• Proceedings of the Korean Society for Bioinformatics Conference
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• 2003.10a
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• pp.288-297
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• 2003

본 논문은 진화 알고리즘(Evolutionary algorithm)의 기법중의 하나인 유전자 프로그래밍(Genetic programming)을 이용하여 miRNA 유전자를 발굴하기 위한 알고리즘을 소개하고 있다 miRNA는 세포내에서 유전자의 전사를 중지시킴으로써 유전자의 발현을 직접적으로 조절하게 되는 작은 RNA 집단 중의 하나이다. 그러므로 miRNA를 유전체 데이터에서 동정해내는 작업은 생물학적으로 상당히 중요하다. 한편 유전체 데이터에서 miRNA를 동정해내는 알고리즘은 생물학적 실험에서의 시간과 비용을 상당히 절감할 수 있으며, 생물학적으로 miRNA를 동정하는 많은 어려움을 덜어주게 된다. 하지만 계산학적으로 miRNA의 동정은 1차 염기서열상의 통계적인 중요도가 부족하여 기존의 유전자 예측 알고리즘을 적용하기에는 어려움이 있다. 따라서 본 연구에서는 miRNA의 염기서열보다는 2차구조에서 더 많은 유사성을 갖는다는 점을 착안하여, 2차구조내에서 공통적인 구조를 찾아내고, 그 정보를 이용하여 miRNA를 동정해내는 방법으로 접근하였다. 이 알고리즘의 성능평가를 위해 우리는 test set을 이용하여 학습된 모델의 특이도(= 34/38)와 민감도(= 38/67)를 계산하였다. 평가결과 본 알고리즘이 기존의 miRNA 예측 프로그램보다 높은 특이도를 갖고 있으며, 유사한 수준의 민감도를 갖고 있음을 보여 주고 있다.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2004.04a
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• pp.277-280
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• 2004

In the research of biomechanical engineering, robotics and neurophysiology, to clarify the mechanism of human bipedal walking is of major interest. It serves as a basis of developing several applications such as rehabilitation tools and humanoid robots Nevertheless, because of complexity of the neuronal system that Interacts with the body dynamics system to make walking movements, much is left unknown about the details of locomotion mechanism. Researchers were looking for the optimal model of the neuronal system by trials and errors. In this paper, we applied Genetic Programming to induce the model of the nervous system automatically and showed its effectiveness by simulating a human bipedal walking with the obtained model.

• Proceedings of the Korean Information Science Society Conference
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• 2003.10b
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• pp.823-825
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• 2003

시간이 흐름에 따라 생화학 시스템이 변화하는 것을 기록한 데이터로부터 이 시스템의 상태 전이 및 시스템을 구성하는 각 생화학 물질간의 관계를 모델링하기 위한 방법으로 S-tree 구조를 제안한다. 이것은 주로 생화학 시스템의 동적 특성을 모델링 하기 위하여 연구되어 온 S-system을 나무 구조로 표현한 것이다. 본 논문에서는 진화 연산을 통해 주어진 시계열 데이터를 잘 설명하는 S-tree의 구조 및 그 변수들을 동시에 효과적으로 탐색하는 방법을 개발하였다. 이 방법에서는 구조 탐색을 위해 유전 프로그래밍(genetic programming)에서 사용되어 온 나무 구조의 교차 및 돌연변이 연산과 더불어 다양한 형태의 구조 탐색 연산자들을 도입하였고, 또한 동시에 알맞은 변수 값들을 찾기 위하여 확률적 돌연변이 연산을 통한 언덕 오르기(hill-climbing)를 수행한다. 제안된 방법을 효모의 혐기성 발효 데이터에 적용한 결과 주어진 시스템을 성공적으로 모델링할 수 있었다.

• Development and Reproduction
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• v.12 no.2
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• pp.117-124
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• 2008

The efficient strategies to cope with unpredictable and/or harmful environmental changes have been developed by every organism in order to ensure its survival and continuity of it's own species. As a results, all living things on earth maintain dynamically internal stability via a process termed 'homeostasis' among physiological parameters despite of external environment changes. Stress is an emotional and physical response to threat homeostasis. Stress may have not only transient but rather permanent effect on the organism; recent evidence clearly show that prenatal stress could organize or imprint permanently physiological systems without any change in genetic codes, a process known as 'epigenetic programming'. In this review, a series of reproduction-associated events occurred in prenatally stressed male rats such as alteration in the structure of sexually dimorphic brain regions, modification of neurotransmitter metabolism, changes in reproductive endocrine status, and finally, disorders of sexual behavior will be introduced. The fetal brain is highly sensitive to prenatal programming and glucocorticoids in particular have powerful brain-programming properties. The chronic hyperactivation of fetal brain by maternal stress-induced glucocorticoid input will provide new program via increasing the neuroplasticities. This 'increased neuroplasticities' will be the basis for the 'increased phenotypic plasticities' rendering the organism's better adaptation to environmental challenges. In conclusion, organism who experienced 'harsh' environment in his fetal life seems to give up a certain portion of reproductive competence to make good chance of survival in his future life by epigenetic (re)programming.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.41 no.2
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• pp.123-131
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• 2021

The buffer is a key component of an engineered barrier system that safeguards the disposal of high-level radioactive waste. Buffers are located between disposal canisters and host rock, and they can restrain the release of radionuclides and protect canisters from the inflow of ground water. Since considerable heat is released from a disposal canister to the surrounding buffer, the thermal conductivity of the buffer is a very important parameter in the entire disposal safety. For this reason, a lot of research has been conducted on thermal conductivity prediction models that consider various factors. In this study, the thermal conductivity of a buffer is estimated using the machine learning methods of: linear regression, decision tree, support vector machine (SVM), ensemble, Gaussian process regression (GPR), neural network, deep belief network, and genetic programming. In the results, the machine learning methods such as ensemble, genetic programming, SVM with cubic parameter, and GPR showed better performance compared with the regression model, with the ensemble with XGBoost and Gaussian process regression models showing best performance.

• Korean Journal of Computational Design and Engineering
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• v.9 no.3
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• pp.183-191
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• 2004

This paper deals with smooth curve fitting of data corrupt by noise. Most research efforts have been concentrated on employing the smoothness penalty function with the estimation of its optimal parameter in order to avoid the 'overfilling and underfitting' dilemma in noisy data fitting problems. Our approach, called DBSF(Differentiation-Based Smooth Fitting), is different from the above-mentioned method. The main idea is that optimal functions approximately estimating the derivative of noisy curve data are generated first using genetic programming, and then their integral values are evaluated and used to recover the original curve form. To show the effectiveness of this approach, DBSP is demonstrated by presenting two illustrative examples and the application of estimating the principal dimensions of bulk cargo ships in the conceptual design stage.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2006.04a
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• pp.185-191
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• 2006

As development of information technology, companies stress the need of knowledge management. Companies construct ERP system including knowledge management. But, it is not easy to formalize knowledge in organization. They experience that constructing information system help knowledge management. Now, we focus on engineering knowledge. Because engineering data contains experts' experience and know-how in its own, engineering knowledge is a treasure house of knowledge. Korean shipyards are leader of world shipbuilding industry. They have accumulated a store of knowledges and data. But, they don't have data minning tool to utilize accumulated data. This paper treats development of data minning tools for the utilization of shipbuilding knowledge based on genetic programming (GP).

• Proceedings of the KIEE Conference
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• 2015.07a
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• pp.1349-1350
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• 2015

풍속은 다른 기상요소들보다 순간 변동이 심하고 국지성이 강하여 수치 예보 모델만으로 예측의 정확성을 높이기가 어렵다. 기상청의 단기 풍속 예보는 전 지구적 통합 예보모델인 UM(Unified Model)의 예측값에 MOS(Model Output Statictics)를 통한 보정을 수행하며, 보정식의 생성에 다중선형회귀분석 방법을 사용한다. 본 연구자는 유전프로그래밍(Genetic Programming)을 이용한 비선형 회귀분석 기반의 보정식 생성을 통하여 이를 개선한 바 있는데, 본 연구에서는 보다 향상된 성능을 얻기 위하여 GP 기법 측면에서 Automatically Defined Functions과 다군집(Multiple Populations) 수행을 통해 성능을 높이고자 한다.

• Korean Management Science Review
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• v.23 no.1
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• pp.63-74
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• 2006

Decision tree induction algorithm is one of the most widely used methods in classification problems. However, they could be trapped into a local minimum and have no reasonable means to escape from it if tree algorithm uses top-down search algorithm. Further, if irrelevant or redundant features are included in the data set, tree algorithms produces trees that are less accurate than those from the data set with only relevant features. We propose a hybrid algorithm to generate decision tree that uses genetic programming with sequentially selected features. Correlation-based Feature Selection (CFS) method is adopted to find relevant features which are fed to genetic programming sequentially to find optimal trees at each iteration. The new proposed algorithm produce simpler and more understandable decision trees as compared with other decision trees and it is also effective in producing similar or better trees with relatively smaller set of features in the view of cross-validation accuracy.

• Korean Journal of Computational Design and Engineering
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• v.14 no.6
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• pp.382-389
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• 2009

Recently, knowledge management has been required in companies as a tool of competitiveness. Companies have constructed Enterprise Resource Planning(ERP) system in order to manage huge knowledge. But, it is not easy to formalize knowledge in organization. We focused on data mining system by genetic programming(GP). Data mining system by genetic programming can be useful tools to derive and extract the necessary information and knowledge from the huge accumulated data. However when we don't have enough amounts of data to perform the learning process of genetic programming, we have to reduce input parameter(s) or increase number of learning or training data. In this study, an enhanced data mining method combining Genetic Programming with Self organizing map, that reduces the number of input parameters, is suggested. Experiment results through a prototype implementation are also discussed.