• Title/Summary/Keyword: 연관통

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Changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis (소아의 전염성 단핵구증에서 사이토카인과 세포자멸사 연관 유전자의 발현의 변화)

  • Jo, Dae Sun;Han, Ji Hye;Kim, Sun Young;Kim, Min Sun;Yi, Ho Keun;Lee, Dae-Yeol;Hwang, Pyoung Han
    • Clinical and Experimental Pediatrics
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    • v.52 no.12
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    • pp.1348-1357
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    • 2009
  • Purpose:The aims of this study were to identify the clinical characteristics and determine the changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis. Methods:Serological examinations of 15 pediatric patients diagnosed with infectious mononucleosis were performed prospectively. Peripheral blood from the patients was used to compare the composition of T cell subsets, cytokines, Epstein-Barr virus (EBV) DNA, and the expression of apoptosis-related genes with those in 10 healthy children. Results:Mean age of the patient group was $5.7{\pm}3.4$ (range, 3-9) years, and the male-to-female ratio was 1.5:1. Fever, sore throat, pharyngitis/tonsillitis, and cervical lymph node enlargement were the most common symptoms and signs. The proportions of CD3+ T cells, CD8+ suppressor cells, and CD56+ natural killer (NK) cells were higher in the patient group than in the control group (P<0.01). The IL-2, IL-6, and interferon $(INF)-{\gamma}$ levels were higher in the early symptomatic period (P<0.01). Mean amount of EBV DNA in the patients was $10^{2.38}copies/{\mu}g$, and the amount was the highest at the beginning of the symptomatic period and normalized during the convalescent phase. Bcl-2 expression increased during the initial phase, while Bax expression increased during the convalescent phase. Further, FasL expression increased 1 week after symptom presentation and decreased during the convalescent phase. There was no significant change in Fas expression. Conclusion:We analyzed the clinical characteristics and changes in the expression ofcytokines and apoptosis-related genes in the patients with infectious mononucleosis.

Characteristics and classification of paddy soils on the Gimje-Mangyeong plains (김제만경평야(金堤萬頃平野)의 답토양특성(沓土壤特性)과 그 분류(分類)에 관(關)한 연구(硏究))

  • Shin, Yong Hwa
    • Korean Journal of Soil Science and Fertilizer
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    • v.5 no.2
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    • pp.1-38
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    • 1972
  • This study, designed to establish a classification system of paddy soils and suitability groups on productivity and management of paddy land based on soil characteristics, has been made for the paddy soils on the Gimje-Mangyeong plains. The morphological, physical and chemical properties of the 15 paddy soil series found on these plains are briefly as follows: Ten soil series (Baeggu, Bongnam, Buyong, Gimje, Gongdeog, Honam, Jeonbug, Jisan, Mangyeong and Suam) have a B horizon (cambic B), two soil series (Geugrag and Hwadong) have a Bt horizon (argillic B), and three soil series (Gwanghwal, Hwagye and Sindab) have no B or Bt horizons. Uniquely, both the Bongnam and Gongdeog series contain a muck layer in the lower part of subsoil. Four soil series (Baeggu, Gongdeog, Gwanghwal and Sindab) generally are bluish gray and dark gray, and eight soil series (Bongnam, Buyong, Gimje, Honam, Jeonbug, Jisan, Mangyeong and Suam) are either gray or grayish brown. Three soil series (Geugrag, Hwadong and Hwagye), however, are partially gleyed in the surface and subsurface, but have a yellowish brown to brown subsoil or substrata. Seven soil series (Bongnam, Buyong, Geugrag, Gimje, Gongdeog, Honam and Hwadong) are of fine clayey texture, three soil series (Baeggu, Jeonbug and Jisan) belong to fine loamy and fine silty, three soil series (Gwanghwal, Mangyeong and Suam) to coarse loamy and coarse silty, and two soil series (Hwagye and Sindab) to sandy and sandy skeletal texture classes. The carbon content of the surface soil ranges from 0.29 to 2.18 percent, mostly 1.0 to 2.0 percent. The total nitrogen content of the surface soil ranges from 0.03 to 0.25 percent, showing a tendency to decrease irregularly with depth. The C/N ratio in the surface soil ranges from 4.6 to 15.5, dominantly from 8 to 10. The C/N ratio in the subsoil and substrata, however, has a wide range from 3.0 to 20.25. The soil reaction ranges from 4.5 to 8.0. All soil series except the Gwanghwal and Mangyeong series belong to the acid reaction class. The cation exchange cpacity in the surface soil ranges from 5 to 13 milliequivalents per 100 grams of soil, and in all the subsoil and substrata except those of a sandy texture, from 10 to 20 milliequivalents per 100 grams of soil. The base saturation of the soil series except Baeggu and Gongdeog is more than 60 percent. The active iron content of the surface soil ranges from 0.45 to 1.81 ppm, easily-reduceable manganese from 15 to 148 ppm, and available silica from 36 to 366 ppm. The iron and manganese are generally accumulated in a similar position (10 to 70cm. depth), and silica occurs in the same horizon with that of iron and manganese, or in the deeper horizons in the soil profile. The properties of each soil series extending from the sea shore towards the continental plains change with distance and they are related with distance (x) as follows: y(surface soil, clay content) = $$-0.2491x^2+6.0388x-1.1251$$ y(subsoil or subsurface soil, clay content) = $$-0.31646x^2+7.84818x-2.50008$$ y(surface soil, organic carbon content) = $$-0.0089x^2+0.2192x+0.1366$$ y(subsoil or subsurface soil, pH) = $$-0.0178x^2-0.04534x+8.3531$$ Soil profile development, soil color, depositional and organic layers, soil texture and soil reaction etc. are thought to be the major items that should be considered in a paddy soil classification. It was found that most of the soils belonging to the moderately well, somewhat poorly and poorly drained fine and medium textured soils and moderately deep fine textured soils over coarse materials, produce higher paddy yields in excess of 3,750 kg/ha. and most of the soils belonging to the coarse textured soils, well drained fine textured soils, moderately deep medium textured soils over coarse materials and saline soils, produce yields less than 3,750kg/ha. Soil texture of the profile, available soil depth, salinity and gleying of the surface and subsurface soils etc. seem to be the major factors determining rice yields, and these factors are considered when establishing suitability groups for paddy land. The great group, group, subgroup, family and series are proposed for the classification categories of paddy soils. The soil series is the basic category of the classification. The argillic horizon (Bt horizon) and cambic horizon (B horizon) are proposed as two diagnostic horizons of great group level for the determination of the morphological properties of soils in the classification. The specific soil characteristics considered in the group and subgroup levels are soil color of the profile (bluish gray, gray or yellowish brown), salinity (salic), depositonal (fluvic) and muck layers (mucky), and gleying of surface and subsurface soils (gleyic). The family levels are classified on the basis of soil reaction, soil texture and gravel content of the profile. The definitions are given on each classification category, diagnostic horizons and specific soil characteristics respectively. The soils on these plains are classified in eight subgroups and examined under the existing classification system. Further, the suitability group, can be divided into two major categories, suitability class and subclass. The soils within a suitability class are similar in potential productivity and limitation on use and management. Class 1 through 4 are distinguished from each other by combination of soil characteristics. Subclasses are divided from classes that have the same kind of dominant limitations such as slope(e), wettness(w), sandy(s), gravels(g), salinity(t) and non-gleying of the surface and subsurface soils(n). The above suitability classes and subclasses are examined, and the definitions are given. Seven subclasses are found on these plains for paddy soils. The classification and suitability group of 15 paddy soil series on the Gimje-Mangyeong plains may now be tabulated as follows.

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The Understanding of the Forest Campers' Attitudes and Their Self-Actualization in Relation to Quality of Forest Resources (야영객(野營客)의 삼림자원(森林資源)에 대한 심리자세(心理姿勢)와 자아실현(自我實現))

  • Shin, Won Sop
    • Journal of Korean Society of Forest Science
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    • v.82 no.2
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    • pp.107-121
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    • 1993
  • This study examines whether or not forest campers' self-actualization, that is the tendency for a person to become actualized in what he or she perceived to be his or her own potential, and their attitudes toward nature were related to quality of forest areas where they visited. People were sampled in three Ontario Provincial Parks in Canada from September of 1988 to August of 1989. From a total of 138,317 campers, 540 were sampled randomly to collect data. People sampled ranged in age from 15 to 75 years with a mean of slightly over 37. They were highly educated. A majority of them resided in urban or suburban areas. Campers' level of self-actualization and their nature attitudes were highly correlated with forest area quality in both perceived or subjective and objective measures. Their self-actualization scores were also highly correlated with their attitudes toward nature. However, there was no significant relationships among campers' self-actualization, attitudes toward nature, and quality of forests where they camped when they were treated simultaneously.

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Genetic Structure and Phylogenetic Relationship of Red Spotted Grouper (Epinephelus akaara) Based on the Haplotypes and Polymorphisms of Mitochondrial COI Gene Sequences (미토콘드리아 COI 유전자 서열의 다형성과 반수체형에 근거한 한국산 붉바리(Epinephelus akaara)의 유전적 구조와 계통 유연관계)

  • Han, Sang-Hyun;Lee, Young-Don;Baek, Hae-Ja;Oh, Hong-Shik;Noh, Choong Hwan
    • Journal of Life Science
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    • v.24 no.6
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    • pp.626-632
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    • 2014
  • The genetic structure and phylogenetic relationship were investigated in Korean red spotted grouper populations using the nucleotide sequence polymorphisms of the mitochondrial DNA (mtDNA) cytochrome c oxidase subunit I (COI) gene. The COI gene was sequenced showed 99.1-99.8% identity with the EF607565 sequence previously reported. A total of twenty haplotypes were found, and the Korean population showed nineteen haplotypes. Among those, Hap_03 and Hap_08 showed Jeju-do and China-specific COI sequences, respectively. However, Hap_07 had twelve COI sequences from South Korea and records from Hong Kong and Taiwan. Neighbor-joining (NJ) trees constructed from the phylogenetic analyses based on the polymorphisms of the COI haplotypes showed a monophyletic branching pattern within the genus Epinephelus. This indicated that the red spotted grouper populations had evolved from common maternal ancestors. In addition, the Hap_08, which had the COI sequence recorded only from China Sea, was found in the middle of the NJ tree nearby Hap_07 and showed a close relationship with Hap_07. This indicates that Chinese red spotted grouper is also maternally related to other populations in East Asia. Consequently, East Asian red spotted grouper populations are maternally related, as well as sharing the same evolutionary history, and are still affected by the East Asian ocean current (Kuroshio). These findings help to explain the genetic structure and phylogenetic relationship of red spotted grouper and also contribute to research on artificial breeding and industrialization.

An Evaluation of Korean Accessibility Standards Supporting the People with Disabilities (실내환경에서 장애인의 접근.이동성을 지원하는 국내법규 평가)

  • 천진희;정회란
    • Archives of design research
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    • v.12 no.3
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    • pp.167-176
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    • 1999
  • This article analyzed the recent Korean accessibility standard supporting the people with disabilities. This is the basic study to make the interior environment more comprehensible and safer for the physically handicapped. Researcher selected the interior elements related to the mobility and accessibility for the physically handicapped. Then the '98 Korean accessibility standard code called 'Pyunui Chungjin Pup' were compared with the previous Korean building code and two other guidelines for evaluations. Result showed that 'Pyunui Chungjin Pup' addressed more obligatory items in facilities used by people with disabilities. That contributed to develope the accessible environments and to offer the independent activity in the society for the disabilities. However dimensions of 'Pyunui Chungjin Pup' showed the minimum standard. Also it did not provide the sufficient design considerations to make up the sufficient design considerations to make up the other types of disabilities including sensory limitations, or cognitive function limitations. Hereafter, the quality of accessibility guideline should be raised with further study.

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생쥐 정소에서 Aquaporin9의 발현

  • 강희정;계명찬
    • Proceedings of the Korean Society of Developmental Biology Conference
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    • 2003.10a
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    • pp.62-62
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    • 2003
  • Aquaporin (AQP) family protein은 일종의 수분 전달 통로 역할을 하는 단백질로 AQP를 통한 수분의 조절은 삼투압을 통한 물의 이동과 함께 조직내 정상적인 수분의 상성 유지에 필수적이다. 현재까지 11종의 AQP이 신장·뇌·정소·안구 등에서 발현이 확인되었다. AQP9은 물 뿐 아니라 carbamide, polyol, purine, pyrimidine, urea, glycerol 등의 이동에 관여한다. 본 연구에서는 생쥐에서 출생 후 성체에 이르는 동안 정소 내 AQP9의 발현, Leydig cell의 분화에 따른 AQP9의 발현을 조사하였다. 1, 2, 4, 8주령의 정소로부터 semiquantitative RT-PCR 및 real time PCR 법으로 AQP9의 발현을 분석한 결과 1주령에서는 발현되지 않았고 2주령에서는 미량이 발현되기 시작하였고, 4주령에서는 성체의 1/2수준으로 발현량이 급격히 증가하였고 성체에서는 다량으로 발현됨이 확인되었다. Semiquantitative RT-PCR 법과 real time PCR법을 비교할 때 주령별 발현 양상은 유사하였으나 4주령과 성체에서는 두 시험법 사이에 양적인 차이가 있었다. 면역조직화학염색 결과 주로 Leydig cell에서 AQP9의 발현이 확인되었다. 성체의 정소 균질액의 Western blot 상에서 분자량 80, 55, 35 및 23 kDa의 항원이 검출되어 dimer, trimer 형태로 존재할 가능성과 당쇄 결합에 의한 단백질의 변형이 있는 것으로 추정된다. 미성숙 개체의 정소에서는 23 form이 확인되는 반면 성체에서는 35 kDa form이 주로 발현되므로 정소에서 발현되는 AQP9의 경우 Post-translation 수준에서 AQP9의 변형이 수반되는 것으로 사료되며 AQP9의 기능과의 연관성은 추후 연구되어야 할 것이다. Leydig cell은 fetal 및 adult type 2종의 세포가 정소발달 과정에 출현, 사멸, 분화하며 이들은 각기 정소발달, 성숙과 정자형성에 필요한 steroidogenesis에 관여한다. 정소 내 AQP9의 발현은 17beta HSD의 발현 양상과 같게 나타나므로 성적 성숙에 따른 정소 내 AQP9의 발현의 증가는 adult type Leydig cell의 분화와 관련된 것으로 추측된다. 성체의 정소로부터 분리한 Leydig cell-enriched culture에 hCG를 처리한 결과 배양체의 AQP9의 발현이 증가하므로 AQP9은 LH 수용체 하위 신호전달과정을 통해 Leydig cell의 steroidogenesis 또는 생성된 steroids의 분비에 요구되는 수분 및 중성용질의 이동에 관여하는 것으로 사료된다.

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Estimation of AADT Using Multiple Linear Regression in Isolated Area (다중선형 회귀분석을 이용한 고립지역에서의 AADT 추정방안 연구)

  • Kim, Tae-woon;Oh, Ju-sam
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.35 no.4
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    • pp.887-896
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    • 2015
  • This study estimates future AADT using historical AADT and socio-economic factors in isolated area. Multiple linear regression method by socio-economic factors are lower MAPE and higher R-square than using historical AADT. Analysis of socio-economic factors influence AADT in isolated typical areas, varied socio-economic factors influence on AADT. In isolated coastal areas, oil price influence on AADT. AADT forecasting model in isolated area is excellent when analysising $R^2$ and MAPE. It is assume that estimation of AADT in isolated area using multiple linear regression is accurate because of a little passed traffic volume and traffic volume fluctuation.

Oceanographic Studies Related to the Tidal front in the Mid-Yellow Sea off Korea: Physical Aspects (황해 중부의 조석전선과 연관된 해양학적 연구 : 물리적 특성)

  • SEUNG, YOUNG HO;CHUNG, JUNG HO;PARK, YONG CHUL
    • 한국해양학회지
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    • v.25 no.2
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    • pp.84-95
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    • 1990
  • Observations by CTD castings, moored current meters and satellite imageries reveal some physical characteristics of the area around the tidal mixing front found in the mid-Yellow Sea off Korea. Tidal mixing is the greatest at the promontory of Taean Peninsula with a front around it. The front appears in April with the start of solar heating, becomes most clear in August and disappears in November with the start of surface cooling. In the north of the front, tidal fluctuations of temperature and salinity induced by tidal currents manifest the existence of the front, Differently from the usual tidal mixing front, the front in Kyunggi Bay is formed by presence of the water discharged from the Han River which meets the offshore water at the front. Near the surface cold center, vertically well-mixed zone extends to about 50 Km offshore from the coast, Farther south, this structure is generally retained but with lesser degree of vertical mixing. Within the relatively well-fixed coastal zone, the fresh water discharged from the Kum River makes another salinity front of smaller extent. At some places around this salinity front, an Upwelling-like feature is remarked.

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An Epidemiology Study on Temporo-mandibular Disorders of Employees Residing at Seoul (서울에 거주하는 직장인의 측두하악장애에 대한 역학적 연구)

  • Lee, Hee-Kyung
    • Journal of Yeungnam Medical Science
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    • v.13 no.2
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    • pp.308-323
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    • 1996
  • This study tried to find the prevalence and distribution of temporo-mandibulr disorders(TMD) for workers (employee) in Seoul area to investigate the correlation between TMD and possible etiological factors such as general muscle and joint symptoms, headache, unilateral chewing and parafunction. This study was an epidemiological investigation of answers obtained from 282 persons by questionaire from Aug. 1995 to Nov. 1995. The major findings from the questionaire were as follows. (1) 43.26% of the subjects(282 persons) has TMD. (41.88% of man and 43.26% of women) (2) The more often people have general muscle and joint symptoms and headache, the more susceptible they are to TMD. Their correlation was very significant(p<0.001). (3) The more people have bad oral habits such as bruxism, clenching and biting habit, the more likely they have TMD. The more sensitive people are to stress, the more frequently they have bad oral habits such as bruxism, clenching and biting habit. (4) Unilateral chewing has higher TMD index than bilateral chewing. There is no relationship between ache areas and TMD index.

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Improvement of National Risk Alarm 4-Stage Criteria for Flood Disaster (홍수재난 대응을 위한 국가위기경보 4단계 설정기준 개선)

  • Lee, Sookyong;Park, Jae-Woo;Oh, Eun-Ho
    • The Journal of the Korea Contents Association
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    • v.18 no.3
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    • pp.369-377
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    • 2018
  • EAP, which is operated on the frame of Risk Alarm 4-stage of National Risk Management Guideline, is a critical method in order to promptly respond to disasters. Korea Flood Control Office issues major and moderate flood alarm at each river station by respectively 50% and 70% of design flood discharge in terms of watermark or sea level, however, the criteria deciding major and moderate floods are vague for field managers to control the disaster situations. On the other hand, Japan and USA use river water level as a main criterion in order to classify the stage of flood disaster, which is higher design flood level than Korea. Thus, the authors analyzed domestic and oversea EAP guidelines and suggested improved criteria showing easy display method and raising the criteria of flood level for reflecting more effective action plans through testing a simulation training on the test-bed.