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http://dx.doi.org/10.7742/jksr.2017.11.5.353

A Study on Development of Composite Ultrasonic Transducer Assembly with Drug Transfer Function  

Noh, Si-Cheol (Department of Radiological Science, International University of Korea)
Kim, Ju-Young (School of Biomedical Engineering, Inje University)
Yoo, Byeong-Cheol (IPS research center, Waseda University)
Jung, Bong-Jae (Department of Radiological Science, International University of Korea)
Publication Information
Journal of the Korean Society of Radiology / v.11, no.5, 2017 , pp. 353-359 More about this Journal
Abstract
The sonophoresis, a representative low-intensity ultrasonic therapy, is a technique for delivering the drugs into the epidermis, dermis and skin appendages by using physical vibration and heat effects of the ultrasonic waves. Sonophoresis could increases the delivering and absorption efficiency of the drugs usually consisting of hydrophilic molecules and macromolecules. In addition, it has the advantage of being effective in delivering drugs with relatively large molecular sizes such as insulin or lipid. In this study, we proposed a multi-structure ultrasonic transducer assembly with a large-size single piezoelectric element and a drug delivery function at the treatment site for efficient sonophoresis treatment. Futhermore, a transducer assembly structure capable of raising and maintaining the temperature of the treatment site was proposed and evaluated for effectiveness. The transducer assembly proposed in this study is expected to improve the efficiency of sonophoresis by providing a constant amount of drug, and assisting drug delivery through heating the treatment site.
Keywords
Sonophoresis; Therapeutic ultrasound; transducer assembly; Drug transfer;
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