• Proceedings of the Korean Society of Computer Information Conference
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• 2011.06a
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• pp.261-264
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• 2011

이 연구에서는 프로젝트 기반 초등수학교육에서 학업성취도와 수학적 태도에 대한 학습양식의 효과를 분석하였다. 이 연구는 프로젝트 기반 초등수학교육이 어떤 양식의 학습자에게 학업성취도와 수학적 태도 신장에 더 효과적인지 검증하여, 학습자 중심교육 환경 설계에 시사점을 제공하는데 목적이 있다. 104명의 초등학생을 대상으로 Kolb의 자기보고식 검사지를 사용하여 분산자, 융합자, 수렴자, 적응자 학습양식으로 분류하고, 4주간 12차시에 걸쳐 프로젝트 기반 수학교육을 실시하였다. 연구결과, 학습양식이 학업성취도와 수학적 태도 향상에 효과를 나타내었다. 프로젝트 기반 초등수학교육은 수렴자 학습양식의 학업성취도 향상에 효과적인 것으로 판단되었다. 또한, 수학적 태도의 세부요인에서는 수렴자 학습양식의 자신감, 목적의식 신장과 융합자 학습양식의 흥미신장에 효과적인 것으로 판단되었다.

• Proceedings of the Korea Information Processing Society Conference
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• 2008.11a
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• pp.1166-1169
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• 2008

이 논문에서는 정보 영재의 사고력 신장을 위한 교수-학습 프로그램으로 트리 구성과 트리 탐색에 기반을 둔 모형을 제시하고 분석한다. 제시된 교수-학습 모형은 문제를 표현하는 트리의 유형에 따라 세 가지 유형으로 구분되며, 각 모형은 다시 네 가지 단계의 학습 단계로 구성된다. 구성되는 트리의 모형에 따라 적용되는 알고리즘에는 recursion, heuristic, minimax 탐색 방법 등이 도입되어 적용된다. 이 모델은 저 수준의 사고력을 요구하는 간단한 모형에서 출발하여 고 수준의 사고력을 요구하는 복잡한 모형으로 발전시키는 교육 방법을 제시함으로써 사고력 신장의 정도에 따라 초등학교 학생들로부터 중학교, 고등학교 학생들에 이르기 까지 대상을 확대하여 점진적으로 적용할 수 있는 교육 방법이 될 수 있을 것으로 사료된다. 이 교육 프로그램 모형을 실제 교육 현장에서 적용하여 교수-학습 프로그램 유형별로 학습 단계간의 적용 결과를 비교 분석한다.

• Proceedings of the Korea Information Processing Society Conference
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• 2008.11a
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• pp.1162-1165
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• 2008

이 논문은 정보영재 교육 중에서 프로그래밍을 위한 사고력 신장에 적합한 교육 프로그램 모형을 개발하고 이의 구현을 위하여 실제적인 예를 보여 교육 프로그램의 타당성과 유효성을 검증하였다. 이 논문은 트리와 트리 탐색을 이용한 사고력 신장 교육 프로그램으로 4단계로 구성되는 교육 프로그램을 제안하였으며, 구성되는 트리의 유형과 탐색 방법에 따라 세 가지 모형으로 세분화된다. 이 모델을 통하여 학생들은 문제를 트리로 표현하는 방법을 학습하게 되며, 트리로 구성된 문제를 해결하기 위하여 각각의 트리 모형에 따른 적절한 트리 탐색 방법을 통하여 문제를 해결하는 방법을 배우게 된다. 이 교육 프로그램 모형을 실제 교육 현장에서 적용하여 각 모형별로 그 결과를 비교 분석한다.

• The Korean Journal of Medicine
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• v.99 no.2
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• pp.61-68
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• 2024

Chronic Kidney Disease (CKD) is a major global health burden. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have demonstrated potential in slowing CKD progression. We evaluated the expanding role of SGLT2 inhibitors, emphasizing their renoprotective benefits in diabetic and non-diabetic CKD patients. We also investigated the underlying mechanisms, including the reduction of glomerular hypertension via modulation of tubuloglomerular feedback. Our study critically analyzed current indications for SGLT2 inhibitor therapy based on recent clinical trial data. To optimize patient outcomes, we present a comprehensive analysis of practical considerations for the prescription of SGLT2 inhibitors, including the potential initial decline in the estimated glomerular filtration rate and a review of adverse events.

• Childhood Kidney Diseases
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• v.2 no.1
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• pp.77-81
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• 1998

The author exprienced a case of glycogen storage disease type Ia(GSD-I) in an 18-year-old male patient who was admitted to our hospital due to proteinuria and hypertension. he was suspected to have GSD when 12 years old because of his family history of short stature and hepatomegaly. On admission, physical examination revealed short stature, heparomegaly, and The diagnosis of GSD-I was confirmed by compatible liver biopsy finding and enzyme assay which erealeddeficiency of glcose-6-phosphatase if hepatocyte. Sympromatic treatment was done using antihypertensive drugs and allopurinol with diet control. The authors report a case of glycogen storage disease type Ia completely confirmed by typical clinical manifestation, pathologic findings of the liver and the kidney, and the result of enzyme assay which revealed deficiency of glucose-6-phosphatase in hepatocytes with brief review fo related literatures.

• Journal of the korean academy of Pediatric Dentistry
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• v.37 no.2
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• pp.193-201
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• 2010

Early childhood caries (ECC) is a comprehensive terminology that includes nursing bottle caries and rampant dental caries occurred in infants and children. In previous studies, ECC was thought to affect body growth of children negatively. The purpose of this study was to evaluate the effect of ECC on body growth of children in respect of their chronologic age and degree of dental caries. Height and body weight were used as means for physical growth measurements. Children, who visited the pediatric department of Yonsei University Dental Hospital, received oral and physical examinations, and they were divided into the control and ECC groups. Then, each group was subdivided according to their age and gender. Two-sample T test was used to compare the mean height and body weight of the control and ECC groups, and Likelihood Ratio Chi-square test was used to compare their growth percentile distribution. When the mean height and weight were compared, there was a common tendency observed even though statistical significance was not found in all cases. Before the age of 3-4, the mean height and weight tended to be greater in the ECC groups compared to the control groups, whereas after the age of 3-4, the mean height and weight of the ECC group tended to be less compared to the control group. In addition, in groups with age equal or greater than 3-4, which presented significant difference in height and body weight, the percentage of children showing less than 3 percentile growth was greater in the ECC group than the control group. These results imply the negative effects of the ECC on physical growth of the infants and children, and its effects on physical growth may present different characteristics according to chronologic age of the patients.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.30 no.4
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• pp.471-480
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• 1985

Recently several synthetic chemicals inhibiting biosynthesis of gibberellic acids were found to be effective in preventing cereal crops from lodging by reducing culm length. The present study aimed to clarify the extent of practical manipulation of the culm length of the rice crop by changing the endogenous level of gibberellic acids with exogenous application of GA$_3$ or GA biosynthesis inhibitor. Three rice cultivars, 'Jinheung', 'Minehikari' (Japonica) and 'Hangangchal' (semi-dwarf Indica x Japonica) were treated with GA$_3$ (0, 20, 50 and 100 ppm solution) and an anti-gibberellin, paclobutrazol (0, 100, 200 and 300 g ai/ha) at three growth stages (maximum tillering, panicle initiation and meiotic stage), respectively. The application of GA$_3$ (50, 100 ppm) at maximum tillering stage and panicle initiation stage promoted the elongation of the 5th internodes from the top and GA$_3$ applied at meiotic stage promoted remarkably the elongation of the 3rd internodes. Culm was most elongated when GA$_3$ was applied at maximum tillering stage in 'Jinheung', at panicle initiation stage in 'Minehikari' and at meiotic stage in 'Hangangchal'. Paclobutrazol shortened the 4th and 5th internodes from the top when it was applied at maximum tillering stage and panicle initiation stage and the 2nd and 3rd internodes when it was applied at meiotic stage in the three cultivars. The semi-dwarf Indica x Japonica variety responded to a greater extent to the GA$_3$ and to a less extent to the anti-gib berellin than the Japonica varieties. The effect of GA$_3$ and paclobutrazol on the panicle length and the number of spikelets per panicle varied with time and dose of their application as well as with variety.

• Childhood Kidney Diseases
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• v.4 no.1
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• pp.63-68
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• 2000

Purpose: MCDK is regarded as a common cause of abdominal masses in children. And the presentation of the MCDK is usually a unilateral flank mass in the a newborn. Bialteral disease results in either fetal demise or necessity fer renal replacement therapy at birth. This study is designed to assess the clinical features and natural history of the unilateral multicystic dysplastic kidney. Patients and Methods: From January 1987 to January 2000 data were obtained retrospectively on 57 patients (28 boys and 29 girls, age ranged 1day-11years) who had a diagnosis of multicystic dysplastic kidney. The diagnosis of multicystic dysplastic kidney was confirmed by a combination of ultrasonography and radionuclide scan. Voiding cystourethrogram study in 31 patients were done to determine the condition of the contalateral kidney. Restllts: $84\%$ of the patients were diagnosed before birth by antenatal ultrasonography Clinical manifestations of children with postnatal diagnoses were palpable abdominal mass($3.5\%$), abdominal distension($17\%$), and incidental($10.5\%$). The abnormalities in contralateral kidney were hydronephrosis($21\%$), compensatory hypertrophy($12\%$), simple cyst($2\%$), bifid pelvis($2\%$). Surgical management was performed in 20 patients($35\%$) due to recurrent infection, for diagnostic purpose to differentiate from malignancy and abdominal distention. Follow-up in the remaining 37 patients continued (mean 18 months) and results of sonogram findings were involution change in 23 patients($40\%$) and no interval changes in 13 patient($23\%$). Conclusions : The apparent tendency to regression of the dysplastic kidney and no difference in the number of complications justify a conservative management rather than operative intervention except in associated severe complications such as urinary tract infection or rupture of cysts.

• Clinical and Experimental Pediatrics
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• v.46 no.7
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• pp.687-694
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• 2003

Purpose : Regeneration and repair after ischemic renal injury appears to be modulated by circulating or locally produced growth factors. This study examined the changes of serum insulin like growth factor(IGF-I) and renal expression of IGF-I and II, vascular endothelial growth factor(VEGF), transforming growth $factor-{\beta}$($TGF-{\beta}$), and connective tissue growth factor(CTGF) during the active regeneration period after acute ischemic injury. Methods : Sera and kidney tissue samples(whole kidney, cortex, outer medullae and inner medullae) were obtained before and after one, three, five and seven days of 40 minutes bilateral renal pedicle clamping. Acute renal failure was assessed by measuring the concentration of serum creatinine. Serum IGF-I level was measured by radioimmunoassay. The mRNA expression in kidney was measured by RT-PCR. The distribution of IGF-I and CTGF was detected by immunohistochemistry. Resuts : Serum IGF-I concentration after one day following acute ischemic renal injury was significantly decreased compared to preischemic value. The mRNA levels of IGF-I, IGF-II, $TGF-{\beta}1$ and VEGF in whole kidney were temporally decreased on day one of ischemic injury. IGF-I and IGF-II expressions in outer medullae were significantly decreased on day one after ischemic injury. $TGF-{\beta}1$, CTGF and VEGF expressions were markedly decreased in medullae after one day of ischemic injury compared to other kidney sections. IGF-I was markedly decreased in cortical tubules on day one of uremic rat. CTGF was markedly increased on tubule within three days of ischemic injury. Conclusion : These findings suggest that IGFs, $TGF-{\beta}1$ and CTGF may involve in the pathogenesis or the recovery from acute ischemic renal injury.

• Investigative Magnetic Resonance Imaging
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• v.17 no.1
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• pp.19-25
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• 2013

Purpose : Renal blood oxygen level-dependent (BOLD) MRI has been used in the evaluation of renal oxygenation. We tried to provide the normal $R2^*$ value of the human kidney with 3.0 T, and evaluated the differences in $R2^*$ values according to gender and location. Materials and Methods: Twenty-four healthy volunteers underwent BOLD MRI at 3.0 T. Multi gradient echo-echo planar imaging sequence with seventeen echoes was used. After generation of the $T2^*$ map, the $R2^*$ was calculated. The statistical differences in $R2^*$ values between the cortex and medulla, males and females, and the right and left kidney were analyzed. The regional differences of $R2^*$ within the both kidneys were evaluated respectively. Results: BOLD MRI was successful in all participants. No gross artifact interfered with $R2^*$ measurement. The mean $R2^*$ at 3.0 T was $17.1{\pm}2.60s^{-1}$ in the cortex and $27.7{\pm}4.83s^{-1}$ in the medulla (p < 0.001). The $R2^*$ value in the medulla was significantly higher in the male than female volunteers (p = 0.025). There were no statistical differences of $R2^*$ according to the side and location in the kidney (p = 0.197). Conclusion: Renal BOLD MRI can be efficiently performed with 3.0 T MRI. Renal medullary hypoxia is present in normal volunteers. Our results may be used as reference values in the evaluation of pathologic conditions using BOLD MRI.