• Clinical and Experimental Pediatrics
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• v.46 no.7
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• pp.687-694
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• 2003

Purpose : Regeneration and repair after ischemic renal injury appears to be modulated by circulating or locally produced growth factors. This study examined the changes of serum insulin like growth factor(IGF-I) and renal expression of IGF-I and II, vascular endothelial growth factor(VEGF), transforming growth $factor-{\beta}$($TGF-{\beta}$), and connective tissue growth factor(CTGF) during the active regeneration period after acute ischemic injury. Methods : Sera and kidney tissue samples(whole kidney, cortex, outer medullae and inner medullae) were obtained before and after one, three, five and seven days of 40 minutes bilateral renal pedicle clamping. Acute renal failure was assessed by measuring the concentration of serum creatinine. Serum IGF-I level was measured by radioimmunoassay. The mRNA expression in kidney was measured by RT-PCR. The distribution of IGF-I and CTGF was detected by immunohistochemistry. Resuts : Serum IGF-I concentration after one day following acute ischemic renal injury was significantly decreased compared to preischemic value. The mRNA levels of IGF-I, IGF-II, $TGF-{\beta}1$ and VEGF in whole kidney were temporally decreased on day one of ischemic injury. IGF-I and IGF-II expressions in outer medullae were significantly decreased on day one after ischemic injury. $TGF-{\beta}1$, CTGF and VEGF expressions were markedly decreased in medullae after one day of ischemic injury compared to other kidney sections. IGF-I was markedly decreased in cortical tubules on day one of uremic rat. CTGF was markedly increased on tubule within three days of ischemic injury. Conclusion : These findings suggest that IGFs, $TGF-{\beta}1$ and CTGF may involve in the pathogenesis or the recovery from acute ischemic renal injury.

• Childhood Kidney Diseases
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• v.15 no.2
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• pp.107-115
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• 2011

Acute kidney injury (AKI) is associated with mortality and may lead to increased medical expense. A modified criteria (pediatric RIFLE [pRIFLE]: Risk, Injury, Failure, Loss, and End-stage renal disease) has been proposed to standardize the definition of AKI. The common causes of AKI are renal ischemia, nephrotoxic medications, and sepsis. A majority of critically ill children develop AKI by the pRIFLE criteria and need to receive intensive care early in the course of AKI. Factors influencing patient survival (pediatric intensive care unit discharge) are known to be low blood pressure at the onset of renal replacement therapy (RRT), the use of vasoactive pressors during RRT, and the degrees of fluid overload at the initiation of RRT. Early intervention of continuous RRT (CRRT) has been introduced to reduce mortality and fluid overload that affects poor prognosis in patients with AKI. Here, we briefly review the practical prescription of pediatric CRRT and literatures on the outcomes of patients with AKI receiving CRRT and associations among AKI, fluid overload, and CRRT. In conclusion, we suggest that an increased emphasis should be placed on the early initiation of CRRT and fluid overload in the management of pediatric AKI.

• Journal of Veterinary Clinics
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• v.29 no.5
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• pp.372-376
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• 2012

Acute kidney injury (AKI) is a serious problem associated with high morbidity and mortality. Ischemia-reperfusion is an important cause of acute kidney injury. This study was performed to ascertain clinically useful biomarkers for the diagnosis of AKI. In three miniature pigs, AKI were induced by 60 minutes of bilateral renal ischemia by the clamping renal artery. Blood and urine samples were collected from the pigs prior to clamping (baseline) and 0, 1, 3 and 5 days post-clamping. Serum blood urea nitrogen (BUN), creatinine, sodium and uric acid were measured in serum and urine samples. Fractional excretion of sodium ($FE_{Na}$) and fractional excretion of uric acid ($FE_{UA}$) were calculated. Also, interleukin (IL)-6, IL-18, liver type fatty acid binding protein (L-FABP) and glutathione-S-transferase (GST) were detected by Western immunoblotting. Serum BUN and creatinine levels were increased significantly at day 1 post-clamping in all three miniature pigs. However, $FE_{Na}$ and $FE_{UA}$ showed marked individual differences. Western immunoblotting revealed significantly increased levels of IL-6, IL-18, L-FABP and GST in post-ischemic urine, compared to pre-clamping. While more research concerning the variance of $FE_{Na}$ and $FE_{UA}$ is needed, serum BUN, creatinine, IL-6, IL-18, L-FABP and GST may be sensitive urine biomarkers for diagnosis of AKI together with other biomarkers in the porcine ischemia-reperfusion model.

• Childhood Kidney Diseases
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• v.15 no.2
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• pp.101-106
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• 2011

Acute renal failure means that the word does not contain a mild kidney injury. In addition, the criteria for acute renal failure per researcher are different, and it is difficult in interpreting the results of research on acute renal failure. Therefore, rather than acute renal failure, a new term "acute kidney injury" meaning to include all the levels of injury is introduced. In 2002, to diagnose by means of serum creatinine, glomerular filtration rate and urine output, a detailed classification of acute kidney injury, the RIFLE criteria has been proposed. In 2007, the RIFLE criteria by transforming, AKIN criteria has been proposed. The pediatric RIFLE criteria for children has also been proposed. The author reviews here these criteria by comparing them.

• Journal of Korean Orthopaedic Sports Medicine
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• v.11 no.1
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• pp.8-16
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• 2012

With the increase of participation in the sport activities, there has been a commensurate rise in the number of sport injuries. A more commonly encountered injured region in the upper-extremity is the wrist. Sport injuries are often characterized as overuse and traumatic. Traumatic injuries include fractures, dislocations, and ligament tears often seen in contact or collision sports. Overuse injuries, represented damages by a level of repetitive microtrauma sufficient to overwhelm the tissues$^{\circ}{\O}$ ability to adapt, include inflammatory conditions such as De Quervain$^{\circ}{\O}s$ disease, extensor carpi ulnaris tendinitis, intersection syndrome. Also included is a traumatic problem such as stress fractures of the hook of the hamate, subluxation of the extensor carpi ulnaris tendon, chronic scapholunate instabilities, and degenerative triangular fibrocartilage tears. This review will focus on both overuse and traumatic injuries of the wrist in the athletes. A significant emphasis will be placed on the evaluation, pearls and pitfalls of conservative and operative treatments.

• Childhood Kidney Diseases
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• v.18 no.1
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• pp.13-17
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• 2014

Continuous renal replacement therapy (CRRT) has become the preferred dialysis modality to support critically ill children with acute kidney injury. As CRRT technology and clinical practice advances, experiences using CRRT on small infants and neonates have increased. In neonates with hyperammonemia or acute kidney injury during extracorporeal membrane oxygenation (ECMO) therapy, CRRT can be a safe and effective technique. However, there are many limitations of CRRT in neonates, including vascular access, bleeding complications, and lack of neonatespecific devices. This review discusses the basic principles of CRRT and the special considerations when using this technique in neonates and infants.

• 한국신재생에너지학회:학술대회논문집
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• 2007.11a
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• pp.221-223
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• 2007

고분자전해질연료전지의 효율과 수명은 고분자 전해질 막과 밀접하게 관련되어있다. 연료전지 상용화를 위해 내구성과 안정성은 반드시 확보되어야 한다. 본 연구에서는 고분자전해질연료전지용 막전극접합체에 대해서 제작과정, 체결과정 및 운전 중에 발생할 수 있는 물리적 손상이 연료전지에 미치는 영향을 알아보고자 하였다. 실제 고분자전해질연료전지 조건에서 구멍이 생기는 경우를 모사하기 위해 막전극접합체에 다양한 크기 및 형상의 물리적 손상을 형성시켰다. 또한 여러 위치에서의 손상도 비교하였다. 손상시킨 막전극접합체에 대해 단위전지 성능평가와 순환전압전류 실험을 비교 분석하였다. 막전극접합체의 결함이 커질수록 수소기체투과도는 증가하고, OCV와 성능은 감소하였다. 또한 성능과 수소기체투과도는 서로 관련이 있음을 알 수 있었다.

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.493-493
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• 2023

매설배관의 피복손상부 탐측법은 CIPS법, DCVG법 등 여러 방법이 있으며, 그중 우리나라에서는 DCVG법이 가장 많이 사용되고 있다. 피복손상탐측기술(DCVG)은 매설된 관로에 대하여 직류 전류로 인해 배관주변에 발생하는 전위구배를 측정하여 비굴착상태에서 관로의 피복손상부를 찾아내는 기술이다. 본 기술을 광역상수도 정밀안전진단 및 성능평가에 적용하였으며, 탐측된 위치에 대하여 위험도(%IR)를 예측하였다. 또한 손상의심부에 대한 굴착을 통해 피복손상부를 확인하였다. 본 기술의 신뢰성 및 상수도 분야에 큰 활용성을 확인하였다. 관경, 현장여건 등에 따른 조사 및 굴착에 일부 한계점을 보였으나, 향후 축적된 데이터를 바탕으로 매설된 관로의 손상을 사전에 확인하여 관로사고를 미연에 방지할 기술로 판단된다.

• Journal of the Korean Geotechnical Society
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• v.16 no.5
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• pp.129-140
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• 2000

최근들어 핵폐기물 지하처분장을 중심으로 터널굴착에 의한 주변 암반의 손상상태와 암반특성의 변화를 정량적으로 평가하기 위한 시도가 이루어지고 있다. 이는 암반의 지지력을 적극적으로 이용하는 NATM개념에 의해 터널을 시공할 셩우 안정성 해석과 최적 보강설계를 위해 필수적인 사항으로 고려된다. 그러나 현재까지 암반 손상영역을 평가하기 위해 제시된 여러 방법들은 아직까지 그 적용성과 타당성이 충분히 검증되지 못한 실정이다. 이 연구에서는 코어시추, 실험실시험, 발파진동측정, 보어홀 카메라 등의 여러 방법에 의해 손상영역을 정량적으로 평가하고자 하였으며 가 방법의 적용성을 검토하였다. 암반상태 및 발파조건을 달리하여 시험발파를 수행하였으며 발파 후에 터널벽면에 수직하게 시추를 하여 암석코어를 채취한 뒤 손상정도에 따른 암석의 물리적, 역학적 특성들？ 변화를 정량적으로 나타내고자 하였다. 코어 채취후 시축공에 보어홀 카메라를 사용하여 손상영역을 시각적으로 판별하고자 하였으며 발파진동 측정결과로부터 손상영역을 예측하고 채취한 암석시표에 대한 실험실시험 결과와 비교하여 적용성을 검토하였다.

• Journal of the Korea institute for structural maintenance and inspection
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• v.9 no.1
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• pp.243-250
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• 2005

In elevated irrigation aquaducts, one can observe a common damage pattern. That is, cracks, and crushing of concrete are usually repeated at a certain interval even if no faults are found in the design and construction of the structures. To investigate the causes of this damage, longitudinal deformations of several aquaducts have been measured. The analysis of the measured data suggests that the damages are mainly caused by cumulative repetition of extension and contraction due to temperature changes.