• Journal of Life Science
• /
• v.17 no.10
• /
• pp.1347-1353
• /
• 2007

The changes of glycoconjuagates (GCs) in rat kidney due to maturation were studied from samples of fetal and postnatal kidneys by lectin histochemistry. Rat kidneys of perinatal ages and adults were fixed in 4% paraformaldehyde and were stained with nine kinds of biotinylated lectins. The immature forms of the renal developmental stage such as vesicles and ureteric bud were observed in the cortex as late as day 14 of postnatal life, but the histological appearance of the weaning kidney was similar to that observed in adults. As for histochemical properties of GCs in the glomeruli, Con A affinity tended to increase with aging, but both RCA-1 and LCA affinities showed a transient increase in immature glomeruli of neonatal rats. DBA affinity with SBA, PNA, BSL-1 and RCA-1, additional Con A one in proximal tubule, were increased in both proximal and distal tubules according to maturation. In contrast to this, transient intensive LCA affinity were demonstrated in immature proximal and distal tubule of neonatal rats. In the collecting tubules, DBA, SBA, PNA and sWGA affinities tended to increase according to maturation, but transient increase for BSL-1, RCA-1 and LCA affinities were detected in neonatal rats. The present results suggest that the mature glycosylation pattern of the kidney undergoes profound changes during maturation and is probably associated with functional maturation of the kidney.

• Journal of Life Science
• /
• v.20 no.7
• /
• pp.1034-1040
• /
• 2010

Plants and their extracts can be utilized as inexpensive and rich resources of active constituents in the cosmetic field, as well as the food, pharmaceutical and medicinal fields. Until now, Aster glehni Fr. Schm. had no known active effect, except on anti-oxidation, that was found during investigations for application in the cosmetic field. In this study, we examined the inhibition of enzymatic reactions to protein levels in inclusive B16F10 melanoma cell lines. Significant inhibition of enzymatic reactions was observed in the EtOAc extract, which advanced to tyrosinase protein and TRP-1 in the B16F10 melanoma cell line. These results indicated that the effect of EtOAc extract inhibited expressions of tyrosinase protein and TRP-1 in the B16F10 melanoma cell line by 30.5% and 41.5% at 100ug/ml respectively. On the other hand, antimicrobial activity was evaluated to the four fractions in normal flora of the skin. Hexane extract was only exhibited in the higher clear zone in all strains. In conclusion, any cosmeceutical effects of Aster glehni Fr. Schm. may have a potential meaning, as well as possible value for further studies regarding the effects of chemical constituents of Aster glehni Fr. Schm.

• Korean Journal of Psychosomatic Medicine
• /
• v.29 no.2
• /
• pp.86-94
• /
• 2021

Objectives : The risk of weight gain is high when using antipsychotic drugs, and the prevalence of obesity in people with mental illness is high. Obesity management in psychiatric patients is important because obesity causes various complications and lowers treatment adherence and quality of life. Methods : In this review, we summarized the management strategies for obesity that can occur when using antipsychotic drugs through a web search. Results : Evaluate obesity-related risk factors and related indicators from the beginning of treatment, and conduct regular monitoring. If an antipsychotic drug is used and obesity is induced, a change to a drug with a low metabolic risk may be attempted. Sufficient interventions are also needed on the need to manage obesity, a healthy diet, and exercises in patients and their families. If weight loss is not achieved and obesity-related complications are associated, the use of anti-obesity drugs may be considered. Pharmacological treatment approaches should be carefully considered. Conclusions : Non-pharmacological and pharmacological therapies can be applied to manage weight gain and obesity caused by the use of antipsychotic drugs. When using anti-obesity drugs, the characteristics of mental disorders, drug safety, and drug interactions should be considered.

• Journal of Life Science
• /
• v.28 no.11
• /
• pp.1379-1385
• /
• 2018

Glycans are attached to proteins as in glycoproteins and proteoglycans. They are found on the exterior surface of cells. O- and N-linked glycans are very common in eukaryotic cells but may also be found in prokaryotes. The interaction of cell surface glycans with complementary glycan binding proteins located on neighboring cells, other cell types, pathogens like virus, or bacteria is crucial in biologically and biomedically important processes like pathogen recognition, cell migration, cell-cell adhesion, development, and infection. Their implication in pathological condition, suggests an important role for glycans as disease markers. In addition, a great amount of research has been shown that appropriate glycosylation of a recombinant therapeutic protein is critical for product solubility, stability, pharmacokinetics and pharmacodynamics, bioactivity, and safety. Besides, cancer-associated glycosylation changes often involve sialic acid in glycan branch which play important roles in cell-cell interaction, recognition and immunological response. This review aims at giving a comprehensive overview of the glycan's biological function and describing the relevance among the glycosylation, disease diagnosis and treatment methods. Furthermore, the high-throughput analytic methods available to measure the profile changing patterns of glycan in the blood serum as well as possible underlying biochemical mechanisms.

• (The) Korean Journal of Educational Psychology
• /
• v.31 no.1
• /
• pp.35-58
• /
• 2017

The achievement emotion experienced by students in their academic settings is directly related with achievement activities or results. As the focuses of researches in the educational psychology have been extended to students' motives and emotion, the achievement emotion is also actively studied in Korea. The purpose of this study is to analyze researches on the achievement emotion according to social/cultural backgrounds by dividing them into domestic and foreign ones and understand flow and trend of the researches by structuring them. On the basis of the findings, it also aims to provide fundamental data necessary to examine the achievement emotion matched for academic settings in Korea. The objects of this study include a total of 105 domestic (n=47) and foreign (n=58) journal articles. The criteria of analysis are divided into period, contents and method of the study: the study was conducted without control of period; the contents include variables and achievement situations; and the method includes design and type of study, analysis methods, measurement tools and objects. The descriptive statistics of the materials were estimated by using the SPSS, and were analyzed by dividing them into domestic and foreign ones. The findings show that the researches on achievement emotion can be divided into examinations of the development of achievement emotion scale and those of the relationship between related variables. Thus, the conclusion suggests comprehensive discussions by arranging the trends of researches on the development of achievement emotion scale and the relationship between related variables.

• Journal of the Korea Convergence Society
• /
• v.12 no.8
• /
• pp.1-11
• /
• 2021

The purpose of this study was to analyze the trends and characteristics of 'stress urinary incontinence' research through word frequency analysis, and their relationships were modeled using word embedding. Abstract data of 9,868 papers containing abstracts in PubMed's MEDLINE were extracted using a Python program. Then, through frequency analysis, 10 keywords were selected according to the high frequency. The similarity of words related to keywords was analyzed by Word2Vec machine learning algorithm. The locations and distances of words were visualized using the t-SNE technique, and the groups were classified and analyzed. The number of studies related to stress urinary incontinence has increased rapidly since the 1980s. The keywords used most frequently in the abstract of the paper were 'woman', 'urethra', and 'surgery'. Through Word2Vec modeling, words such as 'female', 'urge', and 'symptom' were among the words that showed the highest relevance to the keywords in the study on stress urinary incontinence. In addition, through the t-SNE technique, keywords and related words could be classified into three groups focusing on symptoms, anatomical characteristics, and surgical interventions of stress urinary incontinence. This study is the first to examine trends in stress urinary incontinence-related studies using the keyword frequency analysis and word embedding of the abstract. The results of this study can be used as a basis for future researchers to select the subject and direction of the research field related to stress urinary incontinence.

• The Journal of the Convergence on Culture Technology
• /
• v.7 no.4
• /
• pp.613-621
• /
• 2021

This study conducted a network analysis to determine how COVID-19 vaccine-related issue spread on Twitter during the introduction stage of the COVID-19. Issue diffusion tendency is analyzed according to the time period: phase 1 (initiation of vaccine introduction: March 7 - April 3, 2021), phase 2 (stagnant period of vaccination: April 4 - April 22, 2021), and phase 3 (increase of vaccination: April 23 - May 5, 2021). NodeXL was used for data collection and analysis. Daily Twitter network data were collected by entering search terms highly related to the COVID-19 vaccine. This study found that side effects-related opinions were repeatedly formed throughout the analysis period. As the vaccination rate increased and death cases were reported on media, death-related issues also emerged on Twitter. On the other hand, vaccine safety did not receive much attention on Twitter. The results of this study highlight the role of social media as a channel of issue diffusion when a national disaster strikes. We emphasize the need for the government to monitor public opinions on social media and reflect them in crisis communication strategies.

• The Journal of the Korea Contents Association
• /
• v.22 no.4
• /
• pp.222-230
• /
• 2022

Recently, Korea's cultural content industry is developing, and behind the growing recognition around the world is the real-time sharing service of global network users due to the development of science and technology. In particular, in the case of YouTube, its propagation power is fast and powerful in that everyone, not limited users, can become potential video providers. As more than 80% of mobile phone users are using YouTube in Korea, YouTube's information means that psychological factors of users are reflected. For example, information such as the number of video views, likes, and comments of a channel with a specific personality shows a measure of the channel's personality interest. This is highly related to the fact that information such as the frequency of keyword search on portal sites is closely related to the stock market economically and psychologically. Therefore, in this study, YouTube information from a representative entertainment company is collected through a crawling algorithm and analyzed for the causal relationship with major variables related to stock prices. This study is considered meaningful in that it conducted research by combining cultural content, IT, and financial fields in accordance with the era of the fourth industry.

• Journal of the Korea Institute of Building Construction
• /
• v.22 no.3
• /
• pp.281-291
• /
• 2022

This study attempts to use big data to determine the indicators necessary for a fire risk assessment of buildings. Because most of the causes affecting the fire risk of buildings are fixed as indicators considering only the building itself, previously only limited and subjective assessment has been performed. Therefore, if various internal and external indicators can be considered using big data, effective measures can be taken to reduce the fire risk of buildings. To collect the data necessary to determine indicators, a query language was first selected, and professional literature was collected in the form of unstructured data using a web crawling technique. To collect the words in the literature, pre-processing was performed such as user dictionary registration, duplicate literature, and stopwords. Then, through a review of previous research, words were classified into four components, and representative keywords related to risk were selected from each component. Risk-related indicators were collected through analysis of related words of representative keywords. By examining the indicators according to their selection criteria, 20 indicators could be determined. This research methodology indicates the applicability of big data analysis for establishing measures to reduce fire risk in buildings, and the determined risk indicators can be used as reference materials for assessment.

• Journal of Korean Library and Information Science Society
• /
• v.53 no.2
• /
• pp.165-188
• /
• 2022

The purpose of this research is to document the current state of 'One Book, One City' community reading campaign (Hereafter called 'One Book' reading campaign), launched in 2003 in Korea, and the characteristics of the selected books. For this research, the homepages, news and reports of a total of 1,170 public libraries and their local government, and several major institutions and organizations related to reading and culture were analyzed with the research method of content analysis and literature review. Also, online catalogs of the National Library of Korea and the National Library for Children and Young Adults were examined to identify the characteristics of 729 titles and 1,179 volumes of books selected in 57 'One Book' programs, as of 2021. The analysis of 57 'One Book' programs and those selected books shows the selection of more than one books in different age groups in more and more 'One Book' programs, lack of consistency in themes of those selected books, and preference for young adult books, new publications and bestselling novels. This trend has weakened individual 'One Book' programs' concentration on one book or one subject, but helped invite a diverse group of people with various interests. More in-depth analysis and explanation of the process of book selection and its appropriateness with the stated goals of 'One Book' programs are needed.