• Magazine of the Korea Concrete Institute
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• v.23 no.2
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• pp.37-41
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• 2011

• Korean Journal of Biological Psychiatry
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• v.2 no.2
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• pp.248-251
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• 1995

정신분열병의 약물치료에서 중요한 역할을 하는 도파민의 기전은 지금까지 5종류의 수용체들이 발견되고 클론되면서, 새롭고 보다 근본적인 유전학적 접근을 통해 규명될 수 있게 되었다. 특히, 도파민 수용체 D4 (DRD4)는 막단백질의 세포질쪽 세번째굴곡에 48-bp반복 다형성배열을 가지고있다. 이러한 다형성 반복배열이 신호전달에 참여할 가능성이 높은 막단백질의 세포질쪽 굴곡에 있다는것은, 각 개인의 항정신병약물에 대한 민감성의 차이를 포함하여 정신분열병에 대한 개개인의 유전적 차이를 진단할 수 있는 가능성을 제시한다. 이러한 가능성을 검증하기 위하여 주로 손쉽고 빠른 중합효소연쇄반응(PCR)을 사용하여 DRD4의 아형들을 분류하게 되는데, DRD4의 PCR은 그 반복배열과 그 주변배열의 높은 GC함량(78% G+C) 때문에 일반적인 PCR 방법을 변형시켜 사용해야한다. DRD4의 아형을 분류하기 위해 변형된 PCR은 통상적으로 7-deaza dGTP와 10% DMSO를 사용하게된다. 이러한 DRD4 PCR은 대부분의 경우 성공하지만, 항상 모든 시료에서 PCR이 성공되는것은 아니었으며 반복적으로 시도하여 증폭시킬 수 있었다. 이러한 어려움은 대부분이 template DNA에 문제가 있을것으로 의심되며 DNA정제 또는 template DNA를 제한효소로 적절하게 무작위절단하여 성공율을 높일 수 있었다.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.23 no.4
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• pp.387-394
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• 2010

The alternative load path method based on a column removal scenario has been commonly used to protect building structures from being progressively collapsed due to probable blast loading. However, this method yields highly conservative result when the columns still have substantial load resisting capacity after blast. In this study, the behavior of RC columns with rectangular and circular sections under the blast loading was investigated and the remaining capacity of the partially damaged columns was compared. AUTODYN which is a hydrocode for the analysis of the structure on the impact and blast loading was used for this study. The blast loading was verified with the experiment results. The analysis results showed that the circular columns are preferable to the rectangular ones in respect of the blast resistance performance.

• Korean Journal of Microbiology
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• v.43 no.1
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• pp.1-6
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• 2007

We describe a multiplex PCR method that can detect and differentiate simultaneously four different kinds of DNA viruses, Epstein-Barr virus (EBV), cytomegalovirus (CMV), hepatitis B virus (HBV) and parvovirus B19 (B19). Primers for the multiplex PCR reaction were designed to amplify specific regions of the EBV (pol), CMV (pol), HBV (pol) and B19 (ns) viral genomes and used to simultaneously detect individual viruses. In order to achieve optimal sensitivity and specificity for multiplex PCR, the thermo-cycling parameters, primer sequences, and concentration of each reaction components were optimized systematically. The sensitivity of the detection method ranged between 5 and 10 copies of viral genome with a mixture of multiple primer pairs. Furthermore, this highly sensitive test showed no cross-reactivity among the four viruses. Thus, the results obtained in this study provide evidence that the assay system is a good tool for supporting the diagnosis of viral infection and contamination.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.23 no.5
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• pp.517-524
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• 2010

In this paper the progressive collapse resisting capacity of steel moment frames with viscous dampers was evaluated by nonlinear dynamic analysis. The effects of dampers installed in steel beam-column sub-assemblages with varying natural period and yield strength were evaluated after sudden removal of a column. According to the parametric study the vertical displacement general decreased as the damping ratio of the system increased, and the dampers were effective both in elastic and elasto-plastic systems. The nonlinear dynamic analysis results of the 15-story analysis models showed that the decrease in vertical deflection of the structure with 9m span length, which showed larger deflection, was more predominant than that of the structure with 6m span length.

• Journal of Korea Water Resources Association
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• v.33 no.1
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• pp.99-110
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• 2000

In this study we proposed a simple method for generating multi-site daily rainfall based on the 1-order Markov chain and considering the spatial correlation. The occurrence of rainfall is simulated by a simple 1st-order Markov chain and its intensity to be chosen randomly from the observed data. The spatial correlation between sites could be conserved as the rainfall intensity at each site is to be chosen consistently with the target site in time through generation. It is found that the generated daily rainfall data reproduce genera] characteristics of the observed data such as average, standard deviation, average number of wet and dry days, but the clustering level in time is somewhat loosened. Thus, the lag-I correlation coefficient of the generated data gave smaller value than the observed, also the average lengths of wet run and dry run and the wet-to-wet and dry-to-dry probabilities were a bit less than the observed. This drawback seems to be overcome somewhat by choosing a proper site representing overall basin characteristics or by use of more detailed states of rainfall occurrence.

• Journal of Korea Water Resources Association
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• v.35 no.5
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• pp.583-595
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• 2002

The purposes of this study are to perform the management and monitoring of droughts for Mokpo area via the monthly Palmer index(PDSI), the data is obtained from the Mokpo meteorological station, and the used data are in the period of 1906 to 1999. Monthly Palmer index is classified into 7 stochastic classes and its dynamic change of monthly transition probability estimated by Markov chain is investigated. We also estimate the steady state probability of the classified PDSI. The 4th class shows the highest frequency of 49.6% out of 7 classes and the 7th class which is the most extreme drought show that a stochastic transition probability is more or less larger than an empirical one. Also, we found that the monthly steady state probability could be used for the forecasting of changing pattern of drought magnitude for the study area.

• Journal of Korea Water Resources Association
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• v.35 no.5
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• pp.619-629
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• 2002

Water in the atmosphere is circulated by reciprocal action of various factors in the climate system. Otherwise, any climate phenomenon could not occur of itself. Thus, we have tried to understand the climate change by analysis of the factors. In this study, the fuzzy theory which is useful to express inaccurate and approximate nature in the real world is used for forecasting precipitation influenced by the factors. Forecasting models used in this study are neuro-fuzzy system and a Markov chain and those are applied to precipitation forecasting of illinois. Various atmosphere circulation factors(like soil moisture and temperature) influencing the climate change are considered to forecast precipitation. As a forecasting result, it can be found that the considerations of the factors are helpful to increase the forecastibility of the models and the neuro-fuzzy system gives us relatively more accurate forecasts.

• Korean Journal of Soil Science and Fertilizer
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• v.18 no.3
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• pp.276-281
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• 1985

This study was conducted to examine the morphological, physical and chemical characteristics of the Song-jeong (residuum), Dae-gog (local colluvium-alluvium), Ji-san and Og-cheon (local-alluvium) series with fine loamy texture derived from fine granitic parent materials on the drainage catena. 1. These soils consist of a catena, and then a color sequence due to the influence of topography, water table and free iron content. 2. The poorer the drainage, the higher were the silt/clay ratio, soil reaction, organic matter, and available phosphate content in soils but the active iron content was lower.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.42 no.9
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• pp.739-744
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• 2014

Space exploration project usually consists of so many fields of sub projects that it has a diverse ripple effect throughout the economy. Further studies could not consider the complexity of the space exploration project because they regarded it as one project in spite of the diversity. This study found a way to consider complexity of space exploration project using the concept of WAC(weighted average coefficient). The moon exploration project (2014~2020) is the subject of this study. We classified the moon exploration project into 8 industries and calculated the WAC of production inducement coefficient, value added inducement coefficient, and employment inducement coefficient. The result of analysis using these WACs is that production inducement effect amounts to 1,229.6 billion won, value added inducement effect 324.6 billion won, employment inducement effect 4,844 men. And the linkage effect analysis shows that moon exploration project has more backward linkage effect than forward linkage effect.