• Proceedings of the KAIS Fall Conference
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• 2009.12a
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• pp.498-500
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• 2009

본 연구에서는 한국인 아동의 우식치아로부터 분리한 S. mutans K7으로부터 HtrA gene을 동정하고 HtrA expression이 산성환경하에서 S. mutans의 생육에 미치는 영향을 알아보았다. S. mutans K7의 HtrA mutant strain은 산성환경에서 parental strain과 비교하였을 때, 생육에 있어서 상당한 차이를 나타내었다. 또한 Biofilm formation에 관여하는 GtfB, 와 GtfC의 발현량도 현저히 줄어들었다. 그리고 HtrA mutant strain에 HtrA gene을 삽입하여 HtrA의 발현량을 회복하였을 경우에는 acid stress하에서 control과 같은 nomal growth phenotype을 회복하였다. 이러한 결과들은 S. mutans K7에서 HtrA가 acid stress동안에 중요한 역할을 담당함을 제시하고 있다.

• Microbiology and Biotechnology Letters
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• v.31 no.3
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• pp.292-296
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• 2003

The antibacterial effect against cariogenic bacteria was evaluated in combination of 5-FC and intracellular cytosine deaminase from Chromobacterium violaceum YK 391. While S. mutans, L. parabuchneri and A. naeslundii showed antibacterial effect against 10 mM of 5-FU, S. intermedius, S. mitis, S. agalactiae, L. lactis, A. israelii, A. viscosus don't caused antibacterial effect. The addition of the cytosine deaminase and 10 mM of 5-FC to S. mutans, S. sanguis, L. brevis, L. parabuchneri, L. oris and A. naeslundii caused weakly antibacterial effect. S. sanguis caused weakly antibacterial effect against 10 mM of 5-FC. These results suggested that combination of the cytosine deaminase and 5-FC was showed the possibility to precautionary measures of dental caries.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.11 no.1
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• pp.17-20
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• 2015

Autism is a life-long neurodevelopmental disorder characterized by qualitative abnormalities in reciprocal social interactions and patterns of communication. Patients with autism are difficult to manage during dental treatment. Thus they need special consideration like physical restraint, conscious sedation or general anesthesia. A 5-year-old male dental patient with autism was reffered to dental treatment under conscious sedation using intramuscular midazolam that creats anterograde amnesia. Dental procedure using midazolm which cause anterograde amnesia can be effective treatment strategy in autism patient.

• The Journal of the Korean dental association
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• v.10 no.1
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• pp.53-57
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• 1972

저자는 임상적 진단과 치수내 혈액상과이 관계를 규명하기 위하여 치아 우식증에 의하여 심부로 이환된 이십개의 치아를 선택하여 치수절단술을 시행한 후 기 혈액을 검토한 결과 다음과 같은 결론을 얻었다. 1. 임상적으로 치수충혈로 전단된 일곱 개의 치아중, 세 개의 혈액표본을 정상 혈액상을 나타냈고 두개의 혈액표본은 약간의 급성 염증상을 나타냈으나 나머지 두개의 혈액표본은 심한 만성 염증상을 나타냈다. 2. 임상적으로 급성치수염으로 진단된 열세개의 치아중, 열개의 혈액표본은 심한 만성 염증상을 나타냈고 한 개의 혈액표본은 약간의 만성 염증상을 나타냈으며 나머지 두개의 혈액 표본은 급성 염증상을 나타냈다.

• Journal of the korean academy of Pediatric Dentistry
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• v.11 no.1
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• pp.57-74
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• 1984

The purpose of this descriptive in vitro study were to evaluate the enamel-resin interface of the preventive resin restoration with regard to etching patterns and resin-tag morphology by means of scanning electron microscope. The results were as follows; 1. Three basic etching patterns were appeared simultaneously in a same microscopic section, in concentration between 20-50% phosphoric acid. 2. In 35% orthorhosphoric acid group etched for 60 second, the etching pattern was most prominent and demonstrate closely interdigitated with enamel-resin interface without the evidence of microspace, and the resin tags were longest ranged from 10-15 um in length. 3. This pattern of interface could reduce the incidence of marginal leakage and 2ndary caries formation. 4, The preventive resin restoration could serve as sealing a questionable occlusal surface.

• Journal of the korean academy of Pediatric Dentistry
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• v.11 no.1
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• pp.1-6
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• 1984

The author studied the prevalence of proximal dental caries of deciduous molar by observing intraoral radiographies of 478 children aging from 2 to 5 who visited the Dep. of Pedodontics, Seoul National University Hospital. The following results were obtained; 1. The prevalence of proximal caries of deciduous molar did not show significant difference between male and female, right and left side. 2. Mandibular deciduous molar had higher prevalence than maxillary deciduous molar. 3. The prevalence was increased with age. 4. The prevalence was highest in the distal surface of lower 1st deciduous molar and lowest in the distal surface of upper 2nd deciduous molar.

• Journal of Food Hygiene and Safety
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• v.14 no.1
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• pp.22-26
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• 1999

The purpose of this experiment was to examine the antimicrobial effect of the natural flavonoid hesperidin on dental caries and alveolar bone resorption in the albinorats. Twenty five day old male rats were fed with the experimental diets for 42 days. At the end of the 42 day experimental period, the molar tooth occlusal surface was examined by a dissecting microscope. The sulcular caries lesions were recorded: the first molar caries incidence was higher than that of the second molar and the third molar. Alvelolar bone resorption was measured on the buccal and lingual aspects of each molars. Three measurements were taken on the first molar (mesialpoint, midpoint, distalpoint). The results of this experiments, showed that hesperidin is effective in reducing dental caries and alveolar bone resorption.

• Proceedings of the KAIS Fall Conference
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• 2010.05b
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• pp.1221-1223
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• 2010

본 논문에서는 한국인 아동의 우식치아로부터 S. mutans를 분리하고, acid stress하에서 분리한 S. mutans의 유전자의 발현의 변화를 분석하고자 하였다. 치아우식증의 주요한 요소로 작용하는 치태형성에 기여하는 glucan 및 fructan 합성에 관여하는 세포내 효소인 glucosyltransferase, glucosyltransferase, glucosyltransferase 및 fructosyltransferase의 발현량의 변화를 확인한 결과, lactic acid를 처리하지 않은 control의 경우보다 16배에서 3배까지 감소한 것을 확인할 수 있었다. Amino acid ABC transporter, adenylate kinase, fructokinase, 40k cell wall protein precursor에서는 모두 유전자의 발현량이 현저히 증가한 것을 볼 수 있었다. 이들 유전자는 acid stress에 관여하는 특이적 유전자로 추정된다.

• Journal of Korean society of Dental Hygiene
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• v.14 no.4
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• pp.571-576
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• 2014

Objectives : The purpose of this study was to investigate the relationship between early childhood caries(ECC) and breastfeeding. Methods : Data of 670 children were derived from the Forth Korean National Health and Nutrition Examination Survey from 2007 to 2009. Demographic and socioeconomic data, oral health related behavior, and breastfeeding practice data were collected as independent variables. The ECC was used as a dependent variable. The chi-square test and logistic regression analysis were performed to identify the relationship between ECC and the other variables. Results : Multiple logistic regression analysis revealed that ECC was related with age, tooth brushing frequency, and breastfeeding practice. Conclusions : This study confirmed various risk indicators of ECC in Korean children, using Korean national survey data. Parents should begin an early and consistent mouth care regime to decrease the risk of ECC.

• The Journal of the Korean dental association
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• v.48 no.6
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• pp.443-453
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• 2010

We examined progress in oral health of Korean 5 year olds children and dental public health infrastructure since the National Health Promotion Plan 2010 Oral Health Objectives were issued. We summarize trends in the prevalence of dental caries and trends in national public oral health program activities and budget. The Oral Health Objectives were achieved in 2006. Oral health in Korean preschool children improved considerably by improving of lifestyle and consumption of fluoride containing toothpaste. Although the number of public oral health center and the budget of oral health education were increased, the impact of public oral health program for preschool children was not influential. New oral health program for infants such as fluoride varnish application and strengthening of existing public oral health program should be performed for continuing improvement of oral health in Korea.