20~33 times, in five fractions a week), and arm B consisted of CCRT, radiotherapy for 2 weeks(3 Gy given to times, in five fractions a week), followed by 3 week rest period and then radiotherapy 2 more weeks(2.5 Gy given 10 times, in five fractions a week), combined with 6mg cisplatin per square meter, given daily before radiotherapy. We evaluate therapeutic response, compliance, change of performance status, side effects, and radiation pneumonitis by using the author's made scoring system. Results : There was no significant difference in therapeutic response and compliance. But there was a significantly lower laboratory complication and radiation pneumonitis in CCRT group (p < 0.05). There's significant negative correlation between stage and therapeutic response score in both groups(R=0.353, p < 0.05) In both groups, patients with squamous cell carcinoma had a tendency to higher therapeutic response score than those with adenocarcinoma. Conclusion : There was no difference between CCRT and XRT in respect to therapeutic response and compliance. But CCRT had a advantage of decreased side effects.

• Childhood Kidney Diseases
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• v.3 no.1
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• pp.72-79
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• 1999

Renal scarring associated with vesico-ureteral reflux(VUR) is one of the major causes of end stage renal failure and renal hypertension in children. Urinary ${\beta}_2$-microglobulin(MG) has been suggested as a potential marker for presence of renal tubular damage. This study was designed to evaluate the significance of random urine ${\beta}_2$-MG as a predictor of presence of vesico-ureteral reflux in children with urinary tract infection(UTI). 57 children with urinary tract infection were studied. Patients were devided into two groups; 35($78.9\%$) children have UTI without VUR and 12($21.1\%$) children have UTI and VUR. Beta2-MG and creatinine in random urine sample was measured to decide the excretion ratio(${\beta}_2$-MG/creatinine). Among the 57 children with UTI, 44 children were confirmed by urine culture study and 13 children suspected by compatible clinical feature. Random urine ${\beta}_2$-MG of VUR group ($2.2{\pm}5.91$ mg/L) were significantly higher than that of simple UTI group($0.19{\pm}0.16mg/L$)(P=0.03). The ${\beta}_2$-MG/creatinine ratio of VUR group($32.41{\pm}25.7$) were significantly higher than that of simple UTI group($3.93{\pm}3.44$)(P=0.007). In conclusion, random urine ${\beta}_2$-MG and excretion ratio deserved early predictor of presence of VUR in children with UTI. And this method was more simple and inexpensive than the method of measuring ${\beta}_2$-MG with 24 hour urine collection, so might be a useful screening test for VUR in children with UTI.

• Clinical and Experimental Pediatrics
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• v.50 no.2
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• pp.198-204
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• 2007

Purpose : The hope that arresting pubertal developement might increase final adult height has led to an attempt to use GnRH agonist (GnRHa) in children with early puberty and poor growth prognosis. We investigated the growth-promoting effect of GnRH agonists with or without growth hormone (GH) in girls with early puberty and decreased predicted adult height (PAH). Methods : Thirty five girls with advanced bone age and early pubertal signs were randomized for treatment for about 1 year with monthly GnRHa in group 1 (n=18), or with a combination of GH and GnRHa in group 2 (n=17). The following growth parameters were compared between groups, and the difference ($\Delta$) before and after treatment : chronological age (CA), bone age (BA), $\Delta$(BA-CA), height (HT), target height (TH), predicted adult height (PAH), $\Delta$ (TH-PAH), serum insulin-like growth factor (IGF-1) and insulin-like growth factor binding protein (IGFBP-3). Results : Before treatment, BA, TH, PAH Standard deviation scores (SDS), $\Delta$(TH-PAH) were not different between the two groups, but CA was higher in group 2 and $\Delta$(BA-CA) were higher in group 1 (P<0.05). After $1.06{\pm}0.93$ year of treatment, $\Delta$ (BA-CA) decreased and there were significant changes in PAH and $\Delta$ (TH-PAH), especially in group 2 (P<0.05 in group 1, and P<0.001 in group 2). In both groups, IGF-1 and IGFBP-3 were not different before and after treatment, but after treatment, IGF-1 level in group 2 was marginally higher than IGF-1 in group 1 (P<0.1). Conclusion : Compromised predicted adult height in girls with early puberty and advanced bone age was significantly improved with GnRH with/without GH treatment in the short-term period. The addition of GH to GnRHa results in a significant increase in PAH compared to GnRHa alone because GnRHa suppressed growth hormone-IGF-1 axis. For comparison of final adult height, further longitudinal follow-up will be needed.

• The Korean Journal of Financial Management
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• v.18 no.1
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• pp.43-66
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• 2001

본 연구는 투자자 집단에 따라 그 매매에 있어서 주가와의 관련성을 분석하고자 하였다. 투자자 집단의 매매 성향은 월별 순매매율로 측정하였으며 주가의 대용변수는 한국종합주가지수(KOSPI)의 월별 수익률로서 분석에 사용된 기간은 1992년 1월부터 1999년 12월까지이다. 분석을 위한 방법론으로 상관분석과 회귀분석을 이용하였다. 상관분석은 스피어만 순위상관분석을 이용하여 KOSPI와 각 투자자 집단의 순매매 비중의 상관계수를 도출하였으며 그 결과 KOSPI와 개인투자자의 순매매와는 음의 유의적 상관관계를, KOSPI와 외국인 투자자의 순매매율과는 양(+)의 유의적 상관관계를 알 수 있었다. 그러나 기관투자자의 경우 기관투자자 전체 범주로 볼 때 유의적 상관관계가 없었으나 세분화된 기관투자자 일부는 유의적 상관관계를 보였다. 또한 본 연구는 KOSPI와 각 투자자 집단의 매매에 대한 인과관계를 추론한 바 외국인 투자자의 매매는 KOSPI에 영향을 주며 개인투자자의 매매는 오히려 KOSPI에 영향을 받는 것으로 보였다. 그러나 기관투자자의 경우 세부기관마다 그 매매의 성격을 달리하는 것으로 보였다. 이러한 분석결과를 바탕으로 회귀분석을 실시하였으며 그 분석결과 외국인 투자자와 기관투자가 가운데 증권사와 투신사의 경우, 순매수가 늘어날수록 주가는 상승하고 순매도가 늘어날수록 주가는 하락하는 것을 확인할 수 있었으며 반면 개인투자자의 매매는 KOSPI 주가에 따라 영향을 받는 것으로 나타났다. 즉 주가가 상승할수록 매도에 치중하고 주가가 하락할수록 매수에 치중하는 것으로 분석되었다. 기관투자자 가운데 보험사의 매매 역시 주가에 영향을 받는 것으로 나타났다. 본 연구의 성과로는 특정 투자자 집단이 주가의 움직임에 따라 매매를 하는 수동적 전략의 의미보다는 적극적으로 주가를 움직이는 주체로서 외국인투자자와 일부 기관투자자의 존재를 확인할 수 있었다는 점이며, 주가 움직임에 따른 개인투자자와 일부 기관 투자자의 수동적 매매 스타일과 기관투자자 사이의 투자스타일의 이질성을 통계적으로 확인할 수 있었다는 데에 있다.

• Proceedings of the Korean System Dynamics Society
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• 2003.02a
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• pp.29-55
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• 2003

최근의 통신서비스 시장은 경쟁의 도입과 기술의 발전이라는 두 축에 힘입어 양질의 서비스를 보다 저렴한 요금으로 소비자들에게 제공하고자 노력하여 왔다. 그러나 이러한 통신서비스의 질적 향상 노력에도 불구하고 여전히 통신서비스의 품질은 소비자들의 기대수준에는 미치지 못하고 있다는 지적이 있다 더욱이 문제가 되는 것은 소비자가 인지하고 있는 통신 서비스 품질의 기대수준은 시간의 흐름에 따라 동태적으로 변화하는 것이어서 한 시점에서의 통신 서비스 품질 수준의 측정으로는 정책적으로 큰 의미를 설명하기 어려운 실정이다. 이와 관련하여 많은 선행 연구들이 다양한 측면에서 시행되어져 왔지만 이제까지의 많은 선행 연구들은 대부분이 통신서비스의 특성을 제대로 고려하지 않고, 고객만족의 향상과 불일치를 가져오고 있는 성능품질만을 측정한다거나, 시간의 흐름에 따라 변화해 가는 소비자가 서비스에 대해 인지하고 있는 중요도나 기대수준을 고려하지 않고 있으며, 각 구성요소간의 동태적 인과고리에 대한 고려 없이 연구가 이루어져 전반적인 통신 서비스의 고객만족을 전체적인 시각에서 평가한 연구는 극히 드물다. 따라서 본 연구는 통신서비스의 고객만족을 피드백 관점, 동태적 관점, 사실적 관점의 시스템 다이내믹스 방법론을 적용하여 전반적인 동태적 고객만족 모형을 구현하고 이를 정책적으로 활용할 수 있는가에 대한 접근을 시도하였다. 고객만족은 결코 한순간에 머물러 있는 것이 아니며 체감품질 및 기대수준의 영향을 받아 지속적으로 변화해간다 따라서 어떻게 기대수준을 관리하고 고객의 기대에 부응하는 체감품질을 관리하는 것이 지속적인 고객만족을 획득할 수 있는 가를 시뮬레이션 모형을 통해 가시적으로 시스템의 행태를 구현함으로써 그 이해의 폭을 넓히고자 시도하였다.으로써 웹에서의 혁신적이며 크로스 사이트, 크로스 장르적인 컨텐츠 플래닝의 가능성을 시사하는데 의의가 있다고 하겠다.y used to some of interactive storytelling through hyper text in CD-ROM and web sites. More complicated and different structured models were born through games that offered graphics, virtual spaces and interactivity. When drawn onto a structural graph, few attributes and similarities seem to occur. This paper will try to outline and discuss structural graphs of interactive storytelling methods and suggest some ways for better storytelling design.eal sales volume, but the case study could verified that this method is effective to the evaluation of marketability in case of completely new product got on the typical category and the product category could be set up the population clearly.의 무게와 부피는 24주간 다소 감소하는 경향을 보였으나 통계적인 유의차는 없었다. 냉동저장 감자의 무게와 부피 변화는 48주간 전혀 없었다. 상온 냉장저장 감자의 조직의 강도(hardness)는 24주

• Journal of Hospice and Palliative Care
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• v.17 no.3
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• pp.142-150
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• 2014

Purpose: This study was to identify the attitude of Korean HIV (Human Immunodeficiency Virus)-positive men toward death. Methods: A Q-methodology was performed with 20 HIV-positive male individuals. Participants were asked to select and answer questions among a set of 40 Q-statements using a 9-point scale. The collected data were analyzed using the PC QUANL program. Results: Participants' attitudes toward death were categorized into four types. Type I was characterized by respect for life, type II by reality orientation, type III by pain evasion and type IV religious beliefs. Conclusion: It is necessary to develop an assessment tool and an intervention program for HIV-positive individuals.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.10 no.12
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• pp.2132-2139
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• 2006

A parallel program including a nested parallelism has a complex execution aspects and tasks are executed concurrently. This concurrency is a main cause raising most of errors. In this paper, a new method for checking concurrency between two tasks is proposed. The existing techniques for checking the concurrency have their limits to represent a global structure. A new labeling technique that appropriate for image visualization is proposed. To show the global structure by imaging of execution aspects through region partition on 2D plane. On the basis of it, each of the tasks that can distinguish the ordered relation create an independent image. Image information generated by the result simplifies semantic analysis of the related task, and provides an outline of a global execution aspects structure of the program to user effectively.

• Science of Emotion and Sensibility
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• v.14 no.3
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• pp.403-414
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• 2011

The current study examined brain regions associated with aesthetic experience to fractal images using functional MRI. The aesthetic estimations of the images showed that there is a general consensus regarding the perception of beautiful images. Out of 270 fractal images, fifty images rated highest(beautiful images) and fifty images rated lowest(non-beautiful images) were selected and presented to the participants. The two conditions were presented using the block design. Frontal lobes, cingulate gyri, and insula, the areas related to the cognitive and emotional processing in aesthetic experience, were activated when beautiful images were presented. In contrast, the middle occipital gyri and precuneus, the areas associated with experience of negative emotions, were activated when non-beautiful images were presented. The conjunction analysis showed activations in temporal areas in response to beautiful images and activations in parietal areas in response to non-beautiful images. These results indicate that beautiful images elicit semantic interpretations whereas non-beautiful images facilitate abstract processes.

• Clinical and Experimental Reproductive Medicine
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• v.30 no.2
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• pp.151-163
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• 2003

연구목적: Estrogen은 포유류의 생리주기와 착상과정에서 중요한 조절인자로 작용한다. 본 연구에서는 난소 절제된 생쥐의 자궁에서 estrogen에 의해 직접 또는 간접적으로 조절되어 발현하는 유전자를 분석하고자 하였다. 연구재료 및 방법: 생후 8주된 생쥐의 양쪽 난소를 절제하고 14일 동안 회복기간이 지난 후, estrogen (300 ng/mouse)을 피하로 주사하였다. Estrogen 주사 후 6, 12시간째 자궁을 적출하여 cDNA microarray와 laser capture microdissection (LCM) 기술을 이용하여 estrogen에 의해 조절되는 유전자의 시공간적인 발현 양상을 조사하였다. 결 과: Estrogen 주사 후 6시간째에는 조사된 전체 유전자 가운데 0.9% (증가 22, 감소 49), 12시간째에는 8.4% (증가 351, 감소 287)에 해당되는 유전자가 두 배 이상 증가 혹은 감소하는 결과를 보였다. 또한 일부 증감된 유전자를 선택한 후 LCM 기술을 이용하여 시공간적인 발현양상을 확인한 결과 자궁내막상피세포에서만 estrogen에 의해 유전자의 발현이 증가되는 일부 유전자를 선별하였다. 결 론: 이상의 결과들을 종합해보면 1) estrogen에 의해 조절되는 유전자의 수나 증감의 정도는 12시간 이후에 더 많고, 크게 조절되며, 2) 유전자의 조절부위가 자궁의 특이적인 세포층에서 시공간적으로 조절됨을 의미한다. 이러한 유전자의 정보는 생리주기 또는 착상과정의 분자생물학적 기작을 이해하는 데 도움이 될 것이다.

• Journal of Digital Contents Society
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• v.18 no.1
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• pp.87-91
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• 2017

Recently, several kinds of researches using IoT wearable devices are active in the field of sports, design, emotional sciences and so on. The human bio data such as blood pulse, ECG, SKT signal, and GSR Signal producing from IoT wearable devices such as Watch, Smart-band, Grass can adapt to the meaningful future applications. Using the human's emotional data and a physical status with variation and so on, we can individually get the personal status. Due to knowing the personal emotion or physical status is related and connected to the valuable wallet of customers, the approach is more important in nowadays. Therefore, the personal information can effectively adapt to the marketing of the culture industry, which deals with emotions of customers. The research shows implementation steps for explaining overall architecture of the convergence research between Art and Technologies.