• Journal of Gastric Cancer
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• v.5 no.1
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• pp.47-51
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• 2005

Eosinophilic gastroenteritis is a rare clinicopathologic entity of unknown etiology with a variety of digestive symptoms. The pathogenesis is poorly understood. Diagnostic criteria include demonstration of eosinophilic infiltration of the affected bowel wall, lack of evidence of extraintestinal disease, and exclusion of various disorders that could mimic similar conditions. The disease might involve any area of the gastrointestinal tract from the esophagus to the rectum, but the stomach and the proximal small bowel are most commonly affected. The clinical features depend on which layer and site are involved. We report the case of a 59-year-old male patient with a 3-week history of post-prandial vomiting with malnutrition and weight loss. An abdominopelvic CT showed a gastric outlet obstruction with diffuse wall thickening, as with linitis plastica. Three gastrofiberscopic biopsies showed chronic gastritis. We carried out a radical total gastrectomy with D2 lymph node dissection. The pathologic report revealed a mural type eosinophilic gastritis with a marked hypertrophic scar formation at the proper muscle layer. We report this case with a brief review of the literature. (J Korean Gastric Cancer Assoc 2005;5:47-51)

• Korean Journal of Psychosomatic Medicine
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• v.10 no.2
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• pp.130-141
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• 2002

Objectives : Stress induces alteration of gastrointestinal function in which interleukin (IL) and hypothalamo-pituitary-axis are involved. Depression again is associated with functional gastrointestinal disorders (FGID) and interleukins. The author attempted to look into the role of interleukins in the FGID also the association of depression and stress in this context. Methods : Entered were 20 patients with FGID, diagnosed by Rome IT criteria and 20 healthy controls. Depression was measured by Hamilton Rating Scale for Depression (HAM-D), and stress of the last one year by Schedule of Recent Experience (SRE). Serum levels of IL-$1\beta$, IL-2, IL-6 were measured by Enzyme-linked Immunosorbent Assay and serum cortisol by Fluorescence Polarization Immunoassay. The results were as follows : Results: 1) Serum levels of IL-$1\beta$, IL-2 were significantly lower in the patients with FGID than those in the controls, but level of IL-6 did not differ between two groups. 2) The patient group showed significantly higher level of serum cortisol as well as higher degrees of depression and stress. 3) Positive correlation was noted between depression and serum cortisol, and between depression and IL-2. A trend of negative correlation was seen between depression IL-$1\beta$. Positive correlation was noted between SRE and IL-6 and IL-6 and serum cortisol. Conclusions : It was concluded that FGID might be related to depression and stress. Changes of the interleukins might be involved with elevated cortisol level.

• Proceedings of the Korean Society of Dyers and Finishers Conference
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• 2011.03a
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• pp.90-90
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• 2011

스텔스 기능성 섬유의 위장은 주간의 경우, 육안 및 망원경 관측에 의해 결정되며 주변자연환경 color matching과 패턴이 핵심 스텔스 요인으로 구성되고, 가시광선 영역 스텔스로 표현할 수 있으며, 군 위장 체계에 있어 기본이 되는 기술 분야로 모든 군 위장제품에 활용되는 필수적인 기술 분야이다. 따라서 가시영역의 위장은 다양한 색상의 위장포와 포의 펀칭 등에 의한 파형특성을 부여하고 주위환경과 특성 조화를 이룸으로써 대상을 위장한다. 주요인자는 색상별 색도, 색차이다. 야간 위장은 근적외선 관측 장비의 탐지에 의해 결정되며 주변자연환경 NIR 반사율과 위장제품의 NIR 반사율 저하/제어기술이 핵심 스텔스 요인으로 구성되고, 근적외선(NIR) 영역 스텔스로 표시할 수 있으며, NIR 스텔스는 대개의 경우 기본적으로 섬유제품이 NIR 영역에서 높은 반사율을 나타내므로 NIR 반사율 저하/제어기술이 핵심이라 할 수 있다. 따라서 근적외선 영역(600~1250nm)의 적외선 반사특성을 산림지역의 반사특성과 조화시켜 위장효과를 부여한다. 위장포에서는 적외선 흡수 색소를 사용하여 적절한 반사특성을 나타나게 해야 한다. 위장용섬유가 detector의 탐지에서 벗어나려면 현재 700~1250nm의 근적외선파장영역에서 주변환경과 유사한 반사율을 지녀야한다. 이에 본 연구에서는 "숲 연구소" 및 서울대학교 "지반공학연구실"의 자문을 받아서 우리나라에서 가장 많이 존재하는 자연환경시료를 선정하여, 선정된 시료의 근적외선영역에서의 반사율을 분석하였다. 자연시료는 산간, 해안, 평야지형으로 각각 구분하여 주변 자연지형에 따른 자연시료의 근적외선영역의 반사율값을 비교하였다. 북한산에서 산간지형의 시료를 채취하였고, 해안지형의 시료는 강화도 동막해수욕장 부근, 평야지형의 시료는 인천 강화도 평야지역에서 채취하여 분석하였다. 비교분석한 지형별 자연시료의 근적외선 반사율값의 데이터베이스구축을 통하여 기존의 위장복과의 비교 적용 및 차후 개선사항 등을 검토하고자 한다.

• The Journal of Internal Korean Medicine
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• v.22 no.1
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• pp.21-27
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• 2001

목적 : 본 연구는 배기음(排氣飮)이 토끼의 위장관내에서 화학물질에 의해 유발된 장관의 궤양에 유효한 효과를 발휘할 수 있는지를 검증하기 위한 실험이다. 방법 : 토끼 5마리를 한 군으로 하여 정상군과 체중 1kg당 200mg 분량의 mepirizole을 경구 투여한 군과 100mg/kg의 배기음(排氣飮)(경구투여)과 800Units/kg 분량의 catalase(정맥주사)를 mepirizole을 경구투여하기 2시간 전에 각각 전처치한 군으로 나누었다. Mepirizole을 경구 투여한 후 각각 24hr와 48hr에 토끼를 희생시켜 위장, 십이지장부의 궤양성 병변을 관찰하였다. 결과 : Mepirizole을 경구투여하여 위장 및 십이지장 기부의 궤양성 병변이 유발되었다. 배기음(排氣飮)(경구투여)과 catalase(정맥주사)를 전처치하였을 경우 궤양의 크기가 현저하게 줄어들었다. Mepirizole은 십이지장 점막에서 지질의 과산화를 증가시키는데 이는 수산화기와 관련되어 있음을 시사한다. 배기음(排氣飮)과 catalase를 전처치함으로써 mepirizole에 의해 유발된 지질의 과산화가 현저하게 억제되었다. 형태학상의 연구에서도 mepirizole의 처치에 의한 십이지장의 손상과 배기음(排氣飮)에 의한 방지효과가 나타났다. 결론 : 이러한 결과들로 볼 때 반응성산소기는 mepirizole에 의해 유발된 위장관 궤양의 병리변화 형성에 주요한 영향을 미치며 배기음(排氣飮)이 항산화작용을 통해 궤양의 형성을 억제하는 역할을 하고 있음을 나타낸다. 따라서 본 연구는 배기음(排氣飮)이 반응성산소기에 의해 매개된 인체 위장관질환에 치료적 역할을 할 수 있음을 제시하고 있다.

• Proceedings of the Korea Information Processing Society Conference
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• 2012.11a
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• pp.1173-1176
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• 2012

최근 들어 건강에 대한 관심이 증가하면서 건강관리 및 유지 방법으로 식이요법이 널리 사용되고 있다. 또한 IT 융합 기술이 다양한 분야에 적용되면서 체질과 식품과의 연관성 등을 객관적으로 입증하기 위한 식품 IT 기술이 연구되고 있다. 따라서 본 논문에서는 한의학적 진단 이론과 IT 영상처리 기술을 연계하여 칡이 간과 위장에 미치는 영향을 분석하는 실험을 수행하였다. 이를 위해 20대 남성10명을 대상으로 칡즙을 복용하고 간과 위장에 관련된 얼굴 부위인 좌측뺨과 콧등 영역의 색상 변화를 측정하여 칡과 간, 위장과의 상관성을 분석하는 연구를 수행하였다.

• The Journal of Internal Korean Medicine
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• v.44 no.4
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• pp.635-644
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• 2023

Objectives: This study analyzed laboratory serum data results before and after patients took herbal medicine to confirm the clinical safety of herbal medicine. In addition, in the event of liver damage, the case was analyzed to confirm the characteristics of liver damage and the possibility of liver damage caused by herbal medicine. Methods: A retrospective chart review of the effects of herbal medicine on liver function in patients diagnosed with functional dyspepsia was conducted. The electronic medical records of 128 patients in a single hospital were reviewed. Results: The statistical analysis revealed a statistically significant decrease in liver function-related laboratory serum data after taking herbal medicine (p<0.05). In addition, among 128 patients, there were two cases of drug-induced liver injury (DILI) (1.56%). Conclusion: Taking herbal medicine prescribed by experts does not significantly affect liver function in patients with functional dyspepsia. Rather, the liver levels of the subjects showed a significant decrease after taking herbal medicine. To support these results, further large-scale multicenter prospective studies are necessary.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.12 no.2
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• pp.120-132
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• 2009

Purpose: We diagnosed pediatric functional gastrointestinal disorders in Korean children and adolescents using Rome III criteria and investigated the clinical validity of QPGS-Rome III. Methods: Diagnosis based on QPGS was compared with the physician's diagnosis based on Rome III criteria. One hundred and thirty eight children and their parents completed the QPGS. Agreement rates were measured using Kappa method. Results: In physician's diagnoses, the most prevalent disorders were functional dyspepsia (39.1%), irritable bowel syndrome (38.4%), and functional abdominal pain (18.8%). Among QPGS based diagnoses, the most prevalent disorders were irritable bowel syndrome (39.1%), functional dyspepsia (29.7%), and functional abdominal pain (21.7%). The agreement rate was substantial (${\kappa}$=0.72, p=0.00). Diagnostic disagreements probably resulted from different patient responses to bowel movement form and bowel frequency. Conclusion: Functional dyspepsia, irritable bowel syndrome, and functional abdominal pain were the most common disorders by Rome III criteria in the Korean pediatric and adolescent patients. The agreement rate between physician's diagnoses and QPGS based diagnoses supported the validity of the QPGS-Rome III in Korean pediatric and adolescent patients. QPGS seems to be useful in diagnosis of patients with functional gastrointestinal disorders by Rome III criteria.

• Korean Journal of Psychosomatic Medicine
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• v.27 no.1
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• pp.25-34
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• 2019

Objectives : This study aimed to compare the psychosocial characteristics among patients with functional gastrointestinal disorder (FGID), adults with functional gastrointestinal symptoms, and normal control group and investigate factors related to quality of life (QoL) of FGID patients. Methods : 65 patients diagnosed with FGID were selected. 79 adults were selected as normal control group based on the Rome III diagnostic criteria, and 88 adults who showed functional gastrointestinal symptoms were selected as "FGID positive group". Demographic factors were investigated. Psychosocial factors were evaluated using the Korean-Beck Depression Inventory-II, Korean-Beck Anxiety Inventory, Korean-Childhood Trauma Questionnaire, Multi-dimensional Scale of Perceived Social Support, Connor-Davidson Resilience Scale and WHO Quality of Life Assessment Instrument Brief Form. A one-way ANOVA was used to compare differences among groups. Pearson correlation test was used to analyze correlations between QoL and psychosocial factors in patients with FGID. Results : There were group differences in the education level. Depression (F=29.012, p<0.001), anxiety (F=27.954, p<0.001) and Childhood trauma (F=7.748, p<0.001) were significantly higher in FGID patient group than in both FGID-positive and normal control group. Social support (F=5,123, p<0.001), Resilience (F=9.623, p<0.001) and QoL (F=35.991, p<0.001) were significantly lower in the FGID patient group than in others. QoL of FGID patients showed a positive correlation with resilience (r=0.475, p<0.01), and showed a negative correlation with depression (r=-0.641, p<0.01), anxiety (r=-0.641, p<0.01), and childhood trauma (r=-0.278, p<0.05). Conclusions : FGID patients have distinctive psychosocial factors compared to the both FGID-positive and normal control group. Therefore, the active interventions for psychosocial factors are required in the treatment of patients with FGID.

• The Korean Journal of Zoology
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• v.16 no.2
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• pp.119-126
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• 1973

This experiment was performed in order to study the morphological changes of the argentaffin and argyrophile cells in the gastrointestinal mucosae of Rana nigromaclata during development. The specimens from the stomach and the small intestine at different developmental stages were fixed in neutral 10% formalin, sectioned at a thickness of 3 microns, and impregnated by Masson's method for argentaffin cells and by Bodian's method for argyrophile cells. The results of observation were as follows: 1. In the stomach, the argentaffin cells appeared at XIII stage of metamorphosis and the argyrophile cells at X stage and they rapidly increased in number at XXV stage. 2. In the small intestine, the argentaffin cells appeared at XXV stage of metamorphosis and the argyrophile cells at XVII stage and they rapidly increased in number at XXV stage. 3. The argentaffin and argyrophile cells in the gastrointestinal mucosae, appeared prior to forming gastrointestinal mucosal fold following to development of muscle layer. 4. The rapid numeral increase of the argentaffin and argyrophile cells in the last stage of metamorphosis would be due to ecological changes and differentiations of gastrointestinal mucoae in amphilbia.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.4 no.2
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• pp.181-190
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• 2001

Purpose: The aim of this study is to investigate the usefulness of intestinal ultrasonography (US) and upper gastrointestinal endoscopy in the early diagnosis of Henoch-Sch$\"{o}$nlein purpura (HSP) with the gastrointestinal (GI) symptoms preceding the emergence of the skin lesion. Methods: The clinical, intestinal US and upper gastrointestinal endoscopic records of 85 patients (88 cases) with GI symptoms relating to HSP presenting between January 1999 and April 2001 were reviewed. Results: 1) GI symptoms were observed in 52 cases (59%) and skin, joint, renal and scrotal manifestations were observed in 88 (100%), 64 (73%), 15 (17%), 3 cases (3%) respectively. 2) Out of 52 cases with GI symptoms, abdominal pain was observed in all cases (100%). Positive stool occult blood, nausea and vomiting, abdominal tenderness, melena or tarry stool, diarrhea, hematemesis, rebound tenderness and rigidity were observed in 28 (50%), 17 (33%), 17 (33%), 12 (23%), 6 (12%), 4 (8%), 1 (2%) and 1 case (2%) respectively in order of frequency. 3) Intestinal US examination was performed in 27 cases with HSP and GI symptoms (52 cases). Out of 27 sonographic examinations 22 showed abnormal findings. Thickening of the duodeno-jejunal wall was observed in 16 cases (73%). Free peritoneal fluid, enlarged mesenteric lymph node, ileus and abnormal gall bladder were seen in 8 (36%), 8 (36%), 4 (18%) and 1 case (5%) respectively. In three cases of HSP without GI symptoms, those changes were absent. 4) In all of five cases with HSP and GI symptoms, endoscopic study showed mucosal edema and multiple hemorrhagic erosions especially at the second portion of the duodenum. Biopsy specimens from the duodenum of 2 cases out of 5 endoscopic examinations showed acute inflammatory infiltrates in the mucosa with hemorrhage. 5) Both intestinal US and endoscopic studies were performed in 4 cases with HSP and GI symptoms simultaneously. Out of 4 those cases, 3 cases showed the thickened duodeno-jejunal wall on the intestinal US, which suggested erosive hemorrhagic duodenitis by endoscopic findings. Conclusion: The typical but nonpathognomonic intestinal US findings including the thickening of the duodeno-jejunal wall and upper gastrointestinal endoscopic findings including hemorrhagicerosive duodenitis, in children with GI symptoms, should be considered a manifestation of HSP, even in the absence of skin lesion.