• Restorative Dentistry and Endodontics
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• v.28 no.6
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• pp.475-484
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• 2003

동통조절을 위해 국소마취제는 치과임상에서 광범위하게 사용되어진다. 가장 널리 쓰이는 국소마취제는 리도카인이고 이는 마취효과의 지속 및 지혈효과 등의 목적으로 혈관수축제를 포함하고 있다. 대표적 혈관수축제인 에피네프린은 임상에서 1:300,000에서부터 1:50,000의 농도로 다양하게 사용되어진다. 수복치료를 위해서는 통상적으로 1:100.000농도의 에피네프린이 사용되고 있고 외과적 근관치료시 지혈효과를 위해서는 1:50,000농도의 에피네프린이 추천되고 있다. 이들 농도의 에피네프린을 포함한 리도카인으로 국소마취시 에피네프린의 농도가 치수의 혈류 및 치은의 혈류에 미치는 영향을 이해할 필요가 있고 그 영향이 전기치수검사에 대한 치수의 반응성에 미치는 영향도 이해할 필요가 있다. 따라서 혈관수축제를 포함한 국소마취제에 의한 치수혈류의 변화와 치수신경의 반응성을 이해하는 것은 중요하다 하겠다. 본 연구의 목적은 두 가지 농도의 에피네프린을 포함한 국소마취제로 마취시 나타나는 치수 및 치은의 혈류 변화를 치수신경의 반응성과 비교, 관찰함으로써 국소마취제가 치수 및 치은에 미치는 영향을 파악하고자 함에 있다. 24세에서 27세까지의 10명의 피검자의 건전한 상악중절치를 시험에 이용하였다. Laser Doppler flowmeter의 probe을 고정하기 위한 splint를 간접법으로 인상용 putty를 이용하여 제작하고 치수 및 치은의 혈류량, 그리고 전기치수검사에 대한 반응성을 측정하기 위한 3개의 구멍을 만들었다. 피검자를 10분간 안정시킨 후 마취 전 10분간 정상 혈류량과 전기검사치를 측정하고 1:50,000 epinephrine과 1:100,00 epinephrine이 각각 함유된 2% 리도카인 용액 0.9 ml를 상악 좌측 중절치 치근단부위 협점막에 침윤마취하였다. 마취 후 70분간 치수 및 치은 혈류량을 laser Doppler flowmeter를 이용해 연속적으로 측정하여 그 수치를 컴퓨터에 저장하였고, 매 5분 간격으로 전기치수검사를 시행하여 그 측정치를 기록하였다. 매 시간 간격의 평균 혈류량을 정상 혈류량에 대한 백분율로 나타내고, 각각의 농도에서 최소 치수 및 치은 혈류량을 Paired t-test, Wilcoxon's signed rank test. Duncan's multiple range test. Fisher's exact test등을 이용. 통계분석 하여 다음과 같은 결과를 얻었다. 에피네프린이 함유되어 있지 않은 리도카인을 협점막에 주사시 혈류변화가 거의 나타나지 않았으나 1:50,000 및 1:100.000 에피네프린이 함유된 2% 리도카인을 협점막에 침윤마취시 치수 및 치은 혈류 공히 현저히 감소하였다(p<0.01). 1:50,000 에피네프린군은 1:100,000 에피네프린군에 비해 치수 혈류량이 현저히 억제되어 나타났으나(p<0.01), 치은 혈류량에서는 유의성 있는 차이를 나타내지 않았다(p>0.05). 두 농도의 에피네프린 군 공히 치은혈류는 치수혈류에 비해 유의하게 많은 감소를 나타내었다(p<0.05). 1:100,000 에피네프린 군에서 마취액 주입 후 치수혈류 최대감소가 가장 먼저 나타났고 이어서 전기검사에 대한 치수의 반응성 소실 및 치은혈류 최대 감소의 순으로 나타났다(p<0.05). 1:50,000 에피네프린군의 경우가 1:100,000 에피네프린군의 경우에 비해 마취지속시간이 길게 나타났으나 유의성은 없었다(p>0.05).

• Proceedings of the KIEE Conference
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• 2004.07c
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• pp.2140-2142
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• 2004

본 논문은 전기화학 합성으로 형성한 폴리피롤(polypyrrole : PPy) 전극에 신경 전달물질(neurotransmitter)인 에피네프린(epinephrine : Ep)을 치환도핑하여 전압인가에 따른 방출과 자외선 분광법에 의한 검출 결과를 보인다. 폴리피롤 막은 정전압법으로 금 전극에 합성하였고, potassium phosphate buffer(pH 7.0) 내에서 에피네프린을 폴리피롤 막에 치환도핑하였다. 폴리피롤 막에 10mM Ep 농도로 치환도핑한 후 염화나트륨 수용액에서 -0.9V의 환원전압을 인가하여 에피네프린을 방출하였다. 자외선 분광법을 이용하여 파장 250$^{\sim}$400nm 영역에서 방출된 에피네프린 용액의 최대흡광도가 약 0.021 임을 확인하였고 이는 에피네프린 표준용액의 정량선으로부터 16${\mu}$g 이 방출되었음을 의미한다.

• Korean Journal of Psychosomatic Medicine
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• v.16 no.1
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• pp.47-51
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• 2008

Objectives : The aim of this study was to investigate the relationship between the norepinephrine(NET) transporter T-182C polymorphism and anxiety-related traits in Korean adolescent females. Methods : One hundred sixty-nine Korean adolescent females were tested for the NET T-182C polymorphism by PCR based methods; anxiety-related traits were evaluated using the anxiety sensitivity index(ASI) and the trait form of the Spielberg State-Trait Anxiety inventory(STAI-T). Results : Scores of anxiety related traits were not different between genotypes. Comparison between T allele carries and non carriers revealed no significant difference. Conclusion : These findings suggest that the NET T-182C polymorphism is not associated with anxiety-related traits in Korean female adolescents.

• Anxiety and mood
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• v.2 no.1
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• pp.3-8
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• 2006

Anxiety has been suggested to be related to many neurotransmitters in brain, such as norepinephrine, serotonin, dopamine, cholecystokinin, and gamma-amino butyric acid. There are many studies to examine the relationship between anxiety and norepinephrine, and norepinephrine seems to be clearly related to the development of anxiety. We suggest that future studies to explore the pathophysiology of anxiety should be necessary, which include studies on antianxiety drugs, genetic studies, animal model studies, and brain imaging studies.

• Journal of Food Hygiene and Safety
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• v.15 no.3
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• pp.199-203
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• 2000

With a rabbit model, the present study was performed to examine the effect of Escherichia coli lipopolysaccharide (E. coli LPS) on hormones. Cortisol, epinephrine, and norepinephrine concentrations in LPS-treated groups were high at all sampling periods (from 3 hrs to 72 hrs) as compared to control group (p<0.05 or p<0.01). The each peak time was at respectively 24 hrs, 3 hrs, and 12 hrs. Insulin and glucagon concentrations in LPS-treated groups elevated up to 12 hrs (p<0.01 or p<0.05) with a each peak point at 12 hrs or 6 ks, while those of the rest sampling points (from 24 hrs to 72 hrs) were lower than that of control (p<0.05). Increase of cortisol concentration was generally dose-dependent, whereas the changes of the other hormones were irregular patterns. These observations show that E. coli LPS lead to releases of stress hormones such as cortisol, epinephrine, and norepinephrine and disturbances of endocrine systems. These LPS-induced hormonal disorders may cause physiologically fatal results.

• The Korean Journal of Zoology
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• v.38 no.4
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• pp.498-504
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• 1995

The effeds of riboflavin defidency on the biosynthesis of flavin pepddes and levels of flavoenzymes and catecholamines have been investigated. The percentage of 14C. riboflavin radioactivity formed in mitochondria appeared to increase up to 2 weeks but started to decline at 3 weeks. A significant increase of radioactivity incorporation into mitochondria and into trypsin-digestable plus trypsin-non-digestibie flavin peptides was detected in riboflavin-deficient animals. More than 35% of incorporation was observed at the end of the first week and 160% higher incorporation was observed in fiavin peptide after the second week. Activities of MAO and succinate dehydrogenase were affected markedly by riboflavin status whereas those of acetyichoilnesterase were not affected. Riboflavin defidency also brought about marked reductions in levels of epineplrrine and norepinephrine. it is concluded that the levels of flavin peptides, MAO and succinate dehydrogenase, and catecholamines were affected significanily by the availability of riboflavin and in particular the duration of its depiction.

• The Journal of the Korean dental association
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• v.31 no.11 s.294
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• pp.847-853
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• 1993

• The Journal of the Korea Contents Association
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• v.12 no.3
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• pp.214-221
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• 2012

In recent years, some researchers reported that myofascia was innervated by the autonomic nervous system. However, there is no neurophysiological explanation and evidence for the effects of myofascial release(MFR). Thus, the aim of this study was to determine whether the excitability of the autonomic nervous system is modulated by MFR. In this study, thirty healthy subjects in their 20s were randomly assigned to a myofascial release group(MG) and a placebo control group(PCG); each group had 15 subjects. The MG conducted 5 minutes of cranial base release in supine position, and the PCG performed sham cranial base release. Muscle flexibility was measured with the neck range of motion and the changes of the autonomic nervous system excitability was measured by heart rate, blood pressure, and concentration of plasma epinephrine and norepinephrine. The results were as follows: 1. The percentage changes in the cervical range of motion for extension and side flexion were significantly increased in the MG, signifying that more muscle relaxation. 2. There was no significant percentage changes in heart rate, blood pressure, and concentration plasma epinephrine between MG and PCG. 3. The percentage change in concentration plasma norepinephrine was significantly different between MG and PCG. The result of this study suggests that there is no evidence that MFR can modulate the autonomic nervous system excitability.

• Restorative Dentistry and Endodontics
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• v.31 no.4
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• pp.257-262
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• 2006

The aims of the study were to evaluate the effect of epinephrine-containing local anesthetics on pulpal blood flow (PBF) and to investigate its effect on cavity preparation-induced PBF change. PBF was recorded using a laser Doppler flowmeter (Perimed Co., Sweden) from canines of nine cats under general anesthesia before and after injection of local anesthetics and after cavity preparation. 2% lidocaine hydrochloride with 1 : 100,000 epinephrine was administered by local infiltration given apical to the mandibular canine at the vestibular area and the same volume of isotonic saline was injected on the contralateral tooth as a control. A round carbide bur was operated at slow speed with isotonic saline flushing to grind spherical cavities with increasing depth through the enamel and into the dentin on both teeth. The obtained data was analyzed with paired t-test. Cavity preparation caused significant increase of PBF (n = 9, p < 0.05). Local infiltration of lidocaine with epinephrine resulted in decreases of PBF (n = 9, p < 0.05), whereas there was no significant change of PBF with the physiologic saline as a control. Cavity preparation on tooth anesthetized with lidocaine with epinephrine caused significantly less increase of PBF than in control tooth (p < 0.05). Therefore, the result of the present study demonstrates that local infiltration of 2% lidocaine with 1 : 100,000 epinephrine effectively reduces PBF increase caused by cavity preparation.

• The Journal of the Korea Contents Association
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• v.15 no.1
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• pp.350-356
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• 2015

The purpose of this study is effect factors of Pre-Hospital Medication in the Patients with Bee-Sting. This study is to identify the necessity of using epinephrine in prehospital stage from the perspective of early management of anaphylaxis following a bee sting. Methods: Patients suffering from a bee sting who used the 119 rescue between 2013 from 119 center data were included. Age, sex, month of injury, time factors, vital signs, medication, signs, distance factors, presence of cardiac arrest, AVPU triage by EMT were extracted. The severity of bee sting injury was divided into mild, moderate, and severe according to the presenting symptoms and signs. Results: The severe patients treated by using oxygen, IV, ECG, Medication. Anaphylaxis is a serious allergic reaction of rapid onset that may lead to death. One of Anaphylaxis patients lived by using epinephrine. Most patients collapsed at the scene of mount. Bee sting injuries occurred primarily during summer to the farmer. Nine patients collapsed at the scene. Bee sting injuries occurred primarily from June to October. Conclusion: The primary treatment for anaphylaxis is epinephrine. Epinephrine in pre-hospital stage is factors of essential for patients. Also epinephrine will permit to be equipped in the EMT-P and use of epinephrine by law.