• Journal of Physiology & Pathology in Korean Medicine
• /
• v.17 no.1
• /
• pp.77-84
• /
• 2003

Cancer, which is expressed in various forms, is one of the leading causes of human death, Soamsan (SAS) is composed of ten medicinal herb, the prescription was made according to the principles of Oriental traditional medicine based on the concept of synergic effects and interaction of among the components. SAS has been used for the cancer therapy, but the mechanism of it's effect is not well known. In the present study, the cytotoxic effect of the SAS water extract on cancer cell lines was investigated by the method of MTT in A549 cell lines and the anti-angiogenic effect was shown in the assay of chorioallantoic membrane (CAM) and in the cornea of rat administerd orally with SAS water extraction. The viability of A549 cell lines was not affected by the whole extract of SAS but the n-Hexan fraction of SAS water extract showed strong cytotoxicity which was not seemed to be done by the apoptotic mechanism. SAS water extract showed inhibition effects of angiogenesis induced in the cornea of rat and CAM assay. As the above results, it is suggested that SAS can be a candidate for new prescription for cancer therapy.

• Journal of the Korean Society of Environmental Restoration Technology
• /
• v.17 no.4
• /
• pp.43-56
• /
• 2014

In this study, ecological investigation was performed on Yong-neup, Daeam-san for 5 times. This area is considered DMZ zone located between Yanggu-gun and Inje-gun, Gangwon-do, where has been recognized highly valuable for ecological preservation. As a result, Sphagnum and hydrophobic vegetation were found in Little Yong-neup, revealing its characteristics of high moor, where as no Sphagnum were found in Baby Yong-neup. Thereby, the carnification has been investigated in both Little Yong-neup and Baby Yong-neup. A main cause of damage was associated with the creation of stating rink and increases of visitors. The damages of vegetation in Little Yong-neup and Baby Yong-neup have been intensified by road construction or uses of groundwater while relocating military troops to upper stream of Little Yong-neup and Baby Yong-neup, further causing the damages of water circulation system and soil erosion. These artificial factors have caused the carnification of wetland protection areas including Little Yong-neup. The terrestrial vegetations, such as Plantago asiatica, Geranium Koreanum and Artemisia feddei have increased compared to current survey conducted by the Ministry of Environment. 5 endangered species, such as Lychnis wilfordii and Trientalis europaea and 5 other introduced species, such as Aster pilosus and Taraxacum officinale were found. 10 different species of mammal and 2 species of amphibian were investigated; and in addition to this, a original form of Sphagnum fens, the remaining wetland was found. Therefore, this study is to identify the causes of damages in Little Yong-neup and Baby Yong-neup through their ecological survey and accordingly proposing a direction for ecological restoration through the improvement of water circulation system, creation of habitats for plant and animal, restoration of vegetation through eco-friendly materials and indigeneity, relocation of the current military troops, securing of structural stability.

• Journal of the Korean School Mathematics Society
• /
• v.13 no.3
• /
• pp.381-395
• /
• 2010

The purpose of this paper is to examine the competence and the methods of problem solving in four operations word problems based on the informal knowledges by five-year-old children. The numbers which are contained in problems consist of the numbers bigger than 5 and smaller than 10. The subjects were 21 five-year-old children who didn't learn four operations. The interview with observation was used in this research. Researcher gave the various materials to children and permitted to use them for problem solving. And researcher read the word problems to children and children solved the problems. The results are as follows: five-year-old children have the competence of problem solving in four operations word problems. They used mental computation or counting all materials strategy in addition problem. The methods of problem solving were similar to that of addition in subtraction, multiplication and division, but the rate of success was different. Children performed poor1y in division word problems. According to this research, we know that kindergarten educators should be interested in children's informal knowledges of four operations including shapes, patterns, statistics and probability. For this, it is needed to developed the curriculum and programs for informal mathematical experiences.

• Korean Journal of Plant Resources
• /
• v.13 no.1
• /
• pp.80-88
• /
• 2000

External morphology and numerical taxonomy by principal component analysis and cluster analysis were investigated to understand the taxonomic relationships on the populations of Hanabusaya asiatica from 6 different habitats. Additionally H. latisepala was used as a outgroup. The distinct characters to each habitat were not present in the measurement of 21 qualitative characters except for some native individuals in the top of Mt. Sorak and Hyangrobong based on leaf shape and bracts. This results were recognized as the continuous variations of external morphology. The populations of H. latisepala and H. asiatica were identified by calyx lobe shape. The results obtained based on the principal component(PC) analysis of treated 78 OTU were divided into two groups by PC 1,2,3, and the sums of contributions for the total variance were 50.07% (PC1 22.3% , PC2 15.7%, PC3 12.0%, respectively), and six populations were not distinctly identified as illustrated in two dimensions with PC1 and PC2. In cluster analysis based on average linkage cluster analysis and Ward's method, there were similarities in the composition of clustered taxa, and each populations were not identified.

• The Korean Journal of Mycology
• /
• v.16 no.4
• /
• pp.226-229
• /
• 1988

More than one-hundred-twenty specimens of Basidiomycetes, Ascomycetes and slime molds were collected in Seoul National Polytechnic University Campus during the priod from June 1984 to November 1987 and examined for identity. They were classified into 25 families, 53 genera and 81 species. Among them, one genus and 2 species were confirmed as unrecorded taxa in Korea. The unrecorded genus was genus Hapalopilus and was named 'Band Dal Busut' in vernacular. The unrecorded 2 species were Hapalopilus rutilans and Hygrophorus nitratus. They were named 'No Lan Ban Dal Busut' and 'Jil San Beot Geot Busut,' respectively and their characteristics were here reported.

• Journal of Elementary Mathematics Education in Korea
• /
• v.5 no.1
• /
• pp.55-75
• /
• 2001

The purpose of this paper is to find out the full extent of abilities of elementary students on area of operations and the effects on student's affective domain toward mathematics, after providing 3rd grade students with Skemp's play activities instead of providing activities suggested in the textbook of 7th curriculum. For this study, we will first analyse new elementary mathematics curriculum of 3rd grade and then explore mathematical factors for play activities related to operational sections. The play activities are revised from that of Skemp's for our classroom circumstances, but the ideas included from Skemp's such as thinking aloud were not changed. The experimental group while consists of 39 students were taught Skemp's play activities instead of usual textbook activities for 30 hours for the second term. In all other area, both the experimental group and the comparative group were taught the same contents. Statistical data is as follows 1) In addition and subtraction, the experimental group had 5.6% higher score than the comparative's, but the difference of mean of the both groups is not significant within 5% level. 2) In multiplication and division, the experimental group had 7.8% higher score than the comparative's and also the difference of mean of the beth within 5% level is significant. 3) When measured the effects in affective domain, the interests, attitude, and values for mathematics had about 10% higher score after the experiment than before the experiment. So we conclude that Skemp's activities are more effective than the activities suggested in the textbook on the area of operations, especially in multiplication and division.

• Journal of Elementary Mathematics Education in Korea
• /
• v.6 no.1
• /
• pp.23-40
• /
• 2002

Historically, the use of algorithms has been emphasized in the mathematics curriculum at the elementary school mathematics. The current reform movement in our country are seemed to emphasize the importance of algorithms in favor of problem-solving approaches, the conceptualization of mathematical processes and applications of mathematics in real world situations. Recently, children may come to school with a fairly well-developed attitude about mathematics and mathematical ideas. That is, they do not come to school and to learning mathematics with a clean slate. Because they have already formed some partial mathematical concepts in a wide variety of contexts. Many kindergarten children have attended pre-school programs where they played with blocks, made patterns, and started adding and subtracting. It seems that there are psychological change attitudes of the children in upper grades toward learning mathematics. In our elementary school mathematics, almost every student are still math anxious or have developed math anxiety because of paper-pencil test. In these views, this paper is devoted to introduce and apply to second grade students in ND-elementary school in Taegu City the new method for learning addition and subtraction so called ‘Mrs Weill's Hill’, which is believed as a suitable method for children with mathematical teaming disabilities and Math anxiety.

• Journal of Korean Society for Geospatial Information Science
• /
• v.17 no.4
• /
• pp.87-93
• /
• 2009

The increased person interests in health in accordance with improved living standards result in the booming population who enjoy mountain climbing. Although there are more climbers than ever, most existing mountain paths are those which have been made naturally by people utilizing them to get to the peak and therefore cannot meet the various needs of emerging mountain climbers. Thus, this study that establish a data using numerical map and TotalStation aimed to provide them with beneficial information on mountain paths, analyzing each path using GIS. The subjects of this study are limited to Kum-Am which is in Kyungnam province, Korea. According to out research, proper slopes for the majority of mountain climbers, mostly in their from 30s to 50s, are turned out to be HG1 and JG1-JG2-JG3.

• Herbal Formula Science
• /
• v.10 no.2
• /
• pp.113-126
• /
• 2002

Soamsan is known as an anti-cancer remedy in the traditional Korean Medicine. To enhance the synergic effects of anti-cancer activity of Soamsan, this study reconstituted the original components of Soamsan with a slight modification and produced a novel herbal remedy, namely Gamisoamsan. Extracts of Gamisoamsan inhibited the growth of cultured CT-26 cells, mouse colon adenocarcinoma, in a dose-dependent manner $(1\;to\;50{\mu}g/ml)$, and $ID_{50}$ was estimated approximately $16.7{\mu}g/ml$. Using tumor-bearing mouse model, in which was produced by subcutaneous injection of CT-26 cells ($1{\times}10^5$cells). the effects of Gamisoamsan on tumor growth and host survival were examined by evaluating tumor volume and increase in life span. When Gamisoamsan extracts in variable doses of 100, 200 and 500mg／kg body weight per day were orally administered to tumor-bearing mice, following results were obtained: Improvement in the hematological parameters following Gamisoamsan treatment such as hemoglobin contents, red blood cells and white blood cells of the tumor-bearing mice have been observed. Gamisoamsan treatment also showed a prolongation of life span and a reduction of tumor volume in the CT-26 tumor hosts. The results of the present study suggest that Gamisoamsan extracts has a potential anti-tumor activity and may be an useful remedy to prevent and／or treat cancer.

• Polymer(Korea)
• /
• v.28 no.6
• /
• pp.494-501
• /
• 2004

A new alkali developable photosensitive poly(amic acid) (PAA-0) with transmittance at 400 nm was synthesized from cyclobutane-1,2,3,4-tetracarboxylic dianhydride, 2-(methacryloyloxy)ethyl-3,5-diamino-benzoate and 1,3-bis(3-aminopropyl)-1,1,3,3-tetramethyl disiloxane in N-methyl-2-pyrrolidinone. Photosensitivity of the PAA-0 was investigated at 365-400 nm in the presence of a photoinitiator using a high pressure mercury lamp. The photo-cured poly(amic acid) was insoluble toward aqueous 2.38 wt% tetramethylammonium hydroxide solution. Negative pattern of the PAA-0 with 25 ${\mu}{\textrm}{m}$ resolution was obtained by developing with 2.38 wt% tetramethylammonium hydroxide solution after exposure of 600 mJ/$\textrm{cm}^2$ in the presence of 2,2-dimethoxy-2-phenyl-acetophenone as a photoinitiator. The patterned poly(amic acid) was converted to polyimide by thermal curing at 25$0^{\circ}C$ for 50 min, which showed chemical resistance against photoresist stripper as well as good transmittance at 400 nm.