• Journal of Food Hygiene and Safety
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• v.35 no.4
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• pp.326-333
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• 2020

In this work, we developed an analytical method for determining 11 illicit compounds in dietary supplements using high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry. Eleven target compounds, including those meant for weight loss (7-keto-dihydroepiandrosterone, buformin, metformin, phenformin, salbutamol, and tolbutamide), sexual enhancement (dihydroepiandrosterone), and relaxation (asarone, kavain, magnoflorine, and picamilon) were screened and confirmed in dietary supplements. Method validation was performed by evaluating the selectivity, linearity, limit of quantification (LOQ), accuracy, and precision according to the Association of Official Analytical Chemists guidelines. The linearity was > 0.993 for all analytes. The LOQs were ranged in 2.1-9.9 ㎍/mL (HPLC-DAD) and 0.002-0.008 ㎍/mL (LC-MS/MS). The accuracies (expressed as recovery) were 90.0-106% (HPLC-DAD) and 83.0-114% (LC-MS/MS). The precision (expressed as the relative standard deviation) was below 10% using HPLC and LC-MS/MS. The proposed method can be used for the surveillance of illicit compounds in dietary supplements.

• Journal of the Society of Disaster Information
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• v.15 no.4
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• pp.617-625
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• 2019

Purpose: The fields manuals which is managed by the each disaster types are the integrated guideline. When the disaster occurred, all kinds of SOPs which are described in the manual does not need. Therefore, the person in charge is confused which SOP is executed. In this study, we propose the disaster response process model based on the specific disaster situation case. Method: Firstly, we define the disaster situation cases which is mentioned in the field manual, and then, we develop the disaster response process model including indispensible SOPs for the specific disaster situation case. As a verification and feedback process, we apply the model to Safety Korea Exercise scenario. Result: We developed SOP model and disaster response process model reflecting the concept of the disaster situation case. Conclusion: Safety Kore Exercise scenario reflecting the developed model may continuously upgrade the field manual.

• Korean Journal of Environmental Agriculture
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• v.32 no.1
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• pp.70-77
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• 2013

BACKGROUND: Nitroxoline is an antibiotic agent. It is used for the treatment of the second bacterial infection by the colibacillosis, salmonellosis and viral disease of the poultry. When the nitroxoline is indiscreetly used, the problem about the abuse of the antibiotics can occur. Therefore, this study presented the residue analytical method of nitroxoline in food for the safety management of animal farming products. METHODS AND RESULTS: A simple, sensitive and specific method for nitroxoline in chicken muscle by high performance liquid chromatograph with PDA was developed. Sample extraction with acetonitrile, purification with SPE cartridge (MCX) were applied, then quantitation by HPLC with C18 column under the gradient condition with 0.1 % tetrabutylammonium hydroxide-phosphoric acid and methanol was performed. Standard calibration curve presented linearity with the correlation coefficient ($r^2$) > 0.999, analysed from 0.02 to 0.5 mg/L concentration. Limit of quantitation in chicken muscle showed 0.02 mg/kg, and average recoveries ranged from 72.9 to 88.1 % in chicken muscle. The repeatability of measurements expressed as coefficient of variation (CV %) was less than 12 % in 0.02 and 0.04 mg/kg. CONCLUSION(S): Newly developed method for nitroxoline in chicken muscle was applicable to food inspection with the acceptable level of sensitivity, repeatability and reproducibility.

• Analytical Science and Technology
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• v.36 no.6
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• pp.291-299
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• 2023

The benzo[a]pyrene in edible oils is extracted using methods such as Liquid-liquid, soxhlet and ultrasound-assisted extraction. However these extraction methods have significant drawbacks, such as long extraction time and large amount of solvent usage. To overcome these drawbacks, this study attempted to improve the current complex benzo[a]pyrene analysis method by applying the QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) method that can be analyzed in a simple and short time. The QuEChERS method applied in this study includes extraction of benzo[a]pyrene into n-hexane saturated acetonitrile and n-hexane. After extraction and distribution using magnesium sulfate and sodium chloride, benzo[a]pyrene is analyzed by liquid chromatography with fluorescence detector (LC/FLR). As a result of method validation of the new method, the limit of detection (LOD) and quantification (LOQ) were 0.02 ㎍/kg and 0.05 ㎍/kg, respectively. The calibration curves were constructed using five levels (0.1~10 ㎍/kg) and coefficient (R²) was above 0.99. Mean recovery ratio was ranged from 74.5 to 79.3 % with a relative standard deviation (RSD) between 0.52 to 1.58 %. The accuracy and precision were 72.6~79.4 % and 0.14~7.20 %, respectively. All results satisfied the criteria ranges requested in the Food Safety Evaluation Department guidelines (2016) and AOAC official method of analysis (2023). Therefore, the analysis method presented in this study was a relatively simple pretreatment method compared to the existing analysis method, which reduced the analysis time and solvent use to 92 % and 96 %, respectively.

• Korean Chemical Engineering Research
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• v.52 no.5
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• pp.613-619
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• 2014

A flare system is a very important system that crucially affects on the process safety in chemical plants. If a flare system is designed too small, it cannot prevent catastrophic accidents of a chemical plant. On the other hand, if a flare system is designed too large, it will waste resources. Therefore, reasonable relief load estimation has been a crucial issue in the industry. American Petroleum Institute (API) suggests basic guidelines for relief load estimation, and a lot of engineering companies have developed their own relief load estimation methods that use an unbalanced heat and material method. However, these methods have to involve lots of conservative assumptions that lead to an overestimation of relief loads. In this study, the new design procedure for a flare system based on dynamic simulation was proposed in order to avoid the overestimation of relief loads. The relief load of a deethanizer process was tested to verify the performance of the proposed design procedure.

• Journal of Environmental Policy
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• v.5 no.2
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• pp.49-67
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• 2006

The radionuclides in drinking water have been regulated in many countries. In USA, the regulation has been revised for over 30 years since radionuclides have been regulated under Safe Drinking Water Act(SDWA) from 1974. Today, USEPA is finalizing maximum contaminant level goal(MCLG) of zero for radionuclides, maximum contaminant level(MCL) and alternative maximum contaminant level(AMCL) of 300pCi/L and 4,000pCi/L for radon respectively, MCLs of $30{\mu}g/L$ for uranium, and MCLs of 5pCi/L for combined radium 226 and 228. In Canada, Maximum Acceptable Concentration(MAC) value for uranium is $20{\mu}g/L$. WHO revised the guideline value of uranium and radon to $15{\mu}g/L$ and 100Bq/L in september 2004, respectively. On this survey, it has been found that international regulations for radionuclides in drinking water have been established and improved steadily on the knowledge basis from the past decades' studies.

• Journal of Korea Society of Industrial Information Systems
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• v.16 no.5
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• pp.163-171
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• 2011

In e-commerce environment, security should be considered as an essential factor for success. In this paper, we analyze security requirements for e-commerce system, and it is focused on the practical usage, not theoretical contribution, in the field of e-commerce security. To identify the security requirements being specific to e-commerce environment, the researches related to e-commerce security are surveyed and a phase of Delphi method and Analytic Hierarchy Process(AHP) are used to determine the relative importance of e-commerce security factors. Since researchers and practitioners can have significantly different views because of each different work environment, we divide the professionals into two respondents' group. This survey result can be useful security guidelines in the development of e-commerce service system from the initial system development step to the completion.

• Journal of the Korean Society for Railway
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• v.17 no.1
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• pp.52-58
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• 2014

Plastic deformation of roadbed influences the stability and maintenance of concrete slab track. Long-term plastic deformation in a railway roadbed is generated primarily due to accumulated inelastic strains caused by repeated passing of trains. Prediction of cumulative plastic deformation is important in cost-effective maintenance of railway tracks as well as for the safe operation of trains. In this study, the vertical displacements in railway roadbeds with different thicknesses of reinforced roadbed were computed. Parameters of the power model for cumulative plastic strain were calibrated by using the data from triaxial tests and full-scale loading tests. Results of three-dimensional finite element analyses of standard roadbed sections provide us with design guidelines for the selection of the thickness of reinforced roadbed.

• Journal of radiological science and technology
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• v.32 no.1
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• pp.39-43
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• 2009

The medical diagnostic examination using ionizing radiation has improved the patients' life and brought revolution in medical examination along with the mechanical development. However, the development of medical imaging systems has also been the reason to increase the patients' exposure for ionizing radiation. ICRP recommends that each country adopts diagnostic reference levels depending on regional and national situations. The Korea Food & Drug Administration suggested the dosimetry measurement guideline for patients in 2007. Nonetheless, in reality, it is hard to know the skin dose of the patients when applying a x-ray since there is no radiation dosimeter in most of clinical situation. Therefore, this study sets a program based on the bit system to figure out easily the skin dose of a patients using MS Excel program in the PC setting. The results showed 10% better outcome.

• Journal of the Korea Society of Computer and Information
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• v.25 no.7
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• pp.85-92
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• 2020

Following the development of Internet of Things (IoT) technology, the scope of application of IoT technology is expanding to industrial safety areas that detect and prevent possible risks in outdoor environments in advance, away from improving the convenience of living in indoor environments. Although this expansion of IoT service provides many advantages, it also causes security problems such as data leakage and modulation, so research on security response strategies is being actively carried out. In this paper, the IoT-based road construction risk management system in outdoor environment is proposed as a research subject. As a result of investigating the security vulnerabilities of the low-power wide-area (LPWA, BLE) communication protocol applied to the research targets, the security vulnerabilities were identified in terms of confidentiality, integrity, and availability, which are the three major elements of information security, and countermeasures for each vulnerability were proposed. This study is meaningful in investigating and analyzing possible vulnerabilities in the operation of the IoT-based risk management system and proposing practical security guidelines for each vulnerability.