• Title/Summary/Keyword: 위 상관관계

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Evaluation of the Accuracy and usability of Trigger mode in Respiratory Gated Radiation Therapy (호흡동조방사선치료를 위한 Trigger mode 투시영상 획득 시 호흡 속도에 따른 정확성 평가 - Phantom Study)

  • Park, je wan;Kim, min su;Um, ki cheon;Choi, seong hoon;Song, heung kwon;Yoon, in ha
    • The Journal of Korean Society for Radiation Therapy
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    • v.33
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    • pp.25-33
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    • 2021
  • Purpose : The purpose of this study is to evaluate the accuracy and usefulness of the Trigger mode for the Respiratory Gated Radiation Therapy (RGRT) Materials and methods : A QUASAR respiratory phantom that inserted a 3 mm fiducial marker (a gold marker) was used to estimate the accuracy of the Trigger mode. And the 20 bpm was used as reference respiration rate in this study. The marker that placed at the center of the phantom was contoured, and the lower threshold of a gating window was fixed at 2.0 mm using an OBI with Truebeam STxTM. The upper threshold was measured every 0.5 mm from 1.0 mm to 3.0 mm. The respiration rates were changed every 10 bpm from 10 bpm to 60 bpm. We repeatedly measured five times to check the error rate of the trigger mode in the same condition. Result : The differences of a distance from a peak phase to upper threshold, 1.0 to 3.0 mm at a 20 bpm as a reference for 3 days in a row were 0.68±0.05 mm, 0.91±0.03 mm, 1.23±0.03 mm, 1.42±0.04 mm, and 1.66±0.06 mm, respectively. Measurement result of changes in respiratory rate compared to baseline respiratory rate in maximum absolute difference. The coefficient of determination (R2) to estimate the correlation between the respiration velocity and variation of absolute difference was on average 0.838, 0.887, 0.770, 0.850, and 0.906. The p-values of all the variables were below 0.05. Conclusion : Using Trigger mode during respiratory gated radiation therapy (RGRT), accuracy and usefulness of trigger mode at reference breathing rate were confirmed. However, inaccuracies depending on the rate of breathing it could be uncertain in case of respiration rate is faster than 20 bpm as a standard respiration rate compared to slower than 20 bpm. Consequently, when conducting a RGRT using the trigger mode, real time monitoring is required with well educated respiration.

Introduction of the Best Practices in the Pakistan Gulpur HEPP (파키스탄 Gulpur 수력발전 현장의 Best Practices 소개)

  • JANG, Ock Jae;HONG, Won Pyo;CHAE, Hee Moon
    • Proceedings of the Korea Water Resources Association Conference
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    • 2022.05a
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    • pp.216-217
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    • 2022
  • Gulpur 수력발전 프로젝트는 전력난을 겪고 있는 파키스탄에 102 MW 규모의 수력발전소를 건설하여 30년 동안 운영 관리한 후 파키스탄 정부로 양도하는 IPP(Independent Power Producing) 형식의 투자사업이다. 남동발전과 DL E&C, 롯데건설이 Sponsor로서 출자한 자본금과, ADB, IFC, K-EXIM 등의 대주단로부터의 차입금을 재원으로 하여 소요 사업비를 조달하고 사업을 개발하였다. DL E&C와 롯데건설이 EPC(Engineering, Procurement, Construction)를 수행하였고, 이산이 Design consultant의 역할을 수행하였다. Gulpur 수력발전 프로젝트의 발전형식은 수로식(run-of-river)으로 201 m3/s의 발전유량과 102 MW의 발전 시설용량을 이용하여 연평균예상발전량은 398 GWh이다. 주요 구조물로는 설계 재현빈도 1년의 유수전환시설(가물막이댐 & 가배수터널)과 콘크리트 중력식댐(H 67 m, L 205 m), 도수터널(D 6.7 m, L 215 m, 2기), 옥외형 발전소 (H 51 m, W 60 m, L 38 m, Kaplan 2기)가 있으며, 2015년 10월 착공하여 2020년 3월 상업발전을 시작하였다. 본 프로젝트는 DL E&C의 첫 번째 EPC 해외수력발전 프로젝트이다. 따라서 프로젝트의 성공적 수행을 위한 경제적 설계, 시공의 효율성 및 안정성 확보 등을 위하여 많은 연구를 수행하는 과정에서 다양한 기술 개선을 이룰 수 있었다. 본고에서는 Gulpur 프로젝트를 통하여 도출된 성공 사례들을 소개 및 공유하고자 한다. 첫 번째로 콘크리트 중력식댐 시공을 위한 유수전환시설의 최적 설계빈도를 산정하였다. 일반적으로 유수전환시설의 규모는 설계기준에 제시된 설계 재현빈도를 이용하는데, 해외 설계기준에서는 10년, 국내 설계기준에서는 1~2년으로 다르게 제시되어 있는 문제점이 있다. 유수전환시설의 규모는 프로젝트의 경제성에 큰 영향을 미치기 때문에 최적 설계빈도의 결정이 필요하며, 위험도분석기법(Risk Analysis)과 기대화폐가치법(Expected Monetary Value)을 이용하여 유수전환시설의 최적 설계 재현빈도와 이에 영향을 미치는 인자를 분석하였다. 위험도는 몬테카를로 시뮬레이션으로 산정된 가물막이댐 파괴확률과 재현빈도를 이용하여 산정된 가물막이댐 월류확률을 고려하였으며, 비용 및 피해액으로는 유수전환시설의 공사비, 가물막이댐 파괴시의 재건설비용과 지체보상금, 가물막이댐 월류시의 복구비용을 고려하였다. 이에 대한 연구결과로, 유수전환시설의 사용기간과 월류시의 복구비용이 유수전환시설의 설계 재현기간 결정에 가장 큰 영향을 미치는 것으로 나타났고, 특히 월류시의 복구비용이 작을수록 낮은 설계 재현빈도를 선택하는 것이 타당한 것으로 나타났다. 예를 들어, 유수전환시설의 사용기간이 3 ~ 5년, 복구비용이 0.5 ~ 1.0 mil USD 이하인 조건에서 가물막이시설의 최적 설계빈도는 1년 ~ 2년인 것으로 나타났다. 또한, 유수전환시설의 사용기간은 본댐의 규모와 시공기간 등을 고려하여 결정되는 사항으로 설계자가 임의 조정할 수 없지만, 복구비용은 시공 관리자에 따라 결정되는 부분으로, 적극적 홍수 피해 저감 및 복구방안을 마련하는 것이 프로젝트의 경제성을 향상시킬 수 있다는 것을 알 수 있었다. 두 번째로 프로젝트의 경제성 향상, 홍수기 댐 시공시의 안전성 확보를 위하여 홍수 조기경보시스템(Early Warning System)을 개발 및 활용하였다. 수로식(Run-of-river) 수력발전댐은 대부분 산악지역에 위치하기 때문에 국지성 강우 및 급한 지형 경사로 인하여 돌발홍수(flash flood)의 발생 가능성이 높다. 따라서 시공 중 홍수(월류) 발생을 미리 감지하고 현장에 전파할 수 있는, 수로식(Run-of-river) 수력발전댐 현장을 위한 홍수 조기경보시스템이 필요하며, 이를 리스크 인식, 모니터링 및 경보, 전파 및 연락, 반응 능력 향상의 4가지 부분으로 나누어 구축하였다. 리스크 인식 부분에서는 가물막이댐 월류 발생 상황에 대한 위험도, 취약성, 리스크를 제시하였으며, 모니터링 및 경보 부분에서는 상류 측정수위에서 유도된 현장 예상수위와 실제 현장 측정 수위를 대상으로 경보홍수위와 위험홍수위로 나누어 관리하였다. 전파 및 연락 부분에서는 현장 시공 조직을 활용하여 홍수시를 대비한 비상연락체계도(Emergency communication flow chart)를 운영하였으며, 반응 능력 향상을 위해 비상연락체계도의 팀별 Action plan을 상세화 하였다. 세 번째로 현장의 지질특성과 50여 차례 발파시험으로 현장 고유의 발파진동감쇄곡선을 도출하였으며, 이를 통해 현장의 시공성과 콘크리트 품질 확보를 동시에 달성할 수 있는 방안을 제시하였다. 콘크리트댐 공사에서는 제한된 공기 내에 공사를 완료하기 위해 사면부 굴착과 콘크리트 타설이 동시에 수행될 수밖에 없는 문제점을 가지고 있다. 그러나 신규 콘크리트 타설면 근처에서 발파를 수행하는 경우 발파로 발생되는 탄성파가 일정 수준을 초과하게 되면, 콘크리트 양생에 영향을 주게 된다. 따라서 다수의 현장 발파시험을 통해 발파거리와 최대진동속도의 상관관계 즉, 발파진동감쇄곡선을 도출함으로써 현장의 발파진동특성을 도출할 수 있었다. 또한, 기존 연구 논문들을 통해 콘크리트 재령기간 별 안전진동속도를 선정하고, 해당 안전진동속도를 초과하지 않는 범위에서 콘크리트 타설면과 발파위치의 거리에 따라 1회 발파 가능한 장약량을 산정하여 적용하였다. 이와 같은 체계적인 접근을 통해 콘크리트 타설과 발파 작업 동시 수행에 대한 논란을 해소할 수 있었다.

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Analysis of Verbal Interaction and Perception of Elementary Pre-service Teachers in Science Class Demonstration: Focus on Questioning and Feedback (과학 수업시연에 나타난 언어적 상호작용과 초등 예비교사의 인식 - 발문 및 피드백을 중심으로 -)

  • Jung, Hana;Jhun, Youngseok
    • Journal of Korean Elementary Science Education
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    • v.43 no.1
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    • pp.64-80
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    • 2024
  • This study aims to investigate the characteristics of verbal interaction in science class demonstrations conducted by elementary school pre-service teachers. Specifically, the study intends to examine the use of elements of verbal interaction and the progression of these interactions. Additionally, the study intends to analyze the perception of pre-service teachers about effective questioning and feedback and to determine the correlation between the proportions of the types of questioning and feedback positively perceived by the pre-service teachers and of the types of questioning and feedback used during class demonstration. Toward this end, the study analyzed the science class demonstration videos and class evaluation sheets submitted by 38 fourth-year students at the S University of Education. The results are as follows. First, pre-service elementary school teachers generally use close-ended questions during science class demonstrations. Moreover, they predicted that students would primarily provide the correct responses and would not engage in extended interaction by providing immediate feedback for the responses of the majority of the students. Second, pre-service elementary school teachers perceived the utilization of close-ended questions and immediate feedback in science class demonstrations more favorably than they did that of open-ended questions and delayed feedback. The study observed a weak positive correlation between the positive perception of specific types of questions and feedback and the use of such types in class demonstration. The results demonstrated that pre-service elementary school pre-service teachers tend to engage in fragmented verbal interactions during science class demonstrations. They primarily use close-ended questions and immediate feedback. This tendency is seemingly related to their perception of questions and feedback. Therefore, education institutions for training pre-service teachers need to provide opportunities for reflecting on verbal interactions, which tend to involve close-ended questions and immediate feedback. Lastly, assessing the perception of pre-service teachers of questions and feedback is also necessary.

Studies of Liming Effect on the Improvement of an Acid Sulphate Paddy Soil (특이산성답(特異酸性畓) 토양(土壤)의 개량(改良)을 위(爲)한 석회시용(石灰施用) 효과(?果)에 관(關)한 연구(硏究))

  • Park, Young-Sun
    • Applied Biological Chemistry
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    • v.17 no.3
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    • pp.193-218
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    • 1974
  • These studies were carried out for the elucidation of liming effect on the growth of rice seedlings and the chemical characteristics of an acid sulphate paddy that shows not only extremely high acidity of soil but also poor growth of rice plants, consequently low yield. Thus the liming effect on the changes of acidity, oxidation-reduction potential, and the contents of iron, aluminium, sulphate, and phosphorus fractions in the soil was investigated under the waterlogging and drying condition. The reclaimable or inhibitory effect of phosphorus, iron and aluminium on the growth of rice seedlings was also investigated under liming. The results are summarized as follows: 1. After liming, the pH of the acid sulphate subsoil decreased again on drying. 2. The oxidation-reduction potential reached a minimum after 5 days of flooding and greatly decreased on liming but increased after drying. 3. The contents of ferrous iron soluble in water-and Morgan's solution reached a maximum after 15 days of flooding and only the content of water soluble ferrous iron was greatly decreased. 4. The content of aluminium soluble in water-and Morgan's solution decreased by flooding and liming, and showed a tendency to increase on drying. 5. In the limed acid sulphate soil, the content of water soluble calcium showed a highly significant negative correlation with the content of sulphate and liming decreased sulphate content in the soil. 6. The contents of total phosphorus was 496.3 ppm in the acid sulphate topsoil and 387.5 ppm in the subsoil. The content of each phosphorus fraction was in the order of Fe-P>Occ. Fe-P>Ca-P>Occ. Al-P>Al-P and Fe-P content in the soil was the highest fraction among them. 7. Lime application increased greatly Ca-P and Al-P, and Occ. Fe-P and Occ. Al-P only slightly, but decreased Fe-P differently in each soil. 8. Effect of phosphorus on the dry matter yield of rice seedlings was great. The optimum amount of phosphorus to produce maximum dry matter yield of rice seedlings appeared to be 6.8% of maximum absorption (absorption coefficient) without liming and 10.0% with liming. 9. In rice seedlings liming increased the content and uptake of calcium and silica but decreased those of iron and aluminium. Phosphorus application increased the content and uptake of phosphorus and decreased iron while the application of iron and aluminium increased their contents and uptake but decreased those of phosphorus. 10. Liming greatly alleviated such toxicity of iron and aluminium. 11. When phosphorus was applied, the dry matter yield of rice seedlings showed highly significant positive correlations with uptake of phosphorus, calcium and silica each. When iron and aluminium were applied, dry matter yields indicated significant positive correlations with the contents or uptake of calcium and silica each, but significant negative correlations with the content or uptake of iron and aluminium. 12. Under the application of phosphorus and lime, dry matter yields showed significant positive correlations with pH and Morgan's extractable calcium each of the soil samples after harvest. Under the application of lime, iron and aluminium, dry matter yields showed significant positive correlations with pH, calcium and silica each, but negative correlations with iron and aluminium contents each of the soil samples after harvest.

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A Study on the Characteristcs of Soil Parameter (흙의 지수적(指數的) 특성(特性)에 관한 연구(硏究))

  • Kang, Yea-mook;Cho, Seung-seup;Kim, Seung-wan
    • Korean Journal of Agricultural Science
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    • v.4 no.2
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    • pp.157-166
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    • 1977
  • These experiments were carried out to analyse the correlation among various soil parameters which characterize the mechanical properties of the disturbed and undisturbed soil, and to analyse Atterberg Limits for the basin of downstream of Hanriver Keum river, Nakdong river, and Asan bay. 1. Wet density of soil was the lowest in the basin of Nakdong river which contains the highest amount of clay minerals among the soil samples, and was increased in the order of Han river, Keum river and Asan bay. It was appeared that the unit weight of natural soil was changed in accordance with the clay mineral content which determines the moisture content. 2. Curved relationship was recognized, showing that dry density of soil was decreased with increasing the moisture content. Soils from the basin of Asan bay were appeared to have the highest dry density and the next was those of Keum river, the second lowest Han river, and the lowest Nakdong river. 3. When the liquid limit of soils was over 40 percent, their plastic index was above the A-line of plastic chart. 4. Between dry density and void ratio of soils, a curved relationship was found, in which dry density was decreased as void ratio increased, and the differences between them became greater in soils containing higher amount of coarse grained soil. Decreasing tendency of dry density in accordance with increase of void ratio was the most significant at Asan bay which contained the lowest clay content, and other decreasing order of dry density was Keum river, Han river, and Nakdong river.

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ASSOCIATION BETWEEN TOURETTE DISORDER AND CATECHOL-O-METHYL TRANSFERASE(COMT) GENE IN KOREAN SUBJECTS (한국인에 있어서의 뚜렛 장애와 COMT유전자간의 상관 관계에 대한 연구)

  • Kim, Boong-Nyun;Lim, Jae-In;Cho, Soo-Churl
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.15 no.2
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    • pp.178-184
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    • 2004
  • Objectives : This study was conducted to investigate the association of the COMT polymorphism with the TD in Korean sample of families with TD probands. The relationship between risk alleles and specific clinical features (tic severity, comorbidity, drug response) was also explored. Method : Patients were recruited from the Tic Disorder clinic at the Child & Adolescent Psychiatric Division of Seoul National University Hospital and assessed through 2 stage evaluation. Firstly, all the patients and parents received semistructured interview using Korean version of K-SADS-PL. Secondly all the patients received clinical interview and tic severity assessment with Korean version of YGTSS. The subjects in control group were recruited from the health promotion center in out hospital and were evaluated by SCL-90 and SCID-IV. Through these process, total of 42 children and adolescents with TD, their 84 parents and 86 control subjects were finally recruited. Genotyping for The Val158Met polymorphism of the COMT gene was done by standardized method. After collection of genetic data of all the patients, parents and control subjects, case-control comparison and tranmission dysequilibrium test was executed by SPSS version 11. Result : From the case-control comparison, the frequency of L-allele and LL genotype was significantly higher in TD group. However, no differences were found from the TDT. No significant differences were found in in family history of tic, ADHD, OCD, drug response and comorbid conditions among the three different genotypes in patients with TD. Conclusion : Though this study results should be interpreted cautiously due to small sample size and negative finding in TDT test, this study is the first report that there is positive association between the functional polymorphism of COMT gene the TD.

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Runoff and soil loss on newly reclaimed upland (야산개발지(野山開發地)의 토양침식(土壤侵蝕)에 관(關)하여)

  • Jung, Yeong Sang;Shin, Jae Sung;Shin, Yong Hwa
    • Korean Journal of Soil Science and Fertilizer
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    • v.9 no.1
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    • pp.9-16
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    • 1976
  • In order to investigate inherent erodibility of the soil, which is a major factor is soil erosion prediction, a survey on runoff and soil loss of reclaimed upland soil was carried out by using a portable rainulator. The relations of soil loss and some physical properties of the soil were discussed. The soil erodibility factor for Universal soil loss equation was calculated and compared with that of Wischmeier's nomograph. The result were as follows: 1. Total runoff increased for finer textured soil in order of Jeonnam silty clay loam, Songjeong clay loam, Yesan loam, Samgag and Sangju sandy loam. Total soil loss and soil content in runoff were not correspondently related with textural characteristic in order of Jeonnam, Samgag, Sangju, Yesan, and Songjeong. Total runoff, soil loss, and soil content in runoff were increased for steeper slope. 2. Soil loss and soil content in runoff negatively correlated with organic matter content of surface soil, while positively correlated with dispersion ratio, clay ratio, silt content, and significantly correlated with Middleton erosion ratio for coarser textured soil but not correctly related for finer textured soil. 3. The soil erodibilty factor K values for Universal soil loss equation were 0.32 for Jeonnam, 0.22 for Samgag, 0.17 for Sangju, 0.15 for Yesan, and 0.13 for Songjeong respectively. These values were close to those from Wischmeier's nomograph. So, it seems that the nomograph is useful for estimation of soil loss in Korea.

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Factors Influencing Digital Native's Acceptance and Use of 4th Industrial Revolution Technology : Focusing on FinTech and AR (Augmented Reality) Technology (Digital Native의 4차산업혁명 기술수용 영향 요인: FinTech 및 AR(증강현실) 기술을 중심으로)

  • Chung, Byoung-Gyu
    • Journal of Venture Innovation
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    • v.4 no.2
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    • pp.77-95
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    • 2021
  • In the midst of the progress of the 4th industrial revolution, the Corona19 Pandemic was forming giant double wave. Companies riding this wave can win, but companies that do not will fall into the wave and struggle. In connection with the 4th industrial revolution, various technologies are emerging and commercialized. At this point, consumers, especially digital natives, who have been with digital since birth, tried to find out what factors affect the intention to use these technologies and which factors have the most important influence. For this purpose, data were collected through a survey on factors affecting the intention to use FinTech technology and AR technology for 150 digital natives in their 20s. Based on this, statistical analysis was conducted and the following results were obtained. As a result of the overall analysis regardless of the type of technology, it was found that performance expectancy, effort expectancy, social influence, and habits have a positive (+) effect on digital natives' intention to use the 4th industrial technology. On the other hand, a significant influence relationship between the facilitating conditions, hedonic motivation and intention to use the 4th industrial technology was not tested. It was found that the influence was greatly influenced by social influence and habits. In the case of FinTech and AR, which were further subdivided into this study, different aspects were revealed as a result of separate analysis. In the case of FinTech technology that emphasizes utilitarian value, performance expectancy, effort expectancy, social influence, and habits had a positive (+) effect on intention to use. It was found that the influence was greatly influenced by habits and social influence. In the case of AR, which emphasizes the hedonic value, all the variables adopted in this study had a positive (+) effect on the intention to use the technology. It was found that hedonic motivation and social influence had a great influence. Combining the results of the analysis, social influence was found to be an important influence variable regardless of the type of 4th industrial technology. FinTech technologies such as mobile banking, where services are becoming more common, are habits, and in the case of AR, which has not yet been universalized and is provided mainly for entertainment, hedonic motivation was found to be an important factor. This study was able to present academic and practical implications based on the above confirmation of factors affecting digital natives' acceptance and use of the 4th industry technology.

Contribution of Emotional Labor to Burnout and Work Engagement of School Foodservice Employees in Daegu and Gyeongbuk Province (대구·경북 일부지역 학교급식 조리종사자의 감정노동이 직무 소진 및 직무 열의에 미치는 영향)

  • Heo, Chang-Goo;Lee, Kyung-A
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.44 no.4
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    • pp.610-618
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    • 2015
  • The purpose of this study was to analyze differences in emotional labor strategies, burnout, and work engagement according to general characteristics of school foodservice employees as well as verify differential effects of two emotional labor strategies on burnout and work engagement. Our survey was administered to 400 school foodservice employees in Gyeongbuk from March 3 to April 25, 2014. A total of 358 completed questionnaires were returned, and 350 questionnaires were used for final analysis. For verification of mean differences, the mean scores for surface acting, deep acting, burnout, and work engagement were shown to be 2.38/5.00, 3.46, 2.67, and 3.41, respectively. The mean surface acting was significantly different according to cooking certification (P<0.001), turnover number (P<0.001), salary (P<0.001), and school level (P<0.01). The mean deep acting was significantly different according to educational background (P<0.001), cooking certification (P<0.001), employment status (P<0.001), salary (P<0.001), school level (P<0.01), and meal service time (P<0.05). The mean burnout was significantly different according to educational background (P<0.01), cooking certification (P<0.05), employment status (P<0.001), school level (P<0.001), and meal service time (P<0.001). The mean work engagement was significantly different according to cooking certification (P<0.001), employment satus (P<0.001), salary (P<0.001), school level (P<0.01), and meal service time (P<0.05). Verification of causal models found that surface acting and deep acting increased burnout and deep acting, respectively (research model). Additionally, surface acting did not influence work engagement, and deep acting did not influence burnout (alternative models). In other words, we identified that emotional labor strategies have differential influences on burnout and work engagement. Finally, implications and limitations of this study are discussed.

Methacholine Responsiveness of Bronchial and Extrathoracic Airway in Patients with Chronic Cough (만성 기침 환자에서 기관지와 흉곽외 기도의 Methacholine 유발검사의 의의)

  • Shim, Jae-Jeong;Kim, Je-Hyeong;Lee, Sung-Yong;Kwan, Young-Hwan;Lee, So-Ra;Lee,, Sang-Yeub;Lee, Sang-Hwa;Suh, Jung-Kyung;Cho, Jae-Youn;In, Kwang-Ho;Yoo, Se-Hwa;Kang, Kyung-Ho
    • Tuberculosis and Respiratory Diseases
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    • v.44 no.4
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    • pp.853-860
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    • 1997
  • Background : Chronic cough, defined as a cough persisting for three weeks or longer, is a common symptom for which outpatient care is sought. The most common etiologies of chronic cough are postnasal drip, asthma, and gastroesophageal reflux. Methacholine challenge is a useful diagnostic study in the evaulation of chronic cough, particularly useful in chronic cough patients with asthmatic symptom. Patients with chronic cough may have dysfunction of bronchial and extrathoracic airways. To evaluate if dysfunction of the bronchial and extrathoracic airways causes chronic cough, we assessed bronchial (BHR) and extrathoracic airway (EAHR) responsiveness to inhaled methacholine in patients with chronic cough. Method : 111 patients with chronic cough were enrolled in our study. Enrolled patients had no recorded diagnosis of asthma, bronchopulmonary disease, hypertension, heart disease or systemic disease and no current treatment with bronchodilator or corticosteroid. Enrolled patients consisted of 46 patients with cough alone, 24 patients with wheeze, 22 patients with dyspnea, 19 patients with wheeze and dyspnea. The inhaled methacholine concentrations causing a 20% fall in forced expiratory volume in 1s($PC_{20}FEV_1$) and 25% fall in maximal mid-inspiratory flow ($PC_{25}MIF_{50}$) were used as bronchial and extra thoracic hyperresponsiveness. Results : There were four response patterns to methacholine challenge study : BHR in 27 patients, EAHR in 16 patients, combined BHR and EAHR in 8 patients, and no hyperresponsiveness in 60 patients. In patients with cough alone, there were BHR in 3 patients, EAHR in 9 patients, and combined BHR and EAHR in 2 patients. In patients with wheeze and/or dyspnea, there were BHR in 24 patients, EAHR in 7 patients, and BHR and EAHR in 6 patients. Compared with patients with wheeze and/or dyspnea, patients with cough alone had more common EAHR than BHR. In patients with wheeze and/or dyspnea, BHR was more common than EAHR. Conclusion : These results show that among patients with hyperresponsiveness to methacholine, those with dyspnea and/or wheezing had mainly bronchial hyperresponsiveness, whereas those with chronic cough alone had mainly extrathoracic airway hyperresponsiveness.

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