• Korean Journal of Medicinal Crop Science
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• v.21 no.5
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• pp.323-328
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• 2013

Traditionally, Ligustrum lucidum fruits (LL) is one of the well-known oriental herb used in the treatment of skin and lung inflammation. This study investigated anti-inflammatory effects of LL in the pathogenesis of acute pulmonary inflammation in mice. Acute pulmonary inflammation was induced by intratracheal instillation of cigarette smoke condensate (CSC) and lipopolysaccharide (LPS) 5 times within 12 days in mice. LL extract was administered orally at a dose of 50 or 200 mg/kg. Administration of LPS and CSC significantly elevated airway hyperresponsiveness (AHR) to mice, and increased in the levels of inflammatory cells and mediators in mice. However, the LL extract significantly reduced the elevated AHR, and the increase of neutrophils, $CD4^+/CD3^+$ cells and $CD8^+/CD3^+$ cells, along with reducing the expression of TNF-${\alpha}$, IL-6, and MIP-2. Moreover, the LL extract alleviated the infiltration of inflammatory cells in expanded airway walls histologically. These results indicate that the LL extract has an inhibitory effects on acute pulmonary inflammation and AHR in murine model, and plays a crucial role as a immunomodulator which possess anti-inflammatory property.

• Proceedings of the Korea Information Processing Society Conference
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• 2018.10a
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• pp.544-546
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• 2018

하나의 애플리케이션은 기업의 업무를 분석하여 어떻게 만들지 설계를 하고, 설계를 바탕으로 설계의 내용을 그대로 개발로 구현하게 된다. 설계의 내용을 그대로 개발로 반영하기 위해 소스코드에 대한 설계도 이루어져야 한다. 다양한 방법에 대해 연구되어 왔지만, 경험기반의 설계가 반영되어 설계자 및 개발자 간에 의사소통의 오류가 발생하고, 미경험자가 설계절차를 수행하기에는 어려움이 존재한다. 이를 해결하기 위해 본 연구에서는 분석된 업무를 바탕으로 정의된 화면설계를 바탕으로 클래스로 변환되는 절차를 제안하여 초심자가 효율적으로 설계절차를 수행할 수 있을것이며, 개발자 간에 원활한 의사소통이 이루어질 것이라 기대한다.

• The Journal of the Korea Contents Association
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• v.14 no.9
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• pp.76-84
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• 2014

Despite the fact that culture and the industrial market is growing rapidly and becoming competitive, Disney animation studio has kept its reputation. They have their own know-how accumulated for a long time to stimulate the audience's sensibilities beyond time and space. This study is looking for the strategy of Disney animation using effects and forms of Hero's narrative. As a result, the original works have been adapted by 3 spaces of hero's narrative and songs was prepared according to the journey. Characters was constructed by combining original and it made an antithetical Antagonist and the triangle of helpmates. These strategies satisfy contemporary needs, as well as Disney's ideology using transformational resilience. Research will be needed to utilize the elements of culture through the analysis of the common strategy for success in spite of the time change.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.2
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• pp.83-96
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• 2007

Purpose: Ligustri Lucidi Fructus and Ecliptae Herba has long been used for clinical therapy associated especially with menopausal symptoms in Korea. To provide a scientific rationale for such use, we have investigated the antioxidant and vasorelaxant effects of Ligustri Lucidi Fructus, Ecliptae Herba and its mixture. Methods: The antioxidant activity of the extracts from Ligustri Lucidi Fructus, Ecliptae Herba and its mixture were evaluated and compared with that of BHA (butylated hydroxyanisole), BHT (butylated hydroxytoluene), vitamin C and vitamin E, using the ${\alpha}$,${\alpha}-diphenyl-{\beta}-picrylhydrazyl$ (DPPH) radical scavenging method. Results: Antioxidant activity of all extracts using the DPPH radical scavenging method decreased in the order vitamin C>BHA>vitamin E>Ligustri Lucidi Fructus>Ligustri Lucidi Fructus:Ecliptae Herba(1:1)>Ecliptae Herba>BHT. The vasorelaxant effects of extracts were investigated on the vasomotor tone of the rat thoracic aorta in an organ bath. All of the extracts elicited along-term relaxing response in the endothelium-intact as well as endothelium-denuded rat aorta contracted with norepinephrine. This relaxant effect was abolished by Precontraction with 72 mM KCI. Thus, it is suggested that the mechanism of vasorelaxant effect of extracts not involve voltage-operated $Ca^{2+}$ channel blocking but receptor-mediated route. Conclusion: These antioxidant and vasorelaxant effecs of the extracts may contribute to the beneficial effects in postmenopausal women.

• Journal of Haehwa Medicine
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• v.25 no.1
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• pp.133-144
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• 2016

Objectives : This study was aimed to investigate the effect of ACLL extract (Artemisia capillaris Thunb, Curcuma longa L, Lycium chinense, Ligustrum lucidum Aiton complex extract) in a dyslipidemia animal model induced by a high-fat diet. Methods : ACLL extracts was administered at 200 mg/kg, and 400 mg/kg to Apoe mice, where arthritis was induced by high cholesterol diet. After mice were treated with GO for 4 weeks, we measured AST, ALT, BUN and lipid levels (total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride), atherogenic index(AI) and cardiac risk factor(CRF). Results : Serum AST, ALT, creatinine, BUN levels were not changed by ACLL extract do not show any toxic effects. Also, ACLL extract groups were found to have atherogenic Index and cardiac risk factor as well as lipid metabolism improvement (total cholesterol, LDL cholesterol and triglyceride decrease). Conclusions : We suggest that ACLL extract may have the control effects of Dyslipidemia by improving lipid metabolism.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.4
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• pp.674-680
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• 2010

The purpose of this study was to investigate the effects of Fructus Ligustri Lucidi (FLL) on the process of melanogenesis. Cell viability of B16F10 cells was measured by MTT assay and melanin content was assessed using the method of Hosoi with some modifications. Methanol extract of Fructus Ligustri Lucidi (MFLL) significantly inhibited melanin synthesis in a concentration-dependent manner, and it reduced the activity of tyrosinase, the rate-limiting melanogenic enzyme. Additionally, $\alpha$-melanocyte stimulation hormone ($\alpha$-MSH)-induced hyperpigmentation was down-regulated by MFLL. MFLL was fractionated by organic solvent. In the present study, Hexane extract of Fructus Ligustri Lucidi (HFLL) inhibited tyrosinase activity and melanin production of B16F10 cells in the absence or presence of $\alpha$-MSH. Ethyl acetate, butanol and water layers did not affect tyrosinase activity and melanin production. Meanwhile ethyl acetate, butanol and water layers showed DPPH free radical scavenging activity. These results suggest that extract of FLL could be used as functional biomaterial in developing a skin whitening agent having the antioxidant activity.

• The Journal of the Korea Contents Association
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• v.19 no.8
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• pp.370-388
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• 2019

From 2010, new keyword of so-called devising theatre in the Korean performing arts scene has emerged. The backdrop is the antipathy to the hierarchical creative environment, the search for a language that can reflect increasingly complex societies, and the influx of new performances from abroad. Of course, devising theatre can be realized in a wide variety of forms in the actual field, so it cannot be defined as one methodology. But commonly all these various forms of the attempts aim to create a democratic relationship among participants, and process-centered breakthrough in the hierarchy of creative materials such as texts, sounds. light and human body. In 2017, Creative VaQi seeks to find new keyword called 'Reality of Division in Korean Peninsula' and to develop it into performance languages experimenting inter-disciplinary devising methodology. The company conducted a walking trip alongside the division line(300km) and tried to achieve the landscape and traces of division. After the walking, they created a specific form and performing contents called "Walking Holiday" out of their experiences. In this thesis, I will analyze the whole process of the devising "Walking Holiday" and examine what kind of result it led to. Furthermore, I, as the director of "Walking Holiday" will continue to discuss new possibilities and limitations of devising theatre methods that the company tries and aim at this time.

• Journal of the korean veterinary medical association
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• v.46 no.1
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• pp.73-90
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• 2010

지난 10월 4일부터 9일까지 6일간의 여정으로 필자는 충남도 관련 부서 직원들과 같이 일본 오끼나와현 축산연구센터외 4개소를 방문할 기회가 있었는 데, 오끼나와현의 축산기술수준 및 연구인력의 상호 교류방안 등을 파악하여 국립축산과학원과 충남도 축산기술연구소 등과의 중앙-지방연계를 통한 협력방안 모색함과 아울러 현의 축산기술 및 가축위생 연구동향 파악 후, 국내 축산농가의 생산성 향상에 활용과 축산 동향, 가축질병발생현황 파악 및 연구정보의 상호교류촉진을 도모하고자 다녀왔다. 따라서 필자는 일본 오끼나와현의 축산현황, 연구기관 및 연구과제 등을 소개하여 수의 및 축산관련자들에게 정보를 제공하면서, 축산과 수의분야가 상호공조체제를 구축하여 연구과제 및 업무를 수행하고 있는 것을 보고 우리 국내도 빠른 기간내에 이루어졌으면 하는 바램을 피력해본다.

• Women's Health Nursing
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• v.16 no.3
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• pp.215-223
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• 2010

Purpose: This study was intended to explore the essential structure and the meanings of childbirth experiences among Korean women participated in Lamaze childbirth education. Methods: Giorgi's phenomenological method was used to analyze data collected by in-depth interviews with six primiparous women from March to July 2009. Results: Five components identified in the meanings of experience: 'Simplicity', 'Self-control', 'Uncontrollable pain', 'Spiritual maturity', 'Physiologic event'. Conclusion: The study results revealed that the childbirth experience was positive generally, partially influenced by Lamaze childbirth education. But, meanings of childbirth experience with Lamaze childbirth education were mostly physiological respect related to labor pain or one's own efforts to endure labor pain. Therefore, nursing strategies for drawing emotional and socio-environmental experiences from childbirth experience with Lamaze childbirth education is needed.

• Information and Communications Magazine
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• v.34 no.6
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• pp.58-64
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• 2017

공공안전을 위한 ICT 시스템에 있어서 응급 상황의 전력 지원은 매우 중요한 문제이다. 특히 전력 인프라가 취약한 산악 지역 등 야외 환경에서 발생하는 안전 사고의 빈도를 고려하면, 공공 안전을 목적으로 하는 ICT 응용 기술은 비상시의 전력 공급을 반드시 염두에 두고 개발되어야 할 필요가 있다. 본 고에서는 효과적인 에너지 변환 방법에 기반한 양질의 전력 생성과 더불어, 휴대성과 사용 편의성을 극대화하기 위한 착용 형태의 동적 에너지 수확기를 제안하였다. 개발된 착용형 에너지 수확기의 프로토타입은 최대 3W, 평균 0.3W 수준의 양질의 출력이 가능하며, 무엇보다 사용자가 모바일 기기를 사용하는 데 불편함을 주지 않으면서 동시에 전기에너지 생성이 가능함을 입증하였다. 향후 연구를 통해 공공 안전의 여러 이슈에 대응 가능한 응급 상황 지원 기술로 개발할 예정이다.