• Title/Summary/Keyword: 안정하도

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Optimization and Stabilization of Automated Synthesis Systems for Reduced 68Ga-PSMA-11 Synthesis Time (68Ga-PSMA-11 합성 시간 단축을 위한 자동합성장치의 최적화 및 안정성 연구)

  • Ji hoon KANG;Sang Min SHIN;Young Si PARK;Hea Ji KIM;Hwa Youn JANG
    • Korean Journal of Clinical Laboratory Science
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    • v.56 no.2
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    • pp.147-155
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    • 2024
  • Gallium-68-prostate-specific membrane antigen-11 (68Ga-PSMA-11) is a positron emission tomography radiopharmaceutical that labels a Glu-urea-Lys-based ligand with 68Ga, binding specifically to the PSMA. It is used widely for imaging recurrent prostate cancer and metastases. On the other hand, the preparation and quality control testing of 68Ga-PSMA-11 in medical institutions takes over 60 minutes, limiting the daily capacity of 68Ge/68Ga generators. While the generator provides 1,110 MBq (30 mCi) nominally, its activity decreases over time, and the labeling yield declines irregularly. Consequently, additional preparations are needed, increasing radiation exposure for medical technicians, prolonging patient wait times, and necessitating production schedule adjustments. This study aimed to reduce the 68Ga-PSMA-11 preparation time and optimize the automated synthesis system. By shortening the reaction time between 68Ga and the PSMA-11 precursor and adjusting the number of purification steps, a faster and more cost-effective method was tested while maintaining quality. The final synthesis time was reduced from 30 to 20 minutes, meeting the standards for the HEPES content, residual solvent EtOH content, and radiochemical purity. This optimized procedure minimizes radiation exposure for medical technicians, reduces patient wait times, and maintains consistent production schedules, making it suitable for clinical application.

Prevalence and Associated Factors of Depressive Symptoms Among Elderly Individuals in Rural Areas of Jeju Island (제주 농촌 지역 노인들의 우울증상 유병률 및 관련 요인)

  • Hyun Ju Yang;Min Su Oh;Woo Young Im;Sung Wook Song
    • Korean Journal of Psychosomatic Medicine
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    • v.32 no.1
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    • pp.43-51
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    • 2024
  • Objectives : This study aims to explore the prevalence of depressive symptoms among elderly residents in the relatively stable rural areas of Jeju and to examine the relationships between levels of depression, sociodemographic factors, and health habits. Methods : The study site was within rural Jeju, where elderly individuals aged 65 and older were randomly selected from the 'Agricultural Cohort' registered at the Centers for Farmers' Safety and Health Center. Trained interviewers conducted surveys using the Short Form Geriatric Depression Scale (sGDS-K), defining those with scores of 6 or above as experiencing depressive symptoms for the analysis. Other variables such as sex, age, educational level, marital status, annual income, subjective health status, underlying disease, perceived stress levels, smoking, and drinking status were also recorded Results : Out of 533 subjects, the prevalence of depressive symptoms was 35.3%, with 28.5% in male and 45.6% in female (p<0.001). Factors significantly associated with the prevalence of depressive symptoms included marital status (p=0.014), educational level (p<0.001), annual income (p=0.034), subjective health status (p<0.001), perceived stress level (p<0.001), feeling of despair (p<0.001) and suicidal ideas (p<0.001). Multivariate logistic regression analysis revealed that subjective health status, perceived stress level, and feelings of despair were associated with the prevalence of depressive symptoms. Conclusions : The high prevalence of depressive symptoms among the rural elderly in Jeju highlights the need for targeted mental health interventions. Addressing sociocultural factors and improving early detection and intervention strategies can help reduce the socioeconomic impact of depression in this population.

The effect of listening to music on cardiovascular and autonomic reactivity to sympathoexcitation in young adults (음악 청취가 교감신경 활성화에 대한 심혈관 및 자율신경 반응 완화에 미치는 영향)

  • Jeong In Kwon;Hyun Jeong Kim;Min Jeong Cho;Yoo Sung Oh;Sae Young Jae
    • Journal of the Korean Applied Science and Technology
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    • v.40 no.4
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    • pp.674-684
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    • 2023
  • The purpose of this study was to investigate the effect of acute listening to music on the cardiovascular reactivity to sympathoexcitation. In this crossover design study, 15 healthy adults(23.1±1.94(yrs) were randomized to either (1)acute listen to the subject's preferred music for 30 minutes and (2)sat as a time control by an experiment coordinator. After completing each trial, the cold pressor test(CPT) was conducted. Heart rate(HR) and blood pressure(BP) were measured for 4 times at baseline, during and after the CPT. Heart rate variability(HRV) were measured for 3 times at baseline, prior and after the CPT. HR and BP increased during the CPT in both trial and returned to baseline after CPT(time effect, p < .001). After CPT, brachial systolic BP reactivity to the CPT was attenuated in listening to music trial compared to control trial(p = . 008). As a result of heart rate variability(HRV), the difference values between the baseline and prior to the CPT showed a significant increase in standard deviation of the NN intervals(SDNN), total power(TP) and high frequency(HF) only in the music trial (p = .001, p = .002, p = .011). The difference value between prior to and after the CPT did not show significance. But compared with the control trial, the music trial was confirmed that SDNN, TP and HF were more activated. Therefore, listening to music alleviated anxiety and tension before the CPT, and it is estimated that it had a favorable effect on stability after the CPT. This findings showed that listening to music may have a positive effect on brachial systolic BP and HRV to sympathoexcitation.

Studies on the MSM (Methyl Sulfonyl Methane) Treatment Method of Soybeans (콩의 MSM (Methyl Sulfonyl Methane) 처리 방법에 관한 연구)

  • Se Eun Chae;Seung Ka Oh;Young-Son Cho;Doobo Shim;Dong-Kyung Yoon;Seung Ho Jeon
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.69 no.1
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    • pp.25-33
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    • 2024
  • This experiment was conducted at the affiliated farm of the Suncheon University from 2022 to 2023 to investigate the growth, yield, and quality characteristics of soybeans based on the treatment method of Methyl Sulfony Methane (MSM) for the establishment of stable production practices. In the initial investigation of growth characteristics in 2022, an increasing trend in characteristics such as plant height, stem thickness, and branching index was observed as the treatment concentration increased from 50% to 200%. Yield components also followed the same trend, with the basal fertilization + top dressing 3 times at 200% treatment showing the highest yield at 355 kg·10a-1, with the highest number of pods. In the subsequent study to determine the optimal concentration exceeding 200% in 2023, growth characteristics showed a trend of 400% > 200% > 800%. The basal fertilization + top dressing 3 times at 400% treatment exhibited the longest plant height (106.7 cm) and the most branches (6). In terms of seed quality, this treatment also had the highest proportion (66.9%) of seeds with a diameter over 6.7 mm. Additionally, in yield components such as pods, seeds per pod, and 100-seed weight, the basal fertilization + top dressing 3 times at 400% treatment showed the highest values, resulting in a maximum yield of 374 kg·10a-1, representing a 23.4% increase compared to the control. Therefore, for the optimal production of high-quality soybeans, it is recommended to apply the treatment of basal fertilization + top dressing 3 times at 400% concentration, with top dressing occurring at 30-day intervals before harvest.

Characteristics and Changes in Scientific Empathy during Students' Productive Disciplinary Engagement in Science (학생들의 생산적 과학 참여에서 발현되는 과학공감의 특성과 변화 분석)

  • Heesun, Yang;Seong-Joo, Kang
    • Journal of The Korean Association For Science Education
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    • v.44 no.1
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    • pp.11-27
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    • 2024
  • This study aimed to investigate the role of scientific empathy in influencing students' productive disciplinary engagement in scientific activities and analyze the key factors of scientific empathy that manifest during this process. Twelve fifth-grade students were divided into three subgroups based on their general empathic abilities. Lessons promoting productive disciplinary engagement, integrating design thinking processes, were conducted. Subgroup discourse analysis during idea generation and prototype stages, two of five problem-solving steps, enabled observation of scientific empathy and practice aspects. The results showed that applying scientific empathy effectively through design thinking facilitated students' productive disciplinary engagement in science. In the idea generation stage, we observed an initial increase followed by a decrease in scientific empathy and practice utterances, while during the prototyping stage, utterance frequency increased, particularly in the later part. However, subgroups with lower empathic abilities displayed decreased discourse frequency in scientific empathy and practice during the prototype stage due to a lack of collaborative communication. Across all empathic ability levels, the students articulated all five key factors of scientific empathy through their utterances in situations involving productive science engagement. In the high empathic ability subgroup, empathic understanding and concern were emphasized, whereas in the low empathic ability subgroup, sensitivity, scientific imagination, and situational interest, factors of empathizing with the research object, were prominent. These results indicate that experiences of scientific empathy with research objects, beyond general empathetic abilities, serve as a distinct and crucial factor in stimulating diverse participation and sustaining students' productive engagement in scientific activities during science classes. By suggesting the potential multidimensional impact of scientific empathy on productive disciplinary engagement, this study contributes to discussions on the theoretical structure and stability of scientific empathy in science education.

Transplanting Date and Planting Density Affect the Growth Characteristics and Seed Yield of Italian Ryegrass (이앙 시기와 재식 밀도에 따른 이탈리안 라이그라스의 생육 및 종실 수량 특성 평가)

  • Yun-Ho Lee;Jeong-Won Kim;Hyeok-Jin Bak;Hyun-Ki Kim;Hyeon-Soo Jang;Dea-Yuk Kim;Jong-Tak Yoon
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.68 no.4
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    • pp.438-444
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    • 2023
  • Italian ryegrass (Lolium multiflorum Lam.; IRG) sowing season is delayed due to the autumn rainy season. Therefore, to address this problem, transplanting date and plant density were investigated. Transplant times investigated were October 20th, October 30th, and November 10th and planting densities were 50, 70, and 80 hills per 3.3 m2. The plant height, leaf area index, and plant coverage rate were high in the following order: October 20th, October 30th, and November 10th. There was no significant difference among planting densities. In addition, the number of tillers and dry weight before and after wintering were high on October 20th. In terms of yield components, the number of tillers, dry weight, and seed yield per unit area were higher with the transplanting date of October 20th than with transplanting on November 10th. There was no difference in seed yield between the planting densities of 80 and 70 hills per 3.3 m2. However, seed yield was low at 50 hills per 3.3 m2. In conclusion, the transplanting time for stable seed production is late October, and optimal plant density is 70 and 80 hills per 3.3 m2. A stable interplanting number before wintering will contribute to the seed yield.

Agricultural and Sprouts Characteristics of Mung Bean (Vigna radiata L.) Cultivated in Southern Areas According to Sowing Dates (파종시기에 따른 남부지역 재배 녹두의 생육 및 나물특성 변화)

  • Ji Ho Chu;Byeong Won Lee;Yeong Kwang Ju;Ju Seong Im;Seok Bo Song;Myeong Eun Choi;Ji Young Kim;Sang Ik Han
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.68 no.4
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    • pp.327-334
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    • 2023
  • The cultivation period of mung beans (Vigna radiata L.) in Korea has undergone recent variations. However, limited research has been conducted on pod shattering and sprout characteristics of mung beans on different sowing dates. This study aims to compare pod shattering and sprouts productivity based on different sowing dates. The research was was conducted with six different sowing dates (early May, mid-May, early June, mid-June, early July, and mid-July) in 2021 and 2022. Delayed sowing dates resulted in shortened days to germination, flowering time, and maturity time, whereas plant height, branch number, and node number increased. In addition, stem thickness and the number of pods per plant decreased. In the mung bean cultivar 'Sanpo', the pod shattering rate ranged from 10.0% to 19.3%, consistently lower than that of 'Dahyun' across all six sowing dates. The sowing date associated with the lowest shattering rate was early June. 'Sanpo' sown in early July and 'Dahyun' sown in mid-May exhibited the highest sprout production, at 871% and 750%, respectively.

A Study on Effect of Psychological Capital on Turnover Intention & Mediating Effect of Organizational Commitment: Focusing on Construction Industry Workers (심리적 자본이 이직의도에 미치는 영향과 조직몰입의 매개효과에 대한 연구 : 건설업 종사자를 중심으로)

  • Lee, Su-jin
    • Journal of Venture Innovation
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    • v.7 no.1
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    • pp.151-166
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    • 2024
  • The global economic growth rate has been slowed due to changes in the economic and social environment related to the recent trends in the construction market and construction industry, prolonged inflation, intense tensions among countries, and increased interest rates. Since the workers in the construction industry, due to the nature of the industry, move to another site after the completion of an awarded project rather than staying for a long time while performing work at one workplace, various issues are brought out such as poor working environment resulting from unfairness in construction contracts, aging of workers, their anxiety, and job instability. The previous studies on the turnover intention of construction industry workers mainly dealt with external aspects such as leadership, job embeddedness, and organizational citizenship behavior, while the psychological impact was overlooked. The purpose of this study was to develop a measure to reduce or alleviate turnover intention of construction industry workers by verifying empirically the relationship among psychological capital, organizational commitment, and turnover intention among them. For the purpose, whether psychological capital influences organizational commitment and turnover intention, the impact of organizational commitment on turnover intention, and whether organizational commitment has a mediating effect in the relationship between psychological capital and turnover intention, among 310 construction industry workers in the metropolitan area. The results are as follows: First, hope and self-efficacy were found to have a negative (-) effect on turnover intention, while resilience and optimism from psychological capital did not have a significant effect. Second, hope, resilience, and optimism from psychological capital were found to have a positive (+) effect on organizational commitment, while self-efficacy from psychological capital had no significant effect. Third, organizational commitment was found to have a significant mediating effect on the relationship between hope from psychological capital and turnover intention. The results of this study showed that, in construction industry workers, psychological capital affects turnover intention through the mediating effect of organizational commitment. While previous studies mainly considered external influences on the turnover intention of construction industry workers, this study has academic implications in that it sought to strengthen organizational commitment and alleviate turnover intention by approaching psychological aspects. As a practical implication, it was found that higher self-efficacy and hope for work in the organization, from psychological capital, in the construction industry workers were found to lower turnover intention through job performance in a psychologically stable state. It is considered, therefore, that various systems, including job autonomy and flexible work, should be established to improve self-efficacy and hope.

Identifying Distribution Areas and Population Sizes for the Conservation of the Endangered Species Odontobutis obscura (멸종위기종 남방동사리의 보전을 위한 상세 분포 지역 및 개체군 크기 파악)

  • Jeong-Hui Kim;Sang-Hyeon Park;Seung-Ho Baek;Chung-Yeol Baek
    • Korean Journal of Ecology and Environment
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    • v.57 no.2
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    • pp.102-110
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    • 2024
  • This study presents a fine scale distribution of the endangered species, Odontobutis obscura, through field surveys and literature reviews. Using the mark-recapture method, the population size in major habitats was determined. Field surveys conducted on 18 streams in Geoje Island revealed that the O. obscura was only found in the main streams and tributaries of the Sanyang, Gucheon, and Buchun Streams, which are part of the Sanyang Stream watershed. The O. obscura exhibited relative abundances ranging from 0.5% to 35.3% at different locations, with certain spots showing higher relative abundances (18.8% to 35.3%), indicating major habitat areas. A review of six literature studies confirmed the presence of the O. obscura, although there were differences in occurrence status depending on the purpose, scope, and duration of the studies. Combining the results of field and literature surveys, it was found that the O. obscura inhabits the main and tributary streams of the Sanyang, Gucheon, and Buchun Streams, from the upper to lower reaches. Currently, the O. obscura population in the Sanyang Stream watershed maintains a stable habitat, but its limited distribution range suggests potential issues such as genetic diversity deficiency in the long term. The population size of the O. obscura was confirmed at two specific locations, with densities of 0.5 to 1.5 individuals per m2. The average movement distance from the release point was 13.1 m, indicating the limited mobility characteristic of ambush predators. Understanding the distribution and population size of endangered species is the first step towards their conservation and protection. Based on this information, further research could significantly contribute to the conservation of the O. obscura.

Change in the Fish Fauna and Fish Community Characteristics in the Upper Reaches of the Seomgang (River), Korea (섬강 상류의 어류상 변화 및 어류군집 특성)

  • Hyeong-Su Kim;Mee-Sook Han;Myeong-Hun Ko
    • Korean Journal of Environment and Ecology
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    • v.38 no.3
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    • pp.246-262
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    • 2024
  • The survey conducted from 2018 to 2020 aimed to investigate the changes in fish fauna and community characteristics in the upper reaches of the Seomgang River, Korea. During the survey period, 35 sites were selected, resulting in the collection of 7,817 fish belonging to 12 families and 40 species. The dominant species was Zacco koreanus, with a relative abundance of 34.5%, followed by Z. platypus at 28.7%. Other significant species included Rhynchocypris oxycephalus (10.2%), Pungtungia herzi (5.3%), and Squalidus gracilis majimae (4.3%). Notably, four protected species - Acheilognathus signifer, Gobiobotia brevibarba, and Cottus koreanus, designated as class II endangered wildlife by the Ministry of Environment- were identified. These species predominantly inhabit the middle and lower reaches, except for Gobiobotia brevibarba, which is found in the upper reaches. Nineteen species, accounting for a 47.5% endemism rate, were endemic to Korea. The study also noted the presence of one climate-sensitive species, Cottus koreanus, and two exotic species, Carassius cuvieri and Micropterus salmoides. Community analysis indicated a trend of decreasing dominance and increasing diversity and richness from upstream to downstream, with a distinct division into uppermost reaches, upper reaches, middle and lower reaches, and lakes. The construction of the Hwaseong Dam has had a significant direct and indirect impact on the fish community. The habitat and abundance of endangered species such as R. pseudosericeus, A. signifer, and G. brevibarba decreased dramatically immediately after the dam's construction, transforming the submerged area from lotic to lentic environments. Approximately 20 years later, the habitats have stabilized, leading to an increase in the fish population and a recovery of the previously diminished endangered species. The river health (FAI) was also evaluated, with 27 sites rated as very good (A), seven as good (B), and one as fair (C). However, endangered species such as A. signifer continue to face threats from dam and river construction, while C. Koreanus has experienced a severe population decline due to river works. Additionally, the presence of the ecosystem-disrupting species M. salmoides in Hwaseong Lake raises concerns. To ensure a stable habitat for fish in the upper reaches of the Seomgang River, it is crucial to avoid indiscriminate river construction, urgently implement restoration policies for endangered species such as A. signifer, and develop management strategies to control the spread of invasive species such as bass.