• Archives of Craniofacial Surgery
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• v.11 no.1
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• pp.23-27
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• 2010

목적: 모반양 기저세포암 증후군 (Nevoid basal cell carcinoma syndrome) 또는 골린-골츠 증후군은 한국에서는 흔하지 않은 증후군으로 주로 상염색체 우성으로 유전하고 다기관 장애가 나타날 수 있으며 높은 표현율과 다양한 표현도를 특징으로 한다. 모반양 기저세포암 증후군의 진단 기준에는 다발성 기저세포암, 이소성 석회화(ectopic calcification), 손 또는 발바닥 오목 (palma or plantar pits), 치성 각화 낭종(odontogenic keratocysts), 가족력 및 골격계, 신경계, 안, 비뇨생식계 및 심장혈관의 이상 등이 있다. 본원에서 주로 두부의 다발성 기저세포암을 가진 모반양 기저세포암 증후군 환자를 경험하여 보고하고자 한다. 방법: 환자는 2007년 4월 두부의 색소성 모반으로 피부과에서 시행한 펀치 생검에서 기저세포암을 진단받고 의뢰되었으며, 이후 2009년 7월까지 14회의 추가적인 절제 및 조직 검사를 시행하였다. 환자는 갑상샘 유두암종의 재발로 인해 갑상샘 절제술을 2회 시행한 과거력이 있었으며 이학적 검사와 일반 혈액, 소변, 간 기능 및 갑상선 기능 검사를 시행하였고, 흉부와 늑골 방사선 검사, 심전도와 안면부 및 두부 컴퓨터단층촬영과 유전자 검사를 시행하였다. 결과: 두부와 안면부에서 절제한 27개의 병변 중 23개(85%)가 기저세포암으로 진단되었으며, 치성 각화 낭종과 대뇌겸 석회화, 이학적 검사에서 손바닥 오목이 발견되었다. 하복부 초음파에서 난소 낭종이 발견되었으나 조직 검사는 시행되지 않았다. 결론: 한국에서 모반양 기저세포암 증후군에 대한 연구는 주로 치과와 피부과 영역에서 국한되었으며, 특히 치과 영역에서의 보고는 치성 각화 낭종 및 손바닥 오목에 초점을 둔 것이 대부분이었다. 이에 본원에서는 주로 두부의 다발성 기저세포암을 가진 모반양 기저세포암의 환자를 경험하였으며, 초기에 발견된 작은 병변의 제거 시 2mm의 정상 조직을 포함하여 절제하였어도 3년간의 경과관찰 중 재발없이 좋은 결과를 얻을 수 있어 이를 보고하는 바이다.

• Radiation Oncology Journal
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• v.12 no.3
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• pp.315-321
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• 1994

Ameloblastoma is a rare epithelial tumor of the jaw, comprising approximately $1\%$ of all tumors and cysts of odontogenic origin. The tumor has been the subject of much controversy and cliscussion. Amelobiastoma is slow growing, locally invasive, and has a high rate of total recurrence, but rarely metastasizes. This neoplasm has been considered radioresistant, so it has been treated with surgery primarily except some cases. Recently it is suggested that ameloblastoma is radiosensitive, so radiation therapy (RT) would be used in addition to or, in certain cases, in place of surgery. We report these two cases which were referred to the Department of Therapeutic Radiology for deciding tile need of postoperative RT, because amelobiastoma is rare and has been known tot be radioresistant. Postoperative RT was given to one of these two Patients.

• Journal of Yeungnam Medical Science
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• v.3 no.1
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• pp.179-183
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• 1986

The frozen section technique is a means of intraoperative pathological diagnosis, and a procedure of great value to the surgeon. This method should be accurate, rapid and reliable. This method serves useful purposes, such as determining the presence of tumor, its type(especially whether it is benign or malignant), the adequacy of a biopsy of a suspected lesion, and the conditions of the surgical margins. But, it bears many disadvantages, the most of which is the danger of incorrect diagnosis. We studied the indications, the limitations, and the accuracy of the frozen section method and the materials studies was total of frozen section during recent 3 years. The overall accuracy of the frozen section diagnosis of 809 cases was 98.1% with 0.5% of false negative, 0% of false positive, 0.5% of incorrect histological diagnosis or grading errors, and 0.9% of deferred cases. The tissues submitted were lymph node, gastrointestinal tract, skin subcutaneous tissues in decreasing oder of frequency. The false positive case is not present, while the false negative cases were 4.

• Journal of the korean academy of Pediatric Dentistry
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• v.28 no.1
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• pp.171-174
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• 2001

This case describes a case of desmoplastic fibroma of the mandible. A 9-year-old boy was seen with a history of progressive swelling and expansion of the left mandible for one month period. Desmoplastic fibroma was diagnosed on histopathologic examination This report reviews the diagnostic criteria, differential diagnosis and surgical treatment of choice in brief of this uncommon primary bone tumor of the oral and maxillofacial region.

• Neonatal Medicine
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• v.17 no.2
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• pp.232-238
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• 2010

Purpose: An increase in the breastfeeding rate has been followed by an increase in the number of mothers seeking help in relactation. We investigated the factors related to successful relactation by assessing the impact of medications, supplementer, consultations, and family support. Methods: A retrospective review of the medical records and telephone survey of mothers who had visited the relactation clinic were conducted from January 2004 to April 2007. Results: Data from 84 mothers were analyzed to identify the factors associated with success in relactation. Seventy-five percent of the mothers succeeded in obtaining exclusive breastfeeding. Success in relactation was associated with informed referral from medical personnel, the use of galactogogues, and family support. Conclusion: This study provides new and noteworthy insights concerning relactation. This highlights the need to inform the mothers about the data of relactation, to use galactogogues, and to have their families involved for psychological support and endurance during visits to the relactation clinic.

• Journal of Korean Medical classics
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• v.18 no.2 s.29
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• pp.20-44
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• 2005

통과한의학화서양의학적원리연구심신적상호관계(通過韓醫學和西洋醫學的原理硏究心腎的相互關係), 득도료여하결론(得到了如下結論) 경연구심신지간재한의학상구유(經硏究心腎之間在韓醫學上具有): 심양여신음유'심신상교'적'수화기제'관계(心陽與腎陰有'心腎相交'的'水火旣濟'關係). 차외환유신양(명문화)여심양(심화)적상호의존관계(此外還有腎陽(命門火)與心陽(心火)的相互依存關係). 우유심장신여신장정적상호의존관계이지유신정충족시(又有心藏神與腎藏精的相互依存關係而只有腎精充足時), 재가이사심주신지적공능유지정상(才可以使心主神志的功能維持正常). 경연구심신지간재서양의학상구유(經硏究心腎之間在西洋醫學上具有): 제일(第一), 심장여신장재해부학상밀절연계(心臟與腎臟在解剖學上密切聯係), 즉종심장좌심실분지출신동맥(卽從心臟左心室分枝出腎動脈), 진이형성신소구등신장적혈관구화모세혈관강(進而形成腎小球等腎臟的血管球和毛細血管綱). 제이(第二), 심장향신장공응혈액(心臟向腎臟供應血液), 신장시인체중접수혈공최다적장기(腎臟是人體中接受血供最多的臟器). 제삼(第三), 심장통과심납소(ANP)적분비(的分泌), 증가신혈류양급신소체여과율(增加腎血流量及腎小體濾過率). 제사(第四), 신장통과신소(腎臟通過腎素)(renin)적분비조절혈압(的分泌調節血壓). 제오(第五), 신공능부전대심장구성부면영향(腎功能不全對心臟構成負面影響). 제육(第六), 심장여신장지간종서양의학적각도고려(心臟與腎臟之間從西洋醫學的角度考慮), 야존재착상생화상극관계(也存在着相生和相克關係). 경연구심신적상호관계재수행중적작용(經硏究心腎的相互關係在修行中的作用), 득출여하결론(得出如下結論): 제일(第一), 수행영인안정심지(修行令人安定心志), 사심화하강(使心火下降). 제이(第二), 수행시적호흡조절조폐금생신수(修行時的呼吸調節助肺金生腎水), 저시소유적수행법도재중시호흡조절적근본이유(這是所有的修行法都在重視呼吸調節的根本理由). 제삼(第三), 수행시발생수승화강(修行時發生水昇火降). 저실제상시의뢰심화중적일음효여신수중적일양효적발동내완성(這實際上是依賴心火中的一陰爻與腎水中的一陽爻的發動來完成). 제사(第四), 통과수행(通過修行), 가이달도보정적목적(可以達到保精的目的), 유차보장생명적지보(由此保藏生命的至寶). 제오(第五), 통과수행(通過修行), 가이달도연정화기(可以達到煉精化氣), 약능주도연정화기(若能做到煉精化氣), 가사인체불누설정액(可使人體不漏泄精液), 반이화기이증강인체기능(反而化氣以增强人體機能), 시보정적유효수단(是保精的有效手段). 수행적관건시'남자수성불누정(修行的關鍵是'男子修成不漏精), 여자수성온불누경(女子修成不漏經)'.

• Analytical Science and Technology
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• v.11 no.3
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• pp.222-228
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• 1998

Five kinds of packed column and two kinds of capillary column were used to get optimum condition for ethanol analysis by using fifteen different volatile, low molecular weight organic substances. Only two columns, Gaskuropack 54 and DB-1, showed good separation efficiency. In the adding salt-effect experiment 0.6N - perchloric acid, 1M - meta-phosphoric acid and saturated NaCl solution were used for alcohol concentration measurement of biological fluids and tissue specimens. Among adding salt experiment, adding saturated NaCl solution showed the most stable value of alcohol concentration. This fact might be due to the increased vaporization of alcohol in the saturated NaCl solution. In the time-course of blood alcohol concentration, the alcohol level was lineary decreased to the diameter of vessel containing specimens. This result was interpreted in view of ethanol level, weight, water content, and hematocrit value. The ethanol distribution levels were measured from samples of blood and tissue obtained from 25 postmortems cases investigated by NISI. This study showed that the distribution level was decreased in order of brain, blood, kidney, spleen, liver, and lung.

• Korean Journal of Social Welfare
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• v.60 no.3
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• pp.231-251
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• 2008

The purpose of this study was to determine the factors affecting the drop-out from the domestic violence offenders' treatment group programs in Korea, on the assumption that it would be an important challenge to prevent the domestic violence offenders from dropping out from their treatment group programs in order to protect the victim women and improve effectiveness of the programs. For this purpose, the researchers sampled a total of 280 domestic violence offenders who had participated in the domestic violence offenders' treatment programs operated by 65 domestic violence counselling organizations throughout the nation. As a result, it was found that 159(56.8%) out of the 280 offenders had completed the programs, while 121(43.2%) had dropped out from the programs. As a consequence of comparing the two groups, it was disclosed that they differed significantly in terms of cohabitation with spouse and attitude toward sex role. As a result of the logistic regression analysis for the factors affecting the drop outs from the treatment group program, it was found the significant factors were employment, path of being referred to the program and attitude toward sex role.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.18 no.1
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• pp.1-12
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• 2018

Purpose: Disorders of organic acid metabolism have various clinical manifestations and it may be life-threatening. The prognoses of affected children are dependent on early diagnosis and treatment. We report this study to find out detection rate of referred samples, clinical manifestations and age distribution after introduction of neonatal screening test using tandem mass spectrometry in Hallym University Chuncheon Sacred Heart Hospital during 8 years and 9 months. Methods: The 2,794 patients referred from Jan. 2007 to Sep. 2015 were divided into four groups according to age. We conducted organic acid analysis of urine samples of patients and analyzed clinical manifestations and distributions of age at the diagnosis. For patients with ambiguous results, reanalysis of urine organic acid after diet restriction, protein loading and restriction, has been done. Results: A total of 626 patients with 20 disorders were diagnosed. Mitochondrial disorders (482 patients) were the most common diagnosis, followed by ketolytic defects (67), 3-hydroxyisobutyric aciduria (32), EPEMA syndrome (8), 3-methylcrotonyl glycinuria (7), glutaric aciduria type II (6) and type I (4), methylmalonic aciduria (3), isovaleric aciduria (3) and medium chain acyl-CoA dehydrogenase deficiency (3). Conclusion: As neonatal screening test using tandem mass spectrometry is increasingly common and medical environment is changed, detection rate of disorders of organic acid metabolism in this study has decreased compared to previous report. Because the deterioration can be prevented by early diagnosis and treatment, many pediatricians have to pay special attention to possibility of the disorders and make an effort for early diagnosis in clinical setting.

• Journal of Life Science
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• v.20 no.6
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• pp.907-913
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• 2010

Human enteroviruses (HEV) are considered one of the major infectious causes of central nervous system infections such as aseptic encephalomeningitis in pediatrics. This study was focused on providing information related to genetic characteristics and diversities of HEV which prevailed between 2007 and 2009 in Busan, Korea. A total of 2,743 specimens were collected from children and screened for isolation of HEV by cell culture and RT-PCR. Among the specimins, 240 isolates were grouped into 21 different HEV serotypes using VP1 RT-PCR. The major etiological agents were CV-A6 and CV-B2 in 2007, E-6 and E-30 in 2008 and CV-B1 in 2009. The occurrence of HEV infections was the most frequent in the summer (May to August, 188 cases, 78.3%). Most of the isolates were identified from specimens from children under 10 years old, with the highest occurrence in the 2 to 4 year old range (15.2%). However, there were no significant differences between male and female children for the isolates. For analyzing genetic characterization, VP1 gene was amplified by RT-PCR and sequenced. The phylogenetic tree was established by Clustal W method using DNASTAR software. Using the sequence analysis of the VP1 region, it was classified into 2 groups; HEV-A and HEV-B. The HEV-A group contained 6 serotypes and sequences of 31 isolates were compared within each serotype. The HEV-B group contained 10 serotypes and the sequences of 41 isolates were compared within each serotype. Homology analysis of the VP1 region showed that the identity scores of HEV-A and B isolates were different. In conclusion, genetic divergences were observed among the isolates from children between 2007 and 2009 in Busan.