• Childhood Kidney Diseases
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• v.1 no.1
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• pp.38-45
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• 1997

Purpose : Vesicoureteral reflux(VUR) in childhood may be the primary cause of recurrent urinary tract infection and renal scarring. Renal ultrasonography, DMSA, and voiding cystourethrogram are the standard clinical methods for detection of vesicoureteral reflux. But these methods have many disadvantages such as invasiveness and high cost. So, we studied to observe the significance of urine ${\beta}_2$-microglobulin in association with other non-radiologic methods for predictng vesicoureteral reflux. Methods : We evaluated 40 patients with urinary tract infection who were admitted to Korea university Hospital from July 1993 to June 1994. Among them, 24 patients revealed urinary tract infection and vesicoureteral reflux(group A), 16 patients revealed only urinary tract infection(group B). Both groups were compared by presence of fever, hematuria, and proteinuria, positivity of CRP, and level of BUN, Cr, GFR by 99mTc-DTPA, urine ${\beta}_2$-microglobulin, 24 hours urine albumin. Results : 1) Among 24 patients who had vesicoureteral reflux, 14 had unilateral VUR, 10 had bilateral VUR, three kidneys with grade I, nine with grade II, eleven with grade III, eleven with grade IV by classification of International Reflux Study Committee. Among them, 14 patients had renal scar, five with type A, five with type B, four with type C, none with type D by Smellie's classification. 2) The mean of GFR, BUN, Cr, 24hrs urine albumin and the presence of hematuria and proteinuria showed no significant difference between group A and group B. The mean of urine ${\beta}_2$ microglobulin in group A and group B were $283.6{\pm}195.8{\mu}g/l$ and $78.7{\pm}48.5{\mu}g/l$ respectively, showing that group A had a higher value than group B (p<0.01). In case of ${\beta}_2$ microglobulin > $120{\mu}g/l$ and CRP(+), the sensitivity was 93.3% and the specificity is 77.8% for detecting of VUR. In case of ${\beta}_2$-microglobulin>$120{\mu}g/l$ and fever(+), the sensitivity was 92.2%, and the specificity was 62.5% for detecting of VUR Conclusions : If the level of urinary ${\beta}_2$-microglobulin is more than 120ug/l in children with urinary tract infection in association with fever(+) or CRP(+), it can predict VUR. So we can use it for early detection of VUR.

• Environmental and Resource Economics Review
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• v.29 no.2
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• pp.273-292
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• 2020

본고는 코로나19라는 글로벌 팬데믹 상황에서 감염병 역학모형에 관한 내용과 기초재생산수, 집단면역임계, 백신비축 등의 주요 개념을 개론 수준에서 다루었다. 국내 첫 감염자 발생 이후 4월 12일까지의 데이터를 기준으로 분석해 볼 때 한국의 기초재생산수는 약 2의 값을 가지는데 이는 코로나19가 발생한 다른 나라에 비해 현저히 낮은 수치로 평가된다. 만일에 코로나19 백신이 개발되는 것을 가정하여 이의 비축규모를 추정해보면 인구의 최소 62%에 공급할 수 있는 수준이어야 하는 것으로 나타났다. 한편, 한국의 코로나19의 성공적 대응에는 사회적 거리두기 정책이 주된 요인 중의 하나라는 점도 발견하였다. 그러나 5월 이후 사회적 거리두기에 대한 다소 느슨해진 경향이 없지 않은데, 지역감염의 확산을 위해서는 원론적으로 대응할 필요가 있다. 본고는 학술적 관점이 아닌, 방역의 실무적 차원에서 역학모형, 그리고 경제-역학 모형을 활용하는 방법을 소개한 것 뿐이다. 보다 정교한 역학 모형을 제대로 연구하기 위해서는 상당한 규모의 팀워크가 필요하다. 2015년 메르스 이후 역학조사를 위한 자원이 보강되었다 하지만, 앞으로 역학조사 인력, 데이터 시스템 구축, 그리고 보건·경제·통계·수학 분야 등의 연구진이 보강되어야 할 것이다.

• The Journal of the Korea Contents Association
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• v.22 no.9
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• pp.602-613
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• 2022

This study was performed to identify the factors affecting 'the organizational culture for infection control', 'the resource support', 'the knowledge about COVID-19', and 'the resilience' among hospital nurses on the performance of COVID-19 infection control. A total of 150 nurses, registered in Korea, participated in the current study. The data were collected through self-report questionnaires. From 27th July to 10th August, 2022, 147 questionnairesout of 150 were collected. In multiple regression analysis, 'the resource support', 'the knowledge about COVID-19' and 'the resilience' were analyzed as significant factors in performing of the infection control for COVID-19 (β = 0.68, p < .001, β = 0.12, p = .023 and β = 0.20, p = .005 respectively). For improving the nurses' performance of infection control against Coronavirus Disease 2019(COVID-19) during the pandemic, it is necessary to develop and evaluate the programs through the organizational support and strategies to improve individual knowledge.

• Proceedings of the KSCN Conference
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• 2004.05a
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• pp.353-365
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• 2004

전 세계적으로 매년 50만명이 위암으로 사망하고 있으며 그 발생 분포는 지역적으로 큰 차이를 보이고 있다. 이러한 차이는 유전, 감염, 식이, 환경 등에서 기인하는 것으로 그중 환경적인 요인, 특히 식품이 중요한 요인인 것으로 추측된다.(중략)

• 대한임상약리학회:학술대회논문집
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• 1999.12a
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• pp.62-62
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• 1999

• Pediatric Infection and Vaccine
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• v.16 no.2
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• pp.142-149
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• 2009

Purpose : The aim of this study was to determine the diagnostic value of serum procalcitonin (PCT) compared with that of C-reactive protein (CRP) and the total white blood cell count (WBC) in predicting bacterial infections in febrile infants<6 months of age. Methods : A prospective study was performed with infants <6 months of age who were admitted to the Department of Pediatrics with a fever of uncertain source between July and September 2008. Spinal taps were performed according to clinical symptoms and physical examination. Serum PCT levels were measured using an enzyme-linked fluorescent assay. Results : Seventy-one infants (mean age, 2.62 months) were studied. Twenty-six infants (36.6%) had urinary tract infections (UTIs), and 22 infants (31.0%) had viral meningitis. The remaining infants had acute pharyngitis (n=1), herpangina (n=1), upper respiratory tract infections (n=7), acute bronchiolitis (n=8), acute gastroenteritis (n=4), and bacteremia (n=2). The median WBC and CRP levels were significantly higher in infants with UTIs than in infants with viral meningitis. However, there were no differences in the median PCT levels between the groups (0.14 ng/mL vs. 0.11 ng/mL, P=0.419). The area under the receiver operating characteristic curve was 0.792 (95% CI, 0.65-0.896) for WBC, 0.77 (95% CI, 0.626-0.879) for CRP, and 0.568 (95% CI, 0.417-0.710) for PCT. An elevated WBC count (>11,920/${\mu}L$) and an increased CRP level (>1.06mg/dL) were significant predictors of UTIs based on multiple logistic regression analysis. Conclusion : Serum PCT concentrations should be interpreted with caution in infants <6 months of age with a fever of uncertain source.

• Childhood Kidney Diseases
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• v.3 no.1
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• pp.88-94
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• 1999

Purpose : Malformation of urinary tract is among the most common of all congenital anomalies and can progress to irreversible renal damage before diagnosis due to difficulty of early diagnosis. Present study was undertaken to determine the clinical characteristics of urinary tract anomaly and to find out the most appropriate diagnostic and therapeutic measures for children with these anomalies. Methods : During the past 10 years from 1987 to 1998, review of medical records revealed 65 children with congenital anomaly of urinary tract and the following results were obtained. Results : The most common anomalies were ureteropelvic junction obstruction occuring in 26 cases ($36\%$), followed by ureteral duplication in 11 cases, renal agenesis in 10 cases and ureterovesical function obstruction in 7 cases. Complex anomaly of urinary tract was found in 8 cases and anomaly of other systems such as congenital heart disease was detected in 11 cases. The most frequent age group at the time of diagnosis was below 1 year of age constituting 39 cases ($60\%$) and male preponderance was noted as male to female ratio being 2.25:1. Presenting symptoms were urinary tract infection in 25 cases, followed by hematuria, abdominal mass, abdominal pain and voiding difficulty, etc, and in 11 cases, the anomaly was picked up by routine prenatal ultrasonography. Azotemia was noted in 9 cases and the underlying anomaly was obstructive uropathy in 4 out of these 9 cases. Surgical correction was undertaken in 38 cases (most frequently in cases of obstructive uropathy) and in 2 out off cases with obstructive uropathy in whom surgical correction was done, azotemia disappeared during follow up period of 1-5years. No new cases of deteriorating renal function appeared during follow-up period. Conclusion : In spite of high incidence of congenital malformation of urinary tract, early diagnosis is still hampered by nonspecific symptoms and signs. Therefore, in patients with symptoms such as urinary tract infection, abdominal pain and voiding problems, etc, it Is advisable to take various diagnostic tests promptly to pick up any urinary tract anomaly and to apply proper therapy in order to avoid progression to irreversible renal damage. In this regard, prenatal ultrasonography should be utilized more widely as a routine procedure to detect any urinary tract anomalies before birth.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.15 no.4
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• pp.449-456
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• 2008

Purpose: The purpose of this study was to compare the effects of meatal care with 10% betadine or with normal saline on the incidence of urinary tract infection (UTI) for elderly patients with indwelling urinary catheter in the ICU. Method: A quasi experimental design with non-equivalent control group was used. The 37 patients who participated in this study were 65-year-old or older. Patients in the saline group (n=20) received meatal care with normal saline and those in the betadine group (n=17) received meatal care with 10% betadine once a day for 6 days. Urine cultures were done on the 7th day for both groups to detect UTIs. Results: No difference was observed in the incidence of urinary tract infection between the two groups, regardless of patients' gender, ability to communicate or history of operation. Conclusion: The results indicated that use of saline which is cheap and does not irritate the mucous membrane is effective in preventing UTI within the first 7 days, and can be used instead of betadine for meatal care for elderly patients with indwelling urinary catheter in the ICU.

• Childhood Kidney Diseases
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• v.16 no.1
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• pp.58-62
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• 2012

Urinary tract infection (UTI) is most commonly diagnosed bacterial infection in febrile infants. Renal abscess is a very rare complication of UTI in children. Early diagnosis and treatment with appropriate antibiotics are important because renal scar correlates positively with the time of treatment. Renal ultrasonography and abdominal computerized tomography facilitates an earlier diagnosis and is also useful in establishing percutaneous drainage. Extended broad spectrum antibiotics therapy alone can be effective in most types of renal abscesses in infant, but some antibiotics-resistant cases need surgical drainage or nephrectomy. We report a case of a infant UTI, that progressed to renal abscess despite early antibiotic treatment and was treated with US guided percutaneous needle aspiration.

• Research in Community and Public Health Nursing
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• v.29 no.3
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• pp.279-289
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• 2018

Purpose: This study has been conducted to identify factors that influence the initiation of treatment after the diagnosis of Korean patients with HIV. Methods: A cross-sectional study design was used, and 290 patients with HIV from outpatient departments of 7 hospitals participated. Self-report questionnaires included items on the days from the primary diagnosis to the initiation of treatment, and the patients' demographic and disease related characteristics. Negative binomial regression model (NBR) was utilized to determine risk factors influencing the initiation of treatment after the diagnosis of the patients with HIV. Results: The skewness of days was 6.62, and the degree of asymmetry of distribution was severe. In NBR, patients who were in their 40s and 50s, female, unmarried and living with their family, jobless, in a middle or high level of economic status, and diagnosed before 2014 showed a higher risk of delayed treatment than patients who were younger, male, married and living with family, in a low level of economic status, and diagnosed in 2014 or afterwards. Conclusion: The findings suggest the necessity of intervention to promote HIV patients' early entry into treatment based on the participants' characteristics.