• Proceedings of the Korean Society of Medical Physics Conference
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• 2004.11a
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• pp.81-84
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• 2004

자궁암 치료시 고선량률 강내 근접치료기와 병행하여 사용할 초음파 온열 치료기가 개발되었다. 온열치료기는 텐덤형, 오보이드 형, 원통형으로 디자인 되었다. 각각의 치료기들에 사용될 초음파원 으로 PZT물질이 사용되었다. 텐덤형의 경우 외부직경이 2mm 이고 길이가 24.5mm 인 PZT5A가 사용되었고 오보이드형은 직경 20mm, 길이 20mm 인 원통형의 PZT 8 물질을 반으로 나누어 사용하였으며 원통형 치료기는 외경 25.4mm, 길이가 15.2 mm 인 원통형 PZT 8물질이 이용되었다. 각각의 트랜스듀서의 초음파 발생효율을 측정하였다. 텐덤형의 경우 3.2MHz 로 작동하였고 평균효율성은 16.7% 이다. 오보이드형의 작동 주파수는 1.5MHz 이며 효율성을 32${\sim}$46% 이다. 마지막으로 원통형의 작동주파수는 1.7MHz 이며 측정?? 효율성의 범위는 55${\sim}$65%이다. 특성분석 결과 온열치료에 사용될 초음파원으로 사용가능함이 입증되었다. 따라서 3개의 텐덤형 드랜스듀서를 연결하여 자궁내막의 길이가 73.5mm까지 치료가능한 텐덤형 온열치료기가 제작되었고 2개의 반원통형 트랜스듀서를 연결하여 치료길이가 40mm 인 오보이드형 치료기가 제작되었다. 마지막으로 4개의 원통형 트랜스듀서를 연결하여 질암등에 사용이 가능하고 61mm 까지 치료가 가능한 원통형 온열 치료기가 제작되었다.

• Journal of the Korean Chemical Society
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• v.47 no.3
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• pp.257-264
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• 2003

This study has investigated the temperature-sensitive liposomes, which release anticancer drug(doxorubicin) at the hyperthermia temperature$(~40^{\circ}C)$. The temperature-sensitive liposomes were modified with a copolymers of N-isopropylacrylamide(NIPAAm) and acrylamide(AAm), which exhibit a lower critical solution temperature (LCST) at the hyperthermia temperature. The release of doxorubicin from the modified liposomes was determined by measuring the fluorescence intensity with changing temperature and time. The release of doxorubicin from liposomes modified with poly(NIPAAm-co-AAm) copolymer was increased significantly, because poly(NIPAAm-co-AAm) could undergo the conformational transition in the narrow hyperthermia temperature region$(~40{\pm}2^{\circ}C)$. Moreover, we observed that doxorubicin released from liposomes within 5 minutes, and the size of modified liposomes was 120~170 nm. In this study, we have prepared temperature-sensitive liposomes which could be controlled by temperature. They can be applied in the field of a drug delivery system for tumor targeting by temperature control.

• Journal of Korean Association for Spatial Structures
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• v.7 no.3 s.25
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• pp.97-107
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• 2007

The purpose of this study is to grasp the characteristic of indoor thermal environment from large enclosures in connection with heating condition and outdoor environment. This study has measured indoor thermal environment in accordance with heat loads from occupant for large enclosures in winter. We examined indoor thermal environment of the large enclosures in this study which include temperature distribution vertical, horizontal, seat and surface and thermal comfort environment.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2003.09a
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• pp.52-52
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• 2003

악성종양을 치료하는 방법중 방사선과 온열요법은 가장 강력한 치료방법으로 연구되어왔으며 이를 병용함으로 서 상승효과를 얻을 수 있다. 인체조직에 41$^{\circ}C$ 이상의 열을 가하면 세포질의 단백질변성으로 세포에 손상을 주어 세포가 사멸하게 되며 세포의 생존율은 가열시간 즉 열량에 따라 지수적으로 감소한다. 온열은 세포주기중 방사선 저항성이 매우 큰 DNA 합성시기와 산도가 높을 때 감수성이 매우 크기 때문에 방사선과 병용요법은 상호 상승효과를 가져온다. 이와 같이 온열을 이용한 악성종양의 치료가능성은 생물학적 기초연구와 임상시험에서 경이적인 효과를 얻을 수 있었으나 아직 까지 가열방법과 온도분포측정이 큰 과제로 남아있으며 주위건강조직의 가열을 피하면서 인체 깊은 곳에 존재하는 종양에만 집중 가열하는 방법인 삽입형 온열치료방법에 대한 연구가 집중되었다. 한편 방사선 치료방법은 주위 건강조직의 피폭을 최소로 줄이고 종양에만 집중 조사가 요구되며 자궁암, 유방암, 뇌암등 부피가 작고 집중적 치료를 요하는 종양은 방사성동위원소를 이용한 근접 삽입치료 (Brachyradiotherapy)가 큰 효과를 나타내고 있다 방사선과 온열의 병행 치료를 위하여 방사선 삽입 치료에 사용한 선원 삽입관을 그대로 두고 삽입관 속에 방사성 동위원소 대신 온열 전극을 넣어 열을 가하는 방사선 온열 병용치료방법을 고안하였으며 방사선과 온열병용에 사용할 최적 삽입관의 제작과 이에 따른 온도분포의 측정과 최적삽입방법을 결정하였다. 방사선 삽입치료용 폴리에찌렌 삽입관의 외부에 금박을 입혀 라디오파 첨극을 삽입할 때 서로 연결되도록 고안 제작함으로서 방사선 삽입치료와 자입식 온열치료를 동시에 만족하게 수행할 수 있는 병용삽입관 (Flexible thermoradiotherapy probes)을 제작하였다. 전도율이 큰 금박부위가 직접 조직에 접촉됨으로 라디오파의 전달이 용이하며 금박의 길이를 2 cm 에서 5 cm 로 구분제작 함으로서 종양의 크기와 모양에 따라 선택할 수 있도록 하였다. 라디오파를 이용한 온열분포의 측정은 인체조직과 전기적 특성이 비슷한 물질인 한천 팬텀 제작하여 사용하였으며 온도분포 측정은 열전대와 서머그람으로 시행하였다. 생체조직 내에서의 온도분포와 온열효과를 관찰하기 위하여 직접 개의 뇌를 이용하여 시행하였으며 4 개의 전극을 이용하여 43$^{\circ}C$로 50분간 가열하고 일주일후 개를 회생시켜 개 뇌에 대한 조직학적 검사를 시행하였다. 한편 팬텀 표면에서 중앙부로 안테나 길이가 2 cm 인 4 개의 전극을 1 cm 간격으로 정사각형이 되도록 삽입하여 가열하였을 때 90% 등온곡선이 반경 1.25의 원형으로 균일하게 분포되었고 종단면상 삽입관의 길이에 따라 균일한 온도분포가 이루어졌다. 전극을 2 cm 간격으로 삽일 하였을 때 90% 등온곡선이 1.75 반경으로 거의 4 각형의 균일한 분포를 얻었으나 전극의 간격이 증가하면 전도율이 떨어져서 전극 중심부에 불균일한 온도분포를 형성하였다. 동물실험에서 정상 개의 뇌 실질에 자입하여 직접 정방형의 중심을 43$^{\circ}C$로 유지하며 50분간 온열 요법을 시행한 후 관찰한 조직병리학적 소견은 liquefactive necrosis, pyknosis of neuronal element 및 polymorphonuclear leukocytes들의 회백질에서 급성기에 관찰되었고 liquefactive necrosis 주위에 lipid-laden macrophage들이 관찰됨이 공통적인 특정이었으며 후기변화로 괴사조직 주위로 신경교세포의 증식이 관찰되었다.

• The Korean Journal of Nuclear Medicine Technology
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• v.25 no.2
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• pp.48-54
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• 2021

Purpose In ¹⁸F-FDG PET/CT, the absorption of ¹⁸F-FDG due to the activation of Brown Adipose Tissue (BAT) greatly interferes with the discrimination of lymph node malignant metastasis. Warming the patient's body temperature before and after injection of ¹⁸F-FDG to prevent FDG absorption by BAT is a safe and non-pharmacological approach. The purpose of this study was to identify and select patients with a high potential for BAT activation in advance, and to investigate whether BAT can inhibit FDG absorption when the body temperature is raised for a short time by directly applying heat to the target patient. Materials and Methods Among the patients who underwent ¹⁸F-FDG PET/CT at the National Cancer Center from January 2020 to December 2020, 825 female patients (415 in the thermal group, 410 in the non-thermal group) under 50 years old were included. The thermal group was administered heat for 10 minutes before injection of ¹⁸F-FDG. For statistical analysis, the Z test comparing the ratios between the two groups was used, and logistic regression analysis was performed to correct for important variables (BMI, outdoor temperature, blood sugar) according to the results of the previous retrospective study. Results Among 825 patients, 19 patients with BAT activated (Thermal group: 5(1.2%), Non-thermal group: 14(3.41%)) accounted for 2.3% of the total. As a result of performing the Z test to compare the ratios between the two groups, the activation of BAT in the thermal group was significantly decreased (P=0.034). In the univariate logistic regression analysis, the activation of BAT was also decreased in the thermal group (OR: 0.34, P<0.05). In the multivariate results, BAT activation increased in patients younger than 45 years old (OR: 4.46, P<0.05) and outdoor temperature less than 13.2 degrees (OR: 9.97, P<0.05). BAT activation tended to decrease in the thermal group, but there was no significant difference (OR: 0.37, P=0.066). Conclusion We confirmed that the activation of BAT tends to decrease by 62.5% in the group subjected to the thermal method, and it will be of great help in preventing FDG absorption of BAT more effectively in the future.

• KIEAE Journal
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• v.10 no.4
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• pp.67-73
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• 2010

As more and more people desire to live in an apartment complex with a comfortable outdoor space, many construction company became interested in outdoor design. In order to increase the use of outdoor space and create the most pleasant environment, outdoor thermal environment and comfort should be evaluated quantitatively from the design stage. This study utilized ENVI-met 3.1 model to analyze outdoor thermal environment in apartment complex, and evaluated outdoor thermal comfort in 6 points of apartment complex. The physiologically equivalent temperature(PET) was employed as a outdoor thermal index. Playground B had a poor thermal environment with the maximum PET $43^{\circ}C$ (Very hot). Because shading by building and tree didn't affect outdoor thermal environment of playground B. To design comfortable outdoor space from the view point of thermal environment, the factors influencing Mean radiant temperature(MRT) and wind speed should be considered in design stage. Since it is difficult to control outdoor thermal environment compared with indoor environment, we should take into account an assessment for outdoor thermal environment and comfort in outdoor design stage.

• Radiation Oncology Journal
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• v.5 no.1
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• pp.31-36
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• 1987

Radiobiological and clinical evidences indicate that hyperthermia combined with ionizing radiation produces a significant improvement in therapeutic effect of cancer. In general, malignant cells are more sensitive to heat than normal cells in the heat range of $41\~45^{\circ}C$. We report the experiences obtained from 42 patients with advanced malignant neoplasms managed with 2,450MHz microwave-induced local hyperthermia and ionizing radiation at the Department of Radiology, Kangnam St. Mary's Hospital, Catholic University Medical College. A clinical analysis of 42 thermoirradiated patients showed result of 11(26\%),\;15(36\%),\;11(26\%)\;and\;5(12\%)$ patients with complete response (CR), partial response (PR), minor response (MR) and no response (NR), respectively. Histologically there were $17(40.2\%)$ squamous cell carcinomas, $12(28.6\%)$ adenocarcinomas and $6(14.3\%)$ miscellaneous cancers. Eleven patients with CR consisted of five squamous cell carcinomas, five adenocarcinomas, and one chloroma. Among 15 patients with PR were five squamous cell carcinomas, five adenocarcinomas, three unknown primary tumors, and one poorly differentiated, and miscellaneous tumor each.

• Progress in Medical Physics
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• v.16 no.1
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• pp.16-23
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• 2005

The objective of this study was to construct multi-element ultrasound applicators for the treatment of gynecologic cancer with high dose rate brachytherapy. For the treatment of uterus, piezo-ceramic crystal transducer (PZT -5A) with outer diameter of 4 mm, wall thickness of 1.3 mm, and length of 24.5 mm was selected. For the treatment of cervix or vagina, it should be possible to insert the applicator into the vagina. Thus, a cylindrical PZT -8 material with outer diameter of 24.5 mm, wall thickness of 1.3 mm, and length of 15.2 mm was selected. The operating frequencies determined by vector impedance measurement were 3.2 MHz for the PZT 5A cylinder (OD=4 mm) and 1.7 MHz for the PZT -8 cylinder (OD: 24.5 mm). The ratios of generated acoustic output power to applied electric power were 33% and 61% for the tandem type crystal and the cylinder type crystal, respectively. The radiated acoustic pressure fields from both transducers were calculated using a Matlab code and measured in water using hydrophone. There was good agreement between measured and calculated acoustic pressure field distribution. For a tandem type transducer, the calculated acoustic pressure field decreased from 0.023 MPa at 10 mm to 0.010 Mpa at 30 mm, the reduction of 57%. For the cylinder type transducer which will be used for the treatment of vagina showed 78% reduction at 15 mm and 66% at 25 mm as compared to values at 5 mm from the surface. Based on the characteristics of the transducers, this study demonstrated the possibility of using the crystals as a heating source. Finally, a 3-element and 4-element prototype applicators were constructed. The 3-element applicator is 75 mm long and 4 mm thick and will be used for the treatment of uterus. The 4-element applicator is 61 mm long and 24.5 mm thick and will be used for the treatment of vagina. Using these applicators, it is possible to generate enough power to increase temperature to therapeutic level.

• Journal of Conservation Science
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• v.35 no.2
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• pp.99-115
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• 2019

The Royal Tombs at Songsanri is one of the most important historic site for ancient historical study in Korean Peninsula. Since the excavation of the tombs, continuous exposure to the outside environment and the negative effects of the artificial air conditioning system have caused significant threats to the thermal environment stability of the tombs. Unlike the outside temperature that shows significant differences according to seasonal changes, the burial chamber of the tombs had a relatively stable temperature range of 11.4 to $22.2^{\circ}C$ throughout the year, and the standard deviation of temperature was within 3.5. It was revealed that major factors affecting the microclimate of the tombs were inflow of outdoor air, wind direction and speed, and all of them had closely related to airtightness of the tombs. The solar radiation was in inverse proportion to the thickness of burial mounds, and thus Royal Tomb of King Muryeong, which has the thickest burial mound, was least affected by solar radiation. Especially, microclimate of the tombs caused to the highest influence with artificial environmental changes due to access by people, which varied in proportion to the number of accessed people and time of stay. Currently, the inside of the tombs are sealed and always in saturated condition, it is very vulnerable to dew condensation. As a result of analyzing the possibility of condensation in each tomb, all the tomb No. 5, tomb No. 6 and Royal Tomb of King Muryeong had condensation most of the time throughout the year. It is required to make a proper conservation environment for the Royal Tombs at Songsanri.

• The Magazine of the Society of Air-Conditioning and Refrigerating Engineers of Korea
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• v.28 no.1
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• pp.10-15
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• 1999

산업헉명 이후 유리와 철의 이용은 넓은 개구부를 지닌 대형공간을 지닌 건축을 가능케 하였고, 1970년대 이후 새로운 건축양식의 추구라는 시대적 요구는 아트리움의 건축적 응용을 확산하게 하였다. 아트리움은 다층건물의 유리로 덮힌 대형공간으로 건물의 중심적이고 내부적인 공공의 공간이다. 대형공간으로서 아트리움의 가장 큰 특징은 넓은 채광창을 통해 실내로 유입되는 태양광에 있다. 넓은 채광창은 사람들에게 시각적인 개방감을 제공하며, 또한 많은 채광량으로 식재에 의한 조경이 가능해 외부공간과 같은 분위기를 연출하면서도 비·바람·추위 등으로부터 보호되는 쾌적한 온열환경을 제공하고 있다.