[KSCI] Korea Science Citation Index Service

Revelation of Antibacterial Effect Against Cariogenic Bacteria in Combination with 5-Fluorocytosine and Cytosine Deaminase from Chromobacterium violaceum YK 391.

Kim, Jung (Department of Dental Hygiene, Suwon Women's College)
Jung, Hyuk-Jun (Department of Microbiology, Keimyung University)
Yoo, Dae-Sik (Department of Microbiology, Keimyung University)

Publication Information

Microbiology and Biotechnology Letters / v.31, no.3, 2003 , pp. 292-296 More about this Journal

Abstract

The antibacterial effect against cariogenic bacteria was evaluated in combination of 5-FC and intracellular cytosine deaminase from Chromobacterium violaceum YK 391. While S. mutans, L. parabuchneri and A. naeslundii showed antibacterial effect against 10 mM of 5-FU, S. intermedius, S. mitis, S. agalactiae, L. lactis, A. israelii, A. viscosus don't caused antibacterial effect. The addition of the cytosine deaminase and 10 mM of 5-FC to S. mutans, S. sanguis, L. brevis, L. parabuchneri, L. oris and A. naeslundii caused weakly antibacterial effect. S. sanguis caused weakly antibacterial effect against 10 mM of 5-FC. These results suggested that combination of the cytosine deaminase and 5-FC was showed the possibility to precautionary measures of dental caries.

Keywords

Cytosine deaminase; 5-fluorocytosine; 5-fluorouracil; Chromobacterium violaceum YK 391;

Citations & Related Records

Times Cited By KSCI : 2 (Citation Analysis)
Times Cited By SCOPUS : 0

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