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http://dx.doi.org/10.5352/JLS.2008.18.11.1551

Analysis of the Correlations between the Serum Levels of Cytokines and Postoperative Outcomes in Valvular Heart Surgery with Cardiopulmonary Bypass  

Moon, Seong-Min (Department of Biomedical Laboratory of Science, College of Smart Foods and Drugs, Inje University)
Ki, Chong-Rak (Department of Biomedical Laboratory of Science, College of Smart Foods and Drugs, Inje University)
Kim, Yun-Tae (Seoul Medical Science Institute (SMSI))
Choi, Seok-Cheol (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan)
Publication Information
Journal of Life Science / v.18, no.11, 2008 , pp. 1551-1560 More about this Journal
Abstract
Cytokines play a pivotal role in systemic inflammatory response following cardiac surgery with cardiopulmonary bypass (CPB). The purpose of this study was to investigate the perioperative changes in proinflammatory [tumor necrosis factor-$\alpha$ (TNF-$\alpha$) and interleukin-6 (IL-6)] and antiinflammatory cytokines [interleukin-10 (IL-10)], and each correlation between the cytokines and other variables in valvular heart surgery with CPB. Serum IL-6 and IL-10 levels and leukocyte counts significantly increased following CPB. CPB caused hepatic, renal and myocardial dysfunctions. IL-6 levels had positive correlations with IL-10 levels at postoperative periods. TNF-$\alpha$ levels had correlations with leukocyte counts and myocardial marker levels at postoperative 24 hr (PO-24 h). Furthermore, IL-6 or IL-10 levels had positive correlations with other variable such as hepatic, renal or myocardial marker at postoperative periods. These results showed that balance between proinflammatory and antiinflammatory cytokines is maintained during cardiac surgery with CPB, and that these cytokines exert postoperatively inflammatory and antiinflammatory reactions.
Keywords
Cardiac surgery; cardiopulmonary bypass; cytokine; inflammatory response;
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1 Steinberg, B. M., E. A. Grossi and D. S. Schwarz. 1995. Heparin bonding of bypass circuits reduces cytokine release during cardiopulmonary bypass. Ann. Thorac. Surg. 60, 525-529.   DOI   ScienceOn
2 Schurr, U. P., G. Zund, S. P. Hoerstrup, J. Grunenfelder, F. E. Maly, P. R. Vogt and M. I. Turina. 2001. Preoperative administration of steroids: Influence on adhesion molecules and cytokine after cardiopulmonary bypass. Ann. Thorac. Surg. 72, 1316-1320.   DOI   ScienceOn
3 Shottelius, A., M. W. Mayo, R. B. Sartor and A. S. Baldwin. 1999. Interleukin-10 signaling blocks inhibitor of kB kinase activity and nuclear factor kB DNA binding. J. Biol. Chem. 274, 31868-31874.   DOI
4 Van der Poll, T., J. Jansen, M. Levi and S. J. H. Van Deventer. 1994. Regulation of interleukin 10 release by tumor necrosis factor in humans and chimpanzees. J. Exp. Med. 180, 1985-1988.   DOI   ScienceOn
5 Strieter, R. M., S. L. Kunkel and R. C. Bone. 1993. Role of tumor necrosis factor-$\alpha$ in disease states and inflammation. Crit. Care. Med. 21(Suppl), S447-463.   DOI   ScienceOn
6 Stordeur, P. and M. Goldman. 1998. Interleukin-10 as a regulatory cytokine induced by cellular stress: molecular aspects. Int. Rev. Immunol. 16, 501-522.   DOI   ScienceOn
7 Buttler, J., G. M. Rocker and S. Westaby. 1993. Inflammatory response to cardiopulmonary bypass. Ann. Thorac. Surg. 55, 553-559.
8 Cain, B. S., D. R. Meldrum, and C. A. Dinarello. 1999. Tumor necrosis factor-alpha and interleukin-1 beta synergistically depress human myocardial function. Crit. Care. Med. 27, 1309-1318.   DOI   ScienceOn
9 Cremer, J., A. Haverich and H. G. 1996. Borst HG. Systemic inflammatory response after cardiac operations. Ann. Thorac. Surg. 61, 1714-1720.   DOI   ScienceOn
10 Grunenfelder, J., G. Zund and A. Schoeberlein. 2000. Modified ultrafiltration lowers adhesion molecule and cytokine levels after cardiopulmonary bypass without clinical relevance in adults. Eur. J. Cardiothorac. Surg. 17, 77-83.   DOI   ScienceOn
11 Krakauer, T. 1995. IL-10 inhibits the adhesion of leukocyte cells to IL-1-activated human endothelial cells. Immuno. Lett. 45, 61-65.   DOI   ScienceOn
12 Zhang, Y., J. X. Lin, Y. K. Yip and J. Vilcek. 1989. Stimulation of interleukin-6 mRNA levels by tumor necrosis factor and interleukin-1. Ann. NY. Acad. Sci. 557, 548-549.
13 Vary, T., S. Hazens, G. Maish and R. Cooney. 1998. TNF binding protein prevents hyperlactaemia and inactivation of PDH complex in skeletal muscle during sepsis. J. Surg. Res. 80, 44-51.   DOI   ScienceOn
14 Vassalli, P. 1992. The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol. 10, 411-452.   DOI   ScienceOn
15 Kukiella, G. L., C. W. Smith and A. M. Manning. 1995. Induction of interleukin-6 synthesis in myocardium: potential role in postperfusion inflammatory injury. Circulation 92, 1866-1875.   DOI   ScienceOn
16 Levy, J. H. and K. A. Tanaka. 2003. Inflammatory response to cardiopulmonary bypass. Ann. Thorac. Surg. 75, S715-S720.   DOI   ScienceOn
17 Moore, K. W., A. Gorra, R. Waal Malefylt, P. Viera and T. R. Mosmann. 1993. Interleukin-10. Annu. Rev. Immunol. 11, 168-190.
18 Park, K. H., S. C. Choi, I. Y. Han, K. L. Choi, K. J. Choi and K. H. Cho. 2000. Relationship between interleukin-6 production and inflammatory response during cardiopulmonary bypass. Korean Thorac. Cardiovasc. Surg. 33, 407-418.
19 Ostrowski, K., C. Hermann, A. Bangash., P. Schjerling, J. N. Nielsen, and B. K. Pedersen. 1998. A trauma-like elevation of plasma cytokines in humans in response to treadmill running. J. Physiol. 513, 889-894.   DOI   ScienceOn
20 Ostrowski, K., T. Rohde, S. Asp, P, Schjerling and B. K. Pedersen. 1999. Pro-and anti-inflammatory cytokine balance in strenuous exercise in humans. J. Physiol. 515, 287-291.   DOI   ScienceOn
21 Ostrowski, K., Y. Rohde, M. Zacho, S. Asp and B. K. Pedersen. 1998. Evidence that interleukin-6 in produced in human skeletal muscle during prolonged running. J. Physiol. 508, 949-953.   DOI   ScienceOn
22 Opal, S. M. and V. A. De Palo. 2000. Anti-inflammatory cytokines. Chest 117, 1162-1172.   DOI   ScienceOn
23 Steinberg, J. B., D. P. Kapelanski, J. D. Olson and J. M. Weiler. 1993. Cytokine and complement levels in patients undergoing cardiopulmonary bypass. J. Thorac. Cardiovasc. Surg. 106, 1008-1016.
24 Gu, Y. J., W. Van Oeveren, C. Akkerman, P. W. Boonstra, R. J. Huyzen and C. R. H. Wildevuur. 1993. Heparin-coated circuits reduce the inflammatory response to cardiopulmonary bypass. Ann. Thorac. Surg. 55, 917-922.   DOI   ScienceOn
25 Hauser, G. J., J. Ben-Ari and M. P. Colvin. 1998. Interleukin-6 levels in serum and lung lavage fluid of children undergoing open heart surgery correlated with postoperative morbidity. Intensive Care Med. 24, 481-486.   DOI   ScienceOn
26 Finkel, M. S., C. V. Oddis, T. D. Jacob, S. C. Watkins, B. G. Hattler and R. L. 1992. Simmons. Negative inotropic effects cytokines on the heart mediated by nitric oxide. Science 257, 387-389.   DOI
27 Yang, Z., B. Zingarelli and C. Szabo. 2000. Crucial role of endogenous interleukin-10 production in myocardial ischemia/reperfusion injury. Circulation 101, 1019-1026.   DOI   ScienceOn
28 Hovels-Gurich, H., K. Schumacher, J. F. Vazquez-Jimenez, M. Qing, U. Huffneier, B. Buding, B. J. Messmer, G. V. Bernuth and M. C. Seghaye. 2002. Cytokine balance infants undergoing cardiac operation. Ann. Thorac. Surg. 73, 601-609.   DOI   ScienceOn
29 Bogdan, C., Y. Vodovotz and C. Nathan 1991. Macrophage deactivation by IL-10. J. Exp. Med. 174, 1549-1555.   DOI   ScienceOn
30 Hill, G. E., A. Alonso, J. R. Spurzem, A. H. Stammers and R. A. Robbins. 1995. Aprotinin and methylprednisolone equally blunt cardiopulmonary bypass-induced inflammation in humans. J. Thorac. Cardiovasc. Surg. 110, 1658-1662.   DOI   ScienceOn
31 Hong, N. K., D. H. Lee, T. C. Jung, J. C., Lee and S. S. Han. 2000. Changes of IL-10 level in patients undergoing cardiopulmonary bypass. Korean Thorac. Cardiovasc. Surg. 33, 648-654.
32 Jeong, H. Y. Molecular biology of cytokine. 2002. pp. 73-85, World Science Press. Seoul, Korea.
33 Luster, A. D. 1998. Chemokines-chemotactic cytokines that mediate inflammation. New Eng. J. Med. 338, 457-470.