• Korean Journal of Psychosomatic Medicine
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• v.15 no.2
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• pp.73-80
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• 2007

Anumber of prior studies have reported eye movement dysfunction in patients with dementia. The eye movement test which is non-invasive can evaluate the local brain function quantitatively. Therefore, it can be a useful method for characterizing regional brain abnormalities of patients with dementia. The aim of this paper is to review the literatures on eye movement abnormalities in dementia patients. Saccade system dysfunctions in Alzheimer disease include increased latency, reduced accuracy, and increased antisaccade error rates. Patients with frontotemporal dementia showed impaired reflexive saccade inhibition and increased latency and errors of antisaccade task. And delayed initiation of voluntary saccades, slow saccades, and increased errors and latency on antisaccade task were found in Huntington's disease. Patients with Parkinson’s disease dementia and dementia with Lewy bodies have characteristics of impaired in both reflexive saccade execution and complex saccade performance. However, there were few reports of abnormal eye movements in Creutzfeldt-Jakob disease; they could be found at the later stages after symptoms of dementia came to be evident, and secondary to cerebellar and vestibular involvement. Slowing of saccades and hypometric saccades might precede the supranuclear limitation of vertical gaze in PSP. Dysfunction of voluntary eyelid movements was a characteristic finding of PSP as well. In conclusion, patients with dementia can show various abnormal eye movements and they are related with cortial and subcortical brain dysfunctions. The research on localization of brain relevant to each symptom can promise more clinical implications of eye movement of dementia.

• Proceedings of the Korea Contents Association Conference
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• 2018.05a
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• pp.407-408
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• 2018

본 연구는 여성노인을 대상으로 안구운동 훈련을 적용하여 인지기능에 어떠한 영향을 미치는지 알아보고자 하였다. 대상자는 65세 이상 여성 노인 8명을 선정하였고 안구운동은 급속안구운동을 4주 동안 적용하여 사건관련 전위 중 P300을 활용하여 그 변화를 측정하였다. 그 결과 p300의 전위값은 유의하게 상승하였고, 잠복기는 유의하게 짧아졌다. 결론적으로 여성노인에게 적용한 급성안구운동은 뇌의 긍정적 변화를 나타내 인지기능 향상에 영향을 준다는 것을 알 수 있었다.

• Korean Journal of Biological Psychiatry
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• v.13 no.4
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• pp.279-288
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• 2006

Objectives : We investigated the association of SNP A and P1763 polymorphisms on dystrobrevin binding protein 1(DTNBP1) gene with smooth pursuit eye movement(SPEM) abnormality in Korean schizophrenic patients. Methods : We measured SPEM function in 217 Korean schizophrenics(male 116, female 101) and divided them into two groups, one is a good SPEM function group and the other is a poor SPEM function group. We then analyzed SNP A polymorphism and P1763 polymorphism on DTNBP1 gene from their DNAs extracted from their blood. We compared the differences of genotype and allele distributions of the two polymorphisms on DTNBP1 gene between the two groups. Results : The Ln S/N ratio(mean${\pm}$SD) of the good SPEM function group was $4.39{\pm}0.33$ and the ratio of poor SPEM function group was $3.17{\pm}0.71$. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the SNP A polymorphism and P1763 polymorphism on DTNBP1 gene between the two schizophrenic groups divided by SPEM function. Conclusion : The results suggest that SNP A polymorphism and P1763 polymorphism on DTNBP1 gene might not be related to SPEM function abnormality in schizophrenia.

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.2
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• pp.177-184
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• 2012

Purpose: In this study, the effect of the eye movement direction on visual function related to accommodation was investigated when playing computer games for a certain period of time. Methods: Total 60 subjects in 20s who had the visual acuity of 1.0 or higher without any ocular disease and accommodative dysfunction were asked to play computer games separately in horizontal and vertical directions for 40 and 90 minutes and then measured their accommodative amplitude, accommodative facility, accommodative lag and relative accommodations. Thevisual function when not doing the computer game was regarded as a control value, and further compared and analyzed. Results: The accommodative amplitude, accommodative facility, accommodative lag and relative accommodations showed the tendency of decrease after the computer game for 40 minutes, and more reduced values of the visual functions were shown when the computer game extended up to 90 minutes except positive relative accommodation. Positive relative accommodation had a tendency to increase slightly after the computer game for 90 minutes. Meanwhile, the change of the visual functions was primarily influenced by the eye movement in horizontal direction rather than by the eye movement in vertical direction during computer game when analyzed by the direction of eye movement. Conclusions: Over all accommodative functions tended to decrease with the extended VDT working time by computer game, and the frequent eye movement in horizontal direction during VDT tasks could be the main cause of eyestrain since the eye movement in horizontal direction rather than vertical direction significantly affected the change of accommodative function.

• Proceedings of the ESK Conference
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• 1995.04a
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• pp.145-154
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• 1995

복잡한 생산시스템 속에서 빠른 속도로 제품을 생산하기 위해서 도입된 신형 고성 능 기계류의 경우에는 검사 작업자가 제품의 결점을 검출하기가 매우 어렵다. 검사작 업을 위해서 충분한 시간이 주어진다면 정확하게 처리할 수 있겠지만, 실제로는 많은 제약이 있다. 이러한 관점에서 검출오류의 결과에 대한 중요성은 증가되고 있다. 본 연구에서는 검사작업의 개인차에서 비롯하는 작업자의 결점검출방법에 관하여 살펴보고자 한다. 이를 위해서, 먼저 피실험자를 대상으로 두가지 작업방법, 즉 기능적 검사(functional search)를 하는 작업자와 지형적 검사(topographic search)를 하는 작업자로 나누어 실험을 하였다. 또한 이들이 검사작업을 하는 동안 일어나는 안구운동(eye movements)의 몇가지 요인을 측정하여 시각검사작업에 영향을 미치는 안구운동요인을 파악하고자 한다.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.1
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• pp.37-43
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• 2013

Purpose: The present study was conducted to investigate whether the directions of eye movement in playing computer games for certain period affected the change of near point of convergence (NPC) and fusional reserve (FR) or not. Methods: Total 40 subjects in 20s who have the visual acuity of 1.0 or higher without any ocular disease and accommodative dysfunction were asked to successively play computer games. After the subjects were moving eyes in horizontal and vertical directions for 40 and 90 minutes, their horizontal fusional reserves, vertical fusional vergence and near point of convergence were measured. Results: The near point of convergence showed a tendency to be receded after computer gaming in the horizontal and vertical directions, and both of horizontal and vertical fusional reserves were significantly reduced. The range of declined fusional reserves and receded near point of convergence after computer gaming for 90 minutes was smaller than those after computer gaming for 40 minutes. The change of binocular vision was affected by the horizontal eye movement rather than the vertical movement when analyzed by the direction of eye movement. Conclusions: This study revealed that the change in FR and NPC was different along with dominant direction of eye movement during visual display terminal (VDT) tasks. Therefore, the adjustment of VDT working time is required to prevent the dysfunction of binocular vision according to the dominant direction of eye movement during VDT task.

• Sleep Medicine and Psychophysiology
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• v.3 no.1
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• pp.3-14
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• 1996

Eye movement dysfunction has been found in large numbers of schizophrenia patients and their first-degree relatives and can be studied without the interference of deficits in attention, motivation, clinical status and medication effects with relatively easy method. Eye movement dysfunction has been proposed as a useful way of expanding the schizophrenia phenotype in genetic studies. I review the literature on eye movement dysfunction with respect to syndrome and familial specificity and the quantitative assessment of eye tracking. I hope that the etiology and the pathophysiology of schizophrenia can be clarified through this eye movement study.

• Korean Journal of Psychosomatic Medicine
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• v.24 no.1
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• pp.102-108
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• 2016

Objectives : The deficit of recognition memory has been found as one of the common neurocognitive impairments in patients with schizophrenia. In addition, they were reported to fail to enhance the memory about emotional stimuli. Previous studies have shown that bilateral eye movements enhance the memory retrieval. Therefore, this study was conducted in order to investigate the memory enhancement of bilaterally alternating eye movements in schizophrenic patients. Methods : Twenty one patients with schizophrenia participated in this study. The participants learned faces (angry or neutral faces), and then performed a recognition memory task in relation to the faces after bilateral eye movements and central fixation. Recognition accuracy, response bias, and mean response time to hits were compared and analysed. Two-way repeated measure analysis of variance was performed for statistical analysis. Results : There was a significant effect of bilateral eye movements condition in mean response time(F=5.812, p<0.05) and response bias(F=10.366, p<0.01). Statistically significant interaction effects were not observed between eye movement condition and face emotion type. Conclusions : Irrespective of the emotional difference of facial stimuli, recognition memory processing was more enhanced after bilateral eye movements in patients with schizophrenia. Further study will be needed to investigate the underlying neural mechanism of bilateral eye movements-induced memory enhancement in patients with schizophrenia.

• Journal of Biomedical Engineering Research
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• v.22 no.6
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• pp.487-496
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• 2001

In this study, a galvanic stimulator providing bipolar mode controlled by a PIC(peripheral interface controller) was constructed to evaluate vestibular function The maximum load and maximum current intensity of the constant current source were 3$k\Omega$ and 5mA. respectively. and it could Produce DC, sine wavers. or Pulse waves. Eve movements of 20 normal subjects by galvanic stimulation were analyzed using a commercial videooculogragh. During stimulating with DC for 30 sec. we recorded the response of eye movement with current intensity of 0.75. 1 2, and 3 mA. Nystagmus occurred to all the subjects when the galvanic stimulus intensity was larger than 2 mA. Average SPV(slow Phase eye movement velocity) and the number of nystagmus increased from 7.1 to 4.8 deg/sec and from 17 to 48, respectively, when the stimulus current increased from 0.75 to 3 mA. All the fast eye movement of the nystagmus were the direction of the negative electrode. The asymmetry which means the difference between right- and left-eye movements decreased when the stimulus intensity increased. It is expected that this study would be useful in evaluating vestibular function and in studying basic Physiology mechanism of vestibular ocular reflex by galvanic stimulus .

• Journal of The Korean Association For Science Education
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• v.35 no.3
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• pp.383-393
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• 2015

This study analyzed the 6th grade elementary science textbook 'Science stories' reading process of students by utilizing eye movement tracking techniques. Participants read 3 articles in the new experimental science textbooks and solved 9 problems about each article. By understanding and academic achievement results, participants were divided into high-groups, middle-groups, and low-groups. The results of eye movement characteristics of the high-groups and low-groups had the following differences. Number of fixations and number of regressions were higher in high-groups. Average fixation duration and average regressive fixation duration were longer in low-groups. Fixation time for the key sentence of the article was longer in high-groups. Analysis of a scan path and post-interview, high-groups had frequent regression between sentences and they knew where the core of the article is and paid much attention there. In contrast low-groups are sequentially read most articles and some of them had a leap of abnormal range. Problem-solving approach is also different between groups. In conclusion reading style is associated with the science stories comprehension and students who had more regressions, much core search process, effective attention distribution, high concentration showed better understanding results. Also words or sentences used in textbooks are associated with science stories comprehension.