• The Korean Journal of Nuclear Medicine Technology
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• v.18 no.1
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• pp.26-32
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• 2014

Purpose: As PET-MRI which has excellent soft tissue contrast is developed as integration system, many researches about clinical application are being conducted by comparing with existing display equipments. Because PET-MRI is actively used for head and neck cancer diagnosis in our hospital, lymph node metastasis before the patient's surgery was diagnosed and clinical usefulness of head and neck cancer PET-MRI scan was evaluated using pathological opinions and idiopathy surrounding tissue metastasis evaluation method. Materials and Methods: Targeting 100 head and neck cancer patients in SNUH from January to August in 2013. $^{18}F-FDG$ (5.18 MBq/kg) was intravenous injected and after 60 min of rest, torso (body TIM coil, Vibe-Dixon) and dedication (head-neck TIM coil, UTE, Dotarem injection) scans were conducted using $Bio-graph^{TM}$ mMR 3T (SIEMENS, Munich). Data were reorganized using iterative reconstruction and lymph node metastasis was read with Syngo.Via workstation. Subsequently, pathological observations and diagnosis before-and-after surgery were examined with integrated medical information system (EMR, best-care) in SNUH. Patient's diagnostic information was entered in each category of $2{\times}2$ decision matrix and was classified into true positive (TP), true negative (TN), false positive (FP) and false negative (FN). Based on these classified test results, sensitivity, specificity, accuracy, false negative and false positive rate were calculated. Results: In PET-MRI scan results of head and neck cancer patients, positive and negative cases of lymph node metastasis were 49 and 51 cases respectively and positive and negative lymph node metastasis through before-and-after surgery pathological results were 46 and 54 cases respectively. In both tests, TP which received positive lymph node metastasis were analyzed as 34 cases, FP which received positive lymph node metastasis in PET-MRI scan but received negative lymph node metastasis in pathological test were 4 cases, FN which received negative lymph node metastasis but received positive lymph node metastasis in pathological test was 1 case, and TN which received negative lymph node metastasis in both two tests were 50 cases. Based on these data, sensitivity in PET-MRI scan of head and neck cancer patient was identified to be 97.8%, specificity was 92.5%, accuracy was 95%, FN rate was 2.1% and FP rate was 7.00% respectively. Conclusion: PET-MRI which can apply the acquired functional information using high tissue contrast and various sequences was considered to be useful in determining the weapons before-and-after surgery in head and neck cancer diagnosis or in the evaluation of recurrence and remote detection of metastasis and uncertain idiopathy cervical lymph node metastasis. Additionally, clinical usefulness of PET-MRI through pathological test and integrated diagnosis and follow-up scan was considered to be sufficient as a standard diagnosis scan of head and neck cancer, and additional researches about the development of optimum MR sequence and clinical application are required.

• Proceedings of the IEEK Conference
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• 2000.09a
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• pp.795-798
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• 2000

연속음 인식과 음성 합성을 위해서는 정밀한 음성학적 모델과 연속 음성에 적용 가능한 언어 모델의 개발이 중요하다. 이를 위해서는 음성 데이터 베이스에 대한 인식 단위, 혹은 합성 단위의 분할이 필요한데, 수동음성 분할은 일관성의 유지가 어렵고 긴 시간이 소요되므로 최근에는 자동 분할 기술이 많이 연구되고 있다. 자동 음성 분할 기법으로는 시간 영역이나 주파수 영역특징 벡터의 천이를 분석하는 방법과 특징 벡터간의 상관도를 구하여 경계를 추출하는 방법이 있다. LPC smoothed log amplitude spectra는 음성의 주파수 영역의 특징을 잘 나타내며, 동일 음소 내의 상관도가 서로 다른 음소의 상관도보다 더 크고, 음소의 경계구간에서 급격한 상관도의 변화를 보인다. 이 특성을 이용하여 이웃 프레임에 대한 상관도의 방향성이 특정조건을 만족하는가를 검사하여 음소의 경계를 구하는 방법을 찾았다. 또한 LPC. 이득 인자만으로 묵음 구간을 검출하는 방법을 제시한다. 이렇게 하면 묵음 구간검출과 음소 경계 검출의 일관성을 향상시키고 수행 시간을 단축시킬 수 있다. 제안한 기법으로 허용 오차 20ms 이내에서 연속음성에 대한 음소 경계 검출 실험을 수행한 결과, 수작업으로 행한 경계 검출 지점의 약 88%를 정확히 검출하였다.

• Tuberculosis and Respiratory Diseases
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• v.47 no.6
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• pp.747-756
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• 1999

Background: Acid-fast stain and cultures for diagnosis of pulmonary tuberculosis are primary and essential method, but have their limitation : low sensitivity and time consuming. The objective of this study is comparison of amplified Mycobacterium tuberculosis direct test(MTD) by the conventional AFB smears and cultures in the detection of Mycobacterium tuberculosis in respiratory specimens. Methods: During the period between November, 1997 and May, 1998 a total of 267 respiratory specimens (sputum 173, bronchial washing 94) from 187 patients suspected pulmonary tuberculosis were subjected to AFB smears, cultures and MID test. MID is based on nucleic acid amplification. We compared the MID with 3% Ogawa culture method. In positive AFB smear and negative MID specimen, positive culture identification between nontuberculous mycobacterium and M.tuberculosis was assesed by using Accuprobe M.tuberculosis complex probe. In negative AFB smear and negative AFB culture, MTD results are assessed by clinical follow-up. Results : 1) Compared with culture in sputum and bronchial fluid specimens, sensitivity and specificity of MTD in positive AFB smear is 79.7% and 20.0%, sensitivity and specificity of MTD in negative AFB smear specimens is 75.0% and 79.7%. 2) Discrepant analysis is assessed by clinical follow-up and other specimen results beyond study. Culture negative but MTD positive specimens were proved to be true positive and gave MTD sensitivity 79.2%, specificity of 84.4%, positive predictive value 80.5% and negative predictive value 83.2%. 3) 14 out of 31 specimens in negative AFB smear, negative AFB culture and positive MTD showed pulmonary tuberculosis diagnosed on clinical follow-up and sensitivity is 45.2%. 4) 2 out of 13 specimens in positive AFB smear, positive AFB culture and negative MID diagnosed as non tuberculous mycobacterium by Accuprobe culture. Conclusion: This study suggested that MID in respiratory specimens is simple and rapid diagnostic method, but considered adjuvant method rather than replace the conventional AFB smear and culture.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.2
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• pp.260-264
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• 2019

An 84-year-old woman presented to the emergency department with a chief complaint of pressure sores of the anus. She had a urine catheter when she showed pyuria three times but had no fever. A microscopic examination revealed many grapevine-like Gram positive strains and neutrophils. After 24 hours of urine culture on blood agar, non-hemolytic mucous colonies were found and further enlarged after 48 hours of culture. The capsules were identified after India ink stain. The catalase was positive, but the tube coagulase and latex coagulase were both negative. The S. aureus was identified by Vitek-2 and mass spectrometer Vitek MS V-3 IVD. The strain was confirmed by 16S rRNA gene sequencing and multilocus sequence typing (MLST). The phenotypically atypical MRSA found in the tube coagulase and latex coagulase were both negative. MRSA often show no beta hemolysis as in this case but are rarely latex coagulase-negative. We report a woman whose urine culture showed non-hemolytic, tube coagulase-negative, and latex coagulase-negative MRSA.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.7
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• pp.3419-3424
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• 2013

Diverse immunoassays including a chemiluminescent immunoassay (CIA) are used to detect hepatitis B surface antigen (HBsAg) and antibody (anti-HBs). Recently, an increasing number of institutions have been utilizing an immunochromatography assay (ICA), which is easy to use. In this study, We evaluated ICA kits for the rapid detection of HBsAg and anti-HBs by comparing them with a CIA. A total of 120 serum hospital samples, were collected for the whole month, were assayed using ICA kit. The Concordance rate, sensitivity, specificity, positive predictive value and negative predictive value of the ICA for HBsAg based on CIA results were 97%, 97%, 100%, 100%, and 96.8%, respectively. The diagnostic performances of the ICA for Anti-HBs were 90%, 90%, 93.3%, 93.1%, and 90.3%, respectively. The ICA kit failed to detect HBsAg and anti-HBs in low reactive samples. The ICA kits for the rapid detection of HBsAg might be recommended for interpreted with caution and dual analysis in the clinical laboratory.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.19 no.2
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• pp.85-88
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• 2008

Several parameters are used for the assessment of phonatory function and voice quality in clinical settings. Glottic airflow, subglottal pressure, mean phonation time, laryngeal resistance and voice efficiency are the most commonly used aerodynamic parameters. Aerodynamic analysis is developed to evaluate phonatory energy source and to estimate laryngeal efficiency. Also these measurements have shown the good correlation with perceptions of breathiness and findings of glottic competence. Aerodynamic study is important to understand relationships between pulmonary and phonatory function.

• Proceedings of the KSLP Conference
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• 1996.11a
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• pp.78-78
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• 1996

기식성 애성을 객관적으로 평가할 수 있는 음향지표는 아직 많은 연구가 되어 있지 않고 단지 청각심리검사에 의존하고 있는 실정이다. 본 저자들은 컴퓨터음향분석의 한 지표로서 기식성 애성에 대한 객관적인 음향지표로 이용될 수 있는 Multi-Dimensional Voice Program(mode1 4305, Kay Elemtrics Corp, USA)의 VTI(voice turbulance index)를 정상인과 성대병변 환자에서 비교 분석함으로써 기식성 애성의 객관적인 음향지표로서의 유용성을 확인하고자 하였다. (중략)

• Proceedings of the KSLP Conference
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• 1994.06b
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• pp.85-85
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• 1994

본 연구에서는 환자의 쓰기 과제에 있어서 득점에 영향을 주는 요인이 연령차인지 학력 차인지를 검토하였다. 연구대상은 40세 이상의 정상자 162명이며 남성 82명, 여성 80명으로서 다음의 3가지 조건을 갖춘 자로 하였다. 1) 정신·신경학적인 기왕력이 없을 것, 2. 오른손잡이이며, 3. 교육수준은 최저 국민학교 졸업이상인 것 등이다. 검사 항목은 1) 한자 문자의 재현, 2) 한자 단어의 스스로 쓰기, 3) 한자 단어의 받아쓰기 등이며, 검사득점 분석결과 한자의 쓰기 능력 득점에 영향을 주는 것은 학력 차보다는 오히려 연령차이에 의한 영향이 주 요인인 것이 명백하게 되었다. (중략)

• Journal of Veterinary Clinics
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• v.20 no.1
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• pp.7-11
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• 2003

The selection of a test as a reference with no perfect sensitivity and specificity may lead to bias, yielding distortion of the diagnostic performance. This means it is inappropriate to use imperfect diagnostic tests as a reference method to identify infected patients in clinical environments. In this study, diagnostic performance of rapid urease test, polymerase chain reaction (PCR), and histology of gastric biopsy specimens for diagnosing Helicobacter pylori infection separately and in combination was estimated by using non-linear regression. Based on this approach, the sensitivity, specificity and likelihood ration positive and negative values for each test were as follows: urease test 99.9%, 99.9%, 99.9%, 99.6%, respectively; PCR 88.6%, 99.9%, 99.9%, 70.5%, respectively; histology 78.3%, 97%, 78.3%, 97%, respectively. Predictive values for positive and negative changes with varying Combination of three diagnostic tests employed in the study gives no substantial benefit for practitioners to screen infected patients, and urease test or PCR represents an appropriate single test in clinical environments.

• Tuberculosis and Respiratory Diseases
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• v.62 no.6
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• pp.479-485
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• 2007

Background: The purpose of this study was to evaluate the differences in CT findings according to sputum smear-positive or -negative results in patients with active pulmonary tuberculosis having a single cavity. Methods: A total of 32 patients with active pulmonary tuberculosis having a single cavity on CT were classified into two groups: smear-positive (n=19) and smear-negative (n=13). The CT findings were reviewed retrospectively. The presence of consolidation, the number of lobes showing consolidation, ground-glass opacity, micronodules and nodule, the maximum diameter of the cavity, and the shape and maximum thickness of the cavity wall were assessed. Result: The maximum diameter of the cavity was $33.84{\pm}13.65mm$ and $27.08{\pm}9.04mm $ in the smear-positive and -negative groups, respectively (p>0.05). The amount of consolidation and the number of lobes with consolidation were found to be 89.5% and 30.8% (p=0.01) and $1.37{\pm}0.90$ and $0.31{\pm}0.48$ (p=0.0002) in the smear-positive and -negative groups, respectively. Consolidations in two or more lobes were only noted in 31.6% of in the sputum smear- positive group (p< 0.05). There were no other significant differences between the two groups. The sensitivity, specificity, positive and negative predictive values for the presence of consolidation were 89.5%, 69.2%, 73.9%, and 81.8%, respectively. Conclusion: While the absence of consolidation on CT may be associated with sputum smear-negative results in patients with active pulmonary tuberculosis having a single cavity, the presence of consolidation in two or more lobes on CT may be associated with spear-positive results in these patients.