• Journal of Life Science
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• v.29 no.12
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• pp.1345-1350
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• 2019

Our recent study has revealed that in vivo intestinal transit rate (ITR) in normal mice was significantly increased by the administration of an aqueous extract of dried Gentiana scabra rhizomes and roots (GS-W) in a dose-dependent manner. Following on from our previous study, the effect of GS-W on ITR was measured in mice with experimentally induced gastrointestinal motility dysfunctions (GMDs) in the present study. GS-W showed no significant acute toxicity even at an oral dose of 5 g/kg to mice. ITR was significantly retarded in the GMD mice compared with that in normal mice, and this retardation was significantly recovered by the oral administration of GS-W in a dose-dependent manner. Furthermore, the ITR value of GS-W at a dose of 1 g/kg appeared to be higher than that of cisapride, which was predominantly prescribed for human patients with various GMDs in the late 1900s but was withdrawn from the market in 2000 due to its fatal side effects. The current results suggest that GS-W is a potential substitute for cisapride to prevent or alleviate human GMDs.

• Proceedings of the KAIS Fall Conference
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• 2009.05a
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• pp.222-226
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• 2009

본 연구는 40~50대 중년여성을 대상으로 측정한 체내지방분포와 심전도 QTc 간격과의 관련성을 규명하기 위하여 2004년 7월부터 2005년 8월까지 일개 광역도 소재의 일개 군 보건소 운동처방실을 방문한 여자 100명을 대상으로 체내지방분포와 심전도 QTc 간격 등을 측정하였다. 주요 결과는 다음과 같다. 1. 중년여성의 안정시 심전도 QTc 간격과 체내지방분포와의 상관관계에서는 비만도, 체질량지수, 체지방율, 허리둘레, 엉덩이둘레, 허리-엉덩이둘레 비가 유의한 상관관계를 보였다. 2. 체지방율이 30% 이상인 비만군과 30% 미만인 정상군의 QTc 간격은 비만군이 정상군에 비해 QTc 간격이 더 연장된 결과를 보였다. 3. 허리둘레가 80cm 이상인 복부비만군과 80cm 미만인 정상군의 QTc 간격은 복부비만군이 정상군에 비해 QTc 간격이 더 연장된 결과를 보였다. 4. 연구대상자의 안정시 QTc 간격을 종속변수로 한 다중회귀분석을 실시한 결과를 살펴보면, 체지방율과 허리둘레가 유의하게 나타났다. 40~50대 중년여성의 심전도 QTc 간격에 영향을 주는 요인에는 체내지방분포에 따른 비만도, 체질량지수, 체지방율, 허리둘레, 엉덩이둘레 등 여러 요인들이 복합적으로 관련되는 것으로 판단되어지며, 그 중 전체지방분포를 나타내는 체지방율이 가장 크게 관련되는 것으로 판단되어진다.

• Tuberculosis and Respiratory Diseases
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• v.46 no.6
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• pp.795-802
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• 1999

Objective : Cardiopulmonary exercise test is a useful tool to evaluate the operative risk and to plan exercise treatment for the patients with chronic obstructive pulmonary disease(COPD). In cardiopulmonary exercise test, most of the measured parameters are recorded at the time of peak exercise, which are hard to attain in COPD patients. So we evaluated the usefulness of the parameter, breathing reserve index(BRI=minute ventilation [$V_E$]/maximal voluntary ventilation[MVV]) at the time of anaerobic threshold($BRI_{AT}$) for the differentiation of COPD patients with normal controls. Methods : Thirty-six COPD patients and forty-two healthy subjects underwent progressive, incremental exercise test with bicycle ergometer upto possible maximal exercise. All the parameters was measured by breath by breath method. Results : The maximal oxygen uptake in COPD patients (mean$\pm$SE) was $1061.2{\pm}65.6ml/min$ which was significantly lower than $2137.6{\pm}91.4ml/min$ of normal subjects(p<0.01). Percent predicted maximal oxygen uptake was 54.3% in COPD patients and 86.0% in normal subjects(p<0.01). Maximal exercise(respiratory quotient; $VCO_2/VO_2{\geq}1.09$) was accomplished in 7 of 36 COPD patients(19.4%) and in 18 of 42 normal subjects(42.9%). The $BRI_{AT}$ of COPD patients was higher($0.50{\pm}0.03$) than that of control subject($028{\pm}0.02$, p<0.01), reflecting early hyperventilation in COPD patient during exercise. The correlation between $BRI_{AT}$ and BRI at maximal exercise in COPD patients was good(r=0.9687, p<0.01). Conclusion : The $BRI_{AT}$ could be a useful parameter for the differentiation of COPD patients with normal controls in the submaximal cardiopulmonary exercise test.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.6
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• pp.136-144
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• 2017

This study analyzed the influence of Qigong exercise intervention upon a change in glucose, blood lipid, and SFT(senior fitness test) of elderly women and to closely examine the efficacy of a Qigong exercise intervention to promote the health of older women. As research subjects, 24 elderly women aged over 80 were divided into Qigong group(n=12) and control group(n=12), respectively, and the program was carried out for 60 minutes per a day, five times per week for 24 weeks. Data were analyzed using SPSS WIN 20.0, repeated measures ANOVA. The Qigong group had a significantly lower glucose level than the control group. Second, the blood lipid and neutral fat(TG) was reduced significantly in the Qigong group than the control group. The total cholesterol(TC), high-density lipoprotein(HDL-C), and low-density lipoprotein(LDL-C) did not show a significant difference. Third, as for SFT, the leg strength, leg flexibility, and total body endurance were significantly higher in the Qigong group than in the control group. Therefore, Qigong has an influence on the reduction in glucose and neutral fat(TG) and upon the improvement in SFT(leg strength, leg flexibility, and total body endurance) of elderly women, and may show effectiveness as an exercise prescription program for older women.

• Korean Journal of Psychosomatic Medicine
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• v.24 no.1
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• pp.3-8
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• 2016

Functional dyspepsia is one of the most common bowel disorders as prevalent of 7.7% Korean population. The cardinal manifestations include bothersome postprandial fullness, early satiation, epigastric burning or pain. These features are chronic and should be presented recurrently with no other compatible organic disease to explain the symptoms. Even though it is not life-shortening, functional dyspepsia usually make the health-related quality of life worse especially if other functional bowel disorder coexist. The coexistence of functional bowel disorders is called as 'overlap syndrome'. Anxiety, somatization and insomnia is more prevalent in overlap syndrome compared with sole functional bowel disorder. Therefore, it is worthwhile that physician interviews and elucidates whether the dyspeptic patient had other kinds of functional bowel disorders, and manages the underlying psychotic pathology. Placebo effect is large in functional dyspepsia, and there is only four kinds of prokinetics that is proven to be superior to placebo. Adverse events relating prolonged administration of prokinetics sometimes fatal or irreversible, physician willing to describe prokinetics should be familiar to the possible adverse effects and the relating risk factors. Pathologic acid reflux is not uncommon in functional dyspepsia, and acid-suppressant is equivalent to the prokientics in most of dyspeptic patients.

• Journal of Life Science
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• v.29 no.6
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• pp.735-739
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• 2019

The dried rhizomes and roots of Gentiana scabra (GS) have been frequently prescribed as a traditional folk medicine in East Asia (including China, Japan, and Korea) for the treatment of various pathophy-siological conditions, such as inflammatory skin diseases, anorexia, indigestion, gastric infections, and diabetes mellitus. In the present study, the effects of aqueous (GS-W) and ethanolic (GS-E) extracts of GS on gastrointestinal (GI) motor function were investigated by measuring the in vivo gastric emptying rate (GER) and the intestinal transit rate (ITR) in mice. The GER was significantly increased by GS-W at a dose of 1 g/kg. The ITR was significantly increased by GS-W (at doses of 0.1 and 1 g/kg) or GS-E (at a dose of 1 g/kg) in a dose-dependent manner. Furthermore, the ITR value of GS-W (at a dose of 1 g/kg) appeared to be higher than that of cisapride, which was the most prominent prokinetic agent in the 1900s but was removed from the market in 2000 due to its fatal side effects. The above results suggest that GS-W might be a potential prokinetic agent to replace cisapride.

• Journal of muscle and joint health
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• v.13 no.1
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• pp.7-19
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• 2006

Falls are a major sources of death and injury in elderly people. Aged-related changes in the physiological systems which contribute to the maintenance of balance are well documented in older adults. These changes coupled with age-related changes in muscle and bone are likely to contribute to an increased risk of falls in this population. Regular exercise may be one way of preventing falls and fall-related fractures. However, the optimal exercise prescription to prevent falls has not yet been defined. On the literature review of exercise intervention for fall prevention in the elderly, exercise appeared to be a useful tool in fall prevention by improving fall risk factors. The optimum exercise prescription; moderate intensity frequency of 3-4 times per week, duration of 30-60minutes can contribute to decreased hazards and number of fall. Fall prevention protocol should include safety, falling effect, enjoyment, and easiness to follow for older people. Effective exercise programs suggested for fall prevention were such as weight-bearing exercise, resistance exercise, lower muscle strength with elastic band, swiss ball exercise walking, tai chi, and yoga.

• Journal of Korea Society of Digital Industry and Information Management
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• v.6 no.1
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• pp.69-81
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• 2010

Physical manifestations of aging due to the lack of exercise include the slowing down of motor learning, cardiopulmonary degradation, and the increasing difficulty to adapt to the environment. Aging is manifested with the lack of aerobic exercise work, decrease in muscular endurance, decline in skeletal and muscular strength, flexibility and agility, and the decrease in reaction speed and balance. Added to those are aging-related physiological changes, including the reduction of muscle bulk, increased body fat, decrease in total body water and basic metabolic rate as activities are reduced, and a decrease in cell and Lean Body Mass (LBM). These changes are known to cause problems. Interest and participation in appropriate physical activities among the elderly is needed to help them increase stamina, avoid diseases, maintain a clear intellect, and basically enable the elderly to live their daily lives as easy as possible. Therefore, physical activities are necessary for the elderly to enhance health-related factors. Special exercises should be performed for the enhancement of muscle function, muscle endurance, flexibility, agility, and balance. An accurate measurement of cardio-respiratory endurance and stamina through basic physical and cognitive characteristics of older adults is also required to ensure safety. Also, the development of a more scientific resistance exercise prescription system for the elderly is desperately needed.

• Korean Journal of Health Education and Promotion
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• v.16 no.1
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• pp.127-135
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• 1999

The purpose of this study was to verify the effects of the developed exercise prescription program by utilizing PRECEDE(Predisposing, Reinforcing, and Enabling Causes in Educational Diagnosis and Evaluation} model on adult's knowledge related to health, attitudes, behaviors and serum lipoprotein values. This study employed 20 males(40-47 yrs) without any apparent physical defects, who did not experience such physical activities. They were divided into experimental groups and control groups, each group consisted of 10 subjects who performed Jogging. The experimental design of the study utilized “two-way ANOVA Design” conducted by the repeated measurement two time(pre and post-test). As the results of the data, the conclusions were as follows: 1. There were statistically significant effects of the health module exposed to the experimental groups on the higher means of knowledge score in the experimental groups than those in the control groups. 2. There were statistically significant effects of the module exposed to the experimental groups on the positive changes of their attitudes. 3. There were significant changes on the behaviors of the health by doing the health program. Therefore the developed health program formed the improved knowledge about the health and the desirable attitudes and behaviors. 4. There were statistically significant effects of the exercise prescription program exposed to the experimental groups on the reduction of the resting heart rate and systolic blood pressure. 5. There were statistically significant effects of the exercise prescription program exposed to the experimental groups on the positive changes of their plasma TC / HDL-C ratio and triglycerides.

• Journal of Nutrition and Health
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• v.37 no.4
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• pp.291-301
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• 2004

We studied the effects of soy isoflavones supplementation with exercise on bone mineral density and the urinary excretion of deoxypyridinoline as an index of bone resorption rates in postmenopausal women. A total of 67 postmen-opausal women were assigned to Isoflavone (90 mg/day) or placebo groups. These group were further divided into groups that undergone a regular exercise or a rather sedentary state performing daily activity only. Four groups were Placebo-control group (n = 16), Placebo-exercise group (n = 16), Isoflavone-sedentary group (n = 19) and Isofla-vone-exercise group (n = 16). After the intervention, we compared anthropometric mesurement, dietary recall, bone mineral density (femoral neck, lumbar spine), urinary deoxypyridinoline between the groups and between the pre and post studies. There were no significant differences between the four groups in terms of average age, height, weight, period after menopause at the baseline. The average age of the subjects were 55.2 yrs, average height, weight, period after menopause were 154.7 cm, 59.3 kg, 5.58 yrs, respectively. After eight week intervention period, there were no significant differences between the four groups in bone mineral density, but urinary deoxypyridinoline excretion was significantly decreased both in Isoflavone-sedentary and Isoflavone-Exercise groups. These results suggest that Isofla-vone supplementation alone or with exercise may be preventive measures through the decrease of bone reabsorption rate in post-menopausal subjects. Whereas exercise alone did not appear to be an effective measure in bone loss with these subjects.