• 건강소식
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• v.35 no.12
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• pp.38-39
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• 2011

간은 우리 몸에 필요한 단백질과 여러 가지 영양소를 만들고 저장하며 건강에 해로운 물질을 해독하는 일을 한다. 이러한 간에 이상이 생기면 간장질환이 발생하게 되며, 간장질환은 급격히 발생하는 A형 간염에서부터 6개월 이상 지속되는 만성간염, 지방간, 간경변, 간암까지 매우 다양하다. 이 중 대표적인 질환으로 지방간을 들 수 있다. 연말 각종 모임이나 회식, 송년회 등 잦은 술자리로 인한 문제는 과음으로 오는 지방간이다. 지방간은 과음으로 인한 알코올성 지방간과 비만, 당뇨, 고지혈증 등으로 인한 비알코올성 지방간이 있다.

• Journal of Haehwa Medicine
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• v.9 no.1
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• pp.379-386
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• 2000

1. There two parts of alcohol's metabolic system the first one is alcoholdehydrogenase(ADH), and second is microsomal ethanol oxidizing system(MEOS). 2. Alcoholic cirrhosis(fibrosis) leads from cytotoxin, malnutrition, and immunue reaction. 3. In the Oriental medical point of view alcohol has strong heat and toxin, which can cause judal, ju-ka, ju-beack, ju-juck, and ko-chang in other words these means that it can cause hepatasis, fatty liver, fibrosis, and liver cirrhosis. 4. About the Liver cirrhosis(fibrosis) pathological system, in the oriental medical point of view, it effects the liver, kidney and spleen which causes Uy-heulGin-guk(瘀血 積), seup-yeul ne-oun(濕熱內蘊), and in the long term it can cause kansinyumhu(肝腎陰虛), kanbeyumhu(肝脾陰虛). Because of the expand of alcohol liver disease, in the future there must be more studies about these disease in Oriental medicine point of view.

• Journal of Life Science
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• v.33 no.2
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• pp.183-190
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• 2023

Red yeast rice, also known as Hong Qu and red Koji, has been used for a long time in Asian functional food and traditional medicine. It consists of multiple bioactive substances, which can potentially be used as nutraceuticals. Alcoholic liver disease (ALD) can range from simple steatosis or inflammation to fibrosis and cirrhosis, possibly through leaky gut and systemic endotoxemia. This study examined the liver and gut effects of red yeast rice (RYR) (Monascus purpureus) ethanol extract against binge ethanol-induced liver injury in mice. RYR extract was orally administered to C57BL/6N mice at a concentration of 200 mg/kg body weight per day for 10 days. Then, mice were administered binge alcohol (5 g/kg/dose) three times at 12 hr intervals. Binge alcohol exposure significantly elevated the endotoxin, aspartate aminotransferase (AST), and alanine transaminase (ALT) activity of plasma, as well as hepatic triglyceride levels; however, RYR treatments reduced these levels. In addition, RYR pretreatment significantly reduced the alcohol-induced oxidative maker protein and apoptosis maker in binge alcohol-induced gut and liver injuries. These results suggest that RYR may prevent alcohol-induced acute leaky gut and liver damage.

• Herbal Formula Science
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• v.15 no.2
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• pp.161-169
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• 2007

We applied Chunggangunbi-tang-gamibang to a 64 year-old male patient who had alcoholic liver cirrhosis with ascites. Chunggangunbi-tang-gamibang has been used to treat alcoholic liver disease and because of its beneficial effects. The patient with the disease expected several symptoms induced by Alcoholic liver cirrhosis, and we diagnosised differentiation of symptoms, using Chunggangunbi-tang-gamibang while removing dampness through diuresis and invigorating the spleen. After medication we could find remarkable effects on clinical symptoms, blood test results and abdomen ultrasonographic images. From this case, it is thought that using Chunggangunbi-tang-gamibang is very effective to improve the symptom of alcoholic liver cirrhosis with ascites.

• The Journal of Internal Korean Medicine
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• v.37 no.1
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• pp.135-142
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• 2016

Objectives: To introduce the effect of traditional Korean medicine (TKM) treatment with Injinoryeong-san on alcoholic liver cirrhosis (ALC).Methods: A 37-year-old man with a history of alcohol ingestion for the past five years was diagnosed with ALC based upon his clinical symptoms, sonogram results, and laboratory studies. The patient received TKM treatment with acupuncture, moxibustion, and Injinoryeong-san in parallel to Western medicine for two weeks. The clinical assessment was monitored based upon changes in the Child-Pugh score and ultrasonography, body weight, and abdominal circumference for measuring the amount of ascites.Results: The patient’s clinical symptoms improved with decreases in abdominal circumference and body weight. Ultrasound revealed a regression of the amount of ascites in the abdominal cavity. Laboratory results also improved significantly, and the Child-Pugh score increased from class B to A.Conclusions: This case report showed a significant improvement of ALC with relatively simple treatment for only a short period and therefore supported the potential of TKM treatment in ALC.

• Clinical and Experimental Pediatrics
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• v.50 no.8
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• pp.794-798
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• 2007

Hepatopulmonary syndrome is a triad that includes: hepatic dysfunction, intrapulmonary vascular dilatation and abnormal arterial oxygenation. The incidence of intrapulmonary vascular dilatations, in adults with end-stage liver disease, has been reported to be 13% to 47%, however the incidence in children is unclear and the cases in Korean children have never been reported. The hepatopulmonary syndrome may occur as a result of chronic liver disease following nonalcoholic steatohepatitis in children with hypothalamic or pituitary dysfunction. We report a case of hepatopulmonary syndrome in a 13-year-old child who had rapidly progressive liver dysfunction secondary to panhypopituitarism after craniopharyngioma resection. Careful monitoring and treatment of endocrine abnormalities and metabolic status, as well as liver function, are required in all children undergoing pituitary tumor resection.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.13 no.1
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• pp.51-57
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• 2010

Purpose: It has been reported that children with hypopituitarism have features of metabolic syndrome, including obesity, impaired glucose tolerance, and dyslipidemia. The aim of this study was to investigate the clinical features and liver histology of pediatric non-alcoholic fatty liver disease (NAFLD) associated with hypopituitarism. Methods: We reviewed the clinical data of 11 children diagnosed with NAFLD among patients with hypopituitarism. Results: The mean age at the time of diagnosis of hypopituitarism was 10.4${\pm}$3.2 years, and the mean age at the time of diagnosis of NAFLD was 13.1${\pm}$2.7 years. A craniopharyngioma was the most common cause of pituitary dysfunction. At the time of diagnosis of NAFLD, 9 patients (82%) had a body mass index greater than the 85th percentile, 5 patients (45%) had elevated fasting blood glucose levels, and 9 patients (82%) had hypertriglyceridemia. The mean height SD score was significantly lower at the time of diagnosis of NAFLD than at the time of diagnosis of hypopituitarism. Of the six patients who were biopsied, one had cirrhosis, two had non-alcoholic steatohepatitis (NASH) with bridging fibrosis, two had NASH with mild portal fibrosis, and one had simple steatosis. Conclusion: Children with hypopituitarism are at risk of short stature, obesity, dyslipidemia, and NAFLD. The early diagnosis of NAFLD is important in children with hypopituitarism because advanced fibrosis is common.