• Journal of the Institute of Convergence Signal Processing
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• v.12 no.4
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• pp.341-347
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• 2011

This paper presents the performance evaluation. optimal design. and complex obstacle detection of an overlapped ultrasonic sensor ring by introducing a new concept of effective beam width. It is assumed that a set of ultrasonic sensors of the same type are arranged along a circle of nonzero radius at regular spacings with their beams overlapped. First, the global positional uncertainty of an overlapped ultrasonic sensor ring is expressed by the average value of local positional uncertainty over the entire obstacle detection range. The effective beam width of an overlapped ultrasonic sensor ring is assessed as the beam width of a single ultrasonic sensor having the same amount of global positional uncertainty, from which a normalized obstacle detection performance index is defined. Second. using the defined index, the design parameters of an overlapped ultrasonic sensor ring are optimized for minimal positional uncertainty in obstacle detection. For a given number of ultrasonic sensors, the optimal radius of an overlapped ultrasonic sensor ring is determined, and for a given radius of an overlapped ultrasonic sensor ring, the optimal number of ultrasonic sensors is determined. Third, the decision rules of positional uncertainty zone for multiple obstacle detection are provided based on the inequality relationships among obstacle distances by three adjacent ultrasonic sensors. Using the provided rules, the obstacle outline detection is performed in a rather complex environment consisting of several obstacles of different shapes.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.26 no.3
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• pp.270-280
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• 2016

This paper investigates the evolution of EM admittance of piezoelectric transducers mounted on a notched beam from wave propagation perspective. A finite element analysis is adopted to obtain numerical solutions for Lamb waves reverberating on the notched beam. The mode-converted Lamb wave signals due to a notch are extracted by using the polarization characteristics of piezoelectric transducers collocated on the beam. Then, a series of temporal spectrums are computed to demonstrate the evolution of EM admittance through fast Fourier transform of the mode-converted Lamb wave signals which are consecutively truncated in the time domain. When truncation time is relatively small, the corresponding temporal spectrum is governed by the characteristics of the input driving frequency. As truncation time becomes large, however, the modal characteristics of the notched beam play a crucial role in the temporal spectrum within the input driving frequency band. This implies that mode-converted Lamb waves reverberating on the beam contributes to the resonance of the beam. The root mean square values are computed for the temporal spectrums in the vicinity of each resonance frequency. The root mean square values increase monotonically with respect to truncation time for any resonance frequencies. Finally the implications of the numerical observation are discussed in the context of damage detection of a beam.

• Journal of Life Science
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• v.23 no.3
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• pp.462-469
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• 2013

Withaferin A is a steroidal lactone purified from the Indian medicinal plant Withania somnifera. It exhibits a wide variety of activities, including anti-tumor, anti-inflammation, and immunomodulation properties. In this review, we focused on the anti-cancer effects of withaferin A. Withaferin A inhibits cell proliferation, metastasis, invasion, and angiogenesis in cancer cells. Furthermore, it sensitized irradiation, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-, and doxorubicin-mediated apoptosis. The results showed that multiple mechanisms were involved in withaferin A-mediated anti-cancer effects. First, withaferin A increased intracellular reactive oxygen species (ROS) production and induced ER stress- and mitochondria-mediated apoptosis. Second, withaferin A inhibited the signaling pathways (Jak/STAT, Akt, Notch, and c-Met), which are important in cell survival, proliferation, and metastasis. Third, it induced apoptosis and inhibited cancer cell migration through the up-regulation of prostate apoptosis protein-4 (Par-4). Finally, withaferin A up-regulated pro-apoptotic protein expression levels through the inhibition of proteasome activity. Our findings suggested that withaferin A is a potential, potent therapeutic agent.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.1
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• pp.73-79
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• 2018

The primary cilium protrudes from the cell body like a bio-antenna that has many receptors, channels and signaling molecules to sense and response to external stimuli. The external environment such as ultraviolet irradiation, temperature, humidity, gravity and shear stress always influences skin. Skin responds to external stimuli and differentiates by making melanin, collagen and horny layer. Ciliogenesis participates in developmental processes of skin, such as keratinocyte differentiation and hair formation. And it was reported that skin pigmentation was inhibited when ciliogenesis was induced by sonic hedgehog-smoothened-GLI2 signaling. When skin is exposed to ultraviolet irradiation, alpha-melanocyte stimulating hormones (${\alpha}$-MSH) increase melanin synthesis through activation of the cAMP pathway in melanocytes. We observed that ${\alpha}$-MSH and cAMP production inducers inhibited ciliogenesis of melanocytes. Therefore, we thought that regulation of ciliogenesis is potential candidate target for the development of agents to treat undesirable hyperpigmentation of skin. As a result, we found out that an ethanol extract of Glycyrrhiza glabra (EGG) root and 3,4,5-trimethoxy cinnamate thymol ester (TCTE, Melasolv) significantly inhibit melanin synthesis of normal human melanocyte by inducing primary cilium formation. This study proposed new theory to regulate skin pigmentation and cosmetic components for skin whitening.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.44 no.5
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• pp.45-53
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• 2007

To recover transmitted signal perfectly at DTV receiver, we have to acquire carrier frequency synchronization to compensate pilot signal which located in wrong position and rotated phase. Also, we need a symbol timing synchronization to compensate sampling timing error. Conventionally, to synchronize symbol timing, we use Gardner's scheme which used in multi-level signal. Gardner's scheme is well known for its sampling the timing error signal from every symbol and it makes easy to detect and keep timing sync in multi-path channel. In this paper, to discuss the problem when the received power level is out of range and we cannot get synchronization information. With this problem, we use 2 step procedures. First, we put a received signal power compensation block before Garder's timing error detector. Second, adaptive loop filter to get a fast synchronization information and averaging loop filter's output value to reduce the amount of jitter after synchronization in PLL(Phased Locked Loop) circuit which is used to get a carrier frequency synchronization and symbol timing synchronization. Using the averaging value, we can estimate offset. Based on offset changing ratio, we can adapt adaptive loop filter to carrier frequency and symbol timing synchronization circuit.

• Journal of the Korean Institute of Intelligent Systems
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• v.18 no.6
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• pp.754-761
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• 2008

As the automobile industry and technologies are developed, driver's tend to more concern about service matters than mechanical matters. For this reason, interests about recognition of human knowledge and emotion to make safe and convenient driving environment for driver are increasing more and more. recognition of human knowledge and emotion are emotion engineering technology which has been studied since the late 1980s to provide people with human-friendly services. Emotion engineering technology analyzes people's emotion through their faces, voices and gestures, so if we use this technology for automobile, we can supply drivels with various kinds of service for each driver's situation and help them drive safely. Furthermore, we can prevent accidents which are caused by careless driving or dozing off while driving by recognizing driver's gestures. the purpose of this paper is to develop a system which can recognize states of driver's emotion and attention for safe driving. First of all, we detect a signals of driver's emotion by using bio-motion signals, sleepiness and attention, and then we build several types of databases. by analyzing this databases, we find some special features about drivers' emotion, sleepiness and attention, and fuse the results through Multi-Modal method so that it is possible to develop the system.

• Korean Journal of Cleft Lip And Palate
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• v.10 no.1
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• pp.1-16
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• 2007

이차구개는 발생과정에서 구개선반의 형성과 성장, 거상과 융합의 과정을 통해 형성된다. 이와 같은 이차구개의 형성과정은 미세한 분자유전학적 신호전달기전에 의해 조절되는 것으로 알려져 있어서, 신호전달과정에 관여하는 유전인자의 발현이상이 되면 정상적인 이차구개가 형성되지 못하고 구개파열이라는 선천성 기형이 발생된다. 구개파열의 유발인자들에 대한 많은 연구에도 불구하고 현재까지 정상적인 이차구개의 형성을 조절하는 분자유전학적 기전에 대해서는 명확히 알려져 있지 않다. 따라서 본 연구에서는 이차구개의 형태분화를 조절하는 분자유전학적 기전을 알아보고자, 이차구개 형성의 내적 조절인자 중 핵심유전자로 알려져 있는 Osr2가 결손된 생쥐의 이차구개 형성과정에서 정상생쥐에 비해 발현의 변동이 나타나는 유전자를 확인하였다. 유전자 발현의 변동은 발생 14.5일(E14.5)의 구개선반으로부터 추출한 total RNA를 이용하여 ACP-based GeneFishing PCR을 시행하여 확인하였고, 각각의 변동된 유전자를 동정하여 정상생쥐의 이차구개 형성과정에서의 발현양상을 in situ hybridization을 시행하여 확인하였다. 총 120쌍의 primer를 이용한 검색을 통해서 정상생쥐의 구개선반에 비해 mutant에서 발현이 변동된 유전자는 7개가 검출되었고, 이들은 모두 정상생쥐에 비해 mutant에서 발현이 증가되는 것으로 확인되었다. 검출된 유전자는 vimentin(Vim), ${\beta}$-tropomyosin 2(Tpm2), thioredoxin-like 5(Txnl5), procollagen type II alpha 1(Col2a1), Insulin-like growth factor binding protein 7(IGFbp7), Sui 1 homologs(Sui 1), Defender against cell death1(Dad1)이었다. 검출된 유전자를 동정하여 정상생쥐의 구개 형성과정에서의 발현양상을 알아본 결과, Col2a1 을 제외한 유전자들은 모두 E13.5의 구개선반에서 특이적으로 발현되고 있었으나 구개선반이 융합된 E15.5에서는 Vim, Txnl5 그리고 Dad1 만이 봉합선을 따라 발현이 지속되고 있었다. 이상의 결과로 보아 검출된 유전자들은 구개선반의 형태분화과정에서 발현되어 이차구개의 형성과정에 관여할 것으로 여겨진다. 또한 이들은 이차구개 형성의 내적조절인자인 Osr2의 downstream target 으로 구개선반의 성장과 융합과정에 직접적으로 관여하는 유전물질일 것으로 추정된다.

• Journal of KIISE:Information Networking
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• v.30 no.1
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• pp.24-29
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• 2003

In this paper, a new method for the mixed image separation is presented using the independent component analysis, the innovation process, and the expectation-maximization. In general, the independent component analysis (ICA) is one of the widely used statistical signal processing schemes, which represents the information from observations as a set of random variables in the from of linear combinations of another statistically independent component variables. In various useful applications, ICA provides a more meaningful representation of the data than the principal component analysis through the transformation of the data to be quasi-orthogonal to each other. which can be utilized in linear projection.. However, it has been known that ICA does not establish good performance in source separation by itself. Thus, in order to overcome this limitation, there have been many techniques that are designed to reinforce the good properties of ICA, which improves the mixed image separation. Unfortunately, the innovation process still needs to be studied since it yields inconsistent innovation process that is attached to the ICA, the expectation and maximization process is added. The results presented in this paper show that the proposed improves the image separation as presented in experiments.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.3
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• pp.588-594
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• 2015

Although GPS technology for location positioning system has been widely used, it is difficult to be used in intelligent transport systems, due to the large positioning error and limited area for receiving radio signals. Thanks to the rapid development of LED technology, LED lights become popular in many applications. Especially, visible light communications (VLC) has raised a lot of interests because of the simultaneous functioning of LED illumination and communication. Recent studies on positioning system using VLC mainly focused on indoor environments and still difficult to satisfy positioning accuracy and simple implementation simultaneously. In this paper, we propose a positioning system based on VLC using the coordinate information of LEDs installed on the road infrastructure. Extracting the LED signal, obtained through VLC, from the easily accessible camera image, it is possible to estimate the position of the car on the road. Simulation results show that the proposed scheme can achieve a high positioning accuracy of 1 m when large number of pixels is utilized and the distance from the LED light is close.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.2C
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• pp.132-140
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• 2007

In this paper, we proposed a new technique to encode and decode the digital hologram. Since the digital hologram (or fringe pattern) is generated by interference of light, it has much different property from natural 2D (2 dimensional) images. First, we acquisite optical-sensed or computer-generated hologram by digital type, and then extract a chrominance component. The extracted digital hologram for coding is separated into segments to use multi-view properties. The segmented hologram shows the similar characteristics with picturing an object with 2D cameras in various point of view. Since fringe pattern is visually observed like as noise, we expect that the fringe pattern has poor coding efficiency. To obtain high efficiency, the segment is transformed with DCT (Discrete Cosine Transform) which resembles hologram generation process with high performance. Each transformed segment passes the 3D scanning process according to time and spatial correlation, and is organized into a video stream. Since the segment which correspond to frame of a video stream consists of the transformed coefficients with wide range of value, it is classified and re-normalized. Finally it is compressed with coding tools. The proposed algorithm illustrated that it has better properties for reconstruction of 16 times higher compression rate than the previous researches.