• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.1 no.1
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• pp.77-88
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• 1990

Management of the child with Attention-Deficit Hyperativity Disorder(ADHD) reguires a comprehensive approach of cognitive-behavioral, educational, and pharmacological interventions. Establishing the valid diagnosis is the first step of management. After the diagnosis is made, the clinician must then interpret the diagnosis and its impliations to the child, parents, and teachers. The pharmacotherapy is most effeceive, and the CNS stimulants (methylphenidate) is drug of choice. Although generally not as effective as stimulants, triacyclic antidepressants, clonidine, antipsychotics offer the alternatives to stimulants therapy. Additional treatments, including psychotherapy, cogntive-behavioral approach, educational infervention, parental counseling are also essential in managing the child with ADHD. Finally, controversial approaches-diet therapy, mineral therapy, hypoglycemia, megavitamin therapy, refined sugars, neurophysiological retraining approaches are reviewed.

• Journal of Dental Rehabilitation and Applied Science
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• v.35 no.4
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• pp.199-205
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• 2019

Management of migraine, one of common primary headache disorders, involves the diverse strategies non-pharmacological treatment, such as headache diary, lifestyle modification, regular exercise and relaxation, cognitive behavioral therapy and neurostimulation, and pharmacological treatment. Among the treatments, this review described a pharmacologic treatment of migraine, classified into acute and preventive treatment based on the severity and the frequency of headache. It introduced the way to optimize pharmacological treatment and updated the latest treatment for migraine.

• Journal of Dental Rehabilitation and Applied Science
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• v.27 no.3
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• pp.327-336
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• 2011

Reported causes of mandibular nerve injury in relation to neuropathic pain in dentistry include extraction, dental implant surgery, oral and maxillofacial surgery, periodontal treatment, and root-canal therapy. This study analyzed the characteristics of pharmacologic management of neuropathy after root-canal therapy. 32 patients who complain of abnormal sensation or pain after root-canal therapy and were referred to Department of Oral Medicine and the Temporomandibular Joint and Orofacial Pain Clinic at the Dental Hospital of Yonsei University, Seoul, Korea from 2004 to 2011 enrolled in this analysis and improvement of symptom was evaluated after pharmacologic management. Thirty-two patients who had hypoesthesia or dysesthesia at the initial visit were analyzed(9 men, 23 women; mean age: 44 years). The causes of neuropathy were local anesthesia(46.9%), chemical trauma from the sealant in root-canal(25%), endodontic surgery(15.6%), and unknown causes(12.5%). Medications such as steroids, anticonvulsants, antidepressants, and analgesics were took for improvement of symptoms and titrated for a variety of period from 1 week to 11 months. It was found that neuropathy of the inferior alveolar nerve and the lingual nerve was in 25 and 7 patients. The improvement of neurosensory disturbance and no improvement after pharmacotherapy was in 21(66%) and 11(34%) patients respectively. The hypoesthesia and dysesthesia was improved 67% and 65% respectively. These results suggest that symptomatic improvement by pharmacologic management can be possible in patients with neuropathy after root-canal therapy. But improvement of symptoms was influenced by the causes and degree of nerve injury, the periods of pharmacotherapy, and the choice of treatment methods. So, further investigation is needed by quantitative measurement of more variables in more individuals.

• Journal of the Korean Society of Radiology
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• v.11 no.5
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• pp.353-359
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• 2017

The sonophoresis, a representative low-intensity ultrasonic therapy, is a technique for delivering the drugs into the epidermis, dermis and skin appendages by using physical vibration and heat effects of the ultrasonic waves. Sonophoresis could increases the delivering and absorption efficiency of the drugs usually consisting of hydrophilic molecules and macromolecules. In addition, it has the advantage of being effective in delivering drugs with relatively large molecular sizes such as insulin or lipid. In this study, we proposed a multi-structure ultrasonic transducer assembly with a large-size single piezoelectric element and a drug delivery function at the treatment site for efficient sonophoresis treatment. Futhermore, a transducer assembly structure capable of raising and maintaining the temperature of the treatment site was proposed and evaluated for effectiveness. The transducer assembly proposed in this study is expected to improve the efficiency of sonophoresis by providing a constant amount of drug, and assisting drug delivery through heating the treatment site.

• Korean Journal of Psychosomatic Medicine
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• v.15 no.1
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• pp.29-34
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• 2007

Pain is subjective and greatly influenced by prior experiences, but it is real. Pain associated with an organic(objective) pathology is more easily explained and treated. However, atypical or unexplainable pain is usually a source of greater confusion and frustration. Pain may be divided into four general diagnostic categories. 1) pain with anatomic features and objective findings 2) pain with anatomic features and without objective findings 3) pain with non-anatomic features associated with stress and somatization 4) pain with non-anatomic features associated with perceived physical injury. There is a well-established relationship between emotional, physical and/or sexual abuse history and development of chronic pain. It has been suggested that the link between somatization and abuse involves a paradoxical pattern of hiding feelings and reality, while seeking acknowledgment of suffering. History of abuse may physiologically and developmentally increase a person's susceptability to pain and organic changes can be associated with psychogenic disease. Patients with chronic pain should be treated with multidisciplinary approaches including exercise, meditation, cognitive therapy, medications, and biofeedback. Cognitive therapy alters patient's cognition and management of pain and alleviates pain, especially associated with stress. Antidepressants are the most commonly used medications and pain control effects have no relation with mood changes. Biofeedback with relaxation training, exercise and meditation may also be effective in pain control.

• 보건세계
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• v.56 no.1
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• pp.46-49
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• 2009

결핵은 다른 종류의 질환과 달리 완치까지 여러 가지 약제들을 동시에, 6개월 이상 장기간 복용해야 한다. 그러므로 약물치료의 표준요법을 정하고 이에 따라 결핵약을 복용하게 함으로써 잘못된 치료 처방으로 인한 치료실패를 예방하고 있다. 그런데 일부 결핵환자들은 간질환, 신장질환, 에이즈와 같은 질환을 동반하거나 임산과 같은 특수 상황에 직면할 수 있는데, 이 경우 통상적인 방법으로 결핵을 치료했을 때 심각한 부작용, 치료효과의 감소, 태아에 대한 기형유발 등을 초래할 수 있다. 이와 같은 특수 상황에서의 결핵치료 방법과 유의사항에 대해서 알아보도록 한다.

• 보건세계
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• v.56 no.2
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• pp.22-25
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• 2009

결핵은 다른 종류의 질환과 달리 완치까지 여러 가지 약재들을 동시에, 6개월 이상 장기간 복용해야 한다. 그러므로 약물치료의 표준요법을 정하고 이에 따라 결핵약을 복용하게 함으로써 잘못된 치료 처방으로 인한 치료실패를 예방하고 있다. 그런데 일부 결핵환자들은 간질환, 신장질환, 에이즈와 같은 질환을 동반하거나 임신과 같은 특수 상황에 직면할 수 있는데, 이 경우 통상적인 방법으로 결핵을 치료했을 때 심각한 부작용, 치료효과의 감소, 태아에 대한 기형유발 등을 초래할 수 있다. 이와 같은 특수 상황에서의 결핵치료 방법과 유의사항에 대해서 알아보도록 한다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.1 no.1
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• pp.89-93
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• 1990

60 Attention-deficit hyperactive patients treated with stimulant drugs such as methylphenidate and pemoline were evaluated in regards to the therapeutic benefit and side effects of these drugs. The results were as follows : 1) Of the 60 subjects 34 showed considerable imporvement and only 8 showed little or no improvement. 2) Hyperactivity, inattention and impulsivity were improved markedly by stimulants These behavioral changes were accompanied by improved performance in classroom. 3) School age children tended to show more improvement than preschool children or adolescence. 4) Of the 60 subjects 25 showed no side effect and only 6 showed severe side effects, and common side effects were decreased appetite, insomnia and irritability or nervousness. It is the author's impression that despite of the therapeutic efficacy of these drugs when they were administered on a short-term basis, long-term outcome dose not seem to be altered by the administration of these agents.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.129-129
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• 1993

현재 암의 치료에 이용되고 있는 항암제들은 therapeutic index가 낮아서 면역 및 조혈기능 장애 등 해결 되어야 할 문제점 들을 안고 있다. 이에 본 여구자는 우수하고 안전한 항암제를 개발하여 암의 치료에 이바지하고자, 화학연구소에서 in vitro 세로독성을 확인한 화합물에 대하여 in vivo 항암력을 실험, 치료효과가 높은 유도체/유사체 개발에 필요한 정보를 제공함에 본 연구의 목표를 두고 있다. 1차년도 연구에서는 화학연구소측이 제공한 KS 0409를 실험 약물로, sarcoma 180 복수암에 대한 in vivo 항암력을 실험하였다. 약 4주령의 SPE(specific pathogen-free) ICR계 마우스 및 BALB/c 마우스를 실험동물로 하여 sarcoma 180 암세포 부유액(세포 농도, 1$\times$$10^{7}$ cells/ml)을 실험동물의 복강내에 0.1ml 씩 이식하고 암이식 24시간 후부터 매일 1회씩 9회 약물 주사를 시행하였다. 대조약물 cisplatin은 2% DMSO-생리식염수를 주사하였다. 생존일수 관찰은 60dlfRK지 하였으며 % T/C를 계산하여 항암력을 평가하였다. 단 60일 생존 동물은 평균수명 계산에서 제외하였다.

• Sleep Medicine and Psychophysiology
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• v.23 no.2
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• pp.77-83
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• 2016

Objectives: The present study investigated current practices of insomnia treatment among Korean doctors in clinical settings. Methods: A total of 100 doctors participated in the present study and filled out a series of survey questions regarding their treatment of insomnia patients. Results: The results revealed that the primary type of insomnia treatment was pharmacological and that the most popular medication was zolpidem. The majority of doctors reported that they also utilized non-pharmacological treatments such as sleep hygiene education and cognitive-behavioral therapy. However, these treatments tended to result in low satisfaction. In addition, the doctors perceived that patients largely preferred pharmacological treatments to non-pharmacological ones and did not have sufficient knowledge of non-pharmacological treatments. Conclusion: Many doctors believed that non-pharmacological treatments for insomnia were important, but reported that they were difficult to implement in practice. The results of this study suggest that improved medical conditions for non-pharmacological treatments and education of physicians are necessary to appropriately treat insomnia.