• Proceedings of the Korea Information Processing Society Conference
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• 2002.04b
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• pp.1183-1186
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• 2002

DNA 의 염기서열 탐색을 위한 유전체학의 다음 세대인 구조유전체학은 유전체 사업으로 인한 인간 게놈지도의 완성과 축적된 생물정보를 이용한 생물정보학의 발달과 함께 급속한 성장을 계속하고 있다. 포스트 게놈 시대를 맞이하여 생명현상에 대한 궁극적인 이해를 위한 노력으로 단백질의 구조와 기능에 대한 연구가 주목을 받게 되었다. 다양한 구조 규명을 위한 도구들과 단백질 정보를 관리하기 위한 데이터베이스 구축에 따른 관련 기술의 발전은, 앞으로 다가올 생물정보의 방대함을 감안할 때, 가치 있는 지식정보를 얻기 위한 데이터 마이닝 기법들을 통해서만 가능하다. 본 논문은 데이터 마이닝의 근간 기술인 연관규칙 마이닝을 응용한 효율적인 서열 연관 규칙 알고리즘을 제안하며, 단백질 구조의 예측을 위한 단백질 서열 및 DNA 서열간의 패턴 비교 및 연관성을 목적으로 한다. 또한, 공간적 시간적 복잡성을 CMS-tree 라는 자료구조를 통해 알고리즘의 확장성 및 병렬화의 기본 알고리즘으로 사용하도록 개발하였다.

• Bioinformatics and Biosystems
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• v.2 no.2
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• pp.66-70
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• 2007

과거 사회라는 개념 속에서의 관찰과 통계적 인과관계의 규명에 치중하여 이루어졌던 보건학 연구는 유전체 연구와 같은 증거 위주의 기초과학적 측면에서 이루어 지고 있는 것이 현재의 추세이다. 이러한 생물학적 데이터를 이용한 질병과 보건에 대한 연구가 활성화 됨에 따라 보건 분야에서도 컴퓨터를 이용하여 방대한 정보를 다룰 수 있는 생명정보학이 유용한 도구로서 인식되고 있다. 본고에서는 생명정보학이 보건학의 연구분야에서 어떻게 이용되는 가를 학술적인 의미에서 살펴보고 그 활용방안에 대해 논의해 보고자 한다.

• Korean Journal of Plant Taxonomy
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• v.47 no.2
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• pp.161-169
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• 2017

The genome size is one of the basic characters of an organism, and it is widely applied in various fields of biology, such as systematics, breeding biology, population biology, and evolutionary biology. This factor was recently highlighted in genome studies because choosing a representative of a plant group having the smallest genome size is important for the efficiency of a genome project. For the estimation of the genome size, flow cytometry has recently been highlighted because it is a convenient, fast, and reliable method. In this study, we report the genome sizes of 15 taxa of Lamiaceae from nine genera distributed in Korea using flow cytometry. Data pertaining to the genome size for all of our species have not been reported thus far, and the data from Agastache, Clinopodium, Elsholtzia, and Isodon are the first reported for each genus. The genome sizes of 15 genera and 39 species were reported to the Plant DNA C-values Database (http://data.kew.org/cvalues/). Scutellaria indica L. has a genome size of 0.37 pg (1C). This is the fourth smallest value among the 98 Lamiaceae taxa in the Angiosperm DNA C-value Database, indicating that this taxon can be used as a reference species in the genome studies in Lamiaceae as a native Korean species. The largest genome size observed in this study is in Phlomis umbrosa Turcz. (1C=2.60 pg), representing the possible polyploidy origin of this species in the family.

• Korean Journal of Breeding Science
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• v.50 no.4
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• pp.364-377
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• 2018

Hexaploid wheat (common wheat/bread wheat) is one of the most important cereal crops in the world and a model for research of an allopolyploid plant with a large, highly repetitive genome. In the heritability of agronomic traits, variation in gene presence/absence plays an important role. However, there have been relatively few studies on the variation in gene presence/absence in crop species, including common wheat. Recently, a reference genome sequence of common wheat has been fully annotated and published. In addition, advanced next-generation sequencing (NGS) technology provides high quality genome sequences with continually decreasing NGS prices, thereby dawning full-scale wheat functional genomic studies in other crops as well as common wheat, in spite of their large and complex genomes. In this review, we provide information about the available tools and methodologies for wheat functional genomics research supported by NGS technology. The use of the NGS and functional genomics technology is expected to be a powerful strategy to select elite lines for a number of germplasms.

• Korean Journal of Ornithology
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• v.25 no.2
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• pp.77-81
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• 2018

The Korean Crested ibis Nipponia Nippon is an endangered species. A pair of Crested ibis was introduced from China in October 2008, and a successful program of artificial incubation of the species, and over 200 animals have been successfully bred through the restoration project up to 2017 at Upo ibis restoration center. We assessed genetic diversity and sex determination in the Korean Crested ibis. In total, 228 Crested ibis (115 females and 113 males) were identified. And genetic diversity measures, observed heterozygosity, expected heterozygosity, and polymorphic information content values were lower in 2017 than those in 2016. The inbreeding coefficient showed that the degree of ancestry increased in 2017. The decrease in polymorphism and increase in the degree of ancestry is thought to be due to inbreeding in such a small group. In this study provided important insight into protocols for genetic management of the breeding population of Korean Crested ibis in Korea and will help in extending the restoration program.

• Korean Journal of Microbiology
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• v.55 no.1
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• pp.58-60
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• 2019

Anaerobic Gram-negative bacterium Prevotella intermedia is a part of normal flora of the oral cavity and associated with various types of oral and systemic diseases. We present here a draft genome sequence of P. intermedia ATCC 15032, originally isolated from cervicofacial actinomycosis. The genome is 2,848,426 bp in length and has a GC content of 43.45%. The genome includes 2,358 protein-coding genes, 5 rRNAs, and 43 tRNA. The sequence information will provide important clues in understanding the genome diversity within the bacterial species, and genetic basis for phenotypic differences among P. intermedia strains.

• Journal of Genetic Medicine
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• v.8 no.2
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• pp.89-99
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• 2011

Over the years Korean health care system has improved in delivery of quality care to the general population for many areas of the health problems. The system is now being recognized in the world as the most cost effective one. It is covered by the uniform national health insurance policy for which most people in Korea are mandatory policy holders. Genetic counseling service, however, which is well recognized as an integral part of clinical genetics service deals with diagnosis and management of genetic condition as well as genetic information presentation and family support, is yet to be delivered in comprehensive way for the patients and families in need. Two major obstacles in providing genetic counseling service in korean health care system are identified; One is the lack of recognition for the need for genetic counseling service as necessary service by the national health insurance. Genetic counseling consumes a significant time in delivery and the current very low-fee schedule for physician service makes it very difficult to provide meaningful service. Second is the critical shortage of qualified professionals in the field of medical genetics and genetic counseling who can provide the service of genetic counseling in clinical setting. However, recognition and understanding of the fact that the scope and role of genetic counseling is expanding in post genomic era of personalized medicine for delivery of quality health care, will lead to the efforts to overcome obstacles in providing genetic counseling service in korean health care system. Only concerted efforts from health care policy makers of government on clinical genetics service and genetic counseling for establishing adequate reimbursement coverage and professional communities for developing educational program and certification process for professional genetic counselors, are necessary for the delivery of much needed clinical genetic counseling service in Korea.

• Journal of Scientific & Technological Knowledge Infrastructure
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• s.12
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• pp.52-57
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• 2003

바이오인포매틱스 시스템은 생명공학, 의학, 약학 등의 바이오인포매틱스 관련 산.학.연 연구자들의 연구개발의 기반이 되는 대용량의 생물정보를 효율적으로 저장하는 데이터베이스 구축 및 운영에 필요한 검색 처리 및 분석 시스템을 구축하는 정보인프라로서 21세기 가장 각광 받는 분야로 자리잡고있다. 최근 기하급수적으로 증가하고 있는 유전정보와 특정그룹이나 개인별 유전자 변화와 질병 감수성과의 관계 및 특정 질병과 관련된 유전자에 대한 생물학적 2차, 3차 분석정보 등 바이오인포매틱스 연구의 확대 필요성이 증가하고 있으나, 대부분의 생명공학 관련 산.학.연 연구자들은 연구분야에 적합한 IT기술을 적용할 수 있는 적절한 방법을 보유하고 있지못한 실정이다.

• Journal of KIISE:Software and Applications
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• v.32 no.2
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• pp.99-107
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• 2005

In this paper, wc propose a now missing imputation method for minimizing loss of information linkage disequilibrium-based and haplotype-based imputation method, which estimate missing values of the data based on the specificity of Single Nucleotide Polymorphism(SNP) genotype data. Method for imputing data is needed to minimize the loss of information caused by experimental missing data. In general, missing imputation of biological data has used major allele imputation method. but this approach is not optima]. 1'his method has high error rates of missing values estimation since the characteristics of the genotype data are not considered not take into consideration the specific structure of the data. In this paper, we show the results of the comparative evaluation of our model methods and major imputation method for the estimation of missing values.

• Korean Journal of Microbiology
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• v.38 no.4
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• pp.267-275
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• 2002

We have developed GComp as an analysis tool for microbial genome comparison. This tool exploits BLAST or FASTA as a preprocessing program for local alignments to detect homologous regions, parses the homology search results, and generates tables and files to show homology relationship between two genomes at a glance. The interface for graphical representation of the comparative genomic analysis has been also implemented. Our test cases shows that the program can be useful in practice for intuitive and quantitative comparison of microbial genome sequence pairs as well as self-genome analysis. A few additional features have been devised and designed, which will be added in the further development.