• Korean Journal of Clinical Laboratory Science
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• v.50 no.4
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• pp.470-476
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• 2018

Facial motor evoked potential (FMEP) by multi-pulse transcranial electrical stimulation (mpTES) can complement free-running electromyography (EMG) and direct facial nerve stimulation to predict the functional integrity of the facial nerve during cerebello-pontine angle (CPA) tumor surgery. The purpose of this paper is to examine the standardized test methods and the usefulness of FMEP as a predictor of facial nerve function and to minimize the incidence of facial paralysis as an aftereffect of surgery. TES was delivered through electrode Mz (cathode) - M3/M4 (anode), and extracranially direct distal facial muscle excitation was excluded by the absence of single pulse response (SPR) and by longer onset latency (more than 10 ms). FMEP from the orbicularis oris (o.oris) and the mentalis muscle simultaneously can improve the accuracy and success rate compared with FMEP from the o.oris alone. Using the methods described, we can effectively predict facial nerve outcomes immediately after surgery with a reduction of more than 50% of FMEP amplitude as a warning criterion. In conclusion, along with free-running EMG and direct facial nerve stimulation, FMEP is a useful method to reduce the incidence of facial paralysis as a sequela during CPA tumor surgery.

• Korean Journal of Clinical Laboratory Science
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• v.50 no.2
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• pp.211-215
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• 2018

The aim of this study was to preserve the corticospinal tract during surgery and assess more accurately the motor performance in brain tumor patients around the motor cortex. TceMEP is not entirely reliable, even though there has been no change in waveforms due to a mixture of false positive and false negative signals. For a more detailed examination, DCS was employed to selectively stimulate the motor cortex. In both cases, the indications could find the region to which the cortex was responsible, and constantly check and examine the changes in amplitude, thereby preserving the motor pathway and performing surgery. On the other hand, patients who did not implement the DCS but did implement the TceMEP experienced a decrease in their postoperative motor performance. DCS is a very useful examination and it is a method that can reduce the post-surgery disorder that may occur in patients with the TceMEP in brain tumor surgery.

• Journal of Oral Medicine and Pain
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• v.26 no.3
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• pp.261-276
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• 2001

본 연구는 구강안면동통 중에서 빈번히 나타나는 근육성 동통의 주 원인인 저작근의 과활성으로 유발된 근육의 피로 시에 운동단위전위, 압력통각역치, 근전도 power spectrum의 변화 양상과 이들 척도간의 연관성을 조사하기 위해 시행되었다. 두개하악장애의 병력 및 현증이 없고 정상적인 구치부 교합관계를 가진 평균연령 25.8세인 36명의 정상 성인(남자 26명, 여자 10명)을 대상으로 교근과 전측두근의 지속적인 등길이 수축 전후의 압력통각역치 및 운동단위전위를 측정하였고 인내시간까지의 근수축 동안 근전도 power spectrum을 분석하여 다음과 같은 결론을 얻었다. 1. 지속적인 등길이 수축 후 교근과 전측두근의 압력통각역치는 수축 전에 비해 유의하게 감소하였다. 2. 압력통각역치는 수축 전과 수축 후 모두에서 전측두근이 교근보다 유의하게 높게 나타났으며, 전체적으로 남성이 여성보다 높게 나타나는 양상을 보였으나 성별간의 차이는 전측두근의 수축 후 압력통각역치에서만 통계적으로 유의하게 나타났다. 3. 지속적인 등길이 수축말기의 중간주파수는 수축초기에 비하여 유의하게 감소하였고, 전측두근의 수축초기 중간주파수와 수축말기 중간주파수 모두 교근보다 유의하게 높게 나타났다. 4. 교근은 지속적인 등길이 수축 전에 비하여 수축 후의 운동단위전위의 지속시간,진폭, 면적, 상의 4가지 척도에서 유의한 증가를 보였고 전측두근은 진폭을 제외한 나머지 3가지 척도, 즉 지속시간, 면적, 상의 유의한 증가를 보였다. 5. 교근과 전측두근의 지속적인 등길이 수축 전의 압력통각역치와 운동단위전위 척도 사이에는 통계적으로 유의한 상관관계가 없었고 교근에서는 수축 후의 압력통각역치와 운동단위전위의 지속시간, 진폭, 면적, 상 사이에 유의한 상관관계가 존재하였다. 위의 실험결과를 통해 근육피로 검사에 압력통각역치, 근전도 power spectrum 검사 외에 근육수축의 기능적 최소 단위인 운동단위전위의 분석 또한 유용할 수 있고 추후 만성으로 진행된 근막동통환자와 정상 대조군간의 운동단위 수준에서의 비교연구와 근피로에 더욱 민감한 운동단위전위의 다른 척도에 대한 개발과 연구가 필요하다고 사료된다.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.4
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• pp.453-461
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• 2019

Intraoperative neurophysiological monitoring (INM) examination identifies the damage caused to the nervous system during surgery. This method is applied in various surgeries to validate the procedure being performed, and proceed with confidence. The assessment is conducted in an operating room, using subdermal needle electrodes to optimize the examination. There are no textbooks or guides for the correct stimuli and recording areas for the surgical laboratory test. This article provides a detailed description of the correct stimuli and recording parts in motor evoked potential (MEP), somatosensory evoked potential (SSEP), brainstem auditory evoked potentials (BAEP) and visual evoked potentials (VEP). Free-running Electromyography (EMG) is an observation of the EMG that occurs in the muscle, wherein the functional state of most cranial nerves and spinal nerve roots is determined. In order to help understand the test, an image depicting the inserting subdermal needle electrodes into each of the muscles, is attached. Furthermore, considering both the patient and the examiner, a safe method is suggested for removal of electrodes after conclusion of the test.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.2
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• pp.198-204
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• 2019

Various treatments can be attempted in patients with intractable epilepsy, in whom the symptoms of seizures are not controlled by various drugs. On the other hand, in patients requiring a surgical method, a preoperative examination is needed to determine the portion of seizure site to be resected. Electrodes are inserted into the cerebral cortex for accurate lesion measurements and safe operation. The electrodes inserted in the cortex not only record the electroencephalography (EEG), but also allow various tests to confirm the function of the part. One of these methods is the evoked potential test. From January 2015 to December 2018, the trends of measured waveforms in were analyzed 70 patients. The somatosensory evoked potential (SSEP) recorded on the electrode inserted in the cerebral cortex can be searched for the pathway of the central sulcus to avoid the primary motor area and primary sensory area. In addition, using the middle latency auditory evoked potentials (MLAEP) and flash visual evoked potentials (FVEP), the functional cortex in the auditory cortex and the visual cortex were compared with the seizure focus point on the EEG to help determine the location of the ablation and minimize functional impairment after surgery.

• The Journal of Korean Academy of Sensory Integration
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• v.8 no.1
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• pp.41-49
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• 2010

Objective : Multisensory integration (MSI) is the essential process to use diverse sensory information for cognitive task or execution of motor action. Especially, visual and somatosensory integration is critical for motor behavior and coordination. This study was designed to explain spatial and temporal characteristics of visual and somatosensory integration by neurophysiological research method that identifies the time course and brain location of the SI process. Methods : Electroencephalography (EEG) and event-related potential (ERP) is used in this study in order to observe neural activities when integrating visual and tactile input. We calculate the linear summation (SUM) of visual-related potentials (VEPs) and somatosensory-related potentials (SEPs), and compared the SUM with simultaneously presented visual-tactile ERPs(SIM) Results : There were significant differences between the SIM and SUM in later time epochs (about 200-300ms) at contralateral somatosensory areas (C4) and occipital cortices (O1&O2). The amplitude of the SIM was mathematically larger than the summed signals, implying that the integration made some extra neural activities. Conclusion : This study provides some empirical neural evidence of that multisensory integration is more powerful than just combing two unisensory inputs in the brain and ERP data reveals neural signature relating to multisensory integrative process. Since this study is preliminary pilot study, larger population and criteria are needed for level of the significance. Further study is recommended to consider issues including effect of internally-driven attention and laterality of interaction to make the evidence by this study solid.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.7
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• pp.459-466
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• 2016

This study examined the effects of robot-assisted therapy on the motor and functional recovery of the lower limbs in 53 subacute stroke patients. Robot-assisted therapy was performed using Lokomat? (Hocoma AG, Zurich, Switzerland) for thirty minutes per day, five times a week for four weeks. The outcome measures used were the Fugl-Meyer assessment, Motricity index(MI), Functional ambulation category(FAC), Berg balance scale(BBS) for gait function and balance ability, 10m walking test, K-Modified Barthel Index(K-MBI) for the activities of daily living and Mini mental state examination (MMSE), and Beck's depression inventory(BDI) for depression. All patients recruited underwent these evaluations before and after the four week robot-assisted therapy. For the evaluation, the somatosensory evoked potentials were used to assess the functional recovery. Robot-assisted therapy on the lower limb after subacute stroke showed improvement in motor strength, gait function, and the activities of daily living. All changes in terms of MI, FAC, BBS, and K-MBI exhibited a statistically significant difference after the four weeks robot-assisted therapy. The somatosensory evoked potential result showed a correlation with the MI and K-MBI. Robot-assisted therapy is believed to facilitate the motor and functional recovery of the lower limb in subacute stroke patients.

• Journal of Yeungnam Medical Science
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• v.11 no.2
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• pp.248-261
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• 1994

This study was undertaken to evaluate the clinical usefulness of magnetic motor evoked potential (MEP) in the diagnosis of stroke and predicting the motor improvement following stroke. The cortical, cervical and lumbar stimulations were performed in the case of 24 healthy controls and 24 ischemic stroke patients. The central motor conduction time (CMCT) was represented by the difference of latency to a target muscle between after transcranial stimulation and after cervical or lumbar stimulation. There was no case showing no response in controls. But in 11 out of 24 ischemic patients, we could not get cortical MEP. Mean CMCT of abductor pollicis brevis muscle was not significantly different in controls and stroke patients in whom MEPs were recorded. There were significant differences between mean CMCT of normal controls and that of stroke patients showing MEPs in AH Muscle. MEP Results from testing the stroke patients were correlated with site of lesion, degree of motor weakness and motor improvement after 1 to 2 months. These results suggest that magnetic MEP is easy and useful in electrophysiological test of central motor pathway and is useful indicator for representing the motor weakness and predicting the motor outcome in acute ischemic stroke patients.

• Korean Journal of Clinical Laboratory Science
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• v.53 no.2
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• pp.193-198
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• 2021

The purpose of spinal dural arteriovenous fistula (SDAVF) ligation is to prevent neurological injury and the poor blood supply through ligation of arteriovenous fistula. Therefore, intraoperative neurophysiological monitoring (INM) is required via multimodal neurological examination for minimizing the side effects after surgery based on the patient's symptoms. Transcranial electric motor-evoked potentials (TceMEP) help to check the condition of the corticospinal tract. Whenever ligation is performed, TceMEP should be performed every minute to check for abnormalities. However, an examiner's lack of knowledge about the operation procedure and examination and also poor communication between the examiner and surgeon can cause incorrect timing of the stimulation of TceMEP that interferes with the procedure and causes side effects such as paralysis and motor weakness. As a result of this SDAVF ligation survey, it is believed that for proper INM, case reports will be needed along with further research and the examiner will also have to work closely with the surgeon to minimize neurological damage to patients.

• Journal of Korean Ophthalmic Optics Society
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• v.7 no.1
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• pp.51-55
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• 2002

This study was to investigate the effect of EEG wave type of visual cortex on conjugate movement of eyeball according to movement of visual target. Visual evoked potential(VEP) system used the Bio-Pag(production in USA) and recorded to 586 computer. The illumination of test room was 50lux and the visual target was red light dot of 3cm size. The results of dextroversion and levoversion as follows : The visual stimulation waves on the visual cortex have about 71% of delta wave, about 12% of beta wave, about 9% theta wave and about 6% of alpha wave respectively. The dextroversion and levoversion state was similar results on the histogram amplitude of EEG wave, frequency of EEG wave type, EEG wave style and phase diagram of amplitude. Expecially the histogram amplitude of EEG wave appeared almost the Gaussian shape and the phase analysis of amplitude of EEG wave was nearly linear shape. On the fast fourier transform of the amplitude and Hz, the frequency was almost low frequency under 20 Hz, and the dextroversion and levoversion shape was similar results.