• Journal of Life Science
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• v.26 no.12
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• pp.1470-1476
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• 2016

The viral hemorrhagic septicemia virus (VHSV), which belongs to the Novirhabdovirus genus of the Rhabdoviridae family, is a viral pathogen that causes severe losses in the olive flounder farming industry. Among six encoding VHSV proteins, the non-virion (NV) protein has been shown to have an impact on virulence. In our previous studies, transcriptomics microarray analysis by using VHSV-infected olive flounder showed that VHSV infection significantly down-regulated the mRNA expression of glycolytic enzymes. In addition, VHSV NV protein variants decreased the intracellular ATP level. Based on these results, we have tried to examine the effect of VHSV NV protein on glycolytic enzyme glucokinase expression, which phosphorylates glucose to glucose 6-phosphate. Our results indicated that the NV protein significantly decreased the mRNA expression of glucokinase in olive flounder HINAE cells. Furthermore, the NV protein played a negative role in the promoter activation of glucokinase. Furthermore, glucose uptake was effectively inhibited by VHSV infection and NV protein expression in olive flounder HINAE cells. These results suggest that the VHSV NV protein negatively regulates glycolytic enzyme expression by a transcription level and eventually leads to gradual morbidity of olive flounder through cellular energy deprivation. The present results may be useful for the prevention and diagnosis of VHSV infection in olive flounder.

• Korean Journal of Ecology and Environment
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• v.38 no.2 s.112
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• pp.160-180
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• 2005

Long-term data (Ministry of Environment Water Quality Monitoring data) of phytoplankton biomass (chlorophyll a) and water quality were analyzed to investigate trends in biomass of the primary producers and water quality for the estuarine systems in Korea: Sumjin River, Han River, Asan Lake- Bay, Youngsan River, Keum River and Nakdong River. The literatures were also reviewed to examine the characteristics of phytoplankton biomass and water quality in the estuarine systems. The Sumjin River estuary, the single estuary without a dike in Korea showed the characteristics similar to other typical estuarine systems. Phytoplankton biomass was high during the fall at transitional regions (5 ${\sim}$ 15 psu) after riverine freshwater inputs were increased in summer. Concentrations of the nitrate and silicate were increased with the high river discharge rates. Phytoplankton biomass and nutrient concentrations were high during spring at the lower regions in the Han River whereas phytoplankton biomass and nutrient concentrations were high during spring at the upper regions in the Youngsan River. Phytoplankton biomass was the highest in the Asan Lake and nutrient concentrations were high at the upper region of the lake. In Nakdong River, phytoplankton biomass was high during winter and the biomass was slightly higher at upper region than at lower region. Long-term trends showed that total nitrogen and total phosphorus were mostly increased in the river systems. Implications of these results relevant to the water quality management for the river systems were also discussed.

• Korean Journal of Ecology and Environment
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• v.33 no.3 s.91
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• pp.295-303
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• 2000

The water clarification efficiency was examined in a shallow wetland where dense vegetation was formed naturally in an abandoned paddy field. And, also two enclosure experiments were carried out to measure the effects of materials exchange between sediment and the overlying water with the existence of vegetation and accumulated litter. The hydraulic retention time of wetland was regulated in 1.2 day. The removal rates of SS (56%) and $NO_3-N$ (61%) were high, considering its short retention time. However, removal efficiencies of VSS (28%), COD (14%), DOC (1%),and TP (0.2%) were relatively lower. This low removal efficiencies were thought to be due to the release of dissolved form of organic matter and phosphorus from the sediment. Most of constituents except nitrate were higher in the enclosure at the beginning of enclosure installation than that of the outflowing water from wetland. And then, it has fluctuated and decreased with time. The wetland was in equilibrium state of settling, accumulation of organic debris, and regeneration of dissolved material from sediment. So ultimately high primary production by dense vegetation in the wetland may be the reason of unfavorable or low treatment efficiency of wetland after many years of operation for wastewater treatment. However, the water quality of effluent from the wetland showed smaller variation and better condition than that of inflow, especially during storm events. It can be concluded that this wetland is suitable for the improvement of water quality from nonpoint sources.

• Journal of Chest Surgery
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• v.31 no.1
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• pp.32-39
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• 1998

High-dose aprotinin(Hammersmith regimen) has been widely used for years to control postoperative bleeding and reduce blood consumption in cardiac surgery but had known to cause some side-effects and had disadvantage in cost-effectiveness. The prospective controlled study of 33 patients undergoing cardiopulmonary bypass was performed to evaluate the efficacy for reducing postoperative bleeding and unfavorable effects of low-dose aprotinin. The level of hemoglobin and platelet in the blood and the amount of postoperative bleeding were assessed preoperatively, and postoperatively for the study of hemostatic function. The level of BUN and serum creatinine in the blood, levels of urine creatinine, total protein, albumin, alpha-1-microglobulin and creatinine clearance were assessed before and after the operation for the study of renal function. The aprotinin group had a significant reduction in chest tube drainage; 243$\pm$ 123 ml versus 406$\pm$303 ml(P=0.037) during 6 hours immediate-postoperatively, 494$\pm$358 ml versus 869$\pm$570 ml(P=0.045) during 24 hours postoperatively. The ratio of alpha-1-microglobulin/creatinine and microalbumin/creatinine in the urine were slightly increased in the aprotinin group postoperatively in comparison with the control group but there were no statistically significant difference(55$\pm$23 versus 24$\pm$10 in the alpha-1-microglobulin/creatinine, 56$\pm$19 versus 38$\pm$25 in the microalbumin/creatinine at post- operative 3rd day). There were no significant difference between two groups in other parameters of renal function, too. This study showed that low-dose aprotinin is an effective means of reducing postoperative bleeding without inducing significant renal dysfunction.

• Proceedings of the Korea Water Resources Association Conference
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• 2007.05a
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• pp.1076-1080
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• 2007

최근 국내에서는 하천변 생태계를 대상으로 생태구조 및 서식처 평가 등 많은 연구가 진행되었음에도 불구하고 생태적 변화를 예측하고 예측된 결과에 따라 생태복원 대책을 수립할 수 있는 연구는 현재까지 미흡하다고 볼 수 있으며, 이는 생태복원 연구에 있어 주요과제라고 할 수 있다. 이에 반해 유럽과 미국에서는 수문학적 서식처 조건에 따른 식생 반응 예측 등 수문생태 모형에 대한 연구가 꾸준히 이루어져 왔으며, 최근에는 습지, 홍수터 등을 대상으로 생태보전 복원분야에 널리 응용되고 있다. 본 연구에서는 국외의 수문생태모형 적용사례를 분석하여 국내 적용가능성 및 문제점에 대한 타당성을 제시하고자 하였다. 그 대상으로는 유역 내에 홍수량 분담을 위한 천변저류지를 적용하였으며, 의미상으로 홍수터(범람원), 습지 역시 해당 범위에 포함할 수 있다. 천변저류지는 홍수기와 비홍수기에 따라 활용 측면을 구분할 수 있으며, 이런 맥락에서 천변저류지의 수위변화는 식생 변화의 중요한 요소(factor)가 될 수 있다. 그 외 범람시기, 범람일수, 건조기간 등을 포함한 수문요소 역시 수문생태 모델의 예측 변수인 식생 성장에 영향을 미치게 된다. 이러한 수문/생태시스템의 상호관계를 활용하고 모형의 형태를 국내 식생에 대한 생리학적 특성에 맞게 변화시킬 수 있다면 국내 천변저류지에도 충분히 적용 가능할 것으로 판단된다. 또한 잠재적으로 식생 성장에 영향을 줄 수 있는 다양한 환경조건 예를 들면 영양물질, 토양구조, 토사 퇴적 등을 적용대상지 환경에 맞게 포함하거나 고려할 수 있다면 모형의 재현성을 더욱 높일 수 있을 것이다.의 기대효과를 가져올 수 있으리라 생각되며 분석된 인자들은 수달 서식지를 위한 하천정비의 기초자료에 유용할 것으로 보인다.따른 유량측정망을 구축하는 것이다.의 의사결정 지원 도구가 될 것이다. 따라서, 본 연구에서는 도시유역의 물순환 해석을 위한 일련의 과정, 즉 자료의 조사 및 취득에서부터 물순환 해석 모형을 이용한 정량적 현황파악, 물순환 개선 기법 및 평가를 수행함에 있어 주요 착안점 및 실무에서의 기술적 가이드를 제공하고자 하였으며, 보다 세밀한 도시유역의 물순환 해석을 위하여 우리나라와 일본에서 적용이 활발한 물리적 기반의 분포형 모형(WEP, SHER, SWMM)의 적용사례를 통하여 국내 도시하천의 물순환 해석에 활용함에 있어서의 실질적인 적용절차 등을 제시하고자 하였다. 한다.호강유역의 급격한 수질개선을 알 수 있다.世宗實錄) $\ulcorner$지리지$\lrcorner$(地理志)와 동년대에 동일한 목적으로 찬술되었음을 알 수 있다. $\ulcorner$경상도실록지리지$\lrcorner$(慶尙道實錄地理志)에는 $\ulcorner$세종실록$\lrcorner$(世宗實錄) $\ulcorner$지리지$\lrcorner$(地理志)와의 비교를 해보면 상 중 하품의 통합 9개소가 삭제되어 있고, $\ulcorner$동국여지승람$\lrcorner$(東國與地勝覽) 에서는 자기소와 도기소의 위치가 완전히 삭제되어 있다.

• The Journal of Engineering Geology
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• v.21 no.4
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• pp.323-336
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• 2011

The hydro-mechanical behavior of the Earth's crust is strongly dependent on the fractional volume and geometrical structure of effective pore spaces. This study aims to understand the characteristics of pores using electrical impedance. We measured the electric impedance of core samples (diameter, 38-50 mm; length, 70-100 mm) of three types of granite (Hwangdeung, Pocheon, and Yangsan) and two types of sandstone (Boryung and Berea) with different porosities and pore structures, after saturation with saline water of varying salinities. The results show that resistance decreases but capacitance increases with increasing salinity of the pore fluid. For a given salinity, the resistivity and formation factor are reduced with increasing porosity of the rocks, and the capacitance increases. Berea sandstone shows anisotropy in resistance, tortuosity, and cementation factor, with these factors being highest normal to bedding planes. This result indicates that the connectivity of pores is weakest normal to bedding. In conclusion, the electrical characteristics of the tested samples are related not only to their porosity but also to the pore geometry.

• Korean Security Journal
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• no.15
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• pp.265-283
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• 2008

Modern society often faces 3Cs：change, competition, and customer. The main issue of today's police science study, therefore, circles around how public police effectively cope with the radically changed environment. As one of the workable and appealing policy tools to reform the police, the privatization has been not only strongly supported in terms of a theoretical study, but also widely used in practice all over the world. However, Policing has been widely regarded as an exclusively public-sector activity conducted by sworn officer, but a large and increasing share of the aggregate demand for public safety and security is being handled by the private sector. This study examines on the very practical one, how contracting out, most widely used as the privatization alternatives, is perceived and put into practiced in the field of traffic police services. This study is intended to examine recent shifts toward privatization of traffic policing. Although some people regard police services as inappropriate for privatization, most everyone else have persuasively considered that many police services are not public goods or, at least, not pure public goods. We can consider that there are three types of privatization with respect to traffic policing, that is, user-financed police services, contracting out, and some degree of service shedding. As society changes, so must traffic policing. And it is needed to enhance the ability of traffic police and private to accomplish their primary mission, to serve and protect the public.

• Journal of Gifted/Talented Education
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• v.23 no.4
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• pp.567-592
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• 2013

The purpose of this study is to investigate effective teaching and learning method for teaching decision-making on Socio-Scientific-Issues(SSI) in science classroom. So we carried out new teaching and learning trial for decision-making about Global Warming issues. Our new trial focused on self-directed and cooperative learning in decision-making about SSI. And our participants were science gifted or science high-achieved students in middle school. We analysed students' written decision-making of the last process in our new trial. We can find our instruction made progress in informed decision-making, structure of argumentation, reflective thinking stage, using the scientific information and understanding of the nature of science. As a result, self-directed and cooperative learning in decision-making on SSI leads students to the meaningful decision-making scientifically.

• The Journal of the Korea Contents Association
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• v.12 no.11
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• pp.502-510
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• 2012

As defense science and technology are developing, smart weapons are being developed continually. The collection and analysis of the future strategic weapon information from all over the world have become a greater priority because information sharing became active. So, a system to manage and analyze heterogeneous defense intelligence is required. Semantic Web is the next generation knowledge information management technology for integrating, searching and navigating heterogeneous knowledge resource. Recently, Semantic Web is wildly being used in intelligent information management system. Semantic Web supports the analysis with the high reliability because it supports the simple keyword search as well as the semantic based information retrieval. In this paper, we propose the semantic web based multi-dimensional information analysis system on the national defense weapons that constructs ontology for various weapons information such as weapon specifications, nations, manufacturers and technologies and searches and analyses the specific weapon based on ontology. The proposed system supports the semantic search and multi-dimensional information analysis based on the relations between weapon specifications. Also, our system improves the efficiency on acquiring smart weapon information because it is developed with ontology based on military experts' knowledge and various web documents related with various weapons and intelligent search service.

• Journal of Gastric Cancer
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• v.5 no.1
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• pp.34-39
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• 2005

Purpose: KLF6, a member of the KLF family, is a ubiquitous zinc finger tumor suppressor protein that is mutated in several human cancers. Our aim was to determine whether the expression pattern of KLF6 might be associated with gastric cancer development and, if so, to determine to which pathologic parameter it is linked. Materials and Methods: For the construction of the gastric cancer tissue microarray, 85 paraffin-embedded tissues containing gastric cancer areas were cored 3 times and transferred to the recipient master block. The expression pattern of KLF6 was examined on tissue microarray slides by using immunohistochemistry and was compared with pathologic parameters, including histologic type, depth of invasion, lymph node metastasis, and peritoneal dissemination. Results: The KLF6 protein was expressed on superficial and foveolar epithelial cells in the gastric mucosa. We found loss of KLF6 expression in 28 ($32.9\%$) of the 85 gastric cancer tissues. There was a significant correlation between loss of KLF6 expression and lymph-node metastasis. However, other pathologic parameters, such as histologic type, depth of invasion, and peritoneal dissemination, were not statistically associated with loss of KLF6 expression. Conclusion: Our findings suggest that loss of KLF6 expression may contribute to abnormal regulation of gastrointestinal epithelial cell growth and differentiation and to the development and/or progression of Korean gastric cancer.