• Journal of Life Science
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• v.18 no.11
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• pp.1551-1560
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• 2008

Cytokines play a pivotal role in systemic inflammatory response following cardiac surgery with cardiopulmonary bypass (CPB). The purpose of this study was to investigate the perioperative changes in proinflammatory [tumor necrosis factor-$\alpha$ (TNF-$\alpha$) and interleukin-6 (IL-6)] and antiinflammatory cytokines [interleukin-10 (IL-10)], and each correlation between the cytokines and other variables in valvular heart surgery with CPB. Serum IL-6 and IL-10 levels and leukocyte counts significantly increased following CPB. CPB caused hepatic, renal and myocardial dysfunctions. IL-6 levels had positive correlations with IL-10 levels at postoperative periods. TNF-$\alpha$ levels had correlations with leukocyte counts and myocardial marker levels at postoperative 24 hr (PO-24 h). Furthermore, IL-6 or IL-10 levels had positive correlations with other variable such as hepatic, renal or myocardial marker at postoperative periods. These results showed that balance between proinflammatory and antiinflammatory cytokines is maintained during cardiac surgery with CPB, and that these cytokines exert postoperatively inflammatory and antiinflammatory reactions.

• KSBB Journal
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• v.24 no.6
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• pp.591-597
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• 2009

B-type natriuretic peptide is a neurohormone secreted in the cardiac ventricles. BNP levels are elevated in patients with ventricular dysfunction. Therefore, the concentration of BNP is important factor to reflect diagnosis and prognosis for cardiovascular disease. In this respect, anti-BNP scFv is an urgent requirement for early diagnosis in the field of biosensor. Herein, the genetic codes of anti-BNP scFv were chemically synthesized and cloned into both pET22b (+) and pColdⅣ vector, respectively. The recombinant scFv was successfully expressed as a functional form in cytoplasm of E. coli and detected through Western blot and ELISA. The highest level of functional expression of anti-BNP scFv was achieved using pET22b (+) vector at $15^{\circ}C$ by addition of 0.1 mM IPTG. Additionally, being exposed to both BNP and ANP, anti-BNP scFv specifically captured only BNP. Therefore, anti-BNP scFv expressed in this study will be applied to measure the concentration of BNP as a diagnostic recognition molecule.

• Proceedings of the KSMRM Conference
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• 2003.10a
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• pp.76-76
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• 2003

목적： fMRI와 뇌파의 동시측정 방법은 높은 시간적-공간적 해상도를 동시에 달성할 수 있는 뇌기능 측정을 가능케 하고, 각각의 방법이 제공하는 정보를 상호보완적으로 동시에 이용할 수 있도록 하는 유용한 방법이다. 그러나 자기공명영상을 얻기 위한 경사자계가 유발하는 잡음과 높은 자기장 내에서의 심장박동으로 인한 미세한 움직임 때문에 생기는 잡음이 뇌파신호의 질을 크게 저하하는 요소로 작용하여 이를 해결하기 위한 계측시스템의 최적화와 신호처리 방법의 개발이 요구된다. 본 논문에서는 평균차감법과 recursive least square 적응 필터링 방법에 기반한 심장 박동잡음의 감소를 위한 신호처리 방법의 개발 결과에 대한 연구 결과를 제시한다.

• Journal of the Korean Institute of Telematics and Electronics
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• v.26 no.2
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• pp.132-139
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• 1989

We have designed a real-time Cardiac digital substraction angiography system (C-DSA) and tested the system for the diagnosis of Cardiac patients. The system was developed by interfacing a radiographic angiography system to a computerized motional image analysis system. This new cardiac DSA can perform the real time processing of averaging and subtraction of the 32 image frames to measure the volume changes of the left ventricle after elimination of motional artrifacts, caused by the heart contraction of beats per minute in average. Each frame has a resolution of 512 x 512 pixels and 256 gray levels. Two image data with maximal and minimal volume were moved to the interfaced IBM PC computer system by high speed computer link line for computation of the heart's contraction parameters. First, the boundary of the left ventricule was detected using a dynamic programming of the gray levels, and its volume was computered to determine the parameters, such as the maximal volume of end-diastolic volume (EDV), the minimal volume of end systolic volume (ESV), and ejection fraction (EF).

• Journal of Korean Medical classics
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• v.18 no.2 s.29
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• pp.20-44
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• 2005

통과한의학화서양의학적원리연구심신적상호관계(通過韓醫學和西洋醫學的原理硏究心腎的相互關係), 득도료여하결론(得到了如下結論) 경연구심신지간재한의학상구유(經硏究心腎之間在韓醫學上具有): 심양여신음유'심신상교'적'수화기제'관계(心陽與腎陰有'心腎相交'的'水火旣濟'關係). 차외환유신양(명문화)여심양(심화)적상호의존관계(此外還有腎陽(命門火)與心陽(心火)的相互依存關係). 우유심장신여신장정적상호의존관계이지유신정충족시(又有心藏神與腎藏精的相互依存關係而只有腎精充足時), 재가이사심주신지적공능유지정상(才可以使心主神志的功能維持正常). 경연구심신지간재서양의학상구유(經硏究心腎之間在西洋醫學上具有): 제일(第一), 심장여신장재해부학상밀절연계(心臟與腎臟在解剖學上密切聯係), 즉종심장좌심실분지출신동맥(卽從心臟左心室分枝出腎動脈), 진이형성신소구등신장적혈관구화모세혈관강(進而形成腎小球等腎臟的血管球和毛細血管綱). 제이(第二), 심장향신장공응혈액(心臟向腎臟供應血液), 신장시인체중접수혈공최다적장기(腎臟是人體中接受血供最多的臟器). 제삼(第三), 심장통과심납소(ANP)적분비(的分泌), 증가신혈류양급신소체여과율(增加腎血流量及腎小體濾過率). 제사(第四), 신장통과신소(腎臟通過腎素)(renin)적분비조절혈압(的分泌調節血壓). 제오(第五), 신공능부전대심장구성부면영향(腎功能不全對心臟構成負面影響). 제육(第六), 심장여신장지간종서양의학적각도고려(心臟與腎臟之間從西洋醫學的角度考慮), 야존재착상생화상극관계(也存在着相生和相克關係). 경연구심신적상호관계재수행중적작용(經硏究心腎的相互關係在修行中的作用), 득출여하결론(得出如下結論): 제일(第一), 수행영인안정심지(修行令人安定心志), 사심화하강(使心火下降). 제이(第二), 수행시적호흡조절조폐금생신수(修行時的呼吸調節助肺金生腎水), 저시소유적수행법도재중시호흡조절적근본이유(這是所有的修行法都在重視呼吸調節的根本理由). 제삼(第三), 수행시발생수승화강(修行時發生水昇火降). 저실제상시의뢰심화중적일음효여신수중적일양효적발동내완성(這實際上是依賴心火中的一陰爻與腎水中的一陽爻的發動來完成). 제사(第四), 통과수행(通過修行), 가이달도보정적목적(可以達到保精的目的), 유차보장생명적지보(由此保藏生命的至寶). 제오(第五), 통과수행(通過修行), 가이달도연정화기(可以達到煉精化氣), 약능주도연정화기(若能做到煉精化氣), 가사인체불누설정액(可使人體不漏泄精液), 반이화기이증강인체기능(反而化氣以增强人體機能), 시보정적유효수단(是保精的有效手段). 수행적관건시'남자수성불누정(修行的關鍵是'男子修成不漏精), 여자수성온불누경(女子修成不漏經)'.

• The Korean Journal of Physiology
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• v.20 no.1
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• pp.79-88
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• 1986

In an attempt to observe the effects obtained by the regular physical training, nine soldiers performed regularly the rope-skipping for nine weeks. All subjects were healthy and did not experience any special military training Programs. During the course of the training, their cardiopulmonary functions were measured in the resting and the Post-exercise recovery periods, and the values were compared with ones of the pre-trained. The test exercises loaded to the subjects were rope-skipping and step-rising & falling. The results obtained were as follows: 1) By the training, heart rates decreased very significantly in the resting and post-exercise recovery periods. And the effects began to bring out at the early stage, about the 7th day. 2) As the duration of the training increased, the systolic blood pressures decreased meaningfully in the resting and recovery periods. 3) Only in the early recovery phase after the exercise of the rope·skipping, the respiration rates decreased significantly by the training. 4) The lighter the intensity of the test exercise loaded was, the more prominent the effect of the physical training on the cardiopulmonary functions was. The above results suggest that the 9 week training of the rope-skipping would bring about the enhancement of the cardiopulmonary functions.

• Clinical and Experimental Pediatrics
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• v.49 no.4
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• pp.417-423
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• 2006

Purpose : The objectives of this study were to assess ventricular function by tissue Doppler imaging in children who were receiving chemotherapy or who had received chemotherapy, and to apply repeated tissue Doppler imaging to make an early assessment in cardiac toxicity studies. Methods : This study was conducted on 23 oncology patients on-treatment or off-treatment from April 2005 to July 2005 at Dongsan Medical Center, Keimyung University. All patients(group 1) were divided into two groups, fractional shortening(FS) over 29 percent(group 2) and FS under 28 percent (group 3) in the first category. These same patients were also divided into the following groups : group treated with anthracyclin(group 4) and group treated without anthracyclin(group 5). Deceleration time(DT), isovolumic relaxation time(IVRT), FS, peak early diastolic(E), and peak late diastolic (A) velocity of transmitral flow were measured by M-mode and pulsed wave Doppler. Systolic(Sm), peak early diastolic(Em), and peak late diastolic(Am) velocity in apical 4-chamber and 2-chamber views were measured by tissue Doppler imaging. The author calculated a modified Tei index, E/A, E/Em ratio by using measured values. Results : Twenty three patients were enrolled : 12 boys and 11 girls. The average age of patients was 8 years and 4 months. Thirteen out of 23 patients were in the group treated with anthracyclin (group 4) and 6 had FS under 28 percent(group 3). E/Em ratio showed a significant difference between group 1 and control group($6.46{\pm}1.85$ vs $7.06{\pm}1.64$, P<0.05). Other parameters had no difference statistically. Conclusion : This study showed that the change of cardiac function developed earlier in diastolic function than in systolic function, as E/Em ratio reflecting the mean LV diastolic pressure showed a significant difference between the control group and chemotherapy groups. Echocardiography using tissue Doppler imaging is a non-invasive, comfortable and reliable method for post-chemotherapy follow up.

• Journal of Chest Surgery
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• v.31 no.4
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• pp.398-401
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• 1998

A 56-year-old female with a permanent unipolar pacing(VVI) system underwent elective coronary bypass surgery and mitral valve replacement. Because the unipolar sensing is subject to considerable nonmyocardial electrical noise, the pacing function may be disturbed by the use of electrocautery. Temporary atrial and ventricular bipolar epicardial leads and external generator were used for maintaining A-V sequential pacing during the use of electrocautery. Before aortic cross-clamp was released after cardiac operation, regular cardiac rhythm could spontaneously be resumed with an integrated cardioplegic strategy, avoiding the use of defibrillator

• Proceedings of the Korean Information Science Society Conference
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• 2002.04a
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• pp.739-741
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• 2002

좌심실의 파라미터는 심장의 기능을 분석하기 위해 측정되는 정량적인 표현으로, 특히 지역적 파라미터인 두께와 두께의 변화는 심판 기능을 분석하기에 적합한 파라미터이다. 본 연구에서는 이러한 좌심실의 지역적 파라미터를 측정하고, 이를 위해 사용되는 삼자원적 방법을 개선하여 구현함으로써 기존의 폭정 방법의 제약을 극복하고자 하였다. 또한, 측정 결과를 가시화하여 직관적인 분석이 가능하도록 하고, 이를 시스템에 구축하여 임상에서 직접적으로 활용할 수 있도록 하였다.

• Bulletin of Food Technology
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• v.12 no.2
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• pp.3-9
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• 1999

최근 의학의 진보에 따라 체격이나 평균수명은 향상되었으나 다수의 사람들이 특별한 질병의 상태가 아니면서 건강하지도 않은 반쪽 건강 상태에 있으며, 암, 동맥경화, 심장질환, 고혈압, 당뇨병, 간질환 및 만성 위장병의 증가가 문제시 되고 있다. 이들 질병의 예방이 식생활과 밀접한 관련이 있다는 사실이 알려지면서 식품의 영양소와 기호성 이외에 기능성, 건강지향성을 재인식하게 되었으며, 건강한 식생활이 건강관리의 한 방법으로 자리를 차지하게 되었다. 따라서 올바른 식품과 영양에 대한 지식이 일상의 식생활에 적극적으로 반영되면서 많은 사람들이 식원병을 예방하고 건강을 유지할 수 있을 것이다. 본 보고에서는 양과 질의 측면에서 영양학적으로 우수한 특성을 갖거나 민간전승적으로 건강에 좋으며, 식품의 과학적 효과가 입증된 대표적인 농산물의 종류와 활용에 대하여 살펴보았다.