• 대한두경부종양학회:학술대회논문집
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• 1991.11a
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• pp.24.2-26
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• 1991

• 대한두경부종양학회:학술대회논문집
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• 1999.12a
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• pp.274.1-274.1
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• 1999

• Journal of Korea Multimedia Society
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• v.13 no.5
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• pp.702-709
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• 2010

The performance of mass segmentation is greatly influenced by an initial position of a mass. Some researchers performed mass segmentation with the initial position of a mass given by radiologists. The purpose of our research is to find the initial position for mass segmentation and to notify the segmented mass to radiologists without any additional information on mammograms. The proposed system consists of breast segmentation by region growing and opening operations, decision of an initial seed with characteristics of masses, and mass segmentation by a level set segmentation. A seed for mass segmentation is set based on mass scoring measure calculated by block-based variances and masked information in a sub-sampled mammogram. We used a DDSM database to evaluate the system. The accuracy of mass detection is 78% sensitivity at 4 FP/image, and it reached 92% if multiple views for masses were considered.

• Proceedings of the Korean Information Science Society Conference
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• 1999.10b
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• pp.212-214
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• 1999

방사성 동위원소를 체내에 주입한 후 감마 카메라로 방출되는 방사선을 획득하여 전기적 신호로 바꾸어 영상을 구성하고 그 획득 영상을 사용하여 유방암을 진단하는 유방 신티그라피가 최근 유방암 진단에 각광을 받고 있는 영상진단 방법이다. 그러나, 일반 감마 카메라는 주로 전신 영상 획득을 얻기 위한 것으로써 커다란 검출기를 사용한다. 이는 유방암 진단용 영상 획득에는 불필요할 뿐만 아니라 비용도 많이 드는 단점이 있다. 본 논문에서는 이러한 기존의 일반 카메라가 유방암 진단 부분에서 가지는 단점을 보완하고자 보다 정확한 유방암 진단 영상을 획득할 수 있고 저가인 PC용 소형 감마 카메라 시스템을 개발하는데 있어 필요한 신호 획득 과정과 영상 완성 과정을 설명하고 획득영상에 대한 가시적 진단을 돕기 위한 영상 표현 응용 프로그램의 확장기능들을 정의하고 구현한다.

• Proceedings of the Korean Information Science Society Conference
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• 2006.10a
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• pp.1-5
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• 2006

본 논문에서는 유방암의 조기발견에 있어서 중요한 소견중 하나인 군집화된 미세석회질을 유방촬영 영상으로부터 자동으로 분석 및 검출하는 컴퓨터 보조 검출 시스템을 구현하였다. 전처리단계로서 유방영상에 메디안 필터를 사용하여 잡음을 제거하고, 히스토그램과 레이블링 연산을 수행하여 실제 유방영역만을 추출 하는 작업을 구현하였다. 그런 후에 추출된 실제 유방영역에서 LoG (Laplacian of Gaussian)연산을 수행하고 히스토그램을 분석하여 이진화를 수행한후에 후보점을 검출하였다. 마지막으로 이를 이용하여 영역확장 알고리즘을 수행하여 미세석회질의 후보영역을 검출한 후, 미세석회질간의 거리를 분석하여 최종 관심영역을 추출하였다. 데이터베이스는 총 20개의 MIAS Mini Database의 맘모그램 영상을 사용하였으며 실험결과 89%라는 검출 성능을 얻을 수 있었다.

• Journal of Korea Multimedia Society
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• v.8 no.4
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• pp.482-491
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• 2005

In this paper, we proposed the microcalcification detection algorithm which is based on wavelet transform and automatic thresholding method in the X-ray mammographic images. Digital X-ray imaging system is essential equipment in the field diagnosis and is widely used in the various fields such as chest, fracture of a bone, and dental correction. Especially, digital X-ray mammographic imaging is known as the most important method to diagnose the breast cancer, many researches to develop the imaging system are processing in country. In this paper, we proposed a microcalcifications detection algorithm necessary in the early phase of breast cancer diagnosis and showed that a algorithm could effectively detect microcalfication and could aid diagnosis-radiologist.

• Journal of radiological science and technology
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• v.32 no.1
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• pp.45-52
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• 2009

Digital Mammography is an efficient imaging technique for the detection and diagnosis of breast pathological disorders. Six mammographic criteria such as number of cluster, number, size, extent and morphologic shape of microcalcification, and presence of mass, were reviewed and correlation with pathologic diagnosis were evaluated. It is very important to find breast cancer early when treatment can reduce deaths from breast cancer and breast incision. In screening breast cancer, mammography is typically used to view the internal organization. Clusterig microcalcifications on mammography represent an important feature of breast mass, especially that of intraductal carcinoma. Because microcalcification has high correlation with breast cancer, a cluster of a microcalcification can be very helpful for the clinical doctor to predict breast cancer. For this study, three steps of quantitative evaluation are proposed : DoG filter, adaptive thresholding, Expectation maximization. Through the proposed algorithm, each cluster in the distribution of microcalcification was able to measure the number calcification and length of cluster also can be used to automatically diagnose breast cancer as indicators of the primary diagnosis.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.1
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• pp.16-28
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• 2023

Lung adenocarcinoma accounts for about 40% of all lung cancers. With the recent development of gene profiling technology, studies on mutations in oncogenes and tumor suppressor genes, which are important for the development and growth of tumors, have been actively conducted. Companion diagnosis using next-generation sequencing helps improve survival with targeted therapy. In this study, formalin-fixed paraffin-embedded tissues of non-small cell lung cancer patients were subjected to hematoxylin and eosin staining for detecting genetic mutations that induce lung adenocarcinoma in Koreans. Immunohistochemical staining was also performed to accurately classify lung adenocarcinoma tissues. Based on the results, next-generation sequencing was applied to analyze the types and patterns of genetic mutations, and the association with smoking was established as the most representative cause of lung cancer. Results of next-generation sequencing analysis confirmed the single nucleotide variations, copy number variations, and gene rearrangements. In order to validate the reliability of next-generation sequencing, we additionally performed the existing genetic testing methods (polymerase chain reaction-epidermal growth factor receptor, immunohistochemistry-anaplastic lymphoma kinase (D5F3), and fluorescence in situ hybridiation-receptor tyrosine kinase 1 tests) to confirm the concordance rates with the next-generation sequencing test results. This study demonstrates that next-generation sequencing of lung adenocarcinoma patients simultaneously identifies mutation.

• Journal of Biomedical Engineering Research
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• v.25 no.5
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• pp.335-342
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• 2004

This paper describes a trans-admittance scanner for breast cancer detection. A FPGA-based sinusoidal waveform generator produces a constant voltage. The voltage is applied between a hand-held electrode and a scan probe placed on the breast. The scan probe contains an 8x8 array of electrodes that are kept at the ground potential. Multi-channel precision digital ammeters using the phase-sensitive demodulation technique were developed to measure the exit current from each electrode in the array. Different regions of the breast are scanned by moving the probe on the breast. We could get trans-admittance images of resistor and saline phantoms with an anomaly inside. The images provided the information on the depth and location of the anomaly. In future studies, we need to improve the accuracy through a better calibration method. We plan to test the scanner's ability to detect a cancer lesion inside the human breast.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.45 no.1
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• pp.47-54
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• 2008

In this paper, we propose an auto-detection algorithm of basal cell carcinoma(BCC) from the protophorphyrin IX(PpIX) fluorescence image induced by appling the methyl 5-aminolaevulinate(MAL) ointment-induced protophorphyrin IX(PpIX) to the skin tumour area and then shining the wood lamp on the area. The proposed algorithm first generates 3 mask areas-tumor area, suspected tumor area and tumor free area and then applies local watershed algorithm to the turner and the suspected tumor areas to make small watershed regions that include similar luminance value pixels. Next, small watershed regions are merged by hierarchical queue based fast region merging that uses the difference between the average luminance values of adjacent watershed regions as a region merging criterion and finally BCC regions are detected. 50 tissue samples are acquired from the tumour regions of 10 patients with BCC that are extracted by using the proposed algorithm and are performed pathological examination by expert dermatologist. Experiment result shows the rate of tumor detection from BCC lesion using presurgical in vivo of MAL-indeuced PpIX fluorescence has high sensitivity 94.1% and relatively high specificity 82.6%.