• Analytical Science and Technology
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• v.14 no.3
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• pp.221-229
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• 2001

The bioequivalence study of two tiropramide products was evaluated in 16 health male volunteers following intra-muscular injection. Test product was Tiram$^{(R)}$ injection (S Pharm. Co, Ltd.) and reference product was Tiropa$^{(R)}$ injection(D Pharm. Co., Ltd.). The drug concentration in plasma was determined by GC/MS for over a period of 8 hours after injection. Analysis of variance reveal that there are no differences in AUC (area under the plasma concentration-time curve from time zero to infinity), Cmax (maximum plasma concentration) and Tmax (time to reach Cmax). The differences of mean AUC, Cmax and Tmax between two products were 0.73, -1.385 and -12.994%, respectively. Minimum detectable differences (%) at ${\alpha}=0.05$ were all less than 20% given as a guideline (10.05, 17.90 and 19.01% for AUC, Cmax and Tmax, respectively). From these results, the two formulations of tiropramide are bioequivalent and thus, may be prescribed interchangeably.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 1999.11a
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• pp.260-265
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• 1999

멀티빔 음향측심기(Multibeam Echo Sounder)는 기존의 단빔 음향측심기(Singlebeam Echo Sounder)와 달리 탐사선 진행방향의 수직(Crosstrack)으로 해저면을 주사(Swath)하여, 한 번의 송수신(Ping)으로 다중의 빔 자료 - 수심, 후방산란된 음압(Backscattered Amplitude), 사이드 스캔 소나(Side Scan Sonar) 자료 - 를 취득하는 장비이다. 멀티빔 음향 측심기를 이용한 해저면 탐사의 경우, 수심이 변함에 따라 주사폭(Swath width)이 변화하고, 각 빔의 수평 해상도(Footprint)는 수심과 더불어 빔폭(Beam width)에 의하여 동적으로 변화한다. 멀티빔 음향 측심기는 해저면을 전역탐사 할 수 있을 뿐만 아니라, 연속된 음향 탐사를 통하여 이웃한 핑 사이에 발생하는 전방중첩영역(Endlap)과 이웃 측선(Trackline)을 따라 겹쳐지는 측방중첩영역(Sidelap)의 자료들을 이용하여 멀티 뎀 자료들의 전반적인 정확도 및 신뢰도를 평가할 수 있다. 본 논문은 수로 측량(Hydrographic Survey)에서 사용되는 멀티빔 음향 측심기를 운영하여 얻어진 측심 자료를 처리하는 알고리즘 개발에 관한 연구이다. 본 논문에서는 L3사의 Sea Beam 2100 벌티빔 음향 측심기를 대상으로, 멀티빔의 측심 원리와 해저 지형에 대한 일반적 이해를 통하여 획득된 측심 자료의 통계적 특성을 파악하고, 오측심된 수심 자료를 제거하는 방법을 제안하며, 측심 구간의 대표격자 크기를 결정하는 기준을 제시한다. 또한, 항공원격탐사에서 고도 추정시 사용되고 있는, 평균보간법, 가중평균 보간법과, 본 논문에서 제안하는 격자 대표값 선정 알고리즘(Gridding Algorithms)의 결과를 비교하고, 최종적으로 얻어지는 해저 수치지형모델(DEM, Digital Elevation Model)과 후방산란 영상을 제시한다. 빠른 한지형잔디들이 지표면을 피복하도록 하고 여름의 고온기와 장마시기에는 뿌리전단력이 우수한 이러한 초종들로 지표면이 피복되도록 하는 것이 이상적이라 생각된다. 4. 혼파처리간의 토사유출량을 비교한 결과 토사 유출 억제효과는 한지형과 나지형잔디들의 혼합형(MixtureIII)과 자생처리구(MixtureV), Italian ryegrass와 자생식물의 혼합형(MixtureIV)등에서 비교적 낮은 수치를 토사유출량을 기록하였다. 이러한 결과는 자생식물들이 비록 초기생육속도는 외래도입초종에 떨어지지만 토사유출의 억제효과면에서는 이들 외래초종에 필적할 수 있음을 나타낸다고 할 수 있겠다.중량이 약 115kg/$m^2$정도로 나타났다.소 들(환경의 의미, 사람의 목적과 지식)보다 미학적 경험에 주는 영향이 큰 것으로 나타났으며, 모든 사람들에게 비슷한 미학적 경험을 발생시키는 것 이 밝혀졌다. 다시 말하면 모든 사람들은 그들의 문화적인 국적과 사회적 인 직업의 차이, 목적의 차이, 또한 환경의 의미의 차이에 상관없이 아름다 운 경관(High-beauty landscape)을 주거지나 나들이 장소로서 선호했으며, 아름답다고 평가했다. 반면에, 사람들이 갖고 있는 문화의 차이, 직업의 차 이, 목적의 차이, 그리고 환경의 의미의 차이에 따라 경관의 미학적 평가가 달라진 것으로 나타났다.corner$적 의도에 의한 경관구성의 일면을 확인할수 있지만 엄밀히 생각하여 보면 이러한 예의 경우도 최락의 총체적인 외형은 마찬가지로 $\ulcorner$순응$\lrcorner$의 범위를 벗어나지 않는다. 그렇기 때문에도 $\ulcorner$순응$\lrcorner$과 $\ulcorner$표현$\lrcorner$의 성격과 형태를 외형상으로 더욱이 공간상에서는 뚜렷하게 경계

• The Korean Journal of Pesticide Science
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• v.13 no.3
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• pp.190-196
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• 2009

The residues of abamectin 1.8% EC, resisted for control of pine wood nematode, Bursaphelenchus xylophilus in pine tree were surveyed in tissue of Pinus thunbergii and P. koraiensis after injection of a liquid formulation. Limits of detection of abamectin in tissue of P. thunbergii were $0.05\;mg\;kg^{-1}$ and mean recoveries at $0.5\;mg\;kg^{-1}$ trunk injection were 90.9% and 93.1% respectively in stem and trunk of P. thunbergii. Abamectin 1.8% EC, trunk injected in 15 m height P. thunbergii were detected in all stem (edible part of carrier insect of pine wood nematode, Monochamus alternatus) from 0.29 to $0.73\;mg\;kg^{-1}$ after 150 days injection. Amount of residue of abamectin 1.8% EC in 12.6 cm mean breast height diameter (DBH) P. thunbergii were variable depending on individual trees in natural forest. Amount of residues in lower and middle part of trunk were reduced with the passage of the injection time. In upper part of trunk were detected $1.84\;mg\;kg^{-1}$ on 30 days after injection however $0.65\;mg\;kg^{-1}$ on 15 days after injection and under detection limit on 100 and 180 days after injection in P. thunbergii. Bottom and middle parts of crown were detected $0.183\;mg\;kg^{-1}$ and $0.173\;mg\;kg^{-1}$ respectively on 180 days after injection in P. thunbergii. Mean residues of abamectin in crown and trunk were $0.80\;mg\;kg^{-1}$ and $0.30\;mg\;kg^{-1}$ on 170 days after trunk injection in 20 cm DBH and 9 m height P. koraiensis. Mean residues of abamectin in crown and trunk were $0.67\;mg\;kg^{-1}$ and $0.36\;mg\;kg^{-1}$ on 170 days after trunk injection in 15 cm DBH and 6 m height P. koraiensis.

• Journal of Radiation Protection and Research
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• v.14 no.1
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• pp.8-15
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• 1989

After administration of $^{99m}TC,\;^{67}Ga,\;^{131}I,\;^{32}P\;and\;^{238}U(UO_2(NO_2)_3{\cdot}6H_2O)$, in male rats, toxic effects were examined by determining the biological materials in blood. Dosages of radio-nuclides injected are based on the amounts routinely administered to patients, and concentrations of BUN, creatinine, SGOT, SGPT and $PGE_2$ in plasma are determinated as indices to the biochemical response. No increase of creatinine was observed after injection of $^{99m}TC$. Concentrations of BUN, SGOT and $PGE_2$ were not significantly increased in comparison with before-administration. Administration of $^{67}Ga,\;^{131}I\;and\;^{32}P$, did not significantly change BUN, SGPT and SGOT, but largely increased $PGE_2$ than control levels. Besides, $^{238}U$ Showed the most severe toxicity. From the above results, we suggest that the determination of $PGE_2$ in plasma can be used as an index in case of elvaluating the effects of radiation toxicity by nuclides used in nuclear medicine.

• Journal of Korean Society of Environmental Engineers
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• v.36 no.10
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• pp.704-710
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• 2014

Biomass is considered an alternative energy which can solve an greenhouse gas problem like $CO_2$ which is a major contributor to global warming. The biomass can be converted to various energy sources through thermochemical conversion. In this study, a continuous gasifier was engineered for a wood biomass gasification. The biomass was used a waste wood. The experiments of $CO_2$ gasification were achieved as the gasification temperature, moisture content and input $CO_2$ concentration. The results showed that the yield of producer gas increased with an increasing the gasification temperature. The amount of the light tar increased due to the decomposition of gravimetric tar by the thermal cracking, and the char was confirmed pore development through the SEM analysis. The CO concentration was increased with an increased input $CO_2$ concentration from Boudouard reaction. Through the parametric screening studies, the hydrogen and carbon monoxide concentration were 32.91% and 48.33% at the optimal conditions of this test rig.

• Korean Journal of Optics and Photonics
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• v.11 no.1
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• pp.25-32
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• 2000

Comparisons are made between the first hyperpolarizability $\beta$ of pure N-(4-nitrophenyl)-(L)-prolinol (NPP) and poly (methyl metacrylate) (PMMA) or poly-p-(phenylene terephthalates) (PPT) with NPP side group determined with two different methods, electric-field-induced second-harmonic generation (EFISHG) and hyper-Rayleigh scattering (HRS) methods. Both techniques yield the same values within the experimental errors for pure NPP and NPP-PMMA in 1,1,2,2-tetrachloroethane solution. But the measured results of NPP-PPT polymer in 1,1,2,2-tetrachloroethane solution are showing that the first hyperpolarizability was enhanced with an enhencement of a factor 9.7 in EFISHG and a factor 2.4 in HRS relative to pure NPP. These results indicate that nonlinear optical chromophores organized as side groups of polymers with a rigid backbone contribute coherently to the secondorder nonlinear response of the polymer in the dc electric field as polar polymer chains. hains.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.19 no.1
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• pp.1-19
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• 1993

Gas chromatography serves to separate the mixtures into its components, and mass spectrometer is used to analyzing of unknown compounds. But there are many problems the identification of horn compounds using by GC only. As this reason GC/MS a very powerful analyzing technique. Mass spectrometer consists of 1) inlet stem 2) ion source 3) Bass filter 4) detectors and 5) data system. There are two analyzing modes in the GC/MS, those are scan and SIM(selected ion mom toping) modes. Scan mode is used when analyzing unknown compounds and SIM mode al lows the mass spectrometer to detect specific compound with very high sensitivity. As GC/MS applications for the analysis of cosmetic products, volatile compounds in lotion, earn foundation and hair color, and carbon distribution of fatty acids in soap were performed. Also as a new sample pre-treatment technique, head space sampler/GC/MS introduced in order to analyze the volatile compounds in a toothpaste.

• The Korean Journal of Nuclear Medicine
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• v.32 no.3
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• pp.290-297
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• 1998

Purpose : The aim of this study was to evaluate the feasibility of 3-[$^{131}I$]iodo-O-methyl-L-${\alpha}$-methyltyrosine ([$^{131}I$]OMIMT) as an agent for tumor image. Materials and Methods : After synthesis of 4-O-methyl-L-${\alpha}$-methyltyrosine (OMAMT), OMAMT was labeled with [$^{131}I$] using Iodogen method. In vitro cellular uptake study was performed using 9 L gliosarcoma cells at various time points upto 4 hr. The biodistribution (five rats implanted with the 9 L gliosar-coma cells per group) was evaluated at 30 min, 2 hr, 24 hr after iv injection of 3.7 MBq [$^{131}I$]OMIMT or L-3-[$^{131}I$]iodo-${\alpha}$-methyltyrosine [$^{131}I$]IMT). Gamma camera images were obtained at 30 min, 2 hr and 24 hr. Results: [$^{131}I$]OMIMT uptake was 3.3 times and 2.5 times higher than [$^{131}I$]IMT uptake at 30 min and 60 min, respectively and same after 2 hr in in vitro study using 9L gliosarcoma cells. Maximum accumulation in tumor occurred at 30 min for both [$^{131}I$]OMIMT and [$^{131}I$]IMT in tumor bearing rats. The tumor uptake of [$^{131}I$]OMIMT was significantly higher than that of [$^{131}I$]IMT at early time point studied ($3.74{\pm}0.48$ vs $0.38{\pm}0.17%$ ID/g at 30 min and $2.40{\pm}0.17$ vs $0.24{\pm}0.03%$ ID/g at 2 hr, respectively, p<0.01). However, the tumor uptake of both radiolabels were not significantly different at 24 hr ($0.04{\pm}0.01$ vs $0.05{\pm}0.01%$ ID/g). Tumor was visualized as early as at 30 min in gamma camera images. Conclusion: These data suggested that [$^{131}I$]OMIMT might be a useful tumor imaging agent and has more advantage for the tumor imaging compared to [$^{131}I$]IMT

• Korean Journal of Microbiology
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• v.49 no.4
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• pp.301-308
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• 2013

Programmed Death-1 (PD-1) is one of the important immune-inhibitory molecules which was expressed in T cells, B cells, NKT cells, and macrophages activated by various immune activating factors. Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is one of the crucial immunogens for PD-1 expression. However, there are only a few reports on the expression mechanisms of PD-1 in innate immune cells. In this study, we investigate the expression mechanisms of PD-1 in LPS-stimulated Raw264.7 cell lines by RT-PCR, Western Blot, flow cytometry as well as ChIP assay and co-immunoprecipitation. When Raw264.7 cells were stimulated with LPS, PD-1 expression was greatly up-regulated via PI3K and p38 signaling. Primary macrophages isolated from LPS-injected mice were also shown the increased expression of PD-1. In promoter assay, NF-${\kappa}B$ and IRF-1 binding regions in mouse PD-1 promoter are important for PD-1 expression. We also found that the co-activation of NF-${\kappa}B$ and IRF-1 is indispensable for the maximum PD-1 expression. These results indicate that the modulation of PD-1 expressed in innate immune cells could be a crucial for the disease therapy such as LPS-induced mouse sepsis model.

• Journal of fish pathology
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• v.19 no.2
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• pp.155-164
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• 2006

Tissue distribution and residue depletion of oxytetracycline (OTC) and tetracycline (TC) following dipping administration were evaluated in olive flounder (Paralichthys olivaceus), rockfish (Sebastes schlegeli), and red sea bream (Pagrus major) under field conditions. Fishes were held in floating cages placed in sea water and fed a commercial diet for 15 days to acclimate to a new surrounding. Fishes were dipped in OTC 50 g/ton water for 30min and TC 18 g/ton water for 5 hours. Blood and muscle were sampled from fishes on 0th, 1th, 2th, 3th, and 5th day after administration. After solid-phase extraction, OTC and TC analyses were carried out by HPLC. The recovery rate of OTC in serum and muscle samples was 71-77% and 78-84%, respectively. Also, the recovery rate of TC in serum and muscle samples was 70-79% and 73-78%, respectively. The results of recovery rate were similar to previous studies reported. At the termination of dipping administration of OTC and TC, residue concentration in muscle samples of rockfish was significantly higher than those of olive flounder and red sea bream. At day 5, residue concentrations of all samples were believed to decrease to lower than 0.05 mg/kg, the detection limit. The present study showed that residue concentrations of OTC and TC decreased to below 0.05 mg/kg after treatment 5th day, faster than the established withdrawal period. The tissue reside depletion time of dipping administration of OTC and TC seems to be shorter than those of oral or parenteral administration.