• Journal of Korean Society of Forest Science
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• v.89 no.5
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• pp.645-654
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• 2000

The aim of this study was to described the genetic structure of Eleutherococcus senticosus in Korea. We investigated 10 patches, which are eight Korean patches and two foreign patches come from Russia and China growing at Korean habitat, using ISSR(inter-simple sequence repeats) markers. In ISSR PCR, the overall percentage of polymorphic ISSR amplicons was 76% and the mean number of amplicons per ISSR primer was 11.5, which were higher than the RAPD results for the some cultivars collected in Korea(Kim et al., 1998) ; 57% and 5.7, respectively. So ISSR markers provide more powerful tool than RAPD markers for the investigation of genetic variation in E. senticosus. There are relatively high genetic variation among patches as 62.8%, but low variation within eight Korean patches. Such pattern of genetic variation, which is not ordinary in other tree species, may be result from the narrow and limited habitats and the asexual reproduction of this species at the natural stands in Korea. Although the small sample size in this study seemed to be resulted in the high genetic variation among patches, the overall genetic interpretation of this study might not be much affected on the basis of the characteristics of the distribution and the reproduction system of E. senticosus. Analysis of genetic distance between all pairs of the patches did not reveal any trends with regard to geographic distance, which was confirmed by the results obtained from AMOVA(analysis of molecular variance) and PCA(principal component analysis). These results suggest that, in addition to the preservation of the natural stands, the conservation of larger number of patches with small number of individuals per patch is more effective for the ex situ conservation and for maintaining the genetic diversity of E. senticosus in Korea than smaller patches with large number of individuals.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.3
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• pp.201-208
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• 2008

Purpose: We aimed to assess the role of positron emission tomography using fluorodeoxyglucose (FDG-PET) in the diagnosis of recurrence or the assessment of therapeutic response in cervical and ovarian cancer patients through making a comparison between FDG-PET, abdominal computed tomography (CT) and serum tumor marker. Materials and methods: We included 103 cases (67 patients) performed FDG-PET and abdominal CT. There were 42 cervical cancers and 61 ovarian cancers. We retrospectively reviewed the interpretations of PET and CT images as well as the level of tumor marker. We calculated their sensitivity, specificity, positive predictive value and negative predictive value for these three modalities. And then we analyzed the differences between these three modalities. Results: Tumor recurrences were diagnosed in 37 cases (11 cervical cancers and 26 ovarian cancers). For PET, CT and tumor marker, in cervical cancer group, sensitivity was 100% (11/11), 54.5% (6/11) and 81.1% (9/11), respectively. And specificity was 93.6% (29/31), 93.6% (29/31) and 100% (31/31). In ovarian cancer group, sensitivity was 96.2% (25/26), 84.6% (22/26) and 80.8% (21/26), and specificity was 94.3% (33/35), 94.3% (33/35), 94.3% (33/35), PET was highly sensitive to detect the intraperitoneal and extraperitoneal metastasis with the help of the CT images to localize the lesions. However, CT had limitations in differentiation of the recurrent tumor from benign fibrotic tissue, identification of viable tumors at the interface of tissues, and detecting extraperitoneal lesions. Conclusion: FDG-PET can be an essential modality to detect the recurrent or residual tumors in gynecologic cancer patients because of its great field of the application and high sensitivity.

• Journal of Gastric Cancer
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• v.7 no.3
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• pp.160-166
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• 2007

Purpose: Recently, chemosensitivity tests have become widely used for the selection of effective drugs in gastric cancer patients. In this study, a chemosensitivity test was performed to select agents to increase the effectiveness of adjuvant chemotherapy. Materials and Methods: Chemosensitivity testing was performed in 81 gastric cancer patients that received a gastrectomy at the Yeungnam University Hospital. An ATP (adenosine triphosphate) based chemotherapy response assay was used. Clinicopatholgical factors such as sex, age, expression of tumor markers (CEA and CA19-9 levels), location of the tumor, morphology of advanced cancer, histological type, cell differentiation, depth of invasion, Lauren classification, Ming classification, lymphatic invasion, vascular invasion, neural invasion, lymph node metastasis and TNM stage were used to correlate the chemosensitivity and clinicopathological factors. Results: The most effective antitumor agents in gastric cancer patients were (in order of effectiveness) 5-FU, Epirubicin, lrinotecan and Oxaliplatin in our series. The chemosensitivity test showed a significant difference in susceptibility according to clinicopathological factors. Conclusion: Further studies on multidrug therapy are needed to evaluate synergistic effects of drugs. Therefore, for effective chemotherapy, it is more efficacious to select a chemosensitive drug than continue to use the same drug regimen.

• Proceedings of the Korean Information Science Society Conference
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• 2006.10b
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• pp.66-70
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• 2006

웹은 단순한 텍스트와 이미지의 저장소에서 서비스의 제공자로 진화하고 있다. 사용자들은 자신이 필요로 하는 서비스를 찾기 위해 웹 검색을 이용한다. 그러나, 현재의 검색 엔진은 주어진 질의어에 대해 모든 사람들에게 보편적으로 타당한 문서에 높은 우선 순위를 부여해 검색 결과의 상위에 위치시키기 때문에, 사용자의 관심과는 무관한 정보가 검색 결과의 상위에 나타나게 되는 단점이 있다. 이러한 문제를 해결하기 위해 사용자의 방문 내역을 사용자 프로파일에 저장하여, 이후 검색에서 사용자가 방문했던 웹 페이지들에 높은 우선 순위를 부여하여 검색 결과의 상위에 위치시키는 방식이 사용되고 있다. 기존의 사용자 프로파일은 단순 방문 페이지와 사용자가 실제 서비스를 제공받은 페이지에 대한 구별없이, 모든 검색 세션에 대해 동일한 방문 내역을 저장하고 있다. 그러나 이 경우, 잦은 방문 횟수를 가지나 실제 사용자가 서비스를 이용하지 않은 웹 페이지가 적은 방문 횟수를 가지나 실제 사용자가 서비스를 이용한 웹 페이지보다 높은 우선 순위를 갖게 될 수 있는 문제점을 지니고 있다. 본 논문에서는 필요로 하는 서비스를 웹에서 찾고자 할 때, 사용자가 과거에 이용했던 서비스 제공자들의 목록을 이용하여, 사용자 프로파일 기반 웹 서비스 검색의 정확도를 향상시키는 시스템을 설계하였다. 이를 위해 사용자가 웹 서핑 중 서비스를 이용했던 웹 페이지 정보를 서비스 제공자 목록에 저장하였다. 검색 엔진이 특정 질의어에 대해 제공하는 검색 결과는, 우선 사용자 프로파일을 이용해 과거에 자주 방문했던 웹 페이지가 높은 우선 순위를 갖도록 조정된 후, 서비스 제공자 목록을 이용해 과거에 사용자가 서비스를 이용했던 웹 페이지가 가장 높은 우선 순위를 갖도록 재조정된다. 사용자에게 제공되는 최종 검색 결과는 사용자의 과거의 방문 경향 및 실제 서비스 이용 경향을 모두 반영하게 된다.고려할 때 가장 효과적인 라우팅 프로토콜이라고 할 수 있다.iRNA 상의 의존관계를 분석할 수 있었다.수안보 등 지역에서 나타난다 이러한 이상대 주변에는 대개 온천이 발달되어 있었거나 새로 개발되어 있는 곳이다. 온천에 이용하고 있는 시추공의 자료는 배제하였으나 온천이응으로 직접적으로 영향을 받지 않은 시추공의 자료는 사용하였다 이러한 온천 주변 지역이라 하더라도 실제는 온천의 pumping 으로 인한 대류현상으로 주변 일대의 온도를 올려놓았기 때문에 비교적 높은 지열류량 값을 보인다. 한편 한반도 남동부 일대는 이번 추가된 자료에 의해 새로운 지열류량 분포 변화가 나타났다 강원 북부 오색온천지역 부근에서 높은 지열류량 분포를 보이며 또한 우리나라 대단층 중의 하나인 양산단층과 같은 방향으로 발달한 밀양단층, 모량단층, 동래단층 등 주변부로 NNE-SSW 방향의 지열류량 이상대가 발달한다. 이것으로 볼 때 지열류량은 지질구조와 무관하지 않음을 파악할 수 있다. 특히 이러한 단층대 주변은 지열수의 순환이 깊은 심도까지 가능하므로 이러한 대류현상으로 지표부근까지 높은 지온 전달이 되어 나타나는 것으로 판단된다.의 안정된 방사성표지효율을 보였다. $^{99m}Tc$-transferrin을 이용한 감염영상을 성공적으로 얻을 수 있었으며, $^{67}Ga$-citrate 영상과 비교하여 더 빠른 시간 안에 우수한 영상을 얻을 수 있었다. 그러므로 $^{99m}Tc$-transierrin이 감염 병소의 영상진단에 사용될 수 있을 것으로 기대된다.리를 정량화 하였다. 특히 선조체에서의 도파민 유리에 의한 수용체 결합능의 감소는 흡연에 의한 혈중 니코틴의 축적 농도와 양의 상관관계를 보였다(rho=0.9, p=0.04). 결론: $[^{11}C]raclopride$ PET을 이용하여 비

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.17 no.3
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• pp.129-136
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• 2017

Geographic Information System The geographic information system (GIS) has been limited to the government and some public sectors. Recently, the market has been diversified by combining with other areas such as mobile and CRM (Customer Relationship Management). The development direction of GIS technology in the 21st century is Web GIS, 3D GIS, mobile GIS, LBS, etc. as general technology for GIS application system development and spatial information service. In this study, we developed a new concept marking nail (a marking nail with built - in intelligent storage memory device) from the function of simple positioning of a marking nail related to a previously used underground item,, Burial depth, pipe thickness, piping material, management agency, contractor, contact, etc.) and store it in DB server, if necessary.Make it available in the right place. Through this research, it is possible to prevent and minimize various accidents caused by irregular excavation works, etc., and to provide information for establishing countermeasures related to sink holes. In order to provide systematic and reliable information on underground burial management, it was proposed to input information conveniently in the field, and the purpose was to reduce the incidence of buried underground pipes absolutely.

• Progress in Medical Physics
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• v.20 no.3
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• pp.180-190
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• 2009

Depth of prostate volume from the skin can vary due to intra-fractional and inter-fractional movements, which may result in dose reduction to the target volume. Therefore we evaluated the feasibility of automated depth determination-based adaptive proton therapy to minimize the effect of inter-fractional movements of the prostate. Based on the center of mass method, using three fiducial gold markers in the prostate target volume, we determined the differences between the planning and treatment stages in prostate target location. Thirty-eight images from 10 patients were used to assess the automated depth determination method, which was also compared with manually determined depth values. The mean differences in prostate target location for the left to right (LR) and superior to inferior (SI) directions were 0.9 mm and 2.3 mm, respectively, while the maximum discrepancies in location in individual patients were 3.3 mm and 7.2 mm, respectively. In the bilateral beam configuration, the difference in the LR direction represents the target depth changes from 0.7 mm to 3.3 mm in this study. We found that 42.1%, 26.3% and 2.6% of thirty-eight inspections showed greater than 1 mm, 2 mm and 3 mm depth differences, respectively, between the planning and treatment stages. Adaptive planning based on automated depth determination may be a solution for inter-fractional movements of the prostate in proton therapy since small depth changes of the target can significantly reduce target dose during proton treatment of prostate cancer patients.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.2D
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• pp.227-235
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• 2011

At present, the characteristics of drivers are not properly considered when informations are provided via VMS even though the Variable Message Signs(VMS) are one of the key information provision medias on the roads. In this study, the driver's psychological response(stress index) was evaluated using a driving simulator for the position of the VMS provided, the contents of the VMS provided, the size of characters on VMS, and types of VMS expression. It was appeared that the stress is the least when the position of the VMS provided 1.5km proceeded from exit, the contents of the VMS provided are time information and types of VMS expression are character form respectively and the size of characters on VMS is appeared not important. In addition, the change of the users' satisfaction level was measured when increasing the numbers of VMS on unit distance and the size of characters. The size of character was almost not effected in similar to the result of stress index and the satisfaction level increased when increasing the number of VMS on the unit distance. The results of this research can be utilized as basic data for the ITS system design and operation stages.

• Journal of Korean Society of Transportation
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• v.35 no.4
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• pp.321-331
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• 2017

The objective of this study is to analyze the factors affecting the pedestrian accidents of roundabout near schools. To this end, this study has focus on the comparative analysis of pedestrian accidents across different school areas. The traffic accident data from 2007 to 2014 are collected from TAAS data set of Road Traffic Authority. To develop the pedestrian accident rate model, the linear regression model has been utilized in this study. 28 explanatory variables such as geometry and traffic volume factors are used. The main results are summarized as follows. First, the null hypotheses that the number of pedestrian accidents are the same are rejected. Second, 5 multiple linear regression accident models with higher statistical significance (adjusted $R^2$ of 0.651~0.788) have been developed. Third, while the common variables of 3 models (model I~III) related to school location are evaluated to be the pedestrian island, crosswalk, types of roundabout, elementary school and bus stop. Fourth, while the common variable of 3 models (model III~V) related to near school area or not is evaluated to be pedestrian island, type of roundabout, sidewalk, elementary school, speed hump, speed limit sign and number of entry lane. As a result, the installation of pedestrian islands and crosswalk might be expected to decrease the number of pedestrian accidents near schools.

• Journal of Korean Orthopaedic Sports Medicine
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• v.4 no.1
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• pp.29-35
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• 2005

Purpose: The anterior cruciate ligament(ACL) has a neuromuscular control function as evidenced by the presence within it of mechanoreceptor. Although these mechanoreceptors have been identified, the afferent somatosensory pathways from ACL to the cerebrum have yet to be demonstrated in their entirety. In order to trace these afferent pathway, we conducted a viral trans-synaptic tracing experiment using the neurotropic pseudorabies virus(PRV). Material and Methods: The PRV was injected into the ACL of rats and allowed to replicate and spread trans-synaptically for 6 to 7 days. The brain and spinal cord of each sacrificed rat was then removed and processed immunohistochemically to detect the presence of PRV. Results: PRV-immunoreactive neurons were found to be localized in several different regions from the spinal cord to the cerebrum. Four nuclei in the reticular formation of the brain stem demonstrated strong positive labeling: the mesencephalic reticular nucleus, magnocelluar reticular nucleus, paragigantocellular reticular nucleus, and gigantocellular reticular nucleus. Conclusions: This findings suggests that the nerve endings of the rat ACL project into the cerebrum and that the reticular formation may play an important role in the afferent pathway of those nerve endings.

• Nuclear Medicine and Molecular Imaging
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• v.43 no.1
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• pp.60-71
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• 2009

Purpose: We assessed the absorbed dose to the tumor ($Dose_{tumor}$) by using pretreatment FDG-PET and whole-body (WB) planar images in repeated radioimmunotherapy (RIT) with $^{131}I$ rituximab for NHL. Materials and Methods: Patients with NHL (n=4) were administered a therapeutic dose of $^{131}I$ rituximab. Serial WB planar images alter RIT were acquired and overlaid to the coronal maximum intensity projection (MIP) PET image before RIT. On registered MIP PET and WB planar images, 2D-ROls were drawn on the region of tumor (n=7) and left medial thigh as background, and $Dose_{tumor}$ was calculated. The correlation between $Dose_{tumor}$ and the CT-based tumor volume change alter RIT was analyzed. The differences of $Dose_{tumor}$ and the tumor volume change according to the number of RIT were also assessed. Results: The values of absorbed dose were $397.7{\pm}646.2cGy$ ($53.0{\sim}2853.0cGy$). The values of CT-based tumor volume were $11.3{\pm}9.1\;cc$ ($2.9{\sim}34.2cc$), and the % changes of tumor volume before and alter RIT were $-29.8{\pm}44.3%$ ($-100.0%{\sim}+42.5%$), respectively. $Dose_{tumor}$ and the tumor volume change did not show the linear relationship (p>0.05). $Dose_{tumor}$ and the tumor volume change did not correlate with the number of repeated administration (p>0.05). Conclusion: We could determine the position and contour of viable tumor by MIP PET image. And, registration of PET and gamma camera images was possible to estimate the quantitative values of absorbed dose to tumor.