• Title/Summary/Keyword: 암종 분류

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The Correlation Between RMR and Deformation Modulus by Rock masses using Pressuremeter (공내재하시험을 이용한 암종별 변형계수와 RMR의 상관성)

  • Ahn, Taebong
    • Journal of the Korean GEO-environmental Society
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    • v.12 no.1
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    • pp.5-12
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    • 2011
  • In this study, correlation between measured deformation modulus using pressuremeter and RMR value conducted in 10 sites is analyzed, and applicability of the conventional empirical formulas to the rock masses in Korea are analyzed, It is found that if RMR is below 40, the correlation between deformation modulus and RMR accords Kim Gyo-won's formula and Aydan, Serafim and Pereira's one well, but if the RMR exceeds 40, the correlation was lower than those from the formula. Such results may be attribute to the fact that during classification of RMR, scores are weighed relatively more in joint conditions and apertures than such highly correlational items as uniaxial compression strength or RQD, and RMR would not be evaluated qualitatively due to different weathering degrees and rock mass types as well as engineers' personal errors. Sandstone among sedimentary rocks are quite well accord with suggested equation, but correlation of other rocks are due to large variance. In this study, correlation expressions of various rocks are proposed as the function of exponential based on the field test data.

Epithelial origin의 악성종양

  • Go, Gwang-Jun
    • The Journal of the Korean dental association
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    • v.27 no.8 s.243
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    • pp.697-702
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    • 1989
  • 악성종양은 상피성의 암종(carcinoma)과 결체직성의 육종(sarcoma)으로 분류된다. 최근 암환자의 발생은 점차 증가되는 추세이며, 우리나라에서도 사망원인 중 뇌졸증 다음으로 암이 차지하는 비율이 높다. 이러한 암은 침윤성(infiltrative)인 성장으로 인하여 인접 정상조직을 급격히 파괴시키며, 해당 임파절을 따라 신체 다른 부위로 전이(metastasis)된다. 임파절에 전이되기 전에 조기발견된 암은 70%의 5년 생존률을 보이는 반면, 임파절에 전이된 후에 발견된 암은 30%의 5년 생존률을 보인다. 따라서 암의 성공적인 치료를 위해서는 이의 조기발견이 매우 중요하다고 할수 있다. 그러나 불행하게도 많은 환자가 이미 병소가 상당히 진행된 상태에서 내원하기 때문에 이의 근치가 어려우며, 예후 또한 좋지 않다. 이러한 암을 조기발견하기 위해서는 환자 자신의 관심뿐만 아니라 치과의사의 세심한 검진이 필요하리라 생각된다.

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Extrapleural Pneumonectomy for Diffuse Malignant Mesothelioma -Report of four cases- (미만성 악성 중피세포종의 늑막 폐절제술 -4례 보고-)

  • 곽영태;맹대현;배철영;이신영;김정숙;최수전;김성록
    • Journal of Chest Surgery
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    • v.33 no.12
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    • pp.982-987
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    • 2000
  • 미만성 악성 중피세포종은 예후가 불량한 드문 암종으로, 아직까지 적절한 병기 분류가 없고, 병리 조직학적인 진단이 쉽지 않다. 치료에 대해서 논쟁이 많지만 선택된 환자에서 늑막 폐절제술을 시행하고 보조적인항 화학요법과 방사선 요법이 생존 기간을 연장시킬 수 잇다. 저자들은 1992년 6월부터 7년간 미만성 악성 중피세포종 환자 4례에서 늑막 폐절제술을 시행하였으며 수술후 조기 사망은 없었다. 3례의 환자에서 수술후 보조요법을 시행할 수 있었다(보조 화학요법 2례, 보조 화학요법 및 방사선 치료 1례). 그러나 한 예에서는 수술후 발생한 심장염전에 의한 저산소성 뇌손상 및 농흉으로 인하여 보조용법을 시행할 수 없었다. 저자들은 저자들의 늑막 폐 절제술의 경험 및 미만성 악성 중피세포종에 대한 논란이 되는 점을 문헌고찰과 함께 보고하는 바이다.

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A Study on the Correlations between the Physical Characteristics of Rock Types by Multiple Regression Analysis and Artificial Neural Network (다중회귀분석 및 인공신경망을 통한 암종별 물리적 특성간의 상관관계에 대한 연구)

  • Kim, Byong-Kuk;Lee, Byok-Kyu;Jang, Seung-Jin;Lee, Su-Gon
    • The Journal of Engineering Geology
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    • v.28 no.4
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    • pp.673-686
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    • 2018
  • The physical properties of rocks constituting the rock mass were analyzed by using various methods such as 7 kinds of physical properties of about 2,400 data. The correlation equation was derived from the correlation equation with the dependent variables by screening independent variables through the significance level using multiple regression analysis. In order to verify the reliability of this equation, verification was performed through comparison with actual data using artificial neural network learning. The analysis results by petrogenesis and strength confirmed that the elastic wave velocity (compressional wave) and elastic modulus as the main influence factors for the independent variables affecting the dependent variables. This proves that most of the correlation equations using the above items are found in existing studies. And through this study, it is confirmed whether the rock classification is based on the above items in various standards. In addition, the analysis results of representative rocks showed a high correlation as the equation for estimating unconfined compressive strength and elastic modulus exceeds the coefficient of determination 0.8.

Analysis of Weathering Sensitivity by Swelling of Domestic Highway Sites (국내 고속도로현장의 스웰링에 의한 풍화민감도 분석)

  • Jang, Seokmyung;Han, Heuisoo
    • Journal of the Korean GEO-environmental Society
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    • v.23 no.3
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    • pp.15-22
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    • 2022
  • This study aims to observe the swelling representative rocks in Korea and to suggest improvements in the use of test methods and prior analysis in relation to the weathering of rocks. The swelling test and analysis were performed on the drilling cores obtained for the ground investigation at the domestic highway construction site. For the method of determining the absorption expansion index of rocks, the method proposed in "Standard Methods for Sample Collection and Specimen Preparation" of ISRM and Korean Rock Engineers Standard Rock Test Method was used. The specimen for the measurement of the expansion displacement was cylindrical with a height of 10 cm and a diameter of 5 cm. The existing swelling analysis method evaluates the sensitivity to weathering by using the maximum expansion displacement, but since the classification by bedrock grade is unclear, it is reasonable to use the rate of change of the expansion displacement according to the immersion time. It is necessary to conduct an experiment to distinguish between weathering and fault deterioration. In addition, long-term weathering prediction technology for each cancer type is needed through the expansion displacement analysis of the chemical weathering stage.

Preoperative Prediction of Ductal Carcinoma in situ Underestimation of the Breast using Dynamic Contrast Enhanced and Diffusion-weighted Imaging (역동적 유방 자기공명 영상 및 확산 강조영상을 이용한 관상피내암종 저평가 수술전 예측)

  • Park, Mina;Kim, Eun-Kyung;Kim, Min Jung;Moon, Hee Jung
    • Investigative Magnetic Resonance Imaging
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    • v.17 no.2
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    • pp.101-109
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    • 2013
  • Objective: To investigate roles of dynamic contrast enhanced magnetic resonance (DCE MR) and diffusion-weighted (DW) imaging in preoperative prediction of underestimation of ductal carcinoma in situ (DCIS) ${\geq}2cm$ on US guided core needle biopsy. Materials and Methods: Twenty two patients with DCIS on US-guided 14 gauge core needle biopsy were included. Patients were divided into a group with and without DCIS underestimation based on histopathology. MR images including DCE and DW imaging were obtained with a 3.0-T MR. The lesion type (mass or non-mass), enhancement pattern, peak enhancement, and apparent diffusion coefficient (ADC) values of proven malignant masses were generated using software of CADstream and compared between two groups using Fisher's exact test and Mann Whitney test. Results: Eight patients were in the group with underestimation and 14 patients were in the group without underestimation. The lesion type and enhancement pattern were not different between two groups (P values = 1.000 and 0.613, respectively). The median peak enhancement of lesions with underestimation was 159.5%, higher than 133.5% of those without underestimation, but not significant (P value = 0.413). The median ADC value of lesions with underestimation was $1.26{\times}10^{-3}mm^2/sec$, substantially lower than $1.35{\times}10^{-3}mm^2/sec$ of those without underestimation (P value = 0.094). Conclusion: ADC values had the potential to preoperatively predict DCIS underestimation on US-guided core needle biopsy, although a large prospective series study should be conducted to confirm these results.

MicroRNA 155 Expression Pattern and its Clinic-pathologic Implication in Human Lung Cancer (폐암에서 microRNA 155의 발현 양상과 임상병리학적 의의)

  • Kim, Mi Kyeong;Moon, Dong Chul;Hyun, Hye Jin;Kim, Jong-Sik;Choi, Tae Jin;Jung, Sang Bong
    • Journal of Life Science
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    • v.26 no.9
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    • pp.1056-1062
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    • 2016
  • Lung cancer is currently the most common malignant disease and the leading cause of mortality in the world and non-small cell lung cancer (NSCLC) accounts for 75-80% of lung cancer cases. miR-155 gene was found to be over expressed in several solid tumors, such as thyroid carcinoma, breast cancer, colon cancer, cervical cancer, pancreatic ductal adenocarcinoma (PDAC) and lung cancer. The aims of this study were to define the expression of miR-155 in lung cancer and its associated clinic-pathologic characteristics. Total RNA was purified from formalin-fixed, paraffin-embedded NSCLC tissues and benign lung tissues. Expression of miR-155 in human lung cancer tissues were evaluated as mean fold changes of miR-155 in cancer tissues compared to benign lung tissues by quantitative real-time reverse transcriptase polymerase chain reaction (real-time qRT-PCR) and associations of miR-155 expression with clinic-pathologic findings of cancer. Compared with the benign control group, miR-155 expression was significantly overexpressed in NSCLCs (p=<0.001). miR-155 was more overexpressed in squamous cell carcinoma than in adenocarcinoma. Poorly differentiated tumors showed significantly overexpression of miR-155 than well-differentiated tumors (p=<0.001). Overexpression of miR-155 was significantly associated with lymph node metastasis (p=<0.05). In survival analysis for all NSCLC patients, high miR-155 expression was significantly correlated with worse overall survival (p=<0.05). These results suggested that miR-155 might play an important role in lung cancer progression and metastasis.

Rock Support Design of Bakun Tunnelling Project in Sarawak, Malaysia (바쿤 가배수로 터널의 최적지보설계)

  • 지왕률
    • Tunnel and Underground Space
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    • v.8 no.4
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    • pp.296-306
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    • 1998
  • Ongoing huge Bakun Hydropower project is including the construction of a 210 m height hydroelectric rockfill dam with an installed capacity of 2,520 MW and a power transmission system connecting to the existing networks between Sarawak and peninsula Malaysia. In order to allow the main dam construction during the dry season, the Ballui river will have to be detoured through 3 concrete lined diversion tunnels with an internal diameter of 12 m and a length of 1,400 m each. The geology of Bakun site belongs to the several thousand meters thick Belaga formation deposited from the late Cteteceous to the early Teriary in the Northwest Borneo geosyncline. The orientation of the bedding plane, strike at N55$^{\circ}$E to N70$^{\circ}$E and dip at 50$^{\circ}$SE to 70$^{\circ}$SE, is developed uniformly in Bakun sedimentary rocks. Rock mechanical characteristics of Bakun site have been classified into 4 rock mass types(RMT) depending on the degree of weathering and the occurrence of rock jointing with RMR. Graywacke(Sandstone) as well as Shale can take place together in the same rock mass type if their rock mass properties are similar. It was summarized the rock support type and support system design of underground diversion tunnels in view of rock mechanics.

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Conservation Status, Construction Type and Stability Considerations for Fortress Wall in Hongjuupseong (Town Wall) of Hongseong, Korea (홍성 홍주읍성 성벽의 보존상태 및 축성유형과 안정성 고찰)

  • Park, Junhyoung;Lee, Chanhee
    • Korean Journal of Heritage: History & Science
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    • v.51 no.3
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    • pp.4-31
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    • 2018
  • It is difficult to ascertain exactly when the Hongjuupseong (Town Wall) was first constructed, due to it had undergone several times of repair and maintenance works since it was piled up newly in 1415, when the first year of the reign of King Munjong (the 5th King of the Joseon Dynasty). Parts of its walls were demolished during the Japanese occupation, leaving the wall as it is today. Hongseong region is also susceptible to historical earthquakes for geological reasons. There have been records of earthquakes, such as the ones in 1978 and 1979 having magnitudes of 5.0 and 4.0, respectively, which left part of the walls collapsed. Again, in 2010, heavy rainfall destroyed another part of the wall. The fortress walls of the Hongjuupseong comprise various rocks, types of facing, building methods, and filling materials, according to sections. Moreover, the remaining wall parts were reused in repair works, and characteristics of each period are reflected vertically in the wall. Therefore, based on the vertical distribution of the walls, the Hongjuupseong was divided into type I, type II, and type III, according to building types. The walls consist mainly of coarse-grained granites, but, clearly different types of rocks were used for varying types of walls. The bottom of the wall shows a mixed variety of rocks and natural and split stones, whereas the center is made up mostly of coarse-grained granites. For repairs, pink feldspar granites was used, but it was different from the rock variety utilized for Suguji and Joyangmun Gate. Deterioration types to the wall can be categorized into bulging, protrusion of stones, missing stones at the basement, separation of framework, fissure and fragmentation, basement instability, and structural deformation. Manually and light-wave measurements were used to check the amount and direction of behavior of the fortress walls. A manual measurement revealed the sections that were undergoing structural deformation. Compared with the result of the light-wave measurement, the two monitoring methods proved correlational. As a result, the two measuring methods can be used complementarily for the long-term conservation and management of the wall. Additionally, the measurement system must be maintained, managed, and improved for the stability of the Hongjuupseong. The measurement of Nammunji indicated continuing changes in behavior due to collapse and rainfall. It can be greatly presumed that accumulated changes over the long period reached the threshold due to concentrated rainfall and subsequent behavioral irregularities, leading to the walls' collapse. Based on the findings, suggestions of the six grades of management from 0 to 5 have been made, to manage the Hongjuupseong more effectively. The applied suggested grade system of 501.9 m (61.10%) was assessed to grade 1, 29.5 m (3.77%) to grade 2, 10.4 m (1.33%) to grade 3, 241.2 m (30.80%) and grade 4. The sections with grade 4 concentrated around the west of Honghwamun Gate and the east of the battlement, which must be monitored regularly in preparation for a potential emergency. The six-staged management grade system is cyclical, where after performing repair and maintenance works through a comprehensive stability review, the section returned to grade 0. It is necessary to monitor thoroughly and evaluate grades on a regular basis.

Significance of p53 as a Prognostic Factor in Non-Small Cell Lung Carcinoma (비소세포 폐암종에 있어서 p53의 예후 인자로서의 의의)

  • 이상호;한정호;김관민;김진국;심영목;장인석
    • Journal of Chest Surgery
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    • v.37 no.8
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    • pp.672-683
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    • 2004
  • Background: The treatment results of the advanced lung carcinoma is not satisfactory with the present therapeutic modalities: surgical resection, anti-cancer chemotherapy, and radiotherapy or combination therapy. To predict the prognosis of the non-small-cell lung carcinoma, TNM classification has been was as the basic categorization; however, it has been not satisfactory. It is necessary to consider the causes and the prognosis of the lung carcinoma from another points of view rather the conventional methods. We intended to find out the relationship between the major apoptotic factor, p53 gene and the prognosis of the patient with lung carcinoma. Material and Method: Three hundreds and fifty-nine patients with lung carcinoma who underwent surgery were analysed. We observed p53 protein accumulated in the cellular nuclei. The p53 protein was detected by immuno-histo-chemical method. We collected information of the patient retrospectively. Result: p53 protein densities were observed in 40% in average as a whole. The protein density was 44 percent in man, 25 percent in woman, 49 percent in the squamous cell carcinoma, and 38 percent in the adenocarcinoma. There were significant correlations between the p53 protein density and the mortality in the squamous cell carcinoma (p=0.025), follow-up duration in TNM stage I group (p=0.010), and follow-up duration in the lobectomy patient group (p=0.043), and tumor cell differentiation (p=0.009). p53 protein densities were significantly different between the lobectomy and the pneumonectomy group (p=0.044). Conclusion: The authors found that p53 protein had some correlations with the prognosis of the lung cancer partially in some factors. We suggest the p53 protein density could be used as a marker of prognosis in the non-small-cell lung carcinoma.