• Clinical and Experimental Pediatrics
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• 제51권3호
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• pp.293-298
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• 2008

목 적 : 스테로이드 저항성 신증후군에서 cyclosporine의 반응 효과, 반응 시기, 부작용 및 다른 치료제에 대한 반응을 비교 분석하고자 하였다. 방 법 : 1989년 6월부터 2006년 8월까지 서울아산병원 소아과를 방문한 신증후군 환아 중 초기에 스테로이드 치료에 반응하지 않아 신장 조직 검사 시행 후 cyclosporine을 사용한 22명을 대상으로 cyclosporine의 반응 효과, 반응 시기, 부작용 및 다른 치료제에 대한 반응을 후향적으로 조사하였다. 결 과 : 총 22명중 미세변화형은 12명(54.5%), 국소 분절 사구체 경화증 8명(36.4%), 메산지움 증식 사구체 신염 1명(4.5%), 막성 사구체 신염 1명(4.5%) 이었다. 진단 당시의 평균 연령은 $5.2{\pm}3.3$세이었으며 남녀 비는 1.2:1 이었다. 22명중 15명(68.2%)에서 cyclosporine에 반응하였는데, 이중 미세변화형이었던 환아는 11명(91.7%), 국소 분절 사구체경화증이었던 환아는 3명(37.5%)(미세변화형 vs 국소 분절 사구체경화증, P<0.05), 그리고 막성 사구체 신염 1명이었다. 관해 시기는 cyclosporine 사용 후 $31.5{\pm}15.2$일이었다. Cyclosporine에 반응을 보인 15명 중 4명은 약물 사용 없이 관해 상태이고, 7명은 cyclosporine 사용 중이며, 2명은 cyclosporine 중단 후 스테로이드를 간헐적으로 사용하고 있고, 2명은 cyclosporine과 스테로이드를 함께 투여하고 있다. 이들의 cyclosporine 사용 기간은 각각 $546.5{\pm}346.2$일, $1,392.9{\pm}439.7$일, $439.5{\pm}84.1$일, $433.5{\pm}74.2$일이었다. Cyclosporine 사용 기간 중 혈청 크레아티닌의 변화는 없었으나 신장조직검사를 시행한 8 명중 2 명에서 간질의 섬유화와 세뇨관의 위축이 부분적으로 관찰되었다. 결 론 : 스테로이드 저항성 신증후군에 있어 cyclosporine의 반응은 비교적 좋은 편이고, 특히 미세변화 신증후군에서 그 효과가 높다. 그러나 관해를 유지하기 위해서는 장기간 사용하여야 하는 문제점이 있다.

• Childhood Kidney Diseases
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• 제8권2호
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• pp.250-255
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• 2004

월슨병은 구리 대사 이상으로 간, 뇌, 각막, 신 및 건혈구에 구리가 침착되어 생기는 상염색체 열성 유전성 질환이다. D-penicillamine이 주된 치료로서 10% 정도의 환자에서 가역적인 부작용이 발생 할 수 있다 저자는 3세된 여아에서 D-penicillamine치료 3주만에 미세변화형 신증후군이 발생하였고 투약 중단만으로 완전 관해된 증례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Child Health Nursing Research
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• 제3권1호
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• pp.30-41
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• 1997

This is descripitive study conducted to identify educational needs of mothers of nephrotic syndrome patients. The study subjects were composed of 74 mothers of nephrotic syndrome patients whose children were hospitalized in 2 Pediatric wards of University Hospital in Seoul and 1 in Pusan from June to september in 1996. A questionaire for this study was item Kikert type 5 point scale, developed on the basis of previous literature and researcher's clinical experience and the reliability of the used instruments was α=.97. t-test, and ANOVA were used to determine the effect of general characteristics of subjects on their educational needs. Pearson correlation was done to measure relations between general characterictics of subjects and their educational needs and Stepwise Multiple Regression was done to test a variable affecting educational needs. The results were as follows. 1. Mean score of the educational needs of the subjects was 137.06(Maximum 176) . The educational needs of home care was the highest score, but the question numbers are smaller than other categories. So, the educational need of the diagnosis and treatment was regarded as the highest in contents. 2. The number of subject's children, except for patient revealed significant negative correlation to educational need. 3. The number of subject's children, except for patient(R²=.215289 P=.0006)and the age of patient (R²=.23770 P=.0001) were emerged as important variables affecting the degree of mothers' educational need. Suggestion are as follows on the basis of these results. 1. It is proposed that nurses use these results of the study activly for the educational program for Nephrotic Syndrome patients and their mothers. 2. It is identified that the educational needs of the mothers of nephrotic syndrom is high. So, it is suggested to identify and analysis the degree of the nurse's educational performance perceived by mother. 3. It is suggested to make a comparative study of the degree of nurse's understanding of the importance on educational items with the instruments of this study.

• 대한간호학회지
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• 제22권4호
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• pp.604-619
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• 1992

This study was designed to investigate the problems facecl by adolescents who have nephrotic syndrome and who have struggled with their disease over a long time. Information obtained from this study can be utilized as basic data in planning nursing care for these adolescents. The subjects in this study were 13 adolescents who were being treated in the pediatric OPD of one general hospital in Seoul. The treatment period ranged from 2 to 15 years. The tool for this study was constructed after asking patients with nephrotic syndrome about their problems using anunstructured questionalire. Problem items which were observed during nursing cared in the pediatric unit. were also inclucled. Ten problem items were constructed on the basis of Moonlcy's problem check list and two additional items related to diet and physical activity were added to the list. The results of this study can be summerized as follows : adolescents with Nephrotic Syndrome. 1) have a vague knowledge about their illness and have distorted concepts. 2) feel social isolation within their peer group because of their changed appearance, limited physical activity and special diet regimen. 3) have problesm in heterosexual relationship because of short height in boys and changes in body propotions in girls. 4) think that their personality has changed due to illness. In most cases(8) changes were in a negative direct ion but in two cases they were positive. 5) have problems with scholastic achievement due to physical weakness and school absence. 6) who are in late adolescentce are more realistic and plan for their future taking into consideration their prognosis much more so than do patients who are in early adolescence. 7) have problems in their peer relationships. 8) have limitation their enjoy ment of leisure time. 9) have some conflict with their siblings. 10) think religion is significant and it has and influence on their life.

• 대한간호학회지
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• 제27권2호
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• pp.303-314
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• 1997

This is descripitive study conducted to identify educational needs of mothers of nephrotic syndrome patients and tie degree of nerses' educational performances perceived by mothers who look after mainly nephrotic syndrome patients. The study subjects were composed of 74 mothers of nephrotic syndrome patients whose children were hospitalized in 2 Pediatric wards of University Hospital in Seoul and 1 in Pen from June in 1996 to Januaryin 1997. A questionaire for this study was item Kikert type 5 point scale, developed on the basis of previous literature and researcher's clinical experience and the reliability of the used instruments was α=.97. The data analysis was done by SAS. t-test, and ANOVA were done to determine the effect of general characteristics of subjects on their educational needs. Pearson correlation was done to measure relations between general characterictics of subjects and their educational needs and Stepwise Multiple Regression was done to test a variable affecting educational needs. The results were as follows. 1. Mean score of educational needs of subjects was 137.06(Maximum 176). The score of the educational needs of home care was the highes, but the question numbers(of that category) are smaller than others. So, the educational need of the diagnosis art treatment was regarded as the highest in contents. 2. The mean score of nurses' educational performances was very low, 74.91(Maximum 176). Nurse's educational performances score in the diagnosis and treatment of the disease ranked as the highest Burt that score in the care during hoapitalization was the highest in contents as the educational needs was. 3. The number of children excepting the patient (r²=.215289. p=.006) and the age of patient(r²=.23770, p=.001) were emerged as important variables affecting the degree of mother's educational need.

• Child Health Nursing Research
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• 제3권2호
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• pp.169-177
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• 1997

This is descripitive study conducted to identify educational needs of mothers of nephrotic syndrome patients and the degree of the importance of educational activity perceived by nurses who look after nephrotic syndrome patients. The study subjects were composed of 60 mothers & 63 nurses of nephrotic syndrome patients whose children were hospitalized in 2 Pediatric wards of University Hospital in Seoul and 1 in Pusan from Mar. in 1997 to July 1997. A questionaire for this study was item Kikert type 5 point scale, developed on the basis of previous literature and researcher's clinical experience and the reliability of the used instruments was α=.97. The data analysis was done by SAS. t-test, and ANOVA were done to determine the effect of general characteristics of subjects on their educational needs. T-test was done to measure relations between the degree of educational needs and importance of educational activity. The results were as follows. 1. The Educational needs of mothers ranked as the highest in home care. 2. In character of mothers, the degree of education, economic state, the number of child and occupation was significant in statistically. 3. The importance of educational activity of nurses ranked the highest in diagnosis and treatment of the disease. 4. The educational needs of nephrotic syn. children' mother and importance of nurses were different in diagnosis and treatment of the disease and home care. On the basis of these results, we suggest as follows. 1. It is proposed that nurses use these results of the study actively for the educational program for Nephrotic Syndrome patients and their mothers. 2. It is suggested to make a comparative study of the degree of nurses' understanding of the importance on educational items with the instruments of this study.

• 대한예방의학회:학술대회논문집
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• 대한예방의학회 2002년도 제54차 추계 학술대회 연제집
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• pp.343-344
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• 2002

• Clinical and Experimental Pediatrics
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• 제45권7호
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• pp.891-895
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• 2002

목 적 : 터너 증후군에서 신기형은 보고자에 따라 차이가 있으나 대개 33-60%의 발생빈도를 나타낸다. 국내에서는 노 등이 9.2%의 동반율을 보고하면서, 한국 소아 터너 증후군 환자에서 신기형의 동반율이 다른 외국에 비해 낮을 가능성을 제시하였다. 이에 저자 들은 본 연구를 통하여 터너 증후군 환자에서 신기형의 발생빈도를 조사하고, 핵형에 따라 신기형의 발생 빈도에 차이가 있는지를 분석하였다. 방 법: 1995년 1월부터 인제의대 부산백병원과 영남대학교병원에서 염색체 검사를 시행하여 터너 증후군으로 진단된 33명의 환자를 대상으로 하였다. 환자 전원을 대상으로 경정맥 신우 조영술을 실시하였으며, 일부 환자에서는 복부 초음파 검사 및 99mTc-DMSA 신주사(renal scan)를 함께 시행하였다. 환자들은 핵형에 따라 전형적인 45, X형, 모자이시즘(mosaicism)인 경우 그리고 X 염색체의 구조상의 이상(structural aberration)이 있는 경우로 분류하였다. 결 과 : 염색체 핵형의 비율은 전형적인 45, X형이 18명으로 54.5%를 차지하였고, 모자이시즘이 11명으로 33.3% 그리고 X 염색체의 구조상의 이상이 있는 경우가 4명으로 12.2%를 차지하였다. 33명의 터너 증후군 환자 중 12명에서 신기형이 동반되어 전체적으로 36.4%의 빈도를 나타내었다. 동반된 신기형의 종류를 살펴보면 마제신이 4명에서 관찰되었으며, 단일신이 1명, 회전이상이 1명, renal collecting system의 이상이 6명에서 관찰되었다. 핵형에 따른 신기형의 빈도를 살펴보면 전형적인 45, X형의 경우 44.4%로 모자이시즘과 X 염색체 구조적 이상의 26.7%보다 발생 빈도가 높았으나 통계적으로 유의하지는 않았다(P>0.05). 결 론: 본 연구에서 터너 증후군 환자에서의 신장 기형의 동반율은 36.4%였다. 이는 외국의 다른 연구 결과와 비슷한 발생빈도를 보여 준다. 핵형에 따른 신 기형의 빈도는 전형적인 45, X형의 경우 44.4%였으며, 모자이시즘과 X 염색체 구조상의 이상인 경우 26.7%로 나타났다. 그러므로 터너 증후군 환자에서 신장 초음파 검사나 경정맥 신우 조영술 검사를 시행하여 신장 기형의 동반 여부를 조사하는 것이 환자의 질적인 관리에 매우 중요하다고 생각한다.

• 농촌의학ㆍ지역보건
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• 제35권1호
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• pp.36-45
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• 2010

대사증후군으로 확진된 65세 이상 농촌지역 노인의 2년 후 대사증후군 위험인자와 건강생활습관행태의 변화를 보고자 2006년 7월 1일부터 8월31일까지 J군 보건소에서 건강검진을 받았던 134명 중에서 대사증후군에 해당된 65명을 선정하여 이 가운데 2년 후 재방문한 62명의 노인을 최종분석 대상으로 하였다. 본 연구 결과 2006년 대사증후군 62명이 2008년에는 53명으로 감소되어 대사증후군 유병률은 전체적으로 14.5%가 감소하였다. 2년 동안 대상자의 대사증후군 변화 양상을 보면 1차 조사 시 비정상 기준치에서 2차 조사 시 정상으로 변화된 대상자는 허리둘레 8.1%, 수축기혈압 6.5%, 공복혈당 4.8%, 총콜레스테롤 3.2%, 이완기혈압 1.5%순이었다. 이에 반해 2년 전 정상 기준치이었으나 2년 후 비정상 기준치를 보인 대상자는 공복혈당6.4%, 허리둘레 4.8%, 총콜레스테롤 1.6% 순이었다. 교육수준($X^2$=12.691, p=.002), 흡연($X^2$=9.074, p=.001), 운동습관($X^2$=8.880, p=.012), 과거병력($X^2$=7.669, p=.010)에 따라 대사증후군의 차이가 있는 것으로 나타났다. 따라서 대사증후군 예방을 위해서는 향후 교육수준이 낮은 그룹의 행동위험인자를 규명할 것을 제안하며, 대상자의 학력수준별 맞춤식 교육 및 상담이 필요할 것으로 판단된다. 또한 흡연군, 비운동군, 과거병력이 있는 군에게 집중적으로 대사증후군 예방을 위한 정기검진을 강화하고, 스스로 관심을 갖도록 교육과 개별상담이 필요할 것으로 여겨진다.

• Tuberculosis and Respiratory Diseases
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• 제46권4호
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• pp.574-579
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• 1999

저자들은 신증후군에 동반된 거대세포바이러스 폐렴 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.