• The Science & Technology
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• no.5 s.408
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• pp.6-7
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• 2003

뇌, 다른 사람 감정 모방/ '중세가 오늘날 보다 훨씬 더웠다'/ 진통제, 파킨슨병 치료 효과/ 고릴라 · 침팬지, 수십년 내 멸종위기/ 심장병 막으려면 HDL 높여야/ 보톡스, 소아마비 근육이완 효과/ 이집트서 세계 最古 미이라 발견

• Pediatric Infection and Vaccine
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• v.23 no.3
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• pp.209-216
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• 2016

Purpose: This study aimed to evaluate and compare the characteristics of infective endocarditis (IE) between children and adults with congenital heart disease (CHD) at a single tertiary care center. Methods: In this retrospective medical record review, we extracted the demographic characteristics, diagnostic variables, and outcomes of patients diagnosed with IE and CHD between 2000 and 2016. Results: We identified a total of 14 pediatric patients (nine male; median age at diagnosis, 3 years). Of the 14 patients, six had a history of previous open heart surgery, while four had undergone tetralogy of Fallot repair, with transannular patch or Rastelli procedure. Among the 10 children with positive blood cultures, the most common isolated organism was Staphylococcus spp. (8/10, 80%). Eleven adult patients had IE and CHD. Among the adult patients, only four were diagnosed with CHD before IE, and ventricular septal defect was the most common CHD. The most common isolated organism was Streptococcus spp. (6/11, 55%). Compared with adult patients, pediatric patients had a higher incidence of previously diagnosed CHD (P=0.001), with Staphylococcus spp. as the causative organism (P=0.027). The median duration between the onset of symptoms and diagnosis of IE was 9 days in children and 42 days in adults (P=0.012). Conclusions: Significant differences with regard to the diagnosis and progress of IE were observed between children and adults. Age-adjusted and systematic reassessment may be necessary for the diagnosis and management of IE.

• The Monthly Diabetes
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• s.238
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• pp.14-17
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• 2009

당뇨병환자들이 당뇨 자체보다 당뇨로 인한 합병증으로 목숨을 잃는다는 것은 잘 알려진 사실이며 이 중 가장 큰 사인은 관상동맥질환이다. 당뇨병환자는 같은 나이의 일반인에 비해 심근경색증을 포함한 관상동맥질환이 3$\sim$5배 정도 더 발생하는 것으로 알려져 있다. 그러나 당뇨병환자들의 심장병 가운데는 무증상인데다 검사로도 잘 나타나지 않는 사례가 적지 않기 때문에 관상동맥질환에 대한 정확한 이해와 치료, 그리고 예방이 무엇보다 중요하다고 하겠다.

• Proceedings of the Korean Information Science Society Conference
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• 2010.06c
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• pp.205-210
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• 2010

심장질환은 암 다음으로 높은 사망 원인으로 초기 진단은 치료에 매우 중요한 문제로 대두 되고 있다. 심장병을 분석하기 위해서는 임상 데이터에 대해 자세히 알고 분석 하는 것이 중요하다. 본 논문에서는 심장 질환 데이터를 효율적으로 분석하기 위해 배깅 알고리즘을 사용하여 중요 검사 항목을 추출해내고 분석하는 방법을 제안한다. 데이터를 분석하는 과정에 있어서 분류자들을 생성하고 앙상블 하는 과정에 효과적인 결과를 얻기 위해서 다양한 알고리즘들을 결합해야 구성해야한다. 앙상블을 이용하여 가장 좋은 의 분류 효과를 얻기 위해서는 수천가지의 분류자들을 훈련시켜 성능이 좋은 앙상블을 구성한다.

• Clinical and Experimental Pediatrics
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• v.53 no.4
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• pp.532-537
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• 2010

Purpose : Early postoperative arrhythmias are a major cause of mortality and morbidity after open heart surgery in the pediatric population. We evaluated the incidence and risk factors of early postoperative arrhythmias after surgery of congenital heart disease. Methods : From January 2002 to December 2008, we retrospectively reviewed the medical records of the 561 patients who underwent cardiac surgery in Kyungpook National University Hospital. We analyzed patients' age and weight, occurrence and type of arrhythmia, cardiopulmonary bypass (CPB) time, aortic cross clamp (ACC) time, and postoperative electrolyte levels. Results : Arrhythmias occurred in 42 of 578 (7.3%) cases of the pediatric cardiac surgery. The most common types of arrhythmia were junctional ectopic tachycardia (JET) and accelerated idioventricular rhythm (AIVR), which occurred in 17 and 13 cases, respectively. The arterial switch operation (ASO) of transposition of the great arteries (TGA) had the highest incidence of arrhythmia (36.4%). Most cases of cardiac arrhythmia showed good response to management. Patients with early postoperative arrhythmias had significantly lower body weight, younger age, and prolonged CPB and ACC times ($P$<0.05) than patients without arrhythmia. Although the mean duration of ventilator care and intensive care unit stay were significantly longer ($P$<0.05), the mortality rate was not significantly different among the 2 groups. Conclusion : Early postoperative arrhythmias are a major complication after pediatric cardiac surgery; however, aggressive and immediate management can reduce mortality and morbidity.

• Clinical and Experimental Pediatrics
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• v.53 no.1
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• pp.93-96
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• 2010

A 47-year-old male patient in whom atrial septal defect (ASD) had been diagnosed 15 years previously was admitted for cardiac catheterization. He had definite cyanotic lips and nail beds and severe pulmonary arterial hypertension (PAH). He had received medical treatment only for the last few years after being diagnosed with Eisenmenger syndrome. After cardiac catheterization, he received iloprost inhalation therapy pre and postoperation and was discharged after successful surgical closure of the ASD.

• Clinical and Experimental Pediatrics
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• v.50 no.3
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• pp.298-301
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• 2007

Chylothorax is a rare complication following cardiac surgery for congenital heart diseases. Although conservative management is successful in the majority of cases, surgical intervention is required in a refractory one. Recently, subcutaneous or intravenous infusion of octreotide has been used as a safe treatment that helps avoiding surgical intervention. Herein, we report two cases of postoperative chylothorax treated with parenteral octreotide and conservative therapy.

• The Monthly Diabetes
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• s.257
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• pp.54-55
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• 2011

미 의회에서 '미국 상원 영양문제 특별위원회'를 구성하여 2년 동안 미국 사람의 건강과 식사 관계를 조사한 뒤, "모든 성인병은 식사의 잘못에서 비롯된다"라고 결론을 내렸다. 보고서의 내용에 따르면 서구식 식사법을 탈피하면 당뇨병은 50%, 심장병은 25%, 암은 20%의 발생률을 줄일 수 있다고 한다. 그런데 사람들은 병에 걸리면 병원에서 치료하려고만 하지 병의 발생 원인을 고치려고 하지 않는다. 식이요법은 자연치유요법 가운데 가장 확실한 방법이다. 그 중 생식은 성인병 치료에 도움이 되는데 당뇨병, 고지혈증, 고혈압, 위장병 등은 생식 3개월이면 효과를 볼 수 있다. 또, 음식물이 지니는 고유성분을 파괴하지 않고 체내로 공급하기 때문에 식사의 균형을 잡아주는 건강 지킴이 식품으로 바쁜 현대인에게 적합한 식사방법이라 할 수 있다.

• Clinical and Experimental Pediatrics
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• v.46 no.2
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• pp.167-172
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• 2003

Purpose : Pulmonary vascular hypertension is a common problem in congenital heart disease, the most common cardiac condition in childhood. However, the mechanisms responsible for this pathologic change, treatment, and prevention are poorly understood. Therefore, we studied the gene expression of vascular endothelial growth factor(VEGF) by using a hypoxic model of the pulmonary artery smooth muscle cells. Methods : The main pulmonary artery and its proximal branches of a 6 wk old Fischer rat were excised. They were cut into multiple small pieces and suspended in DMEM medium supplemented with 20% fetal bovine serum and incubated in 5% $CO_2$-95% air atmosphere. The smooth muscle cells were confirmed by immunostaining with smooth muscle myosin and ${\alpha}$-smooth muscle actin antibodies. The VEGF gene expression in the hypoxic group was compared with the one in control the group as well as the one in the starved group by RT-PCR and Northern blot hybridization. Results : There was no statistically significant difference among the control, hypoxic and starved groups. Conclusion : There are few studies of pulmonary vascular hypertension at the molecular level in Korea. Therefore, we studied the expression of VEGF gene in hypoxic pulmonary vascular smooth muscle cells. Further studies will be needed to find the difference between newly born and adult rats, or human and rat pulmonary vascular smooth muscle cells in gene expression. We hope that the study will lead to a better understanding of pulmonary vascular hypertension.

• Journal of Chest Surgery
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• v.29 no.12
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• pp.1316-1322
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• 1996

From May 1977 to December 1994, 1.060 cases of open heart surge y for congenital heart disease were performed under cardiopulmonary bypass in Chonnam University Hospital They were divided into two groups; group A(677 cases, from May 1977 lo December 1989), group B(38B cases, from January 1990 to December 1994), to be compared and analized. Of the 1, 060 cases, there were 889 acyanotic (83.9%) and 171 cyanotic(16.1%). The operative mortality was 7.8% in group A and 5.7% in group B (total : 6.6%). The operative mortality for group A was 25% in cyanotic disease and 3.7% in acyanotic disease, respectively in group B, it was 23.8%, 3.2%. There were 19 patients (3.8%) and 78 patients(20.4%) with body weight under 10kg in group A and group B respectively. The operative mortality for these patients were 31.6% in A group and 16.1% in B group. In result, increasing trend in congenital heart disease in patients under 10 kg of body weight has been noted, whereas mortality has decreased. The operative mortality of tetralogy of Fallot has decreased in group B t an group A. These results suggest that the operative result have improved in recent years.