• Journal of Life Science
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• v.28 no.12
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• pp.1536-1544
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• 2018

Depression is a common, serious, and recurring mental disorder. The pathogenesis of depression involves many factors such as environmental factor, genetic factor and alteration of structure and function in neurobiological systems. Increasing evidence supports that epigenetic alteration may be associated with depression. The epigenetics is explained as the mechanisms by which environmental factor causes changes in chromatin structure and alters gene expression without changing DNA base sequence. DNA methylation and histone modification involving histone acetylation and methylation are the main epigenetic mechanisms. Animal studies have shown that stressful environment such as early life stress can leave persistent epigenetic marks in the genome, which alter gene expression and influence neural and behavioral function through adulthood. A potentially important gene in depression is brain-derived neurotrophic factor (BDNF). BDNF plays a central role in depression and antidepressant action. In studies of the rodent, exposure to stress at prenatal, postnatal, and adult stages alters BDNF expression through histone modification and DNA methylation of the BDNF gene which results in anxiety and depressive-like behavior. This review discusses recent advances in the study of the epigenetic mechanisms that contribute to depression, particularly histone modification and DNA methylation of the BDNF gene, that may help in the development of new targets for depression treatment.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.28 no.4
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• pp.425-430
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• 1983

Rice (Oryza sativa L.) anthers collected from different genotypes were cultured to investigate the priority to increase callus production rate among several factors affecting on callus formation. Rice varieties, F$_1$ hybrids and F$_2$ plants differed greatly in their abilities to produce callus from anthers, and it was confirmed that the culturability of rice anther was a heritable characteristic. Cold shock treatment before plating anthers promoted callus formation rate, but combined effect with genotype having high culturability was more significant. The response to sucrose concentration in culture medium in callus induction rate was different between rice genotypes, but combined effect with genotype was not significant. Single supplement of NAA to R$_2$ medium increased callus production rate remarkably only in rice genotype having high culturability. Conclusively selection of genotypes is most important to increase callus initiation frequency from rice anthers.

• Proceedings of the Zoological Society Korea Conference
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• 1998.10b
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• pp.194.2-194
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• 1998

• The Science & Technology
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• no.1 s.452
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• pp.20-20
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• 2007

• Journal of Korea Society of Industrial Information Systems
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• v.25 no.2
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• pp.115-127
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• 2020

In this paper, a sustainable close-loop supply chain (SCLSC) model is proposed for effectively managing the production, distribution and handling process of mobile phone. The proposed SCLSC model aims at maximizing total profit as economic factor, minimizing total CO₂ emission amount as environmental factor, and maximizing social influence as social factor in order to reinforce sustainability in it. Since these three factors are represented as each objective function in modeling, the proposed SCLSC model can be taken into consideration as a multi-objective optimization problem and solved using a hybrid genetic algorithm (HGA) approach. In numerical experiment, three different scales of the SCLSC model are presented and the efficiency of the HGA approach is proved using various measures of performance.

• Journal of the Korean Data and Information Science Society
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• v.27 no.3
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• pp.741-747
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• 2016

The aim of study was to estimate genetic parameter of carcass traits in commercial Hanwoo steer using national animal model for selection of superior bull. Analyzed data (n=5,843) on carcass traits was collected from 107,020 Hanwoo steer. The animal model was used to estimate heritability and genetic correlations. The estimated heritability of carcass traits were 0.19, 0.17, 0.20 and 0.23 for carcass weight, eye muscle area, backfat thickness and marbling score, respectively. The estimated heritability for carcass traits in commercial Hanwoo are low than estimated heritability of national progeny test population for selection of superior bull because breeding environment, genetic performance of cow and feeding day was different. Therefore, we suggests that animal model can include practical genetic variable based on national animal model to improve genetic performance in commercial Hanwoo.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.28 no.4
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• pp.488-496
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• 1983

Narrow and broad sense heritabilities for the characters ranged from 0.1618 to 0.6914 and from 0.7494 to 0.9357, respectively, in F$_1$ hybrids of $5{\times}5$ full diallel crosses. Plant height and days to flowering had the highest heritabilities and yield and quality the lowest. Partial dominance was exhibited by plant height, number of leaves, leaf area per plant and days to flowering. Over dorminance was detected by leaf width and yield of cured leaf. Leaf length and quality would be considered being controlled by a complete dominance effect.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2008.06a
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• pp.349-349
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• 2008

유비쿼터스 시대를 맞이하여 현재의 전자제품은 고주파 환경에서의 소형화된 마이크로파 소자를 요구하고 있다. 현재 구현되고 있는 마이크로파 소자의 형태는 여러 가지 전송선로 중에 하나로서 금속의 그라운드면 위에 유전체 막을 형성하고 그 위에 금속선을 정밀하게 패터닝하여 각 종 소자를 연결하는 microstrip line의 형태가 많이 사용된다. 이러한 microstrip line 형태의 소자를 설계할 시에 소자 자체의 구조나 유전체 막이 그 소자의 성능을 크게 좌우한다. 여기서 유전체 막은 신호선과 그라운드면 간의 전자파를 집중시켜주어 방사손실을 줄여주는 역할을 한다. 유전체 막의 두께는 소자의 전체적인 크기를 결정하는 요인이 된다. 이는 유전체 막의 두께가 감소할 경우 50 $\Omega$ 임피던스 매칭을 위해 막 위에 형성되는 소자들의 선폭도 동시에 줄여야 하므로 소자의 소형화도 가능 하여진다. 하지만 유전체 막의 두께가 감소할 경우 전자파가 유전체 막에 집중되지 못하여 방사손실이 커지게 되고 소자의 성능이 저하된다. 이런 점을 고려할 때 소자의 소형화를 만족시키면서 동시에 소자의 성능을 유지할 수 있는 유전체 막의 최적화 두께에 대한 연구가 필요하다. 볼 연구에서는 유전체 막의 최적화 두께를 제시하기 위해 대표적 마이크로파 소자인 Edge-Coupled Filter에 대하여 3-D Electromagnetic Simulator로 설계하고 유전체 막의 두께와 Filter 성능 간의 관계를 연구하였다. Filter의 성능은 유지하도록 하면서 유전체 막의 두께를 감소시켜 나간 결과, 약 30 ~ 40 ${\mu}m$ 의 최적화 두께를 얻을 수 있었다. 한편 30 ~ 40 ${\mu}m$ 두께의 후막 공정을 고려할 때 기존의 성막공정으로는 성막시간, 공정의 난이도, 공정온도 등의 면에서 난점이 존재하며 이러한 점들을 극복할 수 있는 Aerosol Deposition Method의 적용 가능성에 대해서 연구하였다.

• Journal of the korean academy of Pediatric Dentistry
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• v.40 no.3
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• pp.203-208
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• 2013

Although the first case of supernumerary teeth had been documented almost 20 centuries ago, the etiology of supernumerary teeth still remains unclear. The prevalence of supernumerary teeth in the general Asian population is between 2.7% and 3.4%. The pathogenesis of supernumerary teeth has been attributed to phylogenetic reversion(atavism), splitting of the tooth bud(dichotomy theory), locally induced hyperactivity of the dental lamina and a combination of genetic and environmental factors(unified etiologic explanation). This report describes 3 cases of monozygotic twins with mesiodens who visited the pediatric dental clinic of Kyungpook national university hospital, and this is significant to support genetic factors involoved in the development of supernumerary teeth.

• Proceedings of the Korea Electromagnetic Engineering Society Conference
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• 2001.11a
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• pp.300-303
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• 2001

개방단말 동축선 프로브는 임의의 매질에 접촉하여 복소 유전율을 구하므로 사용이 용이한 측정법이다. 복소 유전율의 측정 과정은 두 단계로 구성된다. 먼저 프로브의 개구면을 미지의 매질에 접촉시켜서 반사계수를 측정한다. 다음에는 반사계수를 환산모델에 대입하여 복소 유전율을 구한다. 그러나 실제 측정시 발생하는 오차들에 대해 취약하다는 단점을 가지고 있다. 정확성을 떨어뜨리는 주요 오차 요인으로는 프로브의 개구면과 측정매질 사이의 공극으로 인한 불완전 접촉오타와 프로브의 제작 한계로 인한 오차를 들 수 있다. 본 논문에서는 이런 오차상황에서 유한 차분 시간영역법으로 반사계수를 계산하고나서 환산모델에 의해 복소 유전율로 환산함으로써 오차에 대한 환산모델들간의 안정성을 살펴보고자 한다.