• Journal of the Korean Data and Information Science Society
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• v.25 no.5
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• pp.987-998
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• 2014

The primary purpose of this paper is to derive a benchmark dose lower limit (BMDL) of lead for the attention deficit/hyperactive disorder (ADHD) based on a longitudinal cohort data set which is referred to as CHEER data set. The CHEER data were recently recruited from the Ministry of Environment of S. Korea to investigate the effect of environment on children's health We first confirm the correlation of ADHD with the blood lead level using a linear mixed effect model. We report from the longitudinal characteristic of CHEER data that ADHD scores tend to have "regression to the mean". A dose-response curve of blood lead level with ADHD being the end point is derived and from this dose-response curve a few BMDLs are derived based on corresponding assumptions on the benchmark region.

• The Korean Journal of Applied Statistics
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• v.26 no.3
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• pp.453-470
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• 2013

In this paper, we consider a Bayesian analysis of the dose-effect relationship of cadmium to evaluate a benchmark dose(BMD). For this purpose, two dose-response curves commonly used in the toxicity study are fitted based on Bayesian methods to the data collected from the scientific literature on cadmium toxicity. Specifically, Bayesian meta-analysis and hierarchical modeling build an overall dose-effect relationship that use a piecewise linear model and Hill model, where the inter-study heterogeneity and inter-individual variability of dose and effect such as gender, age and ethnicity are accounted. Estimation of the unknown parameters is made by using a Markov chain Monte Carlo algorithm based user-friendly software WinBUGS. Benchmark dose estimates are evaluated for various cut-offs and compared with different tested subpopulations with with gender, age and ethnicity based on these two Bayesian hierarchical models.

• Journal of the Korean Vacuum Society
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• v.10 no.4
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• pp.440-448
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• 2001

The operation properties of DBD plasma reactors were observed by using 20 kV square pulse at the cylindrical and planar type of reactors in the condition of air pressure. The optimum operation frequency $f_0$ which optimizes the efficiency of operation was found as such $f_0\proptoexp(-C)$ when the current-voltage curve and charge-voltage curve were observed. Using these properties the dissipated power was evaluated. The dissipated power at the optimum frequency of operation was varied as the value of capacitance which is dependent on the structure and the dielectric material of the reactor, and had the maximum value at the specific value of capacitance. With these value of capacitance, DBD reactors which has a high level of efficiency can be formed.

• Proceedings of the Korea Water Resources Association Conference
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• 2010.05a
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• pp.1350-1354
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• 2010

SWAT 모형에서는 토양수량을 고려하여 유출곡선지수법에 따라 지표유출량과 침투량을 계산하고, 계산된 침투량이 토양수대가 받을 수 있는 최대용량인 토양수 최대보수용량(soil water capacity)을 초과할 경우에는 그 초과분을 강제적으로 토양수량에 더해지도록 처리하고 있다. 즉, 초과침투량이 연직 아래로만 유입되는 것으로 간주하고 있다. 이러한 방식은 경사가 매우 완만한 경우에는 적합하다고 할 수 있으나, 국내 유역에서와 같이 비교적 유역 경사가 급한 경우에는 지표유출량이 작게 계산될 수 있으며 특히 집중호우시 강우에 대한 유출 응답이 둔감하게 모의되어 홍수기 큰 강우로 인해 급격하게 증가하는 유출량을 잘 모사하지 못하게 되는 경우가 발생한다. 따라서 본 연구에서는 홍수기 큰 강우에 대해서 유출량이 민감하게 반응할 수 있도록 초과침투량 재분배 모듈($\underline{R}$edistributing $\underline{EX}$cessive $\underline{INF}$iltration module, 이하 SWAT-REXINF)을 개발하였다. 이 모듈은 토양층의 보수능을 초과하는 침투량 처리 방식을 개선한 것으로 지표유출의 집중시간과 토양수의 침루 유하시간의 상대적인 크기에 따라 초과침투량을 분배하여 지표유출량과 침투량에 할당하는 방식을 취하고 있다. 개발 모듈 SWAT-REXINF을 기 개발한 시간가중평균 유출곡선지수법에 의한 지표유출계산법과 접합-분리 방식의 토양층 구조화 기법 등의 유출계산 개선 기법과 접목하여 그 효과를 충주댐 유역에 대해 분석하였다. 시간가중평균 유출곡선지수법에 의한 지표유출계산법과 접합-분리 방식의 토양층 구조화 기법 등 다른 유출 개선 기법과 혼용하여 적용할 경우에는 지표유출량이 약 2배 증가, 첨두유량은 20~50% 증가하는 등 개선 효과가 매우 크게 나타났다. 모형 개선으로 인해서 강우량에 대한 유출량의 응답 민감도를 증가시켜 유출수문곡선의 증감을 보다 용이하게 모의할 수 있고 정확도 또한 높일 수 있을 것으로 판단된다.

• 한국전기화학회:학술대회논문집
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• 2004.06a
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• pp.293-296
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• 2004

고용량 $LiNi_{1-y}M_yO_2$(M=Al, Zn and Ti, y=0.000, 0.005, 0.010, 0.025, 0.050 and 0.100) 양극재료를 합성하기 위하여 연소법을 사용하였다. 합성한 시료들을 X-선회절 분석, 미세구조관찰, 전자침미세분석(EPMA)을 하였다. battery 충${\cdot}$방전기를 사용하여 리튬의 삽입${\cdot}$추출 반응으로 인하여 나타나는 충${\cdot}$방전 곡선의 변화를 조사하였고, 합성한 각 시편에 대해 충${\cdot}$방전 싸이클 수에 따른 방전용량의 변화를 조사하였다. XRD pattern 분석결과 모든 조성에서 $R\bar{3}m$ 구조를 보여주었다. Ni 자리에 Al, Zn, Ti를 치환한 결과 방전용량은 감소하였으나 M=Al 시료는 싸이클 특성이 증가하였다.

• Tuberculosis and Respiratory Diseases
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• v.45 no.2
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• pp.341-350
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• 1998

Background: Airway hyperreponsiveness is a cardinal feature of asthma. It consists of both an increased sensitivity of the airways, as indicated by a smaller concentration of a constrictor agonist needed to initiate the brochoconstrictor response and an increased reactivity, increments in response induced subsequent doses of constrictor, as manifested by slopes of the dose-response curve. The purpose of this study is to observe the relationship between bronchial sensitivity and reactivity in asthmatic subjects. Method: Inhalation dose-response curves using methacholine were plotted in 56 asthmatic subjects. They were divided into three groups(mild, moderate and severe) according to clinical severity of bronchial asthma. PC20 were determined from the dose-response curve as the provocative concentration of the agonist causing a 20% fall in FEVl. PC40 were presumed or determined from the dose response curve, using the PC20 and the one more dose after PC20. Reactivity was calculated from the dose-response curve regression line, connecting PC20 with PC40. Results: PC20 were 1.83mg/ml in mild group, 0.96mg/ml in moderate, and 0.34mg/ml in severe. PC40 were 7.l7mg/ml in mild group, 2.34mg/ml in moderate, and 0.75mg/ml in severe. Reactivity were $24.7{\pm}17.06$ in mild group, $46.1{\pm}22.l0$ in moderate, and $59.0{\pm}5.82$ in severe. There was significant negative correlation between PC20 and reactivity (r= -0.70, P<0.01). Conclusion: Accordingly, there was significant negative correlation between bronchial sensitivity and brochial reactivity in asthmatic subjects. However, in some cases, there were wide variations in terms of the reactivity among the subjects who have similar sensitivity. So both should be assessed when the bronchial response tor bronchoconstrictor agonists is measured.

• Korean Journal of Soil Science and Fertilizer
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• v.33 no.6
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• pp.405-415
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• 2000

To determine application rate of elemental sulfur to adjust pH of alkaline soil, buffer curve method was investigated. The elemental sulfur required to control pH 8.3 to pH 6.3 by buffer curve calculation was treated in two soils of silty loam and sandy loam, and the sulfur-mixed soils were moistened with 50% of water holding capacity during incubation of 6 weeks at $30^{\circ}C$. Soil pH was lowered with incubation and reached to target point after 4 weeks of incubation, and elemental sulfur was oxidised entirely to sulfate. This means that buffer curve has the accuracy to determine sulfur application rate in alkaline soil. However it is estimated that application rate of sulfur should be carefully determined in the field scale. Excess application of elemental sulfur resulted in extremely low soil pH and caused the hinderance of lettuce growth by nutritional imbalance and ion toxicity. To simplify the determination procedure of sulfur requirement, buffer curve method by addition of 0.1N-HCl solution as unit of mL was developed, it was compared with theroutine methods which diluted $H_2SO_4$ solution and $Ca(OH)_2$ are added as cmolc per kg soil to adjust each pH step. Buffer capacities, cmolc kg $soil^{-1}$ $pH^{-1}$, calculated from two buffer curves were not significantly different. The result indicates that buffer curve method by 0.1N-HCl can be used to adjust high pH of alkaline soil.

• Proceedings of the Korea Water Resources Association Conference
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• 2009.05a
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• pp.1240-1244
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• 2009

최근 들어 홍수조절을 위한 대안으로 검토되기 시작한 천변저류지는 적은 저류용량으로 인해 목표하는 홍수저감효과를 얻기 위해 다수의 천변저류지가 설치되어야 하며, 이들 천변저류지군의 홍수조절효과는 저류지군을 연계한 수문네트워크의 분석에 의해 산정되어야 한다. 특히 천변저류지 등과 같은 소규모 수공구조물은 설계빈도, 저류지 제원 등과 같은 수문학적 및 수리학적 조건에 따라 홍수저감효과가 민감하게 반응한다. 즉 설계빈도 변화에 따른 천변저류지의 홍수조절효과를 분석하고, 이를 바탕으로 목표하는 설계빈도 결정이 선행된 후, 천변저류지의 상세 제원에 대한 설계가 가능할 것이다. 본 연구에서는 설계빈도 변화에 따른 유역의 유입수문곡선변화가 천변저류지군의 홍수저감효과에 미치는 영향을 분석해 보았다. 이를 위해 천변저류지의 최적위치를 결정하기 위해 개발된 기존의 의사결정모형을 안성천 유역에 적용하여 다양한 설계빈도에 따른 천변저류지의 홍수저감효과를 분석해 보았다.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.16 no.6
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• pp.244-257
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• 2017

Traffic congestion occurs from drivers' human factors such as driver reaction time, reckless lane change, and inexperienced driving. When Automated Vehicles are introduced, human factors are excluded, resulting in increased average vehicle speed, stabilizing traffic flow, and increasing road capacity. This study analyzed traffic flow changes through traffic volume-speed-density plots, and increased road capacity due to Automated Vehicles. As a result of the analysis, when rate of automated vehicles gests higher, the traffic flow became stable. Additionally, it was analyzed that when all vehicles were automated, the road capacity increased by about 120 %. It is expected that there will be a positive expectation in terms of traffic congestion and traffic demand management due to the introduction of Automated Vehicles.

• The Korean Journal of Pharmacology
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• v.24 no.1
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• pp.93-101
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• 1988

Pharmacological actions of an antispasmodic agent, oxybutynin were investigated in the isolated procine coronary arteries. The coronary rings were contracted by acetylcholine (ACh) and KCl in a dose-dependent fashion. The ACh-induced contractions were signifcantly potentiated by removal of endothelium and $EC_{50}=0.52\;{\mu}M$ of intact endothelial rings was about 2 times greater than $EC_{50}=0.28\;{\mu}M$ of rings without the endothelium. These results suggest that the endothelium plays an inhibitory role in ACh-induced contraction. Oxybutynin and atropine inhibited dose-dependently $1.0\;{\mu}M$ ACh-induced contraction and atropine inhibited dose-dependently $1.0\;{\mu}M$ ACh-induced contraction and the $IC_{50s}$ were 11.0 nM and 0.47 nM, respectively. Atropine did not affect 35 mM KCl-induced contraction but oxybutynin inhibited the contraction to the basal tension in a dose-dependent manner. The $IC_{50}$ of oxybutynin on the KCl-induced contraction was $49.7\;{\mu}M$. The dose-response curve to ACh was parallelly shifted to the right by pretreating coronary rings with $IC_{50}$ of atropine (0.47 nM) or oxybutynin (11.0 nM) but the curve to KC1 was rightward shifted in a noncompetitive manner under pretreatment with $IC_{50}$ of oxybutynin $(49.7\;{\mu}M$). Oxybutynin inhibited $0.1\;{\mu}M$ Bay K 8644-induced contraction to the basal tension in a dose dependent manner, but $35\;{\mu}M$ histamine-induced contraction was inhibited to only 50e/e of the original level even in maximal concentration $(5{\times}10^{-4}M)$ of oxybutynin. These results suggest that oxybutynin causes antispasmodic action through sensitive blocking action on muscarinic receptors and inhibitory action on calcium influx in the procine coronary artery.