• Journal of Life Science
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• v.20 no.4
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• pp.519-527
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• 2010

Paclitaxel is known as a potent inhibitor of microtubule depolymerization. It leads to mitotic arrest and cell death by stabilizing the spindle in various cell types. Here, we investigated the effects of paclitaxel on the proliferation and cell death of rabbit articular chondrocytes. Paclitaxel inhibited proliferation in a dose- and time- dependent manner, determined by MTT assay in rabbit articular chondrocytes. We also established paclitaxel-induced G2/M arrest by fluorescent activated cell sorter (FACS) analysis. Paclitaxel increased expression of cyclin B, p53 and p21, while reducing expression of cdc2 and cdc25C in chondrocytes, as detected by Western blot analysis. Interestingly, paclitaxel showed the mitotic catastrophe that leads to abnormal nucleus division and cell death without DNA fragmentation through activation of caspase. Cell death by mitotic catastrophe in cells treated with paclitaxel was suppressed by inhibiting G1/S arrest with 2 mM thymidine. These results demonstrate that paclitaxel induces cell death via mitotic catastrophe without activation of casepase in rabbit articular chondrocytes.

• Journal of Korea Water Resources Association
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• v.30 no.6
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• pp.699-708
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• 1997

The effective unsaturated hydraulic conductivity in stratified soils is evaluated using a three-dimensional stochastic approach. Because of the disparity of the correlation scales in a stratified soil, the general stochastic equations are simplified. This allows analytical evaluation of generic expressions for the effective hydraulic conductivities. Simple asymptotic expressions, valid at particular ranges(wetting front, drying condition, wetting condition) of the mean flow characteristics, are also derived. An example of applying the derived theoretical result to a imaginaryl clay soil is presented. It reveals found that the effective unsaturated hydraulic conductivity showed large-scale hysteresis. Such large-scale hysteresis was produced by the spatial variability of hydraulic soil properties rather than hysteresis of the local parameters. In addition the results show that the effective hydraulic conductivities were larger in the case of accommodating heterogeneity of soil preperties rather than neglecting heterogeneity of soil properties.

• Journal of the Earthquake Engineering Society of Korea
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• v.7 no.6
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• pp.71-80
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• 2003

Though a nonlinear time history analysis may be provided to estimate more exactly the seismic performance of building structure, approximation methods are still needed in the aspect of practicality and simplicity, In converting a multi-story structure to an equivalent SDOF system, the mode vectors of the multi-story structure are assumed as the mode shape in elastic state regardless of elastic or elastic-plastic state. However, the characteristics of displacement mode are also changed after the yielding made in the structural elements, because the structure becomes inelastic in each incremental load step. In this research, a method of converting MDOF system to ESDOF system is presented by using nonlinear displacement mode considering the mode change of structures after the yielding. Also, the accuracy and efficiency of the method of the nonlinear displacement mode method of the estimate of seismic response of Mixed Building Structures were examined by comparing the displacements of the roof level of the multi-story building structures estimated from this converted displacement response of ESDOF with the displacement of the roof level through the nonlinear dynamic analysis of the multi-story building structures subjected to an actual earthquake excitation.

• Journal of the Korea Convergence Society
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• v.11 no.10
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• pp.349-353
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• 2020

Background: The dosage of the anesthetic drugs is generally determined by the total body weight of the patients. However, the drugs can be overdosed when the patient is morbidly obese. We have determined anesthetic induction dose based on lean body mass estimated from bioelectrical impedance analysis (BIA). Case: We report a case of morbidly obese patient (161 cm, 138 kg and body mass index 53.1) who had an elective laparoscopic cholecystectomy. The dose of induction agent was determined by lean body mass estimated by BIA, and the sedation was assessed by the observer's assessment alertness/sedation scale. Conclusions: Dose determination through lean body mass measured by BIA is useful in highly obese patients.

• Geophysics and Geophysical Exploration
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• v.24 no.4
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• pp.171-179
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• 2021

We outline a process for estimating Cole-Cole parameters from time-domain induced polarization (IP) data. The IP transients are all inverted to 2D Cole-Cole earth models that include resistivity, chargeability, relaxation time, and the frequency exponent. Our inversion algorithm consists of two stages. We first convert the measured voltage decay curves into time series of current-on time apparent resistivity to circumvent the negative chargeability problem. As a first step, a 4D inversion recovers the resistivity model at each time channel that increases monotonically with time. The desired intrinsic Cole-Cole parameters are then recovered by inverting the resistivity time series of each inversion block. In the second step, the Cole-Cole parameters can be estimated readily by setting the initial model close to the true value through a grid search method. Finally, through inversion procedures applied to synthetic data sets, we demonstrate that our algorithm can image the Cole-Cole earth models effectively.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05d
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• pp.170-175
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• 1996

대형 튜브구조물의 길이방향으로 전파되는 유도형초음파(Ultrasonic Guided Wave)를 이용한 원자력발존소내의 열교환기류에 대한 새로운 건전성 평가법을 제시한다. 이를 위해, 유도형초음파의 물리적 특성을 이론적으로 해석하였고 실험을 통해 열고환기류에 대한 유도형초음파법의 타당성 여부를 검토하였다. 국부적인 평가(Local Inspection)에 근거한 기존의 평가법에 비해 유도형초음파법은 단시간 내에 보다 효율적으로 전체 열교환기에 대한 신뢰성 검사(Global Inspection)가 가능하며 만족할 만한 민감도(Sensitivity)를 갖고 있음을 보였다.

• Proceedings of the KIEE Conference
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• 2011.07a
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• pp.820-821
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• 2011

본 논문은 단상 line-start permanent- magnet (LSPM) 전동기가 가지는 비동기 운전영역에서 나타나는 다양한 토크성분을 해석적 방법으로 분석한다. 비 동기속도에서의 정상상태 전류를 DQ 등가회로를 이용하여 유도하였으며, 이를 이용하여 유도전류와 제동전류의 주파수를 확인하였다. 마지막으로 시간차분 해석을 이용하여 비동기 운전영역의 특정 속도에 대한 토크와 전류를 분석하였으며, 주파수 변환을 이용하여 각 전류의 주파수 성분을 확인하였다.

• Journal of the Korea Society of Computer and Information
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• v.16 no.5
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• pp.61-71
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• 2011

To measure the fatigue of metallic objects at high speed vibration while non-contact precision displacement measurement on how to have a lot of research conducted. Noncontact high-speed vibration detection sensor of the eddy current sensors and laser sensors are used, but it is very expensive. Recently, High-speed vibrations detection using an inexpensive inductive sensor to have been studied, but is still a beginner. In this paper, a new design of an inexpensive inductive proximity sensor has been suggested in order to measure high frequency dynamic displacements of metallic specimens in a noncontact manner. Detection of the existing inductive sensors, detection, integral, and amplified through a process to detect the displacement noise due to weak nature of analog circuits and integral factor in the process of displacement detection is slow. The proposed method could be less affected by noise, the analog receive and high-speed signal processing is a new way, because AD converter (Analog to Digital converter) without using the vibration frequency signals directly into digital signals are converted. In order to evaluate the sensing performance, The proposed sensor module using non-contact vibration signals were detected while shaker vibration frequencies from 30Hz to 1,100 Hz at intervals of vibrating metallic specimens. Experimental results, Vibration frequency detection range of the metallic specimins within close proximity to contactless 5mm could be measured from DC to 1,100Hz and vibration amplitude of the resolution was $20{\mu}m$. Therefore, the proposed non-contact inductive sensor module for precision vibration detection sensor is estimated to have sufficient performance.

• Journal of the Korean Institute of Intelligent Systems
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• v.16 no.1
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• pp.119-123
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• 2006

In this paper, we propose fault diagnosis of induction motor based on PCA and MLP. To resolve the main drawback of MLP, we calculate the reduced features by PCA in advance. Finally, we develop the diagnosis system based on nonlinear classifier by MLP rather than linear classifier by conventional k-NN. By various experiments, we obtained better classification performance in comparison to the results produced by linear classifier by k-NN.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.6
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• pp.1399-1404
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• 2015

This paper analyzed the phenomenon of drain induced barrier lowering(DIBL) for the ratio of channel length vs. thickness of asymmetric double gate(DG) MOSFET. DIBL, the important secondary effect, is occurred for short channel MOSFET in which drain voltage influences on potential barrier height of source, and significantly affects on transistor characteristics such as threshold voltage movement. The series potential distribution is derived from Poisson's equation to analyze DIBL, and threshold voltage is defined by top gate voltage of asymmetric DGMOSFET in case the off current is 10^-7 A/m. Since asymmetric DGMOSFET has the advantage that channel length and channel thickness can significantly minimize, and short channel effects reduce, DIBL is investigated for the ratio of channel length vs. thickness in this study. As a results, DIBL is greatly influenced by the ratio of channel length vs. thickness. We also know DIBL is greatly changed for bottom gate voltage, top/bottom gate oxide thickness and channel doping concentration.