• The Korean Journal of Zoology
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• v.35 no.1
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• pp.87-95
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• 1992

한국의 세 섬집단으로부터 채집한 Drosophila melanogaster를 대상으로 465개의 haploid genome을 추출한 후, 제 2염색체 상에 위치한 Gpdh와 각서 유전자 및 In(2I)t의 빈도를 조사하여 이들간의 연관관계를 분석한 결과 Gpdh와 Adh 효소 좌위 사이 에 유의 한 연관 불평형 이 제주도와 울릉도집 단에서 관찰되었으며 , Gpdh와 In(2I)t, Adh와 In(21)t 사이에 모두 유의한 연관 불평형이 제주도, 영종도 그리고 울릉도집단에서 관찰되었다. 조사된 전체 genome들 중에서 In(21)t 를 가지고 있는 염색체의 98%(48/49)가 Gpdhf와 Adhs형으로 연관된 결과를 보였다. 이러한 결과들로 볼 때 이들 효소 좌위 사이에 나타난 연관 불평형은 In(21)t와의 hitchhiking현상에 의해 나타난 결과로 해석되며 본 섬집단에서 그 정도가 더 심한 것으로 확인되었다.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2009.06a
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• pp.341-341
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• 2009

초전도 케이블의 대용량 전력수송능력을 실계통에 적용하기 위해서는 정상상태 뿐 아니라 계통운용상 발생하는 비정상 상태에 대해서도 안정된 성능을 나타내야 한다. 계통운영시 가장 일반적으로 발생하는 비정상 상태의 하나인 계통불평형부하 상태에서의 초전도 케이블의 특성을 실증적으로 확인하기 위해 한전 고창전력시험센터에서 신뢰성시험을 실시하였다. 삼상 송전계통에서 각 상 도체전류는 각 상의 부하량에 의해 결정이 되므로 과도상태라 해도 상당한 시간동안 도체전류가 불평형일 경우 자기적으로 결합된 차폐층전류의 불평형상태가 발생한다. 차폐층전류는 삼상 순환회로의 중성도체가 존재하지 않는 경우 도체전류와의 차이가 발생하게 되어 자기차폐 실패의 원인이 됨으로서 AC손실 증가요인으로서 영향이 커진다. 본 논문에서는 도체전류의 불평형 상태를 실증적으로 모의 발생시켜 연관된 차폐층 순환전류의 형태 및 특성을 검토함으로서 삼상 초전도 케이블의 불평형 부하특성에 대한 연구 진행경과를 요약한다.

• Journal of Life Science
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• v.22 no.3
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• pp.366-372
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• 2012

This study was conducted to estimate the extent of linkage disequilibrium (LD) and effective population size using whole genomic single nucleotide polymorphisms (SNP) genotyped by DNA chip in Hanwoo. Using the blood samples of 35 young bulls born from 2005 to 2008 and their progenies (N=253) in a Hanwoo nucleus population collected from Hanwoo Improvement Center, 51,582 SNPs were genotyped using Bovine SNP50 chips. A total of 40,851 SNPs were used in this study after elimination of SNPs with a missing genotyping rate of over 10 percent and monomorphic SNPs (10,730 SNPs). The total autosomal genome length, measured as the sum of the longest syntenic pairs of SNPs by chromosome, was 2,541.6 Mb (Mega base pairs). The average distances of all adjacent pairs by each BTA ranged from 0.55 to 0.74 cM. Decay of LD showed an exponential trend with physical distance. The means of LD ($r^2$) among syntenic SNP pairs were 0.136 at a range of 0-0.1 Mb in physical distance and 0.06 at a range of 0.1-0.2 Mb. When these results were used for Luo's formula, about 2,000 phenotypic records were found to be required to achieve power > 0.9 to detect 5% QTL in the population of Hanwoo. As a result of estimating effective population size by generation in Hanwoo, the estimated effective population size for the current status was 84 heads and the estimate of effective population size for 50 generations of ancestors was 1,150 heads. The average decreasing rates of effective population size by generation were 9.0% at about five generations and 17.3% at the current generation. The main cause of the rapid decrease in effective population size was considered to be the intensive use of a few prominent sires since the application of artificial insemination technology in Korea. To increase and/or sustain the effective population size, the selection of various proven bulls and mating systems that consider genetic diversity are needed.

• Environmental Analysis Health and Toxicology
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• v.19 no.2
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• pp.135-140
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• 2004

고혈압에서 지질대사 이상은 빈번히 나타나는 현상으로, 지질대사 이상에 관여하는 유전자들은 고혈압의 발병원인을 규명하기 위한 후보 유전자로 인식되어 왔다. 이에 본 연구에서는 paraoxonase 2(PON2) 유전자에 존재하는 Cys311Ser다형성을 유전자 표지로 이용하여 한국인 집단에서 이 유전자 표지가 고혈압과 관련성이 있는 지를 조사하고자 하였다. 연구 대상은 총 195명으로, 이들 중에서 82명은 고혈압 환자 군이었고, 나머지 113명은 정상 혈압 군이었다. PON2 유전자의 Cys311Ser 다형성을 분석하기 위해서 중합효소 연쇄반응과 제한 효소인 Dde Ⅰ처리를 수행하여 유전자형을 결정하였다. 연구 결과, Cys/Ser이 형접합체를 갖는 사람들이 고혈압군에서 유의하게 높은 빈도로 나타났으며(P<0.05),다른 신체 계측치 및 혈청내 지질 농도와는 유의한 관련성을 나타내지 않았다. 본 연구에서 관찰된 이러한 관련성이 기능적인 연관인지 혹은 연관불평형에 의한 결과인지에 대해서는 보다 더 많은 연구 대상을 이용한 추시를 통해 밝혀질 수 있을 것으로 생각된다.

• Journal of the Korean Data and Information Science Society
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• v.28 no.3
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• pp.597-604
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• 2017

In this study, we investigated the genetic characteristics and the effective population size of domestic dairy cattle using 42,201 SNPs for 923 heads of Holstein cattle. The estimate for the average linkage disequilibrium ($r^2$) among the adjacent SNPs by chromosome was 0.22, and it was highest (0.26) in chromosome 14 and lowest (0.17) in chromosome 27. When the physical distance among SNPs was less than 25Kb, the estimate for the average $r^2$ was $0.31{\pm}0.33$ and it was markedly decreased as the physical distance increased. When the physical distance among SNPs was larger than 25Mb, the estimate for the average $r^2$ was 0.04, and it decreased by 0.27 (87.1%) compared with case of physical distance of less than 25Kb. There was a trend that the effective population size in Holstein dairy cattle decreased over generations and the estimate for the effective population size in the first 5 generations (1~5th generation) was 110 heads.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.9
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• pp.4112-4118
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• 2011

Electrical Railroads provide electric power, which can operate vehicles, via feeder wires. And the supplied current returns to the transformer substation through lines and ground net. The return current, related to signal, power and power line, and track circuit systems, is one of the most important component in the electric railway. Therefore, to prevent system faults and breakdown according to unbalance and overcurrent of the return current, various and detailed analyses for the return current are needed. In the paper, we present measurement and analysis manners in real environment and evaluate its safety. For analysis, we utilize the measured values of return currents measured in track circuits in electric railway. we expect that this research plays a key role to the related fields.

• 한국노년학
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• v.25 no.2
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• pp.73-93
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• 2005

This study explores the determinants of economic status and well-being among elderly Koreans. Particular emphasis is paid to the role of intergenerational support in these processes because institutional responses to an aging population in Korea are currently inadequate. Path model results indicate that status maintenance variables have significant effects on economic status and well-being as measured by comprehensive income. Further, inequality in comprehensive income - as measured by the Gini and Theil's indices - is substantial and increases in successive age groups. However, market-based and family-based income, two components of comprehensive income, show different patterns. Inequality in market-based income is apparently increasing, while inequality in family-based income is decreasing gradually in successive age groups. With respect to the role of intergenerational support, results indicate that family-income-focused persons possess highly vulnerable sociodemographic characteristics, and that for the socially disadvantaged elderly Koreans, intergenerational support plays a crucial role in the later stages of life. This study also discusses the implications of these findings for the transition from latency to manifestation of intergenerational support in Korea.

• Journal of Life Science
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• v.29 no.12
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• pp.1314-1320
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• 2019

This study aimed to identify single nucleotide polymorphisms in exon 8 region of the calmin (CLMN) gene and to evaluate their associations with meat yield and quality traits in Hanwoo (Korean cattle). We compared gene expression pattern of CLMN between high and low marbling score groups with extremely different intramuscular fat content of the longissimus lumborum muscles in Hanwoo. The CLMN gene was highly expressed in the high marbling score group. Total of nine SNPs were identified in the exon 8 region of CLMN gene, genotyping of the SNPs was carried out using direct-sequencing analysis in Hanwoo population (n=300) to evaluate their association with meat yield and quality traits. As a result, g.23249G>C in exon 8 was significantly associated with marbling score. Animals with the CC and GC genotypes had higher marbling score than those with the GG genotype. We constructed haplotypes of CLMN gene by linkage disequilibrium analysis and analyzed association between haplotypes and meat yield and quality traits. Haplotype of CLMN gene was associated with marbling score. As a result, animals with the CC-CC haplotype (g.23249G>C and g.23465T>C SNPs) had higher marbling score than those with CT and GT haplotypes. These findings suggest that the SNPs of bovine CLMN gene may be a useful molecular marker for selection of meat quality traits in Hanwoo.

• Journal of the Korea Convergence Society
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• v.9 no.9
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• pp.337-343
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• 2018

The study is investigated socioeconomic variations in perceived oral health status and contribution of oral health behavioral factors. A nationally representative sample (365 health and 1,787 unhealth aged 20 over years) from the 2015 Korea National Health and Nutrition Surveys was analyzed using logistic regression. Perceived oral health was lower among lower socioeconomic groups compared with higher socioeconomic groups. This association was increased when demo-socioeconomic factors and oral health behavioral were adjusted. When each oral health behavioral factor was considered separately, mediators such as smoking, frequency of tooth brushing and used oral care products or oral health examination explained a large part of the increased socioeconomic oral health status. Subjective bad oral health arise from different socioeconomic status, but this difference is increased by oral health behavioral factors. Therefore, socioeconomic inequity in perceived oral health status can be corrected more effectively by promotional oral health behaviors.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2021.10a
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• pp.161-163
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• 2021

This urban centralization is expected to develop rapidly, with 75% of the population living in the city by 2035. Large cities are becoming unsustainable due to side effects such as environmental pollution, severe traffic jams, excessive energy depletion, and destruction of the natural ecosystem. In addition, the happiness index of citizens of large cities is also falling because of high crime rates and safety accidents, the work-life imbalance caused by inequality and polarization, and overly competitive education. To solve this problem, Smart City, an IT-based future city model, was born. The Korean government is also actively attempting to improve urban competitiveness and promote sustainable development through efficient construction and operation of smart cities as a national focus project. To support the effort, we review the basic directions and strategies of Sejong City's Smart City service infrastructure based on the comprehensive national land plan, Smart City plan, and Smart City strategy plan.