• The Journal of Korean Society for Radiation Therapy
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• v.22 no.1
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• pp.47-51
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• 2010

Purpose: In the treatment of high-energy protons Air gap (the distance between the patient and the exit Beam) Lateral Penumbra of the changes to the increase in the radiation fields can form unnecessary and Increase the maximum dose at the site of treatment and reduced the minimum dose homogeneity of dose distributions can decline. Air gap due to this change in dose distribution compared to investigate studied. Materials and Methods: Received proton therapy at our institution Lung, Liver patients were selected and the size of six other Air gap in Field A and Field B 2, 4, 6, 8, 10 cm Proton external beam planning system by setting up a treatment plan established. Air gap according to the Lateral Penumbra area and DVH (Dose Volume Histogram) to compare the maximum dose and minimum dose of PCTV areas were compared. In addition, the dose homogeneity within PCTV Homogeneity index to know the value and compared. Results: Air gap (2, 4, 6, 8, 10 cm) at each change in field size were analyzed according to the Lateral Penumbra region Field A Change in the Air gap 2~10 cm by 1.36~1.75 cm, the average continuously increased about 28.7% and Field B Change in the Air gap 2~10 cm by 1.36~1.75 cm, the average continuously increased about 31.6%. The result of DVH analysis for relative dose of the maximum dose According to Air gap 2~10 cm is the mean average of 110.3% from 108.1% to a sustained increased by approximately 2.03% and The average relative dose of minimum dose is the mean average of 93.9% percent to 90.8 percent from the continuous decrease of about 3.31 percent. The result of Homogeneity index value to the according to Air gap 2~10 cm is the 2-fold increase from 1.09 to 2.6. Conclusion: In proton therapy case, we can see the increasing of lateral penumbra area when airgap getting increase. And increasing of Dmax and decreasing Dmin in the field are making increase homogeneity index, So we can realize there are not so good homogeneity in the PCTV. Therefore we should try to minimize air gap in proton therapy case.

• The Journal of Korean Society for Radiation Therapy
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• v.30 no.1_2
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• pp.191-199
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• 2018

Purpose : In this study, we evaluated the usefulness of colloid gel(slime) as a compensator for irregular patient surfaces in radiation therapy. Materials and Methods : For this study, colloid gel suitable for treatment was made and four experiments were conducted to evaluate the applicability of radiation therapy. Trilogy(Varian) and CT(SOMATOM, Siemens) were used as treatment equipment and CT equipment. First, the homogeneity according to the composition of colloid gel was measured using EBT3 Film(RIT). Second, the Hounsfield Unit(HU) value of colloid gel was measured and confirmed by CRIS phantom, Eclipse RTP(Eclipse 13.1, Varian) and CT. Third, to measure the deformation and degeneration of colloid gel during the treatment period, it was measured 3 times daily for 2 weeks using an ion chamber(PTW-30013, PTW). The fourth experiment was compared the treatment plan and measured dose distributions using bolus, rice, colloid gel and additional, dose profiles in an environment similar to actual treatment using our own acrylic phantom. Result : First experiment, density of the colloid gel cases 1, 2 and 3 was $1.02g/cm^3$, $0.99g/cm^3$ and $0.96g/cm^3$. When the homogeneity was measured at 6 MV and 9 MeV, case 1 was more homogeneous than the other cases, as 1.55 and 1.98. In the second experiment, the HU values of case 1, 2, 3 were 15 and when the treatment plan was compared with the measured doses, the difference was within 1 % at all 9, 12 MeV and a difference of -1.53 % and -1.56 % within the whole 2 % at 6 MV. In the third experiment, the dose change of colloid gel was measured to be about 1 % for 2 weeks. In the fourth experiment, the dose difference between the treatment plan and EBT3 film was similar for both colloid gel and bolus, rice at 6 MV. But colloid gel showed less dose difference than bolus and rice at 9 MeV. Also, dose profile of colloid gel showed a more uniform dose distribution than the bolus and rice. Conclusion : In this study, the density of colloid gel prepared for radiation therapy was $1.02g/cm^3$ similar to the density of water, and alteration or deformation was not observed during the radiotherapy process. Although we pay attention to the density when manufacturing colloid gel, it is sufficient in that it can deliver the dose uniformly through the compensation of the patient's body surface more than the bolus and rice, and can be manufactured at low cost. Further studies and studies for clinical applications are expected to be applicable to radiation therapy.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.08a
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• pp.315-315
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• 2010

양성자 빔을 이용하여 두경부 암 치료를 South Africa의 iTHEMBA에서 시행하고 있다. 200 MeV의 양성자 빔라인으로부터 진공에서 대기로 인출하여 노즐을 통과하여 종양세포에 조사된다. 치료계획에 적합하게 빔에너지와 모양을 변환하고, 빔을 모니터링하는 기계적 장치들이 노즐에 구성된다. 빔라인에는 이온챔버, Steering Magnet, Multi-wire 이온챔버, Range trimmer plates, lead scattering plate, Double-wedge energy degrader, Multi-layer Faraday cup, Range modulator, Range monitor, occluding ring, Shielding collimators, Quadrant and monitor ionization chamber, Treatment collimator, 그리고 Wellhofer dosimetry tank로 구성되어 있다. 총길이는 6.6m이며 노즐 끝에서 환자의 isocenter 까지는 30cm 정도 아래에 위치한다. 상기의 배치를 갖는 시스템의 양성자 scattering system의 성능을 MCNPX v2.5.0 Monte Carlo simulation을 실시하였다. 또한 정확한 선량을 실시간으로 측정하는 방법인 투과형 검출기를 개발하여 치료와 빔 특성을 동시에 수행하는 기술개발연구가 보고되고 있다. 본 연구에서는 Multileaf Faraday Cup (MLPC) 검출기 설계구조와 데이터 측정방법에 관한 연구를 수행하고자 한다. 빔의 전송 방향으로 3개층의 $4{\times}4$ 배열의 구조로 48 channel의 전류값을 측정하여 입자빔의 분포를 실시간으로 관측하고, 측정된 전류는 ADC를 거쳐 치료계획에 의해 선택된 영역의 SOBP를 유지하도록 range modulation propeller를 조절하는 feed-back system을 갖춘 방사선치료빔 실시간 측정장치 개발에 관한 결과를 보고하고자 한다.

• Journal of the Korean Society of Radiology
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• v.18 no.1
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• pp.1-9
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• 2024

Proton therapy is known for its superior treatment method due to Bragg peak. To enhance the therapeutic effects of protons, research has been conducted on distributing gold nanoparticles within tumors to increase the absorbed dose. While previous studies focused on handling gold nanoparticles at micrometer and nonometer scale, this study proposes a method to computationally estimate the effect of gold nanoparticles at the millimeter scale. The Geant4 toolkit was applied to computational modeling. Assuming a uniform distribution of water, similar to the human body, and gold nanoparticles, the concentration of gold nanoparticles was adjusted using density ratios. When the density ratio was 5%, the gain in absorbed energy due to gold nanoparticles was nearly twice that of the pure water phantom at the Bragg peak. As the density ratio increased, the gain in absorbed energy linearly increased. When gold nanoparticles were distributed in only one voxel at the Bragg peak, the energy of the protons affected only the neighboring voxels. However, in cases where gold nanoparticles were distributed over a wide area, the volume showing 95% of the maximum absorbed energy (9.46 keV) for the pure water phantom (9.95 keV) exhibited an improvement in absorbed energy over a region 16 times larger, and this region increased as the density ratio increased. Further research is needed to quantify the relationship between the density ratio of gold nanoparticles and the relative biological effect (RBE) in the millimeter scale.

• Journal of the Korean Vacuum Society
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• v.13 no.1
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• pp.1-8
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• 2004

The SOI wafer fabrication technique has been developed by using ion-cut process, based on proton implantation and wafer bonding techniques. It has been shown by TRIM simulation that 65 keV proton implantation is required for the standard SOI wafer (200 nm SOI, 400 nm BOX) fabrication. In order to investigate the optimum proton dose and primary annealing condition for wafer splitting, the surface morphologic change has been observed such as blistering and flaking. As a result, effective dose is found to be in the 6∼$9\times10^{16}$ $H^{+}/\textrm{cm}^2$ range, and the annealing at $550^{\circ}C$ for 30 minutes is expected to be optimum for wafer splitting. The depth distribution of implanted hydrogen has been experimentally confirmed by ERD and SIMS measurements. The microstructure evolution in the damaged layer was also studied by X-TEM analysis.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.02a
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• pp.493-494
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• 2011

수 MeV~수십 MeV 양성자빔을 이용해 백금, 은 등의 나노입자 제조실험을 수행하였다. 나노 입자는 의료분야와 산업 분야에서 그 응용성이 다양해 여러 지 방법을 이용한 제조기술이 개발되고 있다. 전자빔, 감마선, 양성자빔 등의 방사선을 이용한 나노입자 제조방법은 가장 널리 이용되고 있는 화학적 제조방법에 비해 비교적 공정이 단순하다는 장점을 가지고 있지만 공정 변수의 제어방법이 확립되어 있지 않아 이에 대한 연구가 필요한 실정이다. 특히, 양성자빔의 경우 에너지에 따른 투과깊이의 조절과 플럭스나 총 선량, LET (Linear Energy Transfer) 등의 변수와 제조된 나노입자의 상관관계 등에 대한 연구가 선행되어야 한다. 본 논문에서는 백금산 용액을 이용한 나노입자 제조 결과와 대면적 양성자빔을 이용하기 위한 초음파 이용 나노입자제조장치의 제작 및 실험결과에 대해 논하고 향후 건설될 100MeV 선형 양성자가속장치의 나노입자 제조실험에의 응용을 위한 이용시설을 소개하고자 한다. 나노입자 제조실험은 한국원자력의학원의 MC-50 싸이클로트론을 이용하여 수행하였으며, 가속기로부터 인출되는 에너지는 35, 45MeV, 빔전류는 수십 nA~수${\mu}A$의 범위 내에서 조절하였다. 제조된 나노입자는 TEM을 이용하여 그 크기와 분포를 관찰하였다. 대면적의 양성자빔을 이용하는 경우, 수mm의 두께와 수십 cm의 직경을 가지는 원반 모양의 시료용기를 사용하여 양성자빔의 에너지와 선량을 정확히 조절할 수 있게 되는데 이 때 용기 내 시료와 양성자빔간의 균일한 반응을 위해 용액을 적절하게 섞어 주어야만 한다. 이러한 목적으로 초음파를 이용하여 나노입자 제조장치를 제작하여 실험을 수행하였다. 나노입자 제조는 현재 교과부의 지원으로 경주 건천지역에 건설되고 있는 100MeV 선형양성자가속기의 주요 이용 분야 중의 하나로 20MeV 빔라인 중 한 개의 빔라인과 표적실을 나노입자 제조 등의 실험을 위한 시설로 구축 중이다. 최대 평균전류 1.6mA 까지 가능하고 펄스폭은 0.05~1.33 msec까지 조절가능하도록 개발되고 있다.

• Journal of radiological science and technology
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• v.36 no.1
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• pp.31-38
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• 2013

The prostate cancer is the most common malignant tumor in males. Prostate cancer is the most common malignant tumor that occurs in the male in Korea in 2007 to an annual average of 5,292 cases and 3.3% of the total cancer incidence seventh occurred. Our study compared property for tomotherapy and proton therapy in radiotherapy of prostate cancer patients. We analyzed DVH(Dose Volume Histogram) and dose distribution for prostate, bladder and rectum for radiation treatment planning of prostate cancer with 11 patients in Ilsan K cancer hospital from June to November 2011. There was no differences between tomotherapy and proton therapy in the purpose of prostate cancer therapy for PTV. The adjacent organs of bladder and rectum of average dose-volume were 2port proton therapy that it was low dose treatment comparing with tomotherapy and 5port proton therapy. $H{\cdot}I$ of proton therapy was less than $H{\cdot}I$ of tomotherapy. Also, 5port was less than 2port in $H{\cdot}I$ of proton therapy. However, 2port proton therapy has more advantage over 5port proton therapy that the bladder and rectum of average dose-volume and control time of equipment in radiotherapy of prostate cancer.

• Progress in Medical Physics
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• v.2 no.2
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• pp.129-139
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• 1991

The method of etching tracks in PN-3 dosimeter has been applied to tracks of recoil protons from a neutron source. Both the etch and the detection response of PN-3 has been studied as a function of etched-track diameters against various parameters. We could obtain very useful informations about charge, energy, and mass of particles and the relationship between the track etching rate and the track forming procedure in order to analyze the particle recorded in the solid state track detector. The best etching condition could be found by means of changing the etching circumstances for various energies and particles in order to detect the charged particle accurately. It could be influenced widely that the polymer plastic detector could develep the detecting technique for the low energy level neutron and could be used as a neutron dosimeter in the radiation field such as the nuclear power station, the medical institute and the nondtructive testing institute.

• The Journal of Korean Society for Radiation Therapy
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• v.28 no.1
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• pp.35-46
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• 2016

Purpose : BoS(Base of Skull) Frame, the fixation tool which is used for the proton of brain cancer increases the lateral penumbra by increasing the airgap (the distance between patient and beam jet), due to the collision of the beam of the posterior oblique direction. Thus, we manufactured the fixation tool per se for improving the limits of BoS frame, and we'd like to evaluate the utility of the manufactured fixation tool throughout this study. Materials and Methods : We've selected the 3 patients of brain cancer who have received the proton therapy from our hospital, and also selected the 6 beam angles; for this, we've selected the beam angle of the posterior oblique direction. We' ve measured the planned BoS frame and the distance of Snout for each beam which are planned for the treatment of the patient using the BoS frame. After this, we've proceeded with the set-up that is above the location which was recommended by the manufacturer of the BoS frame, at the same beam angle of the same patient, by using our in-house Bos frame fixation tool. The set-up was above 21 cm toward the superior direction, compared to the situation when the BoS frame was only used with the basic couch. After that, we've stacked the snout to the BoS frame as much as possible, and measured the distance of snout. We've also measured the airgap, based on the gap of that snout distance; and we've proceeded the normalization based on each dose (100% of each dose), after that, we've conducted the comparative analysis of lateral penumbra. Moreover, we've established the treatment plan according to the changed airgap which has been transformed to the Raystation 5.0 proton therapy planning system, and we've conducted the comparative analysis of DVH(Dose Volume Histogram). Results : When comparing the result before using the in-house Bos frame fixation tool which was manufactured for each beam angle with the result after using the fixation tool, we could figure out that airgap than when not used in accordance with the use of the in-house Bos frame fixation tool was reduced by 5.4 cm ~ 15.4 cm, respectively angle. The reduced snout distance means the airgap. Lateral Penumbra could reduce left, right, 0.1 cm ~ 0.4 cm by an angle in accordance with decreasing the airgap while using each beam angle in-house Bos frame fixation tool. Due to the reduced lateral penumbra, Lt.eyeball, Lt.lens, Lt. hippocampus, Lt. cochlea, Rt. eyeball, Rt. lens, Rt. cochlea, Rt. hippocampus, stem that can be seen that the dose is decreased by 0 CGE ~ 4.4 CGE. Conclusion : It was possible to reduced the airgap by using our in-house Bos frame fixation tool for the proton therapy; as a result, it was possible to figure out that the lateral penumbra reduced. Moreover, it was also possible to check through the comparative analysis of the treatment plan that when we reduce the lateral penumbra, the reduction of the unnecessary irradiation for the normal tissues. Therefore, Using the posterior oblique the Brain cancer proton therapy should be preceded by decreasing the airgap, by using our in-house Bos frame fixation tool; also, the continuous efforts for reducing the airgap as much as possible for the proton therapy of other area will be necessary as well.

• Journal of the Korean Society of Radiology
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• v.15 no.4
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• pp.401-408
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• 2021

Proton therapy using the Bragg peak is one of the radiation therapies and can deliver its maximum energy to the tumor with giving least energy for normal tissue. A cross-sectional image of the human body taken with the computed tomography (CT) has been used for radiation therapy planning. The HU values change according to the tube voltage, which lead to the change in the boundary and thickness of the anatomical structure on the CT image. This study examined the changes in the Bragg peak of the brain region according to the thickness variation in the head phantom composed of several materials using the Geant4. In the phantom composed of a single material, the Bragg peak according to the type of media and the incident energy of the proton beams were calculated, and the reliability of Geant4 code was verified by the Bragg peak. The variation of the peak in the brain region was examined when each thickness of the head phantom was changed. When the thickness of the soft tissue was changed, there was no change in the peak position, and for the skin the change in the peak was small. The change of the peak position was mainly changed when the bone thickness. In particular, when the bone was changed only or the bone was changed together with other tissues, the amount of change in the peak position was the same. It is considered that measurement of the accurate bone thickness in CT images is one of the key factors in depth-dose distribution of the radiation therapy planning.