Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Effects of Soy Isoflavone Supplementation and Exercise on Bone Mineral Density and Urinary Deoxypyridinoline in Postmenopausal Women

폐경 후 여성에서 대두 이소플라본 공급 및 운동처방이 골밀도 및 소변 디옥시피리디놀린에 미치는 영향

  • 승정자 (숙명여자대학교 식품영양학과) ;
  • 윤미은 (숙명여자대학교 식품영양학) ;
  • 이재구 (삼육대학교 생활체육학) ;
  • 김미현 (숙명여자대학교 식품영양학) ;
  • 이행신 (한국보건산업진흥원 보건의료사업단)
  • Published : 2004.05.01
Download PDF
⟨ Previous Next ⟩

Abstract

We studied the effects of soy isoflavones supplementation with exercise on bone mineral density and the urinary excretion of deoxypyridinoline as an index of bone resorption rates in postmenopausal women. A total of 67 postmen-opausal women were assigned to Isoflavone (90 mg/day) or placebo groups. These group were further divided into groups that undergone a regular exercise or a rather sedentary state performing daily activity only. Four groups were Placebo-control group (n = 16), Placebo-exercise group (n = 16), Isoflavone-sedentary group (n = 19) and Isofla-vone-exercise group (n = 16). After the intervention, we compared anthropometric mesurement, dietary recall, bone mineral density (femoral neck, lumbar spine), urinary deoxypyridinoline between the groups and between the pre and post studies. There were no significant differences between the four groups in terms of average age, height, weight, period after menopause at the baseline. The average age of the subjects were 55.2 yrs, average height, weight, period after menopause were 154.7 cm, 59.3 kg, 5.58 yrs, respectively. After eight week intervention period, there were no significant differences between the four groups in bone mineral density, but urinary deoxypyridinoline excretion was significantly decreased both in Isoflavone-sedentary and Isoflavone-Exercise groups. These results suggest that Isofla-vone supplementation alone or with exercise may be preventive measures through the decrease of bone reabsorption rate in post-menopausal subjects. Whereas exercise alone did not appear to be an effective measure in bone loss with these subjects.

Keywords

References

  1. Osteoperosis Int v.14 no.8 Effects of exercise on bone miceral density in calcium-replete postmenopausal women with and without hormone replacement therapy Going,S.;Lohman,T.;Houtkooper,L.;Metcafe,L.;Flint-Wagne H.;Blew,R.;Stanford,V.;Cussler,E.;Martin,J.;Texieira,P.;Harris,M.;Milleken,L.;Figueroa-Galvez A.;Weber,J. https://doi.org/10.1007/s00198-003-1436-x
  2. Calcif Tissue Int v.44 Increasing sge-adjusted rick fragility fractures: a sign of increasing osteoporosis in successive generations: Obrant,K.J.;Bengner,U.;Johnell,O.;Nisson,B.E.;Sernbo,I. https://doi.org/10.1007/BF02556558
  3. Osteopotosis Int v.9 International variation in the incidence of hip fractures: cross-national project on osteopotosis for the World Health Organization Program for research on aging Schwartz,A.V.;Kelsey,J.L.;Maggi,S.;Tuttleman,M.;Ho,S.C.;Jonsson,P.V.;Poor,G.;Sisson de Castro J.A.;X.U.L.;Matkin,C.C.;NElson,L.M.;Heyse,S.P. https://doi.org/10.1007/s001980050144
  4. J Cell Biochem v.22 Rationale for the use of genistein-containg soy matrices in chemoprevention trials for breast and prostate cancer Barnes,S.;Peterson,T.G.;Coward,L.
  5. Chin Med J v.55 How to rduce the risk factors of osteoporosis in Asia Kao,S.C.;P'eng,F.K.
  6. Osteoporosis Int v.2 Hip fractures in the elderly : a world-wide projection Cooper,C.;Campion,G.;Melton,L.J.(3rd) https://doi.org/10.1007/BF01623184
  7. Osteoporos Int v.4 no.4 Racial difference in hip axis lenths might explain racial difference in rates of hip fracture. Study of Osteoporotic fractures Research Group Cunning'S,S.R.;Cauly,J.A.;Palermo,L.(et al.) https://doi.org/10.1007/BF01623243
  8. Clin Orthop v.323 The epidemiology of osteoporosis Lau,E.M.C.;Cooper,C. https://doi.org/10.1097/00003086-199602000-00009
  9. Am J Epidemiol v.144 Very low rates of hip fracture in beijing, Peaple's republic of China Ling,X.;Aimin,L.;Xine,Z.;Xiaoshu,C.;Cumming,S. https://doi.org/10.1093/oxfordjournals.aje.a009024
  10. Am J Epidemiol v.146 Hip fracture incidence among elderly Asian-Ameican populations Lauderdale,D.S.;Jacobsen,S.J.;Furner,S.E.;Levy,P.S.;Brody,J.A.;Godberg,J. https://doi.org/10.1093/oxfordjournals.aje.a009304
  11. J Nutr v.130 Intake of soy products is associated with better plasma lipid profiles in Hong Kong Chinese population Ho,S.C.;Woo,J.L.;Leung,S.S.F.;Sham,A.L.K.
  12. J Ren Nutri v.10 Soyfood, soybean isoflavonse, and bone health: a brief overview Messina,M.;Messina,V. https://doi.org/10.1016/S1051-2276(00)90001-3
  13. J Clin Endocrinol Metab v.86 no.1 High density phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women Mei,J.;Yeung,S.S.;Kung,A.W. https://doi.org/10.1210/jc.86.11.5217
  14. Obster Gynecol v.97 no.1 Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese woman Somekawa,Y.;Chiguchi,M.;Ishibashi,T.;Aso,T. https://doi.org/10.1016/S0029-7844(00)01080-2
  15. Osteopotosis Int v.11 Effect of soy protein on bone metabolism in postmenopausal Japanese women Horiuchi,T.;Onouchi,T.;Takahashi,M.;Ito,H.;Orimo,H. https://doi.org/10.1007/s001980070072
  16. Proc Soc Exo Biol Med v.217 no.3 Biphasic effects of genistein on bone tissue in the ovariectomized, lactating rat model Anderson,J.J.;Ambrose,W.W.;Gamer,S.C.
  17. J Am Coll Nutr v.20 no.5 The Role of Phytoestrogens in the Prevention and Treatment of Osteoporosis in Ovarian Hoemone Deficiency Arjmandi,B.H. https://doi.org/10.1080/07315724.2001.10719175
  18. J Nutr v.133 no.5 Dietary soy protein maintatins some indices of bone mineral density and bone formation in aged ovariectomized rats Blum,S.C.;Heaton,S.N.;Bowman,B.M.;Hegsted,M.;Miller,S.C.
  19. Am J Clin Nutr v.68 Soy protein and isflavones: their effects on blood lipids and bone density in postmenoapusal women Potter,S.M.;Baum,J.A.;Teng,H.;Stillman,R.J.;Shay,N.F.;Erdman,J.R.J.W.
  20. Am J Clin Nutr v.72 Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women Alekel,D.L.;Germain,A.S.;Peterson,C.T.;Hanson,K.B.;Stewart,J.W.;Toda,T.
  21. Presented at Third internatioanl symposium on the role of soy in preventing and treating chronic disease The dffect of soy protein on bone metabolism Gallagher,J.C.;Raggerty,K.;Haynatzka,V.;Wilson,M.
  22. Am J Med Sci v.312 Biochemical makers of bone remodeling Kleerekoper,M. https://doi.org/10.1097/00000441-199612000-00005
  23. Original research v.21 no.2 Beneficial effects of soybean isoflavone supplementation on bone metabolism and serum lipids in postmenopausal Japanese women: A four-week study Uesugi,T.;Fukui,Y.;Yamori,Y.
  24. Abstrno, 96061 Soy phytoestrogens and bone. Ammual Meeting of the North American Menopause Society Pansini,F.;Bonaccorsi,G.;Albertazzi,P.;Costantino,D.;Valerio,A.;Negri,C.;Ferrazzizni,S.;Bonocuore,I.;De Aloysio D.;Fontana,A.;Pansini,N.;Mollica,G.
  25. J Bone Miner Res v.17 no.10 Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double blind placebo-controlled study Morabito,N.;Crisafulli,A.;Vergara,C.;Gaudio,A.;Lasco,A.;Frisina,N.;D'Anna,R.;Corrado,F.;Pizzoleo,M.A.;Cincotta,M.;Altavilla,D.;Lentile,R.;Squadrito,F. https://doi.org/10.1359/jbmr.2002.17.10.1904
  26. Osteoporosis Int v.12 no.3 Bone mineral density during reduction maintanance and regain of body weight in premenopausal, obese women Fogelholm,G.M.;Sievanen,H.T.;Kukkonen-harjula,T.K.;Pasanen,M.E. https://doi.org/10.1007/s001980170130
  27. Calcif. Tissue Int v.66 Serum isoforms of bone akaline phosphatase increase during physical exercise in women Rudberg,A;Magnusson,P.;Larsson,L.;Joborn,H.;Serun,H. https://doi.org/10.1007/s002230010071
  28. Am J Clin Nutr v.66 Effect of calcium intake and physical activity level on bone mass and turn over in healthy, white, postmenopausal women Suleiman,S.;Nelson,M.;Li,F.;Buxton-thomass,M.;Moniz,C.
  29. Kor J Nutr v.32 no.2 A study on the bone mineral density and related factors in Korean postmenopausal women Lee,H.J.;Lee,H.O.
  30. J Rheumatol v.23 Current treatment options for osteoporosis Adachi,J.D.
  31. Bone Miner v.24 Effects of 17 $\beta$-estradiol replacement and treadmill exercise on vertebral and femoral bones of the ovariectomized rat Yeh,J.K.;Aloia,J.F.;Barilla,M.L. https://doi.org/10.1016/S0169-6009(08)80139-0
  32. Calcif Tissue Int v.49 Moderate exercise does not enhance the positive effect of estrogen on bone mineral density in postmenopausal women Heikkinen,J.;Kurttila-Matero E.;Kyllonen,E.;Vuori,J.;Takala,T.;Vaananen,H. https://doi.org/10.1007/BF02555100
  33. J Bone Miner Res v.6 Estrogen therapy and variable-resistance weight training increase bone mineral in surgically menopausal women Notelovitz,M.;Martin,D.;Tesar,R.;Khan,F.Y.;Probart,C.;Fields,C.;Mckenzie,L. https://doi.org/10.1002/jbmr.5650060609
  34. J Bone Miner Res v.10 Additive effect of weight-bearing exercise and estrogen on bone mineral density in order women Kohrt,W.;Snead,D.;Slatoposky,E.;Birge,S. https://doi.org/10.1002/jbmr.5650100906
  35. J Am Geriatr Soc v.51 no.7 Effect of exercise training added to ongoing hormome replacement therapy on bone mineral density in frail elderly women Villareal,D.T.;Binder,E.F.;Yarashesky,K.E.;Williams,D.B.;Brown,M.;Sinacore,D.R.;Kohrt,W.M. https://doi.org/10.1046/j.1365-2389.2003.51312.x
  36. Canadian Medical Association v.166 no.8 Clinical practice guidelines for the care treatment of breast cancer: 14. The role of hormone replacement therapy in women with a previous diagnosis of breast cancer Pichard,K.L.;Khan,H.;Levine,M.
  37. Aust Fam Physician v.31 no.5 Controversies in HRT Teede,H.J.
  38. J Community Nutrition v.5 no.3 Effect of soymilk and exercise on bone mineral density and bone metabolism related markers in underweight college women with low bone mass Sung,C.J.;Kim,S.Y.;Lee,J.K.;Yun,M.E.;Kim,M.H.
  39. Korean J Phys Anthrop v.10 no.1 Effects of bone mineral density in femur and lumber: and the cross-sectional area of thigh by resistance strength training in elderly women Choi,M.S.;Lee,J.K.
  40. Kor J Nutr v.35 no.9 Effect of calcium supplementation and exercise on bone mineral density in middle aged women Na,H.B.;Kim,H.J.;Park,J.
  41. J Korean Soc Food Sci Nutri v.29 Estimated Isoflavones in take from soy products in Korean middle-aged women Lee,S.K.;Lee,M.J.;Yoon,S.;Kwon,D.J.
  42. J Agric Food Chem v.47 Isoflavone levels in soy foods concumend by multiethnic populations in Singapore and Hawaii Franke,A.A.;Hankin,J.H.;Yu Mc;Maskarinec,G.;Low,S.H.;Custer,L.J. https://doi.org/10.1021/jf9808832
  43. USDA-Iowa State University Database on the Isoflavone content of foods
  44. Calcif Tissue Int v.65 no.1 The effect of modifying dietary calcium intake pattern on the circadian rhythm of bone resorption Aerssens,J.;Declerck,K.;Maeyaert,B.;Boonen,S.;Dequeker,J. https://doi.org/10.1007/s002239900654
  45. Principles of ststistics Steel,R.G.D.;Torrie,J.H.
  46. Recommended dietary allowances for koreans The korean nutrition society
  47. National health nutrition survey (Overview) Korean ministry of health and welfare
  48. J Nutr v.130 Intake of soy products is associated with better plasma lipid profiles in Hong Kong Chinese population Ho,S.C.;Woo,J.L.;Leung,S.S.F.;Sham,A.L.K.
  49. J Epidemiol v.8 Japanese intake of flavonoids and isoflavonoids frm foods Kimria,M.;Arai,Y.;Shimoi,K.;Watanabe,S. https://doi.org/10.2188/jea.8.168
  50. Obstet Gyncol v.97 no.1 Soy intake related to menopausal symptoma, serum lipids, and bone mineral density in postmenopausal Japacese women Somekawa,Y.;Chiguchi,M.;Ishicashi,T.;Aso,T. https://doi.org/10.1016/S0029-7844(00)01080-2
  51. J Community Nutrition v.5 A study on dietary isoflavone intake from soy foods and urinary isoflavone excretion and menopausal symptoms in Korean women in rural areas Sung,C.J.;Choi,S.H.;Kim,M.H.;Park,M.H.;Ko,B.S.;Kim,H.K.
  52. J Clin Endocrinol Metab v.88 no.10 Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomixed, controlled trial Chen,Y.M.;Ho,S.C.;Lam,S.S.;Ho,S.S.;Woo,J.L. https://doi.org/10.1210/jc.2003-030290
  53. Bone v.16 no.4 Weight-bearing exercise and ground reaction forces: a 12-month randomized controlled trial of effects on bone mineral density in healthy postmenopausal women Bassey,E.J.;Ramsdale,S.J.
  54. J bone Miner Res v.13 no.12 Pre- and Postmenopausal women have different bone mineral density responses to the same high-impact exercise Bassey,E.J.;Rothwell,M.C.;Littlewood,J.J.;Pye,D.W. https://doi.org/10.1359/jbmr.1998.13.12.1805
  55. J Orhop Res v.7 Gain in mass density of bone following strenuous physical activity Leichter,I.;Simkin,A.;Margulies,J.Y.;Bivas,A.;Steinberg,R.;Giladi,M.;Milgrom,C. https://doi.org/10.1002/jor.1100070112
  56. Clin Chem v.46 Total and free deoxypyridinoline after acute osteoclast activity inhivition Rubinacci,A.;Melzi,R.;Zampino,M.;Soldarini,A.;Villa,I.
  57. Clin Chem Lab Med v.38 no.1 Changes in bone tumover and deoxypyridinoline levels in epileptic patients Telci,A.;Cakatay,U.;Kurt,B.B.;Kayali,R.;Sivas,A.;Akcay,T.;Gokyigit,A. https://doi.org/10.1515/CCLM.2000.008
  58. J Clinical Endocrinology & Metabolism v.88 no.3 Soy protein has a greater effect on bone in postmenopausal women not on hormone replacement therapy, as evidenced by reducing bone resorption and urinary calcium excretion Arjmandi,B.H.;Khalil,D.A.;Smith,B.J.;Lucas,E.A.;Juma,S.;Payton,M.E.;Wild,R.A. https://doi.org/10.1210/jc.2002-020849
  59. Science v.24 Evidence of estrogen receptors in human osteoblast-like cells Eriksen,E.F.;Colvard,D.S.;Berg,N.J.;Graham,M.L.;Mann,K.G.;SpeIsberg,T.C.;Riggs,B.L.
  60. Mol Endocrinol v.13 The actions and interactions of sex steroids and growth factors/cytokines on the skeleton Spelsberg,T.C.;Subramaniam,M.;Riggs,B.L.;Khosla,S. https://doi.org/10.1210/me.13.6.819
  61. J Bone Miner Res v.15 Direct action of anturally occurring estrogen metabolites on human osteoblastic cells Robinson,J.A.;Waters,K.M.;Turner,R.T.;Spelsberg,T.C. https://doi.org/10.1359/jbmr.2000.15.3.499
  62. J Cell Biochem v.32 no.33 (Suppl) Molecular and cellular mechanisms of estrogen action on the skeleton Rickard,D.J.;Subramaniam,M.;Spelsberg,T.C.