• Journal of Pharmaceutical Investigation
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• v.36 no.2
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• pp.137-142
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• 2006

A bioequivalence of Daewoong $Alendronate^{TM}$ (Daewoong Pharmaceutical Co., Ltd., Korea) and $Fosamax^{TM}$ tablets (MSD Korea) was evaluated according to the guideline of Korea Food and Drug Administration (KFDA). A single 70 mg dose of sodium alendronate of each medicine was administered orally to 56 healthy male volunteers. This study was performed in a $2\;{\time}\;2$ crossover design. Concentrations of alendronate in the urine were monitored by a high-performance liquid chromatography (HPLC). $A_{et}$ (cumulative urinary excreted amount from time 0 to last sampling interval) was calculated by the accumulation of the urinary excreted alendronate. $U_{max}$ (maximum urinary excretion rate) and $T_{max}$ (time to reach $U_{max}$) were compiled from the urinary excretion rate - time data. Analysis of variance was performed using logarithmically transformed $A_{et}$ and $U_{max}$. No significant sequence effect was found for all of the bioavailability parameters. The 90% confidence intervals of the $A_{et}$ and $U_{max}$ for Daewoong $Alendronate^{TM}/Fosamax^{TM}$ were 0.89-1.12 and 0.82-1.02, respectively. This study demonstrated the bioequivalence of Daewoong $Alendronate^{TM}$ and $Fosamax^{TM}$ with respect to the rate and extent of absorption.

• Polymer(Korea)
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• v.27 no.2
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• pp.106-112
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• 2003

Poly(trimethylene terephthalate)(PTT) fibers were treated by passing on the plate heater to study the annealing effect on the change of morphological structure and physical properties. In the X-ray diffraction curves of PTT annealed, a sharp peak at 2$\theta$=15.6$^{\circ}$ appeared and the peak intensity became stronger with the increase of annealing temperature and time. This peak was based on the (010) plane of PTT crystals. The crystallinity determined by density measurement was also increased by annealing. With the increases of temperature and time, the dynamic viscoelastic behaviors were shown to be a large reduction in T(tan $\delta$$_{max}$). The birefringence and $T_g$ were also reduced, but the melting temperature was the same. These results mean that the molecular chains in armorphous region are transfered into the crystalline legion, making the remained chains relaxed during annealing at tensionless state.

• Korea journal of population studies
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• v.35 no.1
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• pp.181-209
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• 2012

Employment form and gender as stratification factors may generate health disparities in Korea. Previous studies have examined the existence of health disparities by employment form and gender. However, few studies examined how the health disparities can be reduced effectively. This study intends to confirm the existence of health disparities between employment-gender groups and explore the effective health resources which can reduce the possible disparities. Using a national probability sample of Korean adults collected in 2011, we attempts to test the interaction effects between employment-gender groups and health resources on self-rated health. For health resources, 24 variables of five dimensions(social relationship, psychological resource, activity factor, health behavior, and usage of medical service) are taken into account. In results, first, the health levels of the other three employment-gender groups are worse than that of male-regular workers. Second, the effective health resources which can reduce the health disparities are different across the employment-gender groups. An effective health resource for female-nonregular workers is a peaceful relationship with her children. Effective health resources for male-nonregular workers are peaceful relationships with his parents and siblings, low stress, religious activity, and exercise. An effective health resource for female-regular workers is interpersonal trust. These results imply that personal or social interventions for health of specific disadvantaged groups need to focus on specific resources which are more effective for the groups.

• Food Science and Preservation
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• v.16 no.3
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• pp.321-326
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• 2009

We assessed quality changes in and washing effects (time and method) on lettuce (Lactuca sativa L.) treated with micro-bubbles. Samples were treated with micro-bubbling for 1, 3, or 5 min, and the 5-min treatment yielded the best results in terms of reduced total microorganism counts, sensory aspects, and degree of washing. Total microorganism counts were 4.30 log colony-forming units (CFU)/g in unwashed lettuce(CT), 4.10 log CFU/g in hand-washed lettuce (HW), 3.98 log CFU/g in conventional, bubble-washed lettuce (BW) and 3.25 log CFU/g in micro-bubble-washed lettuce (MW). In comparison, total counts of samples examined after 10 days of storage were 7.00 log CFU/g for CT, 6.19 log CFU/g for HW, 6.02 log CFU/g for BW, and 5.89 log CFU/g for MW. The lowest counts were seen after micro-bubble treatment. BW and MW samples showed significantly higher counts than did CT and HW samples. In general, BW and MW samples did not vary significantly in count numbers. MW showed a 2.3-fold lower residual pesticide level compared with CT, and also had the lowest level of impurities. HW and BW samples were not well washed.

• Tuberculosis and Respiratory Diseases
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• v.47 no.2
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• pp.272-278
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• 1999

The primary lymphoma in the lung is very rare. Moot of the primary pulmonary lymphomas, which represent 3-4 % of extra-nodal lymphomas, are low-grade B-cell lymphoma. The low-grade B-cell lymphomas progress slowly and the prognosis of these are more favorable than that of the nodal lymphomas. However, high-grade forms progress rapidly with more severe course. The diagnosis of primary pulmonary lymphomas generally relies on the histopathologic findings of lung specimens obtained by surgical excision of the lesions or open-lung biopsy. Recently, less aggressive biopsies(transbronchial, transthoracic) and/or immunocyto-chemical, immunochemical and gene rearrangement studies on materials obtained by bronchoalveolar lavage have been used occasionally. The treatment of the primary pulmonary lymphomas has not been precisely codified. Several clinical data suggest that limited surgery or non-aggressive chemotherapy can provide long-term survival in patients with such slowly developing neoplasm, and demonstrated the need for the development of noninvasive diagnootic methods. In this study, we report a case of high-grade B-cell lymphoma of the lung which was treated with combination chemotherapy.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.17 no.3
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• pp.121-127
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• 2007

We have applied mechanical alloying (MA) to get $Mg_2Si$ thermoelectric material with nano-sized grains. An optimal milling and heat treatment conditions to obtain the single phase of $Mg_2Si$ compound with fine microstructure were investigated by X-ray diffraction and differential scanning calorimetry (DSC) measurement. The $Mg_{66.7}Si_{33.3}$ MA samples ball-milled for $20{\sim}180\;hrs$ exhibit two broad exothermic heat releases around $220^{\circ}C$ and $570^{\circ}C$. On the other hand, MA sample ball-milled far 260 hrs exhibits only a sharp exothermic peak at $230^{\circ}C$ Single phase Mg2Si powder can be obtained by MA of $Mg_{66.7}Si_{33.3}$ mixture for 60 hours and subsequently heated up to $620^{\circ}C$. Sintering of the MA powders was performed in a spark plasma sintering (SPS) machine using graphite dies at $800{\sim}900^{\circ}C$ under 50 MPa. The shrinkage of sintering sample during SPS was significant at about $200^{\circ}C$. All compact bodies have a high relative density above 94% with metallic glare on the surface.

• Journal of the korean academy of Pediatric Dentistry
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• v.35 no.3
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• pp.516-522
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• 2008

In the case of the impacted teeth, the clinician has to consider development of tooth, site of impaction, eruption path, and cooperation of patient. If there are genetic or general factors to effect the eruption of tooth, the clinician treats these first and then takes the early treatment for eruption guidance. If there are physical factors to intercept eruption, the clinician put them off first. However, if there are no factors to effect eruption of tooth and enough space for eruption, the clinician can consider extraction of deciduous teeth, forced eruption and surgical reposition. In case of surgical repositioning, proper time for root development, proper socket formation, and minimal trauma are important for success. This case presents displaced impacted maxillary central incisor with dilacerated root. The development of root is Nolla's stage 7, and the tooth was treated by surgical repositioning. We can observe no root resorption and good healing pattern.

• Journal of Gifted/Talented Education
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• v.23 no.5
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• pp.817-833
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• 2013

The study aims to analyze Thomas Young's problem solving processes of analogical reasoning during the formation of the interference theory of light, and to draw its implications for secondary science education, particularly for enhancing creativity in science. The research method employed in the study was literature review of the papers which Young himself had written about sound wave and property of light. His thinking processes and specific features in his thought that were obtained through analysis of his papers about light are as follows: Young reconsidered Newton's experiments and observations, and reinterpreted Newton's results in the new viewpoints. Through this analysis, Young discovered that Newton's interpretation about his own experiments and observations was faulty in a certain point of view and new interpretation is necessary. Based on the data, it is hypothesized that colors observed on thin plates and colors appeared repeatedly on Newton's ring are appeared because of the effect of light interference. Young used analogical reasoning during the process of inference of similarity between sound and light. And he formulated an hypothesis on the interference of light through using abductive reasoning from interference of water wave, and proved the hypothesis by constructing an creative experimental device, which is called a critical experiment. It is implicated that the analogical reasoning and experimental devices for explaining the light interference which Young created and used can be utilized for school science education enhancing creativity in science.

• The Journal of the Petrological Society of Korea
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• v.27 no.2
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• pp.73-84
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• 2018

In the northern Cheongsong, there are occurred igneous intrusions: Cheongsong dike swarm, Jungtaesan laccolith, Galpyeongji stock. The swarm is composed of rhyolitic dikes that have developed many various spherulites. The dikes represent an geometrically radical pattern centering the Galpyeongji stock, but also geochemistry of the intrusions indicate the swarm source. Here we report the compositional data for 28 samples from the three intrusions. All of the intrusions belong to rhyolitic composition, but according to compositional correlation, there are considerable overlaps between intrusion compositions. In particular, the Cheongsong dike swarm is divided into several dike groups by rock color and shows compositional diversity, but the composition of the dikes generally overlap with compositions of other intrusions. The Jungtaesan laccolith is enriched in alkali, $K_2O$ and $Al_2O_3$ and depleted in $Fe_2O_3{^t}$, $TiO_2$ and REE compared to the Cheongsong dike swarm. In contrast, the Galpyeongji stock is narrow in composition range, and commonly has sharp compositional overlaps with the Cheongsong dike swarm. According to the compositional correlations, the stock is considered to be a source of the swarm and it is connected to an episode of volcanism.

• Korean Journal of Food Science and Technology
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• v.45 no.6
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• pp.763-769
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• 2013

Soybean oil was stored in polyethylene for 12 weeks at $20^{\circ}C$. The influence of LED (light emitting diode) irradiation on four different wavelengths and fluorescent light was investigated. The pattern changes of volatile components in soybean oil was analyzed by electronic nose based on mass spectrometer. The obtained data from electronic nose were analyzed by discrimination function analysis. Under fluorescent light, the discriminant function first score (DF1) was significantly moved from positive position to negative one after 4-12 weeks. It means that the volatile compounds related to quality of lipid. It was shown to increase slowly due to green light of LED treatment, while blue and white LED light was influenced significantly as well as fluorescent light irradiation. Selection of LED irradiation would provide to keep good quality of soybean oil under distribution chain system.