• Applied Biological Chemistry
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• v.40 no.2
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• pp.152-156
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• 1997

Platycodon root contains abundant pharmaceutical substances and is widely used as a food and a medicinal herb. The three-year-old and the 24-year-old Platycodon roots cultivated in a local farm were analysed and compared with their pharmaceutical substances to identify the major components. Reverse column HPLC analysis of ethanol extracts from the 24-year-old roots showed some distintive peaks after the retention time of 50 min which were absent in the extracts from the three-year-old roots. This indicates that several pharmaceutical substances are present in the older roots. There were no differences in sterol composition and saponin content between the 24-year and three-year-old roots. The 15-year-old and the 23-year-old Platycodon roots, the 6-year-old Ginseng root, and the three-year-old Condonopsis root all did not show significant anticomplement activity.

• The Science & Technology
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• v.32 no.8 s.363
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• pp.28-29
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• 1999

한림대 의대 약리학교실 서홍원교수는 마약성분이 없고 부작용도 적은 강력한 진통제 개발에 땀을 흘리고 있다. 신경약리 및 신경과학 분야가 주 전공인 서교수는 마약과 같은 성분으로 우리 몸 안에서 통증을 없애주는 엔도르핀의 진통작용과 엔도르핀을 생성시키는 Opioid peptide유전자 발현 조절기전에 대한 연구를 발표하여 학계의 관심을 모으고 있다. 마약성 성분을 보유하고 있지 않은 강력한 진통제의 탄생을 기대한다.

• Applied Biological Chemistry
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• v.40 no.2
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• pp.148-151
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• 1997

Platycodon root contains abundant pharmaceutical substances and is widely used as a food and a medicinal herb. To identify the major components of the three-year-old and the 24-year-old platycodon roots cultivated in a local farm were analyzed and compared with their chemical compositions prior to their pharmaceutical substances, which were used as the fundamental data. There were no differences in chemical composition, inorganic compositions and fatty acid compositions between the 24-year-old and three-year-old roots. Total amino acid contents were 375.8 mg% and 891.6 mg% in the 24-year-old and three-year-old platycodcon roots, respectively. Sixteen species of amino acid were identified by amino acid autolyzer except cysteine both in the 24-year-old and three-year-old roots. Linoleic acid, which was the highest fatty acid contained both in the 24-year-old and three-year-old roots, was estimated to be 48.7% and 39.1% of total fatty acids, respectively.

• Korean Deer Journal
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• v.7 no.10 s.48
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• pp.60-64
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• 2002

알려진 녹용의 효능을 과학적으로 증명하고 활성성분을 이용하여 신의약품 개발에 기여하고자 한다. 본 연구실에서는 녹용의 가장 대표적인 효능인 조혈작용을 하는 성분을 구조 분석하여 MADG임을 밝히었다. MADG는 조혈촉진기능뿐만 아니라 대식세포 증식기능 그리고 비장세포성장을 촉진하는 등 면역활성 조절제로써의 기능도 나타내었다. 그리고 녹용에 존재하는 인지질 중에서 포화지방산을 가지고 있는 phophatidylcholine도 면역활성을 촉진시키었다. 항진균작용을 하는 성분을 구조 분석한 결과 lysophophatidylcholine임을 밝히었으며 그 유도체인 CHJ-ester가 숙주세포에는 해를 주지 않으면서 항진균작용을 하는 것을 관찰하였다. 그리고 골다공증치료효과를 검색하기 위해 녹용 정제성분으로 연구한 결과 파골세포로의 분화를 100$\%$ 저해함을 밝히므로 녹용이 골다공증 치료효과가 있음을 증면하였다. 녹용성분의 유도체인 SCOH가 파골세포분화를 억제함을 밝혀 현재 골다공증치료제로써의 가능성을 조사하고 있다. 본 연구실에서는 1999년부터 녹용연구를 시작하여 현재까지 10여 개의 활성성분을 분석한 바 있다. 현재 조혈세포촉진작용, 면역증진작용, 골다공증치료작용, 대식세포 증식작용, 항진균작용, 항간질작용에 대한 성분 분석 및 그 약리 기전을 연구하고 있다.

• Journal of the Korea Society of Computer and Information
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• v.28 no.10
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• pp.113-121
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• 2023

Network pharmacology in traditional Korean and Chinese medicine studies the molecular and biological aspects of herbal medicine using computational methods. Despite variations in databases, techniques, and criteria, most studies follow similar steps: constructing herb-compound networks, compound-target networks, and target interpretation. To ensure efficient and consistent analysis in herbal medicine network pharmacology, we designed and implemented a common analysis pipeline. We showed its reliability with existing databases. The proposed system has a potential to facilitate network pharmacology analysis in traditional medicine, ensuring consistent analysis of various herbal medicines.

• KSBB Journal
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• v.18 no.2
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• pp.100-106
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• 2003

An on-line frontal analysis HPLC system was developed to determine the unbound concentration of (S)-perillyl alcohol, an potential anti-cancer agent, in human serum albumin (HSA) solution, The analysis was performed on a Develosil 100 Diol 5 (10 cm x 4.6 mm I.D.) high-performance frontal analysis (HPFA) column. Sodium phosphate solution was used as the mobile phase (pH 7.4, ionic strength 0.17) at a flow rate of 1 $m\ell$/min. UV wavelength was set at 205 nm. A injection volume of 600${mu}ell$ was chosen to ensure the compound eluted formed a zonal peak with a plateau. By Scatchard analysis, it was found that the binding constant(K) and binding number(n) of (S)-perillyl alcohol to molecular HSA were 2.05 x $10^6$ [$M{-1}$], 0.00428, respectively.

• Korean Journal of Medicinal Crop Science
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• v.9 no.3
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• pp.220-224
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• 2001

To obtain the basic information for commercial process and high quality production of Saururus chinensis, the yield and the contents of available component were determined at different compost application amounts and cultural methods. Fresh weight of aerial part was increased by increasing of the compost application amounts. The contents of quercetin, quercitrin and tannin were the highest in the compost 2,000kg/10a. Fresh weight of aerial part at different cutting times was no difference between one harvesting/year and two harvesting/year in S. chinensis. On occasion of two harvesting/year, the contents of component was more collected on July 16 than collected on October 16. Fresh weight of aerial part was less in the field than in the greenhouse culture method, but the contents of quercetin, quercitrin and tannin were more in the field than in the greenhouse culture method.

• Korean Journal of Medicinal Crop Science
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• v.16 no.1
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• pp.57-61
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• 2008

This experiment was carried out to search for changes of growth and pharmacological component contents by cultivation years in Artemisia capillaris. Percentage of ovenwintering in 1-year old was high as 95.3% but that in 2-years old was very low as 64.2%. Plant height was the highest in 2-years old among the treatments. By the way, number of stems and branches were shown wide difference by cultivation years, so those were the best in 3-years old. It was thought that 3-years old plants dispersed and used their nutrients by increasing branches. Fresh weight was the highest as 200.0 g in 3-years old, whereas weight of capitulum included scoparone, effective component, was the highest as 109.6 g in 2-years old and low as 96.4 g in 3-years old. In general components, crude protein and ash were more included in 1-year old and crude lipid and fiber were more included in 2 and 3-years old. Especially, content of crude fiber in stem was the highest in 3-years old. Pharmacological components were the most existed in capitulum of 2-years old, so contents of scoparone and capillarisin were 6.5 mg/g DW, 1.65 mg/g DW, respectively.

• Korean Deer Journal
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• v.8 no.1 s.49
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• pp.80-84
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• 2003

• Korean Deer Journal
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• v.8 no.2 s.50
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• pp.102-106
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• 2003