• Journal of Genetic Medicine
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• v.4 no.2
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• pp.200-203
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• 2007

Niemann-Pick type C is an inborn error of metabolism that affects lipid degradation and storage, which is characterized by hepatosplenomegaly and progressive neurological symptoms. A 7-month-old girl with jaundice was presented cholestasis and hepatosplenomegaly. Laboratory study showed elevated acid phosphatase, angiotensin converting enzyme and mild decrease of cholesterol. Characteristic foamy cell and sea-blue histiocytes in bone marrow biopsy consistent with Niemann-Pick disease. Niemann-Pick type C was suspected by past medical history and findings of physical examination. Therefore, molecular analysis was performed and found mutations of NPC1 gene. We report the first Korean case of type C Niemann-Pick disease confirmed by mutation analysis.

• Korean Journal of Microbiology
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• v.43 no.1
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• pp.1-6
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• 2007

We describe a multiplex PCR method that can detect and differentiate simultaneously four different kinds of DNA viruses, Epstein-Barr virus (EBV), cytomegalovirus (CMV), hepatitis B virus (HBV) and parvovirus B19 (B19). Primers for the multiplex PCR reaction were designed to amplify specific regions of the EBV (pol), CMV (pol), HBV (pol) and B19 (ns) viral genomes and used to simultaneously detect individual viruses. In order to achieve optimal sensitivity and specificity for multiplex PCR, the thermo-cycling parameters, primer sequences, and concentration of each reaction components were optimized systematically. The sensitivity of the detection method ranged between 5 and 10 copies of viral genome with a mixture of multiple primer pairs. Furthermore, this highly sensitive test showed no cross-reactivity among the four viruses. Thus, the results obtained in this study provide evidence that the assay system is a good tool for supporting the diagnosis of viral infection and contamination.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.1
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• pp.15-21
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• 2016

In this paper, we considered a design method of a compact quasi-Yagi antenna for portable UHF RFID readers. The antenna consists of a dipole driver and a reflector printed on a dielectric substrate, and it is fed by a microstrip line. In order to reduce the antenna size, the dipole and reflector are bent and the balun between the feeding microstrip line and coplanar strip (CPS) line is integrated within the CPS line. The effects of the geometrical parameters of the proposed antenna on the antenna performance are examined, and the parameters are adjusted to be suitable for the operation in UHF RFID band (902-928 MHz). The size of the fabricated antenna is $70mm{\times}75mm$, and the experiment results reveal a frequency band of 892-942 MHz for a voltage standing wave ratio < 2, a gain > 3.5 dBi, and a front-to-back ratio > 6.6 dB over the frequency band for UHF RFID.

• Journal of Sericultural and Entomological Science
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• v.42 no.1
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• pp.14-23
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• 2000

The mitochondrial genome of domesticated silkworm (Bombyx mori) was mapped with five restriction endonucleases (BamHI, EcoRI, HindIII, PstI and XbaI), the entire genome was cloned with HindIII and EcoRI. From the end sequencing results of 5$^1$and 3$^1$region for full genome set of eleven mitochondrial clones, the seven mitochondrial genes (NADH dehydrogenase 6, ATPase 6, ATPase 8, tRN $A^{Lys}$, tRN $A^{Asp}$, tRN $A^{Thr}$ and tRN $A^{Phe}$ of mori were identified on the basis of their nucleotide sequence homology. The nucleotide composition of NADH dehydrogenase 6 was heavily biased towards adenine and thymine, which accounted for 87.76%. On basis of the sequence similarity with published tRNA genes from six insect species, the tRN $A^{Lys}$, tRN $A^{Asp}$ and tRN $A^{Thr}$ were showed stable canonical clover-leaf tRNA structures with acceptible anticodons. However, both the DHU and T$\psi$C arms of tRN $A^{Phe}$ could not form any stable stem-loop structure. The two overlapping gene pairs (tRN $A^{Lys}$ -tRN $A^{ASP}$ and ATPase8-ATPase6) were found from our sequencing results. The genes are encoded on the same strad. ATPase8 and ATPase6 overlaps (ATGATAA) which are a single example of overlapping events between abutted protein-coding genes are common, and there is evidence that the two proteins are transcribed from a single bicistronic message by initiation at 5$^1$terminal start site for ATPase8 and at an internal start site for ATPase6. Ultimately, this result will provide assistance in designing oligo-nucleotides for PCR amplification, and sequencing the specific mitochondrial genes for phylogenetics of geographic races, genetically improved silkworm strains and wild silkworm (mandarina) which is estimated as ancestal of domesticated silkworm.sticated silkworm.

• Journal of Digital Convergence
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• v.12 no.12
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• pp.265-275
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• 2014

This paper introduces a new algorithms for reconstructing the suffix tree of character string, when a substring id deleted from the string or a string is inserted into the string as a substring. The algorithem has two main functions, delete-structure and insert-structure. The main objective of this algorithm is to save the time for constructing the suffix tree of an edited string, when the suffix tree of the original string is available. We tested the performance of this algorithm with some DNA sequences. This test shows that delete-reconstructing can save time when the length of the subsequence deleted is less than 30% of the original sequence, and the insert-reconstructing takes less time with regard to the length of inserted sequence.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.20 no.9
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• pp.967-973
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• 2009

In this paper, X-band satellite communication oscillator of double phase locked is implemented by constructing a couple of phased-locked loop, and then we have analyzed the phase noise of designed PLL-DRO. The designed phase-locked oscillator is consist of series feedback DRO, frequency divider, phase detector, loop filter and programmable PLL-IC. By dividing oscillation frequency of 12.6 GHz into two frequencies, it exhibits output power of 15.32 dBm at 6.3 GHz. Phase noises of implemented oscillator are -81 dBc/Hz@100Hz, -100.86 dBc/Hz@1 kHz, -111.12 dBc/Hz@10 kHz, -116 dBc/Hz@100 kHz and -140.49 dBc/Hz@1 MHz respectively. These indicate excellent stable operation of oscillator and very good phase noise characteristics.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.20 no.9
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• pp.823-828
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• 2009

A small UHF RFID tag antenna for a key-chain installed inside of a metallic key-management cabinet has been designed. The tag antenna has been designed as small size as $66\;mm{\times}6\;mm$ with consideration of coupling among the tag antennas and metallic parts of key-chain and cabinet. The tag antenna is fabricated with a meander line dipole using T-matching method with FR-4 substrate. One tag antenna has been designed with consideration of coupling of adjacent tag antennas, and the other has been designed for the location close to the metallic part in the cabinet. The characteristics of tag antennas and reading distance have been analyzed based on the different numbers of adjacent tag antennas. As a results, the 360 tag antennas installed in the cabinet have been successfully recognized.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.25 no.7
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• pp.516-520
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• 2012

In this paper, we have theoretically analyzed and designed a dielectric multi-layer sensor with a SPR (surface plasmon resonance) using analytical calculation and FDTD (finite difference time-domain) methods. The proposed structure is composed of periodic layer and thin metal film. It has many advantages. One of that is a high sensitivity of the SPR. Another is a high Q-factor of the characteristics in the PhC (photonic crystals) micro-cavity structure. The incident light has double resonance characteristics, because the filtered light by PhC structure, dielectric multi-layer, is met the thin metal film for SPR effect. We have also observed the change of resonance characteristics according to the variation of effective index on the metal film.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.41 no.6 s.324
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• pp.93-99
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• 2004

According to rapid increment of demand for wireless Local Area Network (LAN), the HyperLAN of 5.1-533GHz and 5.725-5.825GHz is newly allocated for wireless LAM in many regions over the world. Also, because most of mobile communication equipments are small, the size of antenna is important factor of effective design. In this paper, the compacted and wide bandwidth antenna is designed for wireless LAN at 5GHz band. Although the structure of U-shaped slot antenna is simple, It has large bandwidth of $10-40\%$. Also, the U-slot antenna has good radiation pattern. However, in general, the size of U-slot antenna is large. Therefore, it is difficult to apply to wireless equipment such as PDA and Notebook. This proposed antenna has a wide bandwidth by U-shaped slot in rectangular patch and is compacted by using two layered dielectric substrates and foam. For the design of U-slot antenna, the Finite Difference Time Domain method is applied. Also, the method of MPI parallel program is used for the enhancement of the analyzing speed of the FDTD method.

• Korean Journal of Optics and Photonics
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• v.18 no.4
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• pp.235-240
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• 2007

A ceramic stem based TO package incorporating a coplanar waveguide feed-line has been proposed allowing for 10 Gbps grade data transmission. The frequency response of a cylindrical feed-line fer a conventional metal based TO package was first analyzed, and compared with that of the CPW feed-line used for a ceramic based package such as a butterfly package. For the case where a DFB LD chip is packaged to an LD module, the measured 3 dB frequency bandwidths for the conventional and proposed packages were 3.5 GHz and 7.8 GHz respectively, which agree well with the theoretical results obtained from the modeling based on the small signal equivalent circuits. Consequently, we proposed a novel ceramic based TO package with a CPW feed-line in ceramic material as a stem to improve the frequency characteristics of the conventional one. And, its performance was theoretically observed to confirm that the proposed package provides even wider frequency bandwidth compared to the conventional one.